Berbamine (dihydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAV2 neuron navigator 2 0.0902292
IGFBP3 insulin-like growth factor binding protein 3 0.0893738
GRB10 growth factor receptor-bound protein 10 0.0808959
EIF4H eukaryotic translation initiation factor 4H 0.0630295
SMAD3 SMAD family member 3 0.0626407
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0606619
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0530515
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0515616
NAMPT nicotinamide phosphoribosyltransferase 0.0478128
ZCCHC7 zinc finger, CCHC domain containing 7 0.0465463
DOCK5 dedicator of cytokinesis 5 0.0459944
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0451327
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0440314
FLNB filamin B, beta 0.0437388
VEGFA vascular endothelial growth factor A 0.0421318
CALU calumenin 0.041202
NBAS neuroblastoma amplified sequence 0.0410564
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0406674
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0405354
SEC31A SEC31 homolog A (S. cerevisiae) 0.0404355
AKAP12 A kinase (PRKA) anchor protein 12 0.0378787
PCBP2 poly(rC) binding protein 2 0.0378721
TNIP1 TNFAIP3 interacting protein 1 0.0375555
AKAP13 A kinase (PRKA) anchor protein 13 0.0374217
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0374026
OPTN optineurin 0.0372968
BASP1 brain abundant, membrane attached signal protein 1 0.0365654
CD44 CD44 molecule (Indian blood group) 0.0363912
SEC23A Sec23 homolog A (S. cerevisiae) 0.0362908
SRRM2 serine/arginine repetitive matrix 2 0.0361725
RUNX2 runt-related transcription factor 2 0.0359267
MAML2 mastermind-like 2 (Drosophila) 0.0350851
MYH9 myosin, heavy chain 9, non-muscle 0.0347635
NDRG1 N-myc downstream regulated 1 0.0345168
TTC3 tetratricopeptide repeat domain 3 0.0339731
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0337439
YEATS2 YEATS domain containing 2 0.0326624
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0322517
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0315605
GOLGA4 golgin A4 0.0314732
DOCK4 dedicator of cytokinesis 4 0.0312554
ASXL1 additional sex combs like transcriptional regulator 1 0.0306094
ADD3 adducin 3 (gamma) 0.0302869
MSN moesin 0.0291531
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0289695
EEF2 eukaryotic translation elongation factor 2 0.0285331
PTEN phosphatase and tensin homolog 0.0279993
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.027807
ZEB2 zinc finger E-box binding homeobox 2 0.0274391
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0272523
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.027152
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0269924
LUZP1 leucine zipper protein 1 0.0267054
AKAP9 A kinase (PRKA) anchor protein 9 0.0265995
TFG TRK-fused gene 0.0264221
EIF3B eukaryotic translation initiation factor 3, subunit B 0.026405
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0260632
CCNY cyclin Y 0.0259276
CD109 CD109 molecule 0.0256929
DPYSL3 dihydropyrimidinase-like 3 0.0255568
ZMIZ1 zinc finger, MIZ-type containing 1 0.0255069
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0253073
STRN3 striatin, calmodulin binding protein 3 0.025257
SHB Src homology 2 domain containing adaptor protein B 0.0251761
RAB10 RAB10, member RAS oncogene family 0.0250169
SNX9 sorting nexin 9 0.0249827
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0246221
SAMD4A sterile alpha motif domain containing 4A 0.0244463
CEP250 centrosomal protein 250kDa 0.0242845
LRRC49 leucine rich repeat containing 49 0.0239706
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0235306
CLTC clathrin, heavy chain (Hc) 0.0235015
FAM120A family with sequence similarity 120A 0.0234202
ANXA2 annexin A2 0.0233865
KANSL3 KAT8 regulatory NSL complex subunit 3 0.0231867
NPC1 Niemann-Pick disease, type C1 0.0227942
DMXL2 Dmx-like 2 0.022698
PCNX1 pecanex 1 0.0226458
MRPS6 mitochondrial ribosomal protein S6 0.0220557
ANXA5 annexin A5 0.021918
FNIP1 folliculin interacting protein 1 0.0219174
PICALM phosphatidylinositol binding clathrin assembly protein 0.0218488
ZNF292 zinc finger protein 292 0.0217432
ARID3B AT rich interactive domain 3B (BRIGHT-like) 0.0217236
MON2 MON2 homolog (S. cerevisiae) 0.0216582
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.021557
BBX bobby sox homolog (Drosophila) 0.0214928
ATP13A3 ATPase type 13A3 0.021461
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0212652
GDI2 GDP dissociation inhibitor 2 0.0211096
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0211086
PRRC2B proline-rich coiled-coil 2B 0.021076
AOPEP aminopeptidase O (putative) 0.0210031
BACE2 beta-site APP-cleaving enzyme 2 0.021002
CNOT12 CCR4-NOT transcription complex subunit 12 0.0205452
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0204571
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0203994
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0202043
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0201028
