Berbamine (dihydrochloride)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.113952
EFNA5 ephrin-A5 0.0943054
PLEC plectin 0.0385463
FLNA filamin A, alpha 0.0374377
PRKCE protein kinase C, epsilon 0.0363537
SAMD4A sterile alpha motif domain containing 4A 0.0336726
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0319829
LOC112694756 uncharaterized LOC112694756 0.0286834
TRIO trio Rho guanine nucleotide exchange factor 0.0278077
SRRM2 serine/arginine repetitive matrix 2 0.0275547
RUNX1 runt-related transcription factor 1 0.0260553
EXT1 exostosin glycosyltransferase 1 0.0243303
LSAMP limbic system-associated membrane protein 0.0242854
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0221966
PRKG1 protein kinase, cGMP-dependent, type I 0.0212569
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0207013
LIMCH1 LIM and calponin homology domains 1 0.0197751
PHACTR1 phosphatase and actin regulator 1 0.0189648
PRRC2A proline-rich coiled-coil 2A 0.0189112
EEF2 eukaryotic translation elongation factor 2 0.0186389
ZCCHC7 zinc finger, CCHC domain containing 7 0.0181445
MARCHF4 membrane associated ring-CH-type finger 4 0.017612
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0170697
FGFR1 fibroblast growth factor receptor 1 0.0168454
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.016698
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0164636
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0154919
INTS6 integrator complex subunit 6 0.0153933
NBAS neuroblastoma amplified sequence 0.015073
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0149289
YEATS2 YEATS domain containing 2 0.0146108
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0144911
KDM3A lysine (K)-specific demethylase 3A 0.0143164
KDM4B lysine (K)-specific demethylase 4B 0.0140961
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0140746
HOOK2 hook microtubule-tethering protein 2 0.0137737
FMNL2 formin-like 2 0.0136111
WDR45B WD repeat domain 45B 0.0135779
HSPA8 heat shock 70kDa protein 8 0.0134449
CTIF CBP80/20-dependent translation initiation factor 0.0130255
MSI2 musashi RNA-binding protein 2 0.0127267
ZNF638 zinc finger protein 638 0.0126974
MYO10 myosin X 0.0126821
AGO2 argonaute RISC catalytic component 2 0.012551
RPL3 ribosomal protein L3 0.0125343
AEBP2 AE binding protein 2 0.0125125
CFAP251 cilia and flagella associated protein 251 0.0123583
MYH9 myosin, heavy chain 9, non-muscle 0.0123529
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0123421
FLNC filamin C, gamma 0.0123302
EIF4H eukaryotic translation initiation factor 4H 0.0122965
ADAM32 ADAM metallopeptidase domain 32 0.0121572
CCDC200 coiled-coil domain containing 200 0.0121296
RPTOR regulatory associated protein of MTOR, complex 1 0.0121147
PRELID2 PRELI domain containing 2 0.0118819
SAFB2 scaffold attachment factor B2 0.0118237
IRS2 insulin receptor substrate 2 0.0116172
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0115728
PFKP phosphofructokinase, platelet 0.0111216
KLHL29 kelch-like family member 29 0.0109858
ARHGAP32 Rho GTPase activating protein 32 0.0107168
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0105273
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0105016
CTBP2 C-terminal binding protein 2 0.0104469
GRAMD1B GRAM domain containing 1B 0.0102154
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0101987
FOXO3 forkhead box O3 0.0101819
AFDN afadin, adherens junction formation factor 0.0100801
SAMD3 sterile alpha motif domain containing 3 0.0100057
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00976999
TRIM44 tripartite motif containing 44 0.00974167
DOCK1 dedicator of cytokinesis 1 0.0097103
DGKI diacylglycerol kinase, iota 0.00964764
PBX3 pre-B-cell leukemia homeobox 3 0.00962818
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.00955805
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.00932358
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00929945
SDCCAG8 serologically defined colon cancer antigen 8 0.00928964
PDIA5 protein disulfide isomerase family A, member 5 0.0091997
NCOR2 nuclear receptor corepressor 2 0.00907341
BACE2 beta-site APP-cleaving enzyme 2 0.00904796
NTM neurotrimin 0.00899045
KDM4C lysine (K)-specific demethylase 4C 0.00898221
KMT2D lysine (K)-specific methyltransferase 2D 0.00895956
UBE3C ubiquitin protein ligase E3C 0.00888919
CHD7 chromodomain helicase DNA binding protein 7 0.0088822
GNPDA1 glucosamine-6-phosphate deaminase 1 0.00860537
KMT2C lysine (K)-specific methyltransferase 2C 0.00855895
RASA3 RAS p21 protein activator 3 0.00855685
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.00848068
TFRC transferrin receptor 0.00844982
DENND1A DENN/MADD domain containing 1A 0.00828963
EP400 E1A binding protein p400 0.00826632
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.00819422
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.00817665
TIAM2 T-cell lymphoma invasion and metastasis 2 0.00799443
