Berbamine (dihydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.203778
GRB10 growth factor receptor-bound protein 10 0.123194
NDRG1 N-myc downstream regulated 1 0.0970408
IGFBP3 insulin-like growth factor binding protein 3 0.08513
MYH9 myosin, heavy chain 9, non-muscle 0.0688522
LAMB3 laminin, beta 3 0.068053
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0666126
LOC112694756 uncharaterized LOC112694756 0.0619645
TRIO trio Rho guanine nucleotide exchange factor 0.059815
TSC22D2 TSC22 domain family, member 2 0.0594175
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0571274
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0494381
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0476454
KMT2E lysine (K)-specific methyltransferase 2E 0.0463799
VEGFA vascular endothelial growth factor A 0.0449245
FLNB filamin B, beta 0.040674
EEF2 eukaryotic translation elongation factor 2 0.0404931
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.04022
STRN3 striatin, calmodulin binding protein 3 0.037051
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0362179
ARRDC3 arrestin domain containing 3 0.036156
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0358284
RCOR1 REST corepressor 1 0.0353344
PPARD peroxisome proliferator-activated receptor delta 0.0349019
JUP junction plakoglobin 0.03407
TPM4 tropomyosin 4 0.0321601
KMT2C lysine (K)-specific methyltransferase 2C 0.0319691
PTK2 protein tyrosine kinase 2 0.0319269
LIMCH1 LIM and calponin homology domains 1 0.0307191
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0306787
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0306266
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.030519
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0303585
CD109 CD109 molecule 0.0301962
DTNA dystrobrevin, alpha 0.0289094
LDHA lactate dehydrogenase A 0.0288328
TMEM165 transmembrane protein 165 0.028664
CTBP2 C-terminal binding protein 2 0.0285968
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0279557
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0277475
EIF4H eukaryotic translation initiation factor 4H 0.0276373
FLNA filamin A, alpha 0.0275449
FAM13A family with sequence similarity 13, member A 0.0264021
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0263882
IRF6 interferon regulatory factor 6 0.0263443
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0262153
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0256518
EZR ezrin 0.0254993
COPA coatomer protein complex, subunit alpha 0.0254436
FNDC3B fibronectin type III domain containing 3B 0.0254307
AHDC1 AT hook, DNA binding motif, containing 1 0.0254151
UBA6 ubiquitin-like modifier activating enzyme 6 0.0252366
LMNA lamin A/C 0.0251512
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0251208
ZNF207 zinc finger protein 207 0.0250916
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0249621
NIBAN2 niban apoptosis regulator 2 0.0248045
HLA-C major histocompatibility complex, class I, C 0.0246868
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0243768
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0243711
MCL1 myeloid cell leukemia 1 0.0242703
KDM6A lysine (K)-specific demethylase 6A 0.0242498
HELZ helicase with zinc finger 0.023874
UBE2H ubiquitin-conjugating enzyme E2H 0.0234641
RHOA ras homolog family member A 0.02299
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0228838
PICALM phosphatidylinositol binding clathrin assembly protein 0.0228732
CCNY cyclin Y 0.0227453
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0221607
MSI2 musashi RNA-binding protein 2 0.0220716
RPL3 ribosomal protein L3 0.021844
KDM5B lysine (K)-specific demethylase 5B 0.0218429
NPEPPS aminopeptidase puromycin sensitive 0.0215386
KRT7 keratin 7, type II 0.0212287
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0209523
RREB1 ras responsive element binding protein 1 0.0203737
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0203202
ADAM9 ADAM metallopeptidase domain 9 0.0199894
DUSP10 dual specificity phosphatase 10 0.0199258
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0198719
ITCH itchy E3 ubiquitin protein ligase 0.0197853
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0196534
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0196016
PKM pyruvate kinase, muscle 0.019433
SH3KBP1 SH3-domain kinase binding protein 1 0.019331
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0192011
FLNC filamin C, gamma 0.019052
ARHGAP29 Rho GTPase activating protein 29 0.0190223
MKRN1 makorin ring finger protein 1 0.0187047
PTPRF protein tyrosine phosphatase, receptor type, F 0.0187002
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0186625
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.018255
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0181724
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0179648
