Berbamine (dihydrochloride)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0782294
SORBS1 sorbin and SH3 domain containing 1 0.0414242
GNPDA1 glucosamine-6-phosphate deaminase 1 0.036835
ERRFI1 ERBB receptor feedback inhibitor 1 0.0320144
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0308168
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0291896
SCARB1 scavenger receptor class B, member 1 0.0279634
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0259875
LOC112694756 uncharaterized LOC112694756 0.024106
SRRM2 serine/arginine repetitive matrix 2 0.0240784
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0237671
RAD51B RAD51 paralog B 0.0226817
ZMYND8 zinc finger, MYND-type containing 8 0.0223062
NKD1 naked cuticle homolog 1 (Drosophila) 0.0216924
TC2N tandem C2 domains, nuclear 0.0209057
ABHD2 abhydrolase domain containing 2 0.0206353
EFHD2 EF-hand domain family, member D2 0.0206312
SH3PXD2A SH3 and PX domains 2A 0.0204482
ALPK1 alpha-kinase 1 0.0199878
RNF149 ring finger protein 149 0.0199369
BCLAF1 BCL2-associated transcription factor 1 0.0198389
ARRDC3 arrestin domain containing 3 0.0197852
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0191258
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.01908
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.018903
KIF16B kinesin family member 16B 0.0183732
STK39 serine threonine kinase 39 0.0179876
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0174632
STYXL2 serine/threonine/tyrosine interacting like 2 0.0174036
EIF4H eukaryotic translation initiation factor 4H 0.0172594
IGF1R insulin-like growth factor 1 receptor 0.0171694
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0171574
DYNC2I1 dynein 2 intermediate chain 1 0.01693
PTBP3 polypyrimidine tract binding protein 3 0.0161392
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.0156791
GRK3 G protein-coupled receptor kinase 3 0.0154558
ZNF395 zinc finger protein 395 0.0154227
SERINC5 serine incorporator 5 0.0154225
USP54 ubiquitin specific peptidase 54 0.0153153
CORIN corin, serine peptidase 0.0152874
PADI1 peptidyl arginine deiminase, type I 0.0151077
CEMIP2 cell migration inducing hyaluronidase 2 0.0147782
PCED1B PC-esterase domain containing 1B 0.0144168
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0140878
MUC13 mucin 13, cell surface associated 0.0140727
KCTD3 potassium channel tetramerization domain containing 3 0.0140643
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0138456
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0138409
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0137541
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0136623
MYH9 myosin, heavy chain 9, non-muscle 0.0135219
HGD homogentisate 1,2-dioxygenase 0.0134476
MEIS2 Meis homeobox 2 0.0134322
SP3 Sp3 transcription factor 0.0134186
PDZD8 PDZ domain containing 8 0.0134067
NUMA1 nuclear mitotic apparatus protein 1 0.0133594
AFF1 AF4/FMR2 family, member 1 0.01329
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.013226
KIF2A kinesin heavy chain member 2A 0.0131883
ENOSF1 enolase superfamily member 1 0.0131719
NCOR2 nuclear receptor corepressor 2 0.0131676
FOSL2 FOS-like antigen 2 0.0129293
JUP junction plakoglobin 0.0128749
MYO7B myosin VIIB 0.0128635
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0127413
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0126585
WDR45B WD repeat domain 45B 0.0125711
MSI2 musashi RNA-binding protein 2 0.0124696
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.012446
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0123823
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0122826
APOL2 apolipoprotein L, 2 0.0119194
CLMN calmin (calponin-like, transmembrane) 0.0116413
STEAP3 STEAP family member 3, metalloreductase 0.0116344
MYO10 myosin X 0.0114335
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0113174
OCLN occludin 0.0112865
TMEM63A transmembrane protein 63A 0.0112838
OASL 2'-5'-oligoadenylate synthetase-like 0.0112165
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0112164
YEATS2 YEATS domain containing 2 0.0110463
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0109632
SPATA6L spermatogenesis associated 6-like 0.0109531
GAK cyclin G associated kinase 0.0109455
NEK6 NIMA-related kinase 6 0.0106884
DNM2 dynamin 2 0.0106695
SYTL3 synaptotagmin-like 3 0.0105561
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0104511
GUCD1 guanylyl cyclase domain containing 1 0.0103292
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.010311
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0102799
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0102417
DAPK2 death-associated protein kinase 2 0.0102249
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0101955
TMEM245 transmembrane protein 245 0.0101919
MPRIP myosin phosphatase Rho interacting protein 0.010158
CCNL1 cyclin L1 0.0101459
