Berbamine (dihydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.149274
IGFBP3 insulin-like growth factor binding protein 3 0.118471
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.107069
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0954015
PRELID2 PRELI domain containing 2 0.0842851
PLEC plectin 0.0779794
ERRFI1 ERBB receptor feedback inhibitor 1 0.0708125
FNDC3B fibronectin type III domain containing 3B 0.0671072
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0664989
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0656982
PAX8 paired box 8 0.0645606
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0614475
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0614132
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0607014
PSD3 pleckstrin and Sec7 domain containing 3 0.0569732
LIMCH1 LIM and calponin homology domains 1 0.0568363
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0546971
CCND1 cyclin D1 0.0525533
RAD51B RAD51 paralog B 0.0522613
FHIT fragile histidine triad 0.0515541
ANXA2 annexin A2 0.0506674
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0475411
HELZ helicase with zinc finger 0.0473475
EGFR epidermal growth factor receptor 0.0446606
FLNA filamin A, alpha 0.0430056
CDCP1 CUB domain containing protein 1 0.0406484
RUNX1 runt-related transcription factor 1 0.0396571
KRT19 keratin 19, type I 0.0380999
CD44 CD44 molecule (Indian blood group) 0.0378391
HMGA1 high mobility group AT-hook 1 0.0369254
TPM4 tropomyosin 4 0.0368647
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0361661
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0358592
ZFHX3 zinc finger homeobox 3 0.0351397
DIAPH2 diaphanous-related formin 2 0.0349848
LPP LIM domain containing preferred translocation partner in lipoma 0.0337372
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0331639
VCAN versican 0.0330324
FLNB filamin B, beta 0.0328299
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0327173
ADAM10 ADAM metallopeptidase domain 10 0.032465
PDGFC platelet derived growth factor C 0.0319366
ZFP36L1 ZFP36 ring finger protein-like 1 0.0313652
SEPTIN9 septin 9 0.031233
TNIK TRAF2 and NCK interacting kinase 0.0312055
TMEM245 transmembrane protein 245 0.0305054
FMNL2 formin-like 2 0.0303661
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 0.02941
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0288081
ITGA6 integrin, alpha 6 0.0284435
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0281854
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.0279074
MYOF myoferlin 0.0278066
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0277427
YEATS2 YEATS domain containing 2 0.0277173
AKAP12 A kinase (PRKA) anchor protein 12 0.0272045
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0270981
WWOX WW domain containing oxidoreductase 0.0268911
NUP58 nucleoporin 58 0.0268843
ARHGAP29 Rho GTPase activating protein 29 0.0266665
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0264305
TBC1D5 TBC1 domain family, member 5 0.0260964
NEK6 NIMA-related kinase 6 0.0259405
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.025653
INSIG2 insulin induced gene 2 0.0255511
HMGA2 high mobility group AT-hook 2 0.0254132
THSD4 thrombospondin, type I, domain containing 4 0.0252394
ARFGEF3 ARFGEF family member 3 0.0249694
MACC1 metastasis associated in colon cancer 1 0.0249291
VDAC1 voltage-dependent anion channel 1 0.0249261
KPNB1 karyopherin (importin) beta 1 0.0248708
FDPS farnesyl diphosphate synthase 0.0247368
DLC1 DLC1 Rho GTPase activating protein 0.0244349
SREBF2 sterol regulatory element binding transcription factor 2 0.0243529
ESYT2 extended synaptotagmin-like protein 2 0.0242928
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0240806
AGRN agrin 0.0240537
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0239753
BCLAF1 BCL2-associated transcription factor 1 0.0236168
UBASH3B ubiquitin associated and SH3 domain containing B 0.0235141
CAPN2 calpain 2, (m/II) large subunit 0.0234156
ANLN anillin, actin binding protein 0.0232777
CDK19 cyclin-dependent kinase 19 0.0231535
INSIG1 insulin induced gene 1 0.0230844
SMYD3 SET and MYND domain containing 3 0.0230693
HSPG2 heparan sulfate proteoglycan 2 0.0228953
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0227629
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0224917
TBC1D22A TBC1 domain family, member 22A 0.0224409
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.022354
OSBPL10 oxysterol binding protein-like 10 0.0222944
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.0221388
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0221325
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0218534
DIAPH3 diaphanous-related formin 3 0.0218206
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0217879
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0217165
