Berbamine (dihydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.11264
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0834353
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0824139
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0667761
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0553557
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0494592
NAV2 neuron navigator 2 0.0493409
LDHA lactate dehydrogenase A 0.0408005
UBA6 ubiquitin-like modifier activating enzyme 6 0.0384606
FNDC3B fibronectin type III domain containing 3B 0.0358766
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0309118
TPM3 tropomyosin 3 0.0307566
DLG1 discs, large homolog 1 (Drosophila) 0.0305132
MMP12 matrix metallopeptidase 12 0.0295088
MYH9 myosin, heavy chain 9, non-muscle 0.029426
PLIN2 perilipin 2 0.0289947
PKM pyruvate kinase, muscle 0.0287715
MYOF myoferlin 0.0280643
DTNA dystrobrevin, alpha 0.0264153
FN1 fibronectin 1 0.0262504
IGFBP3 insulin-like growth factor binding protein 3 0.0257093
RUNX1 runt-related transcription factor 1 0.0255482
MSN moesin 0.0253482
VEGFA vascular endothelial growth factor A 0.0250005
ATXN1 ataxin 1 0.0247089
ENO1 enolase 1, (alpha) 0.0246592
AKAP12 A kinase (PRKA) anchor protein 12 0.024426
RND3 Rho family GTPase 3 0.0243832
PLEC plectin 0.023183
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.02268
KDM2A lysine (K)-specific demethylase 2A 0.0220503
PDE10A phosphodiesterase 10A 0.0220175
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0218244
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0217327
AFAP1 actin filament associated protein 1 0.0213731
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0212678
DST dystonin 0.0210182
ASPH aspartate beta-hydroxylase 0.0209853
EGFR epidermal growth factor receptor 0.0205474
PCBP2 poly(rC) binding protein 2 0.0200772
HPS3 Hermansky-Pudlak syndrome 3 0.0195453
MCL1 myeloid cell leukemia 1 0.0193466
FRMD6 FERM domain containing 6 0.0192193
YEATS2 YEATS domain containing 2 0.0189274
SOD2 superoxide dismutase 2, mitochondrial 0.0188612
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0187981
POTEF POTE ankyrin domain family, member F 0.0186943
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0186539
ERRFI1 ERBB receptor feedback inhibitor 1 0.0186236
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.018592
STC2 stanniocalcin 2 0.0184021
ANXA1 annexin A1 0.0184011
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0183388
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.018284
TNIK TRAF2 and NCK interacting kinase 0.018197
RPL3 ribosomal protein L3 0.0181098
KMT2E lysine (K)-specific methyltransferase 2E 0.0180429
PFKP phosphofructokinase, platelet 0.0180099
APLP2 amyloid beta (A4) precursor-like protein 2 0.0179965
ANO6 anoctamin 6 0.0174928
ADAM9 ADAM metallopeptidase domain 9 0.0173935
LIMCH1 LIM and calponin homology domains 1 0.0171777
SQSTM1 sequestosome 1 0.0171175
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0163528
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0163121
ZEB2 zinc finger E-box binding homeobox 2 0.0162969
PDIA3 protein disulfide isomerase family A, member 3 0.0162737
CENPF centromere protein F, 350/400kDa 0.0162402
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0161247
MIDEAS mitotic deacetylase associated SANT domain protein 0.0160834
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0156948
ZNF292 zinc finger protein 292 0.0156646
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0155014
TOX thymocyte selection-associated high mobility group box 0.0154947
AFF1 AF4/FMR2 family, member 1 0.0153313
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0151282
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0150176
PTPRM protein tyrosine phosphatase, receptor type, M 0.0150172
SDK1 sidekick cell adhesion molecule 1 0.0149786
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0148418
B2M beta-2-microglobulin 0.0147961
ZHX2 zinc fingers and homeoboxes 2 0.0147127
FNIP1 folliculin interacting protein 1 0.0146677
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0146607
KMT2C lysine (K)-specific methyltransferase 2C 0.014593
NDRG1 N-myc downstream regulated 1 0.0145553
ESYT2 extended synaptotagmin-like protein 2 0.0145138
YBX1 Y box binding protein 1 0.0144979
ARRDC3 arrestin domain containing 3 0.0144916
RAI1 retinoic acid induced 1 0.0143528
MYO1B myosin IB 0.0143316
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0142042
KDM6A lysine (K)-specific demethylase 6A 0.0142
SHB Src homology 2 domain containing adaptor protein B 0.0140081
HYOU1 hypoxia up-regulated 1 0.0139983
KTN1 kinectin 1 (kinesin receptor) 0.0138506
PIAS2 protein inhibitor of activated STAT, 2 0.0138274
FHIT fragile histidine triad 0.0137381
PLK2 polo-like kinase 2 0.0137124
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0135892

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.176527