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0100542
SLC22A23 solute carrier family 22, member 23 0.00995177
DERA deoxyribose-phosphate aldolase (putative) 0.00985311

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.221094
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.206317
TPT1 tumor protein, translationally-controlled 1 -0.206169
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.173205
B2M beta-2-microglobulin -0.154811
UBC ubiquitin C -0.141305
LCN2 lipocalin 2 -0.129855
PTMA prothymosin, alpha -0.112062
ENO1 enolase 1, (alpha) -0.0830859
HLA-B major histocompatibility complex, class I, B -0.0812115
CANX calnexin -0.0790861
LMO7 LIM domain 7 -0.0767509
TMSB10 thymosin beta 10 -0.0756479
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0743413
FTL ferritin, light polypeptide -0.0705349
JUN jun proto-oncogene -0.0661537
PKM pyruvate kinase, muscle -0.0636106
CALR calreticulin -0.0634011
RPL23 ribosomal protein L23 -0.062616
PERP PERP, TP53 apoptosis effector -0.0620999
IFI6 interferon, alpha-inducible protein 6 -0.0612985
PDIA3 protein disulfide isomerase family A, member 3 -0.0603767
GCLC glutamate-cysteine ligase, catalytic subunit -0.0599336
RPS6 ribosomal protein S6 -0.0593099
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0588392
PDIA4 protein disulfide isomerase family A, member 4 -0.0570939
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0540595
INTS6 integrator complex subunit 6 -0.0540438
AHNAK AHNAK nucleoprotein -0.0512943
SP100 SP100 nuclear antigen -0.0511019
AHI1 Abelson helper integration site 1 -0.0509479
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0504728
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0503261
EPCAM epithelial cell adhesion molecule -0.0492477
VMP1 vacuole membrane protein 1 -0.0482375
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0474789
TTC3 tetratricopeptide repeat domain 3 -0.0469983
GOLGB1 golgin B1 -0.0462106
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0457188
PGK1 phosphoglycerate kinase 1 -0.0454615
EIF1 eukaryotic translation initiation factor 1 -0.0450507
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.044452
RPS8 ribosomal protein S8 -0.0443555
RPL12 ribosomal protein L12 -0.0434715
WSB1 WD repeat and SOCS box containing 1 -0.0432979
AKAP13 A kinase (PRKA) anchor protein 13 -0.0426381
RNF213 ring finger protein 213 -0.0420714
RAB7A RAB7A, member RAS oncogene family -0.041291
RPS27A ribosomal protein S27a -0.039502
LYZ lysozyme -0.0394829
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0391303
TM4SF1 transmembrane 4 L six family member 1 -0.0387246
RPL19 ribosomal protein L19 -0.0386514
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0377885
RPL26 ribosomal protein L26 -0.0377826
FNDC3B fibronectin type III domain containing 3B -0.037751
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0377236
MAP7 microtubule-associated protein 7 -0.0372456
RRBP1 ribosome binding protein 1 -0.0372053
SPAG9 sperm associated antigen 9 -0.0368778
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0364548
RIGI RNA sensor RIG-I -0.0364467
RPS24 ribosomal protein S24 -0.0362437
RPLP1 ribosomal protein, large, P1 -0.0357907
EGR1 early growth response 1 -0.0356838
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0352179
RPS3 ribosomal protein S3 -0.03521
ACBD3 acyl-CoA binding domain containing 3 -0.0348865
GOLGA4 golgin A4 -0.0346179
MX2 MX dynamin-like GTPase 2 -0.0340481
ASPH aspartate beta-hydroxylase -0.0340088
TM9SF2 transmembrane 9 superfamily member 2 -0.0338302
TJP1 tight junction protein 1 -0.0337946
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0333793
S100A10 S100 calcium binding protein A10 -0.0330137
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0326247
FNDC3A fibronectin type III domain containing 3A -0.0325706
COPB1 coatomer protein complex, subunit beta 1 -0.0319201
LDHA lactate dehydrogenase A -0.0315721
MYO1E myosin IE -0.031505
H1-0 H1.0 linker histone -0.0313237
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0311619
XAF1 XIAP associated factor 1 -0.0311561
S100A6 S100 calcium binding protein A6 -0.0310944
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0310211
NAMPT nicotinamide phosphoribosyltransferase -0.0309637
MORF4L2 mortality factor 4 like 2 -0.0303851
EXT1 exostosin glycosyltransferase 1 -0.0303698
ARHGAP5 Rho GTPase activating protein 5 -0.030318
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0303026
MT2A metallothionein 2A -0.0302697
RPS19 ribosomal protein S19 -0.0302099
HM13 histocompatibility (minor) 13 -0.0297161
TMEM87A transmembrane protein 87A -0.0296111
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0296088
STAU1 staufen double-stranded RNA binding protein 1 -0.0294786
RPL37A ribosomal protein L37a -0.0293641
TMC5 transmembrane channel-like 5 -0.0292099
ZC3H13 zinc finger CCCH-type containing 13 -0.0291461
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0291048