Berbamine (dihydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0920587
GCLC glutamate-cysteine ligase, catalytic subunit 0.0302946
VEGFA vascular endothelial growth factor A 0.0298112
FAM13A family with sequence similarity 13, member A 0.0291201
TNS1 tensin 1 0.0179134
ARF4 ADP-ribosylation factor 4 0.017166
DYNC2I1 dynein 2 intermediate chain 1 0.0132527
ERRFI1 ERBB receptor feedback inhibitor 1 0.0130661
ITPKC inositol-trisphosphate 3-kinase C 0.0129172
DSPP dentin sialophosphoprotein 0.012544
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 0.0112038
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0104499
SRRM2 serine/arginine repetitive matrix 2 0.00988753
JUP junction plakoglobin 0.0097171
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.00946004
AKR1C1 aldo-keto reductase family 1, member C1 0.00930952
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.00913818
GRAMD1B GRAM domain containing 1B 0.00903985
VIM vimentin 0.00898881
DDIT4 DNA-damage-inducible transcript 4 0.00889514
FAM162A family with sequence similarity 162, member A 0.00888677
SPIRE1 spire-type actin nucleation factor 1 0.00886706
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00882082
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.00848941
MIDEAS mitotic deacetylase associated SANT domain protein 0.00845781
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00835846
MT2A metallothionein 2A 0.00835546
CCNL1 cyclin L1 0.00830498
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00828337
NUCB2 nucleobindin 2 0.00813233
MKRN1 makorin ring finger protein 1 0.0081187
ABHD2 abhydrolase domain containing 2 0.0080421
GOLGA2 golgin A2 0.00788932
FTH1 ferritin, heavy polypeptide 1 0.00774208
OPTN optineurin 0.0076607
FOSL1 FOS-like antigen 1 0.00760953
CA9 carbonic anhydrase IX 0.00760953
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.00747073
TRIM31 tripartite motif containing 31 0.00745696
IGFBP3 insulin-like growth factor binding protein 3 0.00738268
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.00731208
MXI1 MAX interactor 1, dimerization protein 0.00705704
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.00698712
HILPDA hypoxia inducible lipid droplet-associated 0.00696854
EPS8L1 EPS8-like 1 0.00685442
CDH13 cadherin 13 0.00680487
ZNF395 zinc finger protein 395 0.00676273
CCNY cyclin Y 0.0067097
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.00669706
GRB10 growth factor receptor-bound protein 10 0.00660077
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.00659724
PER2 period circadian clock 2 0.00644966
PLAUR plasminogen activator, urokinase receptor 0.00640637
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.00626285
BACE2 beta-site APP-cleaving enzyme 2 0.00623374
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.00621804
CPAP centrosome assembly and centriole elongation protein 0.00617827
RAB6A RAB6A, member RAS oncogene family 0.00617121
MYRF myelin regulatory factor 0.00611469
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.00608819
HGD homogentisate 1,2-dioxygenase 0.00598153
RPL21 ribosomal protein L21 0.00592359
KIF16B kinesin family member 16B 0.0058811
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.00583562
PTGR1 prostaglandin reductase 1 0.00579104
TCP11L2 t-complex 11, testis-specific-like 2 0.00566184
ANXA1 annexin A1 0.005618
MIMS1 mitochondrial inner membrane scaffold 1 0.0056157
TOGARAM1 TOG array regulator of axonemal microtubules 1 0.00555702
USP6NL USP6 N-terminal like 0.00552389
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.00541717
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.00540789
HOXB6 homeobox B6 0.00540523
EFNA1 ephrin-A1 0.00539444
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 0.00533768
TSC22D4 TSC22 domain family, member 4 0.00523884
CDK11A cyclin-dependent kinase 11A 0.00523559
PDGFC platelet derived growth factor C 0.00522955
RBMS3 RNA binding motif, single stranded interacting protein 3 0.00522908
TMEM260 transmembrane protein 260 0.00522041
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.00520713
WEE1 WEE1 G2 checkpoint kinase 0.00518838
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.00515008
TJP3 tight junction protein 3 0.00514486
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00514087
ESYT2 extended synaptotagmin-like protein 2 0.00511662
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.00509764
RAB5B RAB5B, member RAS oncogene family 0.00509481
ASS1 argininosuccinate synthase 1 0.00505372
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 0.00504291
MBD6 methyl-CpG binding domain protein 6 0.00502938
CGN cingulin 0.00502407
NXPH4 neurexophilin 4 0.00501986
MSN moesin 0.00501781
C1ORF21 chromosome 1 open reading frame 21 0.00500315
SDCBP2 syndecan binding protein (syntenin) 2 0.00497363
ANXA3 annexin A3 0.00496234
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00495597