HLA-B major histocompatibility complex, class I, B -0.167295
MT1X metallothionein 1X -0.115445
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.114324
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0946808
FTL ferritin, light polypeptide -0.0882043
EXT1 exostosin glycosyltransferase 1 -0.0820745
TMSB10 thymosin beta 10 -0.0643037
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0642938
CD44 CD44 molecule (Indian blood group) -0.0638501
TPT1 tumor protein, translationally-controlled 1 -0.0537525
FTH1 ferritin, heavy polypeptide 1 -0.0515295
HLA-C major histocompatibility complex, class I, C -0.0486733
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0466359
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0463186
RPL35A ribosomal protein L35a -0.0444671
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0431868
GLIS3 GLIS family zinc finger 3 -0.0412807
CAVIN1 caveolae associated protein 1 -0.040915
DEK DEK proto-oncogene -0.0396542
PTMA prothymosin, alpha -0.0370984
BASP1 brain abundant, membrane attached signal protein 1 -0.0352964
OSMR oncostatin M receptor -0.0348264
RPLP2 ribosomal protein, large, P2 -0.0329308
ACTG1 actin gamma 1 -0.0320287
KPNB1 karyopherin (importin) beta 1 -0.0312362
GNAS GNAS complex locus -0.030847
LOC112694756 uncharaterized LOC112694756 -0.0294193
RPL37 ribosomal protein L37 -0.0270162
IFITM3 interferon induced transmembrane protein 3 -0.0268091
WSB1 WD repeat and SOCS box containing 1 -0.0267123
S100A10 S100 calcium binding protein A10 -0.0266736
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0258584
STAU1 staufen double-stranded RNA binding protein 1 -0.0258253
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0255684
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0252824
HMGB1 high mobility group box 1 -0.0241296
NAMPT nicotinamide phosphoribosyltransferase -0.0230931
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0229886
PGK1 phosphoglycerate kinase 1 -0.0228859
RAB2A RAB2A, member RAS oncogene family -0.0224476
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0220773
RPS6 ribosomal protein S6 -0.0214626
RPL12 ribosomal protein L12 -0.0212533
MYL12B myosin, light chain 12B, regulatory -0.0211669
RPS19 ribosomal protein S19 -0.020877
HLA-A major histocompatibility complex, class I, A -0.0208385
TUBB tubulin, beta class I -0.0205777
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0201915
CTSD cathepsin D -0.0200188
RPS21 ribosomal protein S21 -0.0196533
EIF1 eukaryotic translation initiation factor 1 -0.0196499
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0195259
PRRC2B proline-rich coiled-coil 2B -0.0194564
RRBP1 ribosome binding protein 1 -0.019415
RPL34 ribosomal protein L34 -0.0193427
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0192676
RBM25 RNA binding motif protein 25 -0.019167
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0190348
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0190299
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0190168
RPL26 ribosomal protein L26 -0.0188132
CELF1 CUGBP, Elav-like family member 1 -0.0188029
RPLP1 ribosomal protein, large, P1 -0.0188011
PRRC2C proline-rich coiled-coil 2C -0.0187843
F3 coagulation factor III (thromboplastin, tissue factor) -0.0187124
RAD21 RAD21 homolog (S. pombe) -0.0185736
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0185722
ERBIN erbb2 interacting protein -0.018405
RPL31 ribosomal protein L31 -0.0183551
GOLGA4 golgin A4 -0.0181233
ANKRD10 ankyrin repeat domain 10 -0.0178609
CD59 CD59 molecule, complement regulatory protein -0.0175467
RAP1B RAP1B, member of RAS oncogene family -0.0173803
MARCHF6 membrane associated ring-CH-type finger 6 -0.0172297
LOX lysyl oxidase -0.0168804
TMEM263 transmembrane protein 263 -0.0168401
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.0168058
RPS13 ribosomal protein S13 -0.0167733
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0167197
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.016678
ARF1 ADP-ribosylation factor 1 -0.0166741
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.016631
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0166203
RPL35 ribosomal protein L35 -0.0164455
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0162852
S100A6 S100 calcium binding protein A6 -0.0162518
IER3 immediate early response 3 -0.016224
EIF5B eukaryotic translation initiation factor 5B -0.0161463
AHNAK AHNAK nucleoprotein -0.0160321
SERF2 small EDRK-rich factor 2 -0.0158827
PTPRF protein tyrosine phosphatase, receptor type, F -0.0158689
IFI6 interferon, alpha-inducible protein 6 -0.0157756
VDAC1 voltage-dependent anion channel 1 -0.0157298
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0157024
NALF1 NALCN channel auxiliary factor 1 -0.0156334
RAB7A RAB7A, member RAS oncogene family -0.0154655
RPS24 ribosomal protein S24 -0.0154433
TRIM56 tripartite motif containing 56 -0.0150819
SMC5 structural maintenance of chromosomes 5 -0.0149886