Berbamine (dihydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.379481
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.10839
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0857817
CD109 CD109 molecule 0.0741629
IGFBP3 insulin-like growth factor binding protein 3 0.0735583
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0696822
GDA guanine deaminase 0.067154
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0625866
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0552661
NEK7 NIMA-related kinase 7 0.0504083
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0493735
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0490006
NRCAM neuronal cell adhesion molecule 0.0466932
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0446361
BZW1 basic leucine zipper and W2 domains 1 0.0433251
PM20D1 peptidase M20 domain containing 1 0.0432395
TPT1 tumor protein, translationally-controlled 1 0.0418206
STC1 stanniocalcin 1 0.0414147
KPNB1 karyopherin (importin) beta 1 0.0397141
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0383303
ZEB2 zinc finger E-box binding homeobox 2 0.0380467
IFIH1 interferon induced with helicase C domain 1 0.0362552
RPL35A ribosomal protein L35a 0.0360691
NAMPT nicotinamide phosphoribosyltransferase 0.0360026
ANXA2 annexin A2 0.035984
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0358218
PTGR1 prostaglandin reductase 1 0.0344516
ELL2 elongation factor, RNA polymerase II, 2 0.0338966
CTSC cathepsin C 0.0338581
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0331395
TMX4 thioredoxin-related transmembrane protein 4 0.033048
GPRIN3 GPRIN family member 3 0.0311421
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0308562
ITPRID2 ITPR interacting domain containing 2 0.0305585
COL5A2 collagen, type V, alpha 2 0.0301146
FNDC3B fibronectin type III domain containing 3B 0.0297553
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0295784
HLA-B major histocompatibility complex, class I, B 0.0283882
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0277879
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0274383
TBXT T-box transcription factor T 0.0271457
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0268271
SPAG9 sperm associated antigen 9 0.0266472
ERRFI1 ERBB receptor feedback inhibitor 1 0.0265798
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0265197
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.026466
CENPF centromere protein F, 350/400kDa 0.0264354
RPLP0 ribosomal protein, large, P0 0.0263792
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0263274
ESM1 endothelial cell-specific molecule 1 0.0250509
BIRC6 baculoviral IAP repeat containing 6 0.0241606
LAMB1 laminin, beta 1 0.0241444
LMNA lamin A/C 0.0240807
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0233579
DPYD dihydropyrimidine dehydrogenase 0.0233379
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0232286
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0231336
PGK1 phosphoglycerate kinase 1 0.0229718
CTSL cathepsin L 0.0226054
FOXC1 forkhead box C1 0.0216102
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0215343
ZBTB38 zinc finger and BTB domain containing 38 0.0214864
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0211795
HLA-A major histocompatibility complex, class I, A 0.021053
BDNF brain-derived neurotrophic factor 0.0202725
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0197985
MKI67 marker of proliferation Ki-67 0.0193416
SEPTIN10 septin 10 0.0190433
BCLAF1 BCL2-associated transcription factor 1 0.0185156
TMSB4X thymosin beta 4, X-linked 0.0183481
EIF4H eukaryotic translation initiation factor 4H 0.0181098
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0176807
PRKD3 protein kinase D3 0.0176428
CDK17 cyclin-dependent kinase 17 0.0172551
UGCG UDP-glucose ceramide glucosyltransferase 0.0171847
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0171022
INHBA inhibin, beta A 0.0170668
PRSS23 protease, serine, 23 0.0169219
SLC38A2 solute carrier family 38, member 2 0.0167998
TENT5A terminal nucleotidyltransferase 5A 0.0165958
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.016587
HLA-C major histocompatibility complex, class I, C 0.0165368
SLK STE20-like kinase 0.0164725
SCCPDH saccharopine dehydrogenase (putative) 0.0164693
CRLF2 cytokine receptor-like factor 2 0.0162848
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0162156
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0161227
BCAR3 breast cancer anti-estrogen resistance 3 0.0160877
SFTPA2 surfactant protein A2 0.0160734
ARRDC3 arrestin domain containing 3 0.0159427
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0158235
TPM4 tropomyosin 4 0.0156173
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0155755
OASL 2'-5'-oligoadenylate synthetase-like 0.0154488
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0154001
ITGB5 integrin, beta 5 0.0151233
NDRG1 N-myc downstream regulated 1 0.0151029
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0150597
TPI1 triosephosphate isomerase 1 0.0146782
PDE4B phosphodiesterase 4B, cAMP-specific 0.0144214

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.212859
PDE10A phosphodiesterase 10A -0.171665
TMSB10 thymosin beta 10 -0.142844
RPS27A ribosomal protein S27a -0.120285
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11926
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.114026
UBC ubiquitin C -0.108505
RPS12 ribosomal protein S12 -0.0797064
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0756291
ASPH aspartate beta-hydroxylase -0.0740618
EEF2 eukaryotic translation elongation factor 2 -0.0737024
PRKN parkin RBR E3 ubiquitin protein ligase -0.0725265
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0720145
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0704251
VIM vimentin -0.0688199
NAP1L1 nucleosome assembly protein 1-like 1 -0.0682541
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0679185
MT2A metallothionein 2A -0.0656607
RPL23 ribosomal protein L23 -0.0653014
NALF1 NALCN channel auxiliary factor 1 -0.0607953
RPL37A ribosomal protein L37a -0.0578081
ADGRD1 adhesion G protein-coupled receptor D1 -0.0574359
RPL26 ribosomal protