Berbamine (dihydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.180064
FLNB filamin B, beta 0.160344
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.157171
TIMP3 TIMP metallopeptidase inhibitor 3 0.13594
PODXL podocalyxin-like 0.102807
SLC35F3 solute carrier family 35, member F3 0.0860546
ITGA6 integrin, alpha 6 0.0773029
DPYD dihydropyrimidine dehydrogenase 0.0756884
LAMA5 laminin, alpha 5 0.0740613
MTSS1 metastasis suppressor 1 0.0737315
HSPG2 heparan sulfate proteoglycan 2 0.0736823
LOC112694756 uncharaterized LOC112694756 0.0718118
SULF1 sulfatase 1 0.0698689
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0684549
KRT6A keratin 6A, type II 0.0680926
NCOR2 nuclear receptor corepressor 2 0.0609563
ANO1 anoctamin 1, calcium activated chloride channel 0.0605627
FLNA filamin A, alpha 0.0601628
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0500805
CEMIP cell migration inducing protein, hyaluronan binding 0.0498645
MPRIP myosin phosphatase Rho interacting protein 0.0486272
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.048113
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0479634
PDLIM5 PDZ and LIM domain 5 0.0478601
ZMIZ1 zinc finger, MIZ-type containing 1 0.0474091
MYH9 myosin, heavy chain 9, non-muscle 0.0454247
BLCAP bladder cancer associated protein 0.045037
RASAL2 RAS protein activator like 2 0.0447263
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0440635
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0435498
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0419783
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0416312
ACTN4 actinin, alpha 4 0.0413913
IGF2 insulin-like growth factor 2 0.0377336
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0376531
MYOF myoferlin 0.0376369
DOK5 docking protein 5 0.0367888
MEGF6 multiple EGF-like-domains 6 0.0358736
AKAP13 A kinase (PRKA) anchor protein 13 0.0356609
BCL2L1 BCL2-like 1 0.0352455
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0347128
DOCK5 dedicator of cytokinesis 5 0.0342773
PALLD palladin, cytoskeletal associated protein 0.0341368
AMOTL1 angiomotin like 1 0.0336345
TSC22D1 TSC22 domain family, member 1 0.0334872
EGFR epidermal growth factor receptor 0.0330667
ARHGAP23 Rho GTPase activating protein 23 0.0329934
UTRN utrophin 0.0328931
TGM2 transglutaminase 2 0.0328417
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0327662
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0324856
COL17A1 collagen, type XVII, alpha 1 0.0324831
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.032092
CMIP c-Maf inducing protein 0.031606
BCAR3 breast cancer anti-estrogen resistance 3 0.0315385
MSN moesin 0.0308622
SLC45A4 solute carrier family 45, member 4 0.0304772
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0299577
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0298879
TNS4 tensin 4 0.0293075
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0288655
ITGB4 integrin, beta 4 0.0287443
FOSL1 FOS-like antigen 1 0.0286751
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0285916
PYGL phosphorylase, glycogen, liver 0.0282991
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0282163
EFHD2 EF-hand domain family, member D2 0.028143
EIF4H eukaryotic translation initiation factor 4H 0.0278414
PLXNA2 plexin A2 0.0278366
F3 coagulation factor III (thromboplastin, tissue factor) 0.0277221
RAD51B RAD51 paralog B 0.027638
RIN2 Ras and Rab interactor 2 0.0275899
MYO10 myosin X 0.0273211
MEF2A myocyte enhancer factor 2A 0.0272798
EPHA2 EPH receptor A2 0.0266557
GRK5 G protein-coupled receptor kinase 5 0.0265569
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0265328
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0256011
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0255952
CSMD2 CUB and Sushi multiple domains 2 0.0253663
MECOM MDS1 and EVI1 complex locus 0.0248387
FLG filaggrin 0.0248072
SOX7 SRY (sex determining region Y)-box 7 0.0247881
EFNA5 ephrin-A5 0.0247498
RCOR1 REST corepressor 1 0.0247341
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0247333
SULF2 sulfatase 2 0.0243909
DPYSL2 dihydropyrimidinase-like 2 0.0243751
NRG1 neuregulin 1 0.0243124
CAPRIN2 caprin family member 2 0.0239551
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0239364
PLAT plasminogen activator, tissue 0.0239312
NIBAN2 niban apoptosis regulator 2 0.0231521
HMGA2 high mobility group AT-hook 2 0.0231118
CYRIB CYFIP related Rac1 interactor B 0.0230202
RPL3 ribosomal protein L3 0.0229641
FOXO1 forkhead box O1 0.022728
CEP250 centrosomal protein 250kDa 0.0226644
VCL vinculin 0.0224485
PCDH1 protocadherin 1 0.0223947

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.198605
NAMPT nicotinamide phosphoribosyltransferase -0.117136
ANXA1 annexin A1 -0.105631
CLU clusterin -0.0984481
TMSB10 thymosin beta 10 -0.0926542
GARS1 glycyl-tRNA synthetase 1 -0.0890777
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0846364
MT2A metallothionein 2A -0.0841513
PTMA prothymosin, alpha -0.0818643
RBM39 RNA binding motif protein 39 -0.08083
RPS21 ribosomal protein S21 -0.0714139
TPT1 tumor protein, translationally-controlled 1 -0.0690002
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0685928
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0671285
SQSTM1 sequestosome 1 -0.0644336
GOLGA4 golgin A4 -0.0623218
KRT17 keratin 17, type I -0.0597643
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0585297
TOP1 topoisomerase (DNA) I -0.0565255
H1-0 H1.0 linker histone -0.055801
IARS1 isoleucyl-tRNA synthetase 1 -0.0555376
CANX calnexin -0.0550738
KDM3A lysine (K)-specific demethylase 3A -0.0544339
DLG1 discs, large homolog 1 (Drosophila) -0.0535899
FNDC3B fibronectin type III domain containing 3B -0.0531252
OGA O-GlcNAcase -0.0526525
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0525013
RPS6 ribosomal protein S6 -0.0523487
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0520162
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0515374
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0510735
FTH1 ferritin, heavy polypeptide 1 -0.0500119
MBNL2 muscleblind-like splicing regulator 2 -0.0482391
TMSB4X thymosin beta 4, X-linked -0.0474555
PGK1 phosphoglycerate kinase 1 -0.0472261
RPS8 ribosomal protein S8 -0.0463071
RPLP1 ribosomal protein, large, P1 -0.0454318
CARS1 cysteinyl-tRNA synthetase 1 -0.0452659
ENO1 enolase 1, (alpha) -0.0449015
YBX3 Y box binding protein 3 -0.0448784
RPS13 ribosomal protein S13 -0.0437102
HLA-B major histocompatibility complex, class I, B -0.0430844
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0420928
COPB1 coatomer protein complex, subunit beta 1 -0.0416494
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0414867
IFI16 interferon, gamma-inducible protein 16 -0.0411159
QKI QKI, KH domain containing, RNA binding -0.0410744
VEGFA vascular endothelial growth factor A -0.0408461
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0404253
SQLE squalene epoxidase -0.040313
STC1 stanniocalcin 1 -0.0398309
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0397112
RPLP2 ribosomal protein, large, P2 -0.0384096
SDC4 syndecan 4 -0.0383875
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0371531
RLF rearranged L-myc fusion -0.0367782
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0366318
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0363417
ITCH itchy E3 ubiquitin protein ligase -0.0360728
SLC38A1 solute carrier family 38, member 1 -0.0358785
RB1CC1 RB1-inducible coiled-coil 1 -0.0356527
EIF1 eukaryotic translation initiation factor 1 -0.0355331
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0352741
WASF2 WAS protein family, member 2 -0.0347431
RPL5 ribosomal protein L5 -0.0346232
RPS19 ribosomal protein S19 -0.0344774
RPS27A ribosomal protein S27a -0.0341857
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0340445
NAP1L1 nucleosome assembly protein 1-like 1 -0.0338486
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0336119
COG5 component of oligomeric golgi complex 5 -0.0334094
CD44 CD44 molecule (Indian blood group) -0.0332999
RPS24 ribosomal protein S24 -0.0329945
IER3 immediate early response 3 -0.0326895
ATF4 activating transcription factor 4 -0.0320349
ASPH aspartate beta-hydroxylase -0.0316562
LRRC49 leucine rich repeat containing 49 -0.0309375
RPL32 ribosomal protein L32 -0.0309323
RPL8 ribosomal protein L8 -0.0308074
SUCO SUN domain containing ossification factor -0.0306035
FTL ferritin, light polypeptide -0.0305692
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0301963
DSCAM Down syndrome cell adhesion molecule -0.0299829
BHLHE40 basic helix-loop-helix family, member e40 -0.0297147
UBE2H ubiquitin-conjugating enzyme E2H -0.0296996
S100A10 S100 calcium binding protein A10 -0.0296412
NDRG1 N-myc downstream regulated 1 -0.0295316
YARS1 tyrosyl-tRNA synthetase 1 -0.029493
LDHA lactate dehydrogenase A -0.0294566
MXI1 MAX interactor 1, dimerization protein -0.0294323
RPL12 ribosomal protein L12 -0.0294092
KMT2E lysine (K)-specific methyltransferase 2E -0.0293831
CCNL1 cyclin L1 -0.0292007
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0286846
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0286089
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0283876
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0283031
ZFR zinc finger RNA binding protein -0.0281411
RSL1D1 ribosomal L1 domain containing 1 -0.0277144
RPL19 ribosomal protein L19 -0.0277076