ANKRD36 ankyrin repeat domain 36 0.0200474

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.295989
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.164458
SDK1 sidekick cell adhesion molecule 1 -0.132192
HMGA2 high mobility group AT-hook 2 -0.109529
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0983341
FTL ferritin, light polypeptide -0.0900392
PDE4D phosphodiesterase 4D, cAMP-specific -0.0747057
TMSB10 thymosin beta 10 -0.0731691
STC1 stanniocalcin 1 -0.0663165
FN1 fibronectin 1 -0.0660492
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0644158
MT2A metallothionein 2A -0.0638732
LOX lysyl oxidase -0.059892
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0595661
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0567748
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0500059
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.049209
ZNF804A zinc finger protein 804A -0.0487026
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0486711
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0480766
PSD3 pleckstrin and Sec7 domain containing 3 -0.0459547
IER3 immediate early response 3 -0.0459454
SP100 SP100 nuclear antigen -0.0445209
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0444876
SAMD9 sterile alpha motif domain containing 9 -0.0441921
INTS6 integrator complex subunit 6 -0.0429629
FAM20C family with sequence similarity 20, member C -0.0426456
LMAN1 lectin, mannose-binding, 1 -0.0418112
VIM vimentin -0.0409469
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0405913
RPLP1 ribosomal protein, large, P1 -0.0399773
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0382892
CDH13 cadherin 13 -0.0382137
PTMA prothymosin, alpha -0.0380649
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0374383
CA12 carbonic anhydrase XII -0.0373994
CANX calnexin -0.0369649
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0365706
GLCCI1 glucocorticoid induced 1 -0.0365275
AHNAK AHNAK nucleoprotein -0.0363694
TPT1 tumor protein, translationally-controlled 1 -0.0358953
PDIA3 protein disulfide isomerase family A, member 3 -0.0352081
LRMDA leucine rich melanocyte differentiation associated -0.0351383
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0336581
NAP1L1 nucleosome assembly protein 1-like 1 -0.0334217
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0333751
RAB1A RAB1A, member RAS oncogene family -0.0326912
NLK nemo-like kinase -0.0324409
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0323067
MAP1B microtubule-associated protein 1B -0.0319088
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0316764
ATG7 autophagy related 7 -0.0314944
MTSS1 metastasis suppressor 1 -0.0314843
MECOM MDS1 and EVI1 complex locus -0.0314781
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0311564
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0311324
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0307498
C15ORF48 chromosome 15 open reading frame 48 -0.0305335
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.030401
BTG1 B-cell translocation gene 1, anti-proliferative -0.0301231
AADAC arylacetamide deacetylase -0.0297984
CDK14 cyclin-dependent kinase 14 -0.0294245
PARD3 par-3 family cell polarity regulator -0.0293385
IFI6 interferon, alpha-inducible protein 6 -0.0292572
CFAP20DC CFAP20 domain containing -0.0292367
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0291897
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0290058
NAV1 neuron navigator 1 -0.0286892
TAS2R14 taste receptor, type 2, member 14 -0.0286731
GLIS3 GLIS family zinc finger 3 -0.0286051
MX2 MX dynamin-like GTPase 2 -0.0284624
TGFB1 transforming growth factor, beta 1 -0.0284473
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0280621
UBC ubiquitin C -0.0277746
CUX1 cut-like homeobox 1 -0.0277473
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0276069
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0276019
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0275927
TFPI2 tissue factor pathway inhibitor 2 -0.0274175
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0272996
H1-0 H1.0 linker histone -0.0272607
ZBTB20 zinc finger and BTB domain containing 20 -0.0272012
COL7A1 collagen, type VII, alpha 1 -0.0269302
HDAC4 histone deacetylase 4 -0.026871
RPS24 ribosomal protein S24 -0.0262529
RPS16 ribosomal protein S16 -0.0262441
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0257757
EFCAB13 EF-hand calcium binding domain 13 -0.0257333
TRIO trio Rho guanine nucleotide exchange factor -0.0257239
NRG1 neuregulin 1 -0.0255503
PLSCR1 phospholipid scramblase 1 -0.025362
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0251909
RPS25 ribosomal protein S25 -0.0250515
S100A10 S100 calcium binding protein A10 -0.0246963
TNNC1 troponin C type 1 (slow) -0.0246614
VCL vinculin -0.0245936
RPS6 ribosomal protein S6 -0.0244212
PGK1 phosphoglycerate kinase 1 -0.0242688
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0241987
RPL32 ribosomal protein L32 -0.0238248