MMP12 matrix metallopeptidase 12 0.00493455
AKR1C3 aldo-keto reductase family 1, member C3 0.00492087

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.190029
TPT1 tumor protein, translationally-controlled 1 -0.159772
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.134418
EXT1 exostosin glycosyltransferase 1 -0.122521
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.119018
PTMA prothymosin, alpha -0.11431
UBC ubiquitin C -0.111572
RPL23 ribosomal protein L23 -0.0959253
AHNAK AHNAK nucleoprotein -0.0923086
TMSB10 thymosin beta 10 -0.0919403
RPS27A ribosomal protein S27a -0.0801421
SMAD3 SMAD family member 3 -0.0797767
PDIA4 protein disulfide isomerase family A, member 4 -0.0761378
RAD21 RAD21 homolog (S. pombe) -0.0731049
KRT8 keratin 8, type II -0.0729748
ACTG1 actin gamma 1 -0.0721867
RPLP1 ribosomal protein, large, P1 -0.071904
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0714446
ACTN4 actinin, alpha 4 -0.0693336
RPS8 ribosomal protein S8 -0.0681197
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0673083
TJP1 tight junction protein 1 -0.0646379
FTL ferritin, light polypeptide -0.0641284
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0622939
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0618324
CTNND1 catenin (cadherin-associated protein), delta 1 -0.06174
RPS6 ribosomal protein S6 -0.0607726
MYH14 myosin, heavy chain 14, non-muscle -0.0593688
RPS24 ribosomal protein S24 -0.0584486
S100A10 S100 calcium binding protein A10 -0.0576194
LAMA4 laminin, alpha 4 -0.0558054
RPLP2 ribosomal protein, large, P2 -0.0537957
RPS19 ribosomal protein S19 -0.0536592
RPS11 ribosomal protein S11 -0.0520219
RPS5 ribosomal protein S5 -0.0514459
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0504124
RAB7A RAB7A, member RAS oncogene family -0.0498341
SLC45A4 solute carrier family 45, member 4 -0.0494933
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0491993
RPS3 ribosomal protein S3 -0.0484738
RPL28 ribosomal protein L28 -0.0479154
MYO1E myosin IE -0.0478689
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0474891
VMP1 vacuole membrane protein 1 -0.0468652
RPS16 ribosomal protein S16 -0.0467302
CANX calnexin -0.0464789
PDIA3 protein disulfide isomerase family A, member 3 -0.0456395
PTK2 protein tyrosine kinase 2 -0.0456325
JUN jun proto-oncogene -0.0453136
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0435961
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0435384
ENO1 enolase 1, (alpha) -0.0434735
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0429152
TRAPPC9 trafficking protein particle complex 9 -0.0425317
RPS21 ribosomal protein S21 -0.0421017
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0419813
RPLP0 ribosomal protein, large, P0 -0.0419517
RPS25 ribosomal protein S25 -0.041872
EEF2 eukaryotic translation elongation factor 2 -0.0416349
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0415038
RPL34 ribosomal protein L34 -0.0411882
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0408661
RPS13 ribosomal protein S13 -0.0408109
ANKRD11 ankyrin repeat domain 11 -0.0402603
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0395104
ANKRD12 ankyrin repeat domain 12 -0.0394959
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0389067
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0387852
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0383986
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0381919
RPS23 ribosomal protein S23 -0.0381759
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0379883
S100A6 S100 calcium binding protein A6 -0.0377536
RPL12 ribosomal protein L12 -0.0377365
VCL vinculin -0.037677
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.03756
RPL8 ribosomal protein L8 -0.0368391
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0366221
RAB1A RAB1A, member RAS oncogene family -0.0365933
PCBP2 poly(rC) binding protein 2 -0.0364942
RPL11 ribosomal protein L11 -0.0364539
FNDC3B fibronectin type III domain containing 3B -0.036392
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0362531
TRIB1 tribbles pseudokinase 1 -0.0359296
OGA O-GlcNAcase -0.035353
LMO7 LIM domain 7 -0.0352752
ASPH aspartate beta-hydroxylase -0.0352733
RPL31 ribosomal protein L31 -0.0351812
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0348696
GMDS GDP-mannose 4,6-dehydratase -0.0345016
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0342632
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0341217
TOP1 topoisomerase (DNA) I -0.0339025
LOC102724023 ES1 protein homolog, mitochondrial -0.0332364
ATAD2 ATPase family, AAA domain containing 2 -0.0331861
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0330249
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0327783
NTN4 netrin 4 -0.0327731
RPL35A ribosomal protein L35a -0.0327514
AKAP13 A kinase (PRKA) anchor protein 13 -0.0326791