Berbamine (dihydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.131462
AKAP12 A kinase (PRKA) anchor protein 12 0.119834
KTN1 kinectin 1 (kinesin receptor) 0.108999
TPM3 tropomyosin 3 0.0842916
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0810585
RAD51B RAD51 paralog B 0.0777948
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0741634
PRRC2A proline-rich coiled-coil 2A 0.0710463
TPI1 triosephosphate isomerase 1 0.0673245
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0659541
KRT18 keratin 18, type I 0.0649671
SET SET nuclear proto-oncogene 0.0613497
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0603014
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0572929
RPS3 ribosomal protein S3 0.0571626
RPL37 ribosomal protein L37 0.0567609
CSDE1 cold shock domain containing E1, RNA-binding 0.0567107
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0563222
CEP250 centrosomal protein 250kDa 0.055865
PRELID2 PRELI domain containing 2 0.0554467
SRRM2 serine/arginine repetitive matrix 2 0.0540848
YBX1 Y box binding protein 1 0.0504269
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0499916
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0496461
VIM vimentin 0.0488758
PTMA prothymosin, alpha 0.0461729
CENPF centromere protein F, 350/400kDa 0.0448654
EIF4H eukaryotic translation initiation factor 4H 0.0444935
PCBP2 poly(rC) binding protein 2 0.0440139
PLEC plectin 0.043826
RPS21 ribosomal protein S21 0.0432628
HSPA8 heat shock 70kDa protein 8 0.0431518
NACA nascent polypeptide-associated complex alpha subunit 0.0425514
RTN4 reticulon 4 0.0417188
HDGF hepatoma-derived growth factor 0.0415144
RPS4X ribosomal protein S4, X-linked 0.0406256
RPL11 ribosomal protein L11 0.0404007
RPL35A ribosomal protein L35a 0.0403157
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0395735
MCL1 myeloid cell leukemia 1 0.0387837
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.038752
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0386923
RPL5 ribosomal protein L5 0.0382052
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0381591
LOC112694756 uncharaterized LOC112694756 0.036261
CCDC88A coiled-coil domain containing 88A 0.0360999
RPS12 ribosomal protein S12 0.0358873
SREBF2 sterol regulatory element binding transcription factor 2 0.0357967
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0351277
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0343966
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0330334
PDE4D phosphodiesterase 4D, cAMP-specific 0.0326413
MYL12B myosin, light chain 12B, regulatory 0.0321213
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0320153
RNF213 ring finger protein 213 0.031594
RPL37A ribosomal protein L37a 0.0306719
ERBIN erbb2 interacting protein 0.0305494
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0300503
RPL3 ribosomal protein L3 0.0299571
RPS27 ribosomal protein S27 0.0296628
ENO1 enolase 1, (alpha) 0.0296525
ANKRD36B ankyrin repeat domain 36B 0.029107
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0288942
RPL36 ribosomal protein L36 0.0288472
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0288094
ZNF148 zinc finger protein 148 0.028762
MSN moesin 0.0286574
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0284436
TPM2 tropomyosin 2 (beta) 0.0283563
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0281006
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0280464
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0280216
MT2A metallothionein 2A 0.0280031
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0279702
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0277706
MYH9 myosin, heavy chain 9, non-muscle 0.0274318
RPS17 ribosomal protein S17 0.027199
RPL34 ribosomal protein L34 0.0271733
LDHB lactate dehydrogenase B 0.0270281
CHD4 chromodomain helicase DNA binding protein 4 0.0269576
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0268916
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0262409
NUP58 nucleoporin 58 0.0262182
PA2G4 proliferation-associated 2G4, 38kDa 0.0261397
RACK1 receptor for activated C kinase 1 0.0260673
RPS8 ribosomal protein S8 0.0257095
PFDN2 prefoldin subunit 2 0.0257035
DCAF8 DDB1 and CUL4 associated factor 8 0.0256586
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0255238
TMSB10 thymosin beta 10 0.0254931
CHD1L chromodomain helicase DNA binding protein 1-like 0.0253568
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0253216
IGF2 insulin-like growth factor 2 0.0251323
ENAH enabled homolog (Drosophila) 0.0251212
ZNF292 zinc finger protein 292 0.0250121
ACTN1 actinin, alpha 1 0.0248564
CHD3 chromodomain helicase DNA binding protein 3 0.024815
IQGAP3 IQ motif containing GTPase activating protein 3 0.0247937
FKBP4 FK506 binding protein 4, 59kDa 0.0245524
NCOR2 nuclear receptor corepressor 2 0.0245191

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.227663
TFPI2 tissue factor pathway inhibitor 2 -0.16172