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0179615
CAPN1 calpain 1, (mu/I) large subunit 0.0175024
AGRN agrin 0.0174458
FAM3C family with sequence similarity 3, member C 0.0174418
ESYT2 extended synaptotagmin-like protein 2 0.0174233
PLAU plasminogen activator, urokinase 0.017218

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.315609
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.175817
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.160028
FTL ferritin, light polypeptide -0.132302
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.11686
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0935154
TPT1 tumor protein, translationally-controlled 1 -0.0900598
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0755542
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0721834
NAMPT nicotinamide phosphoribosyltransferase -0.0712871
RPS6 ribosomal protein S6 -0.068903
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0683247
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0612043
MT2A metallothionein 2A -0.0546182
PTMA prothymosin, alpha -0.0536876
TMSB10 thymosin beta 10 -0.0530439
ASPH aspartate beta-hydroxylase -0.0520255
ALCAM activated leukocyte cell adhesion molecule -0.0508621
CANX calnexin -0.0499845
RPLP0 ribosomal protein, large, P0 -0.0499747
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0498994
FN1 fibronectin 1 -0.0495566
RPS8 ribosomal protein S8 -0.0486194
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0471889
LAMC2 laminin, gamma 2 -0.0461415
EIF1 eukaryotic translation initiation factor 1 -0.0459447
DSG2 desmoglein 2 -0.0445619
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0440923
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0439077
S100A10 S100 calcium binding protein A10 -0.0436977
RPL32 ribosomal protein L32 -0.0431599
RPL12 ribosomal protein L12 -0.041336
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0407557
RPS23 ribosomal protein S23 -0.0404298
RPLP2 ribosomal protein, large, P2 -0.0400064
RPLP1 ribosomal protein, large, P1 -0.0398964
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0384315
HMGA1 high mobility group AT-hook 1 -0.0371443
RPS24 ribosomal protein S24 -0.0370479
RPL19 ribosomal protein L19 -0.0359398
IFI16 interferon, gamma-inducible protein 16 -0.0354337
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0351978
RPL26 ribosomal protein L26 -0.0334899
BHLHE40 basic helix-loop-helix family, member e40 -0.0331007
RPS19 ribosomal protein S19 -0.032735
RPS2 ribosomal protein S2 -0.0318577
ENO1 enolase 1, (alpha) -0.0318403
RPS25 ribosomal protein S25 -0.0314947
MKI67 marker of proliferation Ki-67 -0.0312063
RPL8 ribosomal protein L8 -0.0311456
G0S2 G0/G1 switch 2 -0.0311136
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0305803
RPS29 ribosomal protein S29 -0.0303083
FTH1 ferritin, heavy polypeptide 1 -0.0302765
RPL11 ribosomal protein L11 -0.0298494
HMGB2 high mobility group box 2 -0.0290397
TM4SF1 transmembrane 4 L six family member 1 -0.0290277
RPS12 ribosomal protein S12 -0.0287566
RYBP RING1 and YY1 binding protein -0.0278423
RPS16 ribosomal protein S16 -0.0275821
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0268186
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0265237
RPS27A ribosomal protein S27a -0.026513
MDK midkine (neurite growth-promoting factor 2) -0.0263998
RPS5 ribosomal protein S5 -0.0263297
SQSTM1 sequestosome 1 -0.0259608
RPL23 ribosomal protein L23 -0.0256955
ARHGAP5 Rho GTPase activating protein 5 -0.0253024
RPL37A ribosomal protein L37a -0.0252524
CENPF centromere protein F, 350/400kDa -0.0246507
MAP4 microtubule-associated protein 4 -0.0243852
RPL15 ribosomal protein L15 -0.0242639
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0239425
LY6E lymphocyte antigen 6 complex, locus E -0.0234226
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0233731
RPL34 ribosomal protein L34 -0.0233635
RPS15 ribosomal protein S15 -0.0233486
HSPA8 heat shock 70kDa protein 8 -0.0230883
RPL7 ribosomal protein L7 -0.0230404
UBC ubiquitin C -0.0230087
RPS3 ribosomal protein S3 -0.0227882
CD2AP CD2-associated protein -0.0227715
RPL9 ribosomal protein L9 -0.0225861
RPL28 ribosomal protein L28 -0.0224007
PAPOLA poly(A) polymerase alpha -0.0223968
PEG10 paternally expressed 10 -0.0223702
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0218793
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0218527
WSB1 WD repeat and SOCS box containing 1 -0.0216992
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0215326
SEPTIN11 septin 11 -0.0214836
STEAP4 STEAP family member 4 -0.0213973
FHIT fragile histidine triad -0.0213914
ANXA1 annexin A1 -0.0212466
EXT1 exostosin glycosyltransferase 1 -0.0210413
RPL5 ribosomal protein L5 -0.0207574
OSMR oncostatin M receptor -0.0205974
RPL37 ribosomal protein L37 -0.0205505
H1-0 H1.0 linker histone -0.0204793
RAD21 RAD21 homolog (S. pombe) -0.0204023