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0215711
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0213751
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0213561

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.139778
RPS27A ribosomal protein S27a -0.13342
UBC ubiquitin C -0.100291
RPL23 ribosomal protein L23 -0.0993444
B2M beta-2-microglobulin -0.0976603
RPS8 ribosomal protein S8 -0.0968073
FTL ferritin, light polypeptide -0.0959157
APP amyloid beta (A4) precursor protein -0.0953487
EEF2 eukaryotic translation elongation factor 2 -0.0938807
TPT1 tumor protein, translationally-controlled 1 -0.0928529
PTMA prothymosin, alpha -0.0915774
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0840309
RPL31 ribosomal protein L31 -0.0825675
RPS19 ribosomal protein S19 -0.0778517
RPL26 ribosomal protein L26 -0.0738434
RPS3 ribosomal protein S3 -0.0725463
RPL19 ribosomal protein L19 -0.0695934
RPS12 ribosomal protein S12 -0.0669927
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0654379
SET SET nuclear proto-oncogene -0.0630831
RPL12 ribosomal protein L12 -0.0597084
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0575968
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0555138
RACK1 receptor for activated C kinase 1 -0.0549531
RPL37A ribosomal protein L37a -0.0529761
RPL18 ribosomal protein L18 -0.0519672
RPLP2 ribosomal protein, large, P2 -0.0511097
NAP1L1 nucleosome assembly protein 1-like 1 -0.0503607
EEF1G eukaryotic translation elongation factor 1 gamma -0.0492397
AHNAK AHNAK nucleoprotein -0.0489357
RPL28 ribosomal protein L28 -0.0480798
RBM25 RNA binding motif protein 25 -0.0477142
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.047347
RPL13A ribosomal protein L13a -0.0469713
RPLP1 ribosomal protein, large, P1 -0.0465015
TMSB4X thymosin beta 4, X-linked -0.0462623
RPS29 ribosomal protein S29 -0.0453209
RPS17 ribosomal protein S17 -0.0444246
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0442397
RPS5 ribosomal protein S5 -0.0421074
RPS6 ribosomal protein S6 -0.0419839
RPL35 ribosomal protein L35 -0.0411259
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0407311
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0402881
RPL32 ribosomal protein L32 -0.0402538
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.039763
RPL5 ribosomal protein L5 -0.039668
RPL9 ribosomal protein L9 -0.0392413
RPS16 ribosomal protein S16 -0.0387718
RPL36 ribosomal protein L36 -0.0384839
YBX1 Y box binding protein 1 -0.0383538
CANX calnexin -0.0378636
EIF1 eukaryotic translation initiation factor 1 -0.0369706
RPL4 ribosomal protein L4 -0.0364327
RPS27 ribosomal protein S27 -0.0364166
GOLGA4 golgin A4 -0.0363012
TOP2B topoisomerase (DNA) II beta 180kDa -0.036293
SQSTM1 sequestosome 1 -0.0350278
RPS14 ribosomal protein S14 -0.0343744
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0343678
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0340935
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0335912
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0334232
KDM3A lysine (K)-specific demethylase 3A -0.0329642
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0327114
TXNRD1 thioredoxin reductase 1 -0.0325184
RPL38 ribosomal protein L38 -0.0322711
SDC4 syndecan 4 -0.0321741
RPL37 ribosomal protein L37 -0.0319994
TPR translocated promoter region, nuclear basket protein -0.0315633
RPL7 ribosomal protein L7 -0.031047
ENO1 enolase 1, (alpha) -0.0305888
OGA O-GlcNAcase -0.0301487
CCNL1 cyclin L1 -0.0299841
RPL30 ribosomal protein L30 -0.0294351
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0293808
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0291916
ANKRD28 ankyrin repeat domain 28 -0.0291865
RPL7A ribosomal protein L7a -0.0291486
SEPTIN7 septin 7 -0.028903
SKP1 S-phase kinase-associated protein 1 -0.0288799
RANBP2 RAN binding protein 2 -0.0279098
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0274521
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0273752
RPL34 ribosomal protein L34 -0.0273674
PAPOLA poly(A) polymerase alpha -0.0271425
AHI1 Abelson helper integration site 1 -0.0271265
RPL14 ribosomal protein L14 -0.0267999
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0266281
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0264443
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0263726
RPS11 ribosomal protein S11 -0.0263238
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0261939
BHLHE40 basic helix-loop-helix family, member e40 -0.0260821
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0255983
WWC1 WW and C2 domain containing 1 -0.0255248
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0254305
PDIA4 protein disulfide isomerase family A, member 4 -0.0254134
SENP5 SUMO1/sentrin specific peptidase 5 -0.0253697
SRRM1 serine/arginine repetitive matrix 1 -0.0253088