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0706489
EGR1 early growth response 1 -0.0688345
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0544799
EXT1 exostosin glycosyltransferase 1 -0.0530385
OSMR oncostatin M receptor -0.0499113
CCDC200 coiled-coil domain containing 200 -0.0474209
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0451674
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0443592
ELL2 elongation factor, RNA polymerase II, 2 -0.0431437
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.043031
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0429521
NABP1 nucleic acid binding protein 1 -0.0417908
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0399754
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0371149
ATF6 activating transcription factor 6 -0.0365071
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0356351
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0351877
FUS FUS RNA binding protein -0.034862
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.033412
TM4SF1 transmembrane 4 L six family member 1 -0.0320511
USP34 ubiquitin specific peptidase 34 -0.0317604
SENP6 SUMO1/sentrin specific peptidase 6 -0.0316375
CDK17 cyclin-dependent kinase 17 -0.0313059
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0304334
TAOK1 TAO kinase 1 -0.0298152
GPHN gephyrin -0.0296829
MMP12 matrix metallopeptidase 12 -0.0290073
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0289667
TXNRD1 thioredoxin reductase 1 -0.0288721
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0287245
RPL6 ribosomal protein L6 -0.0283751
H1-0 H1.0 linker histone -0.0283317
RAB10 RAB10, member RAS oncogene family -0.027868
ZNF217 zinc finger protein 217 -0.0277114
PDLIM5 PDZ and LIM domain 5 -0.0272146
SETD5 SET domain containing 5 -0.0264137
RHEB Ras homolog enriched in brain -0.0262296
RAB7A RAB7A, member RAS oncogene family -0.0262187
STAU1 staufen double-stranded RNA binding protein 1 -0.0249934
PDE10A phosphodiesterase 10A -0.0248396
IER3 immediate early response 3 -0.0245288
EML4 echinoderm microtubule associated protein like 4 -0.0244217
TAS2R14 taste receptor, type 2, member 14 -0.024366
VMP1 vacuole membrane protein 1 -0.024309
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0242032
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0237401
ZMYM4 zinc finger, MYM-type 4 -0.0236774
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0236583
GOLT1B golgi transport 1B -0.023605
KLF6 Kruppel-like factor 6 -0.0235743
ZFR zinc finger RNA binding protein -0.0235259
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0233835
SPAG9 sperm associated antigen 9 -0.0231648
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0231239
SPIDR scaffolding protein involved in DNA repair -0.0226989
DCAF10 DDB1 and CUL4 associated factor 10 -0.0220934
LOC102724023 ES1 protein homolog, mitochondrial -0.0215923
YAP1 Yes-associated protein 1 -0.0215213
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -0.0214748
NSUN6 NOP2/Sun domain family, member 6 -0.021419
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0213117
COPA coatomer protein complex, subunit alpha -0.021276
DHFR dihydrofolate reductase -0.021231
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0211378
TMEM263 transmembrane protein 263 -0.0209989
PDIA4 protein disulfide isomerase family A, member 4 -0.0209701
RAP1B RAP1B, member of RAS oncogene family -0.0207688
SRP72 signal recognition particle 72kDa -0.0206844
PHF3 PHD finger protein 3 -0.0202588
STC1 stanniocalcin 1 -0.0201713
RPS15 ribosomal protein S15 -0.0201693
NBEAL1 neurobeachin-like 1 -0.0200901
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0200387
UBE3C ubiquitin protein ligase E3C -0.0199913
CLDN1 claudin 1 -0.0198054
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0197525
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0196009
TMX3 thioredoxin-related transmembrane protein 3 -0.0191767
PCNX4 pecanex 4 -0.0190353
BMAL2 basic helix-loop-helix ARNT like 2 -0.0190007
RBBP6 retinoblastoma binding protein 6 -0.0189142
MORF4L2 mortality factor 4 like 2 -0.0184691
CLIP1 CAP-GLY domain containing linker protein 1 -0.0184191
VCL vinculin -0.0183827
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0182878
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0182758
WNT2B wingless-type MMTV integration site family, member 2B -0.0182299
RAD21 RAD21 homolog (S. pombe) -0.0181563
TASOR2 transcription activation suppressor family member 2 -0.0180201
RAB5A RAB5A, member RAS oncogene family -0.0180195
BLTP1 bridge-like lipid transfer protein family member 1 -0.0179616
RSU1 Ras suppressor protein 1 -0.0179261
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0178641
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0178006
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0177506
GPATCH8 G patch domain containing 8 -0.0177304
WNK1 WNK lysine deficient protein kinase 1 -0.0177057
CANX calnexin -0.0176442