USP34 ubiquitin specific peptidase 34 0.00797504
SND1 staphylococcal nuclease and tudor domain containing 1 0.00791452
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00788524
MPRIP myosin phosphatase Rho interacting protein 0.00771246

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.440661
VIM vimentin -0.333293
AKAP12 A kinase (PRKA) anchor protein 12 -0.142616
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.125356
RPS6 ribosomal protein S6 -0.105531
TMSB10 thymosin beta 10 -0.102109
PTMA prothymosin, alpha -0.0905224
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0676925
ALCAM activated leukocyte cell adhesion molecule -0.064486
RTN4 reticulon 4 -0.063101
TPT1 tumor protein, translationally-controlled 1 -0.0618889
CD44 CD44 molecule (Indian blood group) -0.060808
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0538084
RPLP0 ribosomal protein, large, P0 -0.0520612
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0513583
HMGA1 high mobility group AT-hook 1 -0.049297
VCL vinculin -0.0492575
JMJD1C jumonji domain containing 1C -0.0448602
MMP12 matrix metallopeptidase 12 -0.0437733
ACTG1 actin gamma 1 -0.0432937
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0421371
FTL ferritin, light polypeptide -0.0418289
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0411314
TPM4 tropomyosin 4 -0.0404641
EGR1 early growth response 1 -0.0402261
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0394269
FNDC3B fibronectin type III domain containing 3B -0.0389063
UGCG UDP-glucose ceramide glucosyltransferase -0.0378313
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0376445
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0373246
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0372158
MAP1B microtubule-associated protein 1B -0.0370762
RPS8 ribosomal protein S8 -0.0366119
ELL2 elongation factor, RNA polymerase II, 2 -0.0335765
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0326153
ENO1 enolase 1, (alpha) -0.0322166
TM4SF1 transmembrane 4 L six family member 1 -0.0321116
PKM pyruvate kinase, muscle -0.0316358
LDHA lactate dehydrogenase A -0.0311481
RPS24 ribosomal protein S24 -0.0307361
YBX3 Y box binding protein 3 -0.0304821
RAB7A RAB7A, member RAS oncogene family -0.030472
ANXA2 annexin A2 -0.0304533
ANKRD28 ankyrin repeat domain 28 -0.030375
POTEF POTE ankyrin domain family, member F -0.0300403
RPS25 ribosomal protein S25 -0.0299471
FN1 fibronectin 1 -0.029732
TNNC1 troponin C type 1 (slow) -0.0296872
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0292868
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0292336
RPS23 ribosomal protein S23 -0.0291973
TXNIP thioredoxin interacting protein -0.0291148
AHNAK AHNAK nucleoprotein -0.0287827
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0287473
MT2A metallothionein 2A -0.0280504
RAD21 RAD21 homolog (S. pombe) -0.0279514
IFI16 interferon, gamma-inducible protein 16 -0.0276533
EIF1 eukaryotic translation initiation factor 1 -0.0275073
ERBIN erbb2 interacting protein -0.0272797
EMP1 epithelial membrane protein 1 -0.0270289
RPL23 ribosomal protein L23 -0.0265716
KPNB1 karyopherin (importin) beta 1 -0.0264319
PDE4D phosphodiesterase 4D, cAMP-specific -0.0263018
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.025828
PFN1 profilin 1 -0.0257395
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.025675
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0253995
RPL19 ribosomal protein L19 -0.0253176
RPL8 ribosomal protein L8 -0.025096
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.025016
GPC6 glypican 6 -0.0250145
JUN jun proto-oncogene -0.024886
RPS27A ribosomal protein S27a -0.0247532
KLF6 Kruppel-like factor 6 -0.024572
STC1 stanniocalcin 1 -0.0240956
RPS13 ribosomal protein S13 -0.0236985
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0235425
PGK1 phosphoglycerate kinase 1 -0.0233672
RPL35A ribosomal protein L35a -0.0232506
BTG1 B-cell translocation gene 1, anti-proliferative -0.0231879
TXNRD1 thioredoxin reductase 1 -0.0231322
NAP1L1 nucleosome assembly protein 1-like 1 -0.0229778
CDK17 cyclin-dependent kinase 17 -0.0229662
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0229469
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0228083
FRMD6 FERM domain containing 6 -0.0226607
HAS2 hyaluronan synthase 2 -0.0225574
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0224757
H1-0 H1.0 linker histone -0.0224159
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0223598
RPS19 ribosomal protein S19 -0.0222911
RPLP1 ribosomal protein, large, P1 -0.0222613
RPL12 ribosomal protein L12 -0.0218752
NAMPT nicotinamide phosphoribosyltransferase -0.0218542
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0218261
PTBP3 polypyrimidine tract binding protein 3 -0.0215536
MKI67 marker of proliferation Ki-67 -0.0214659
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0211197
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0210526
CTSB cathepsin B -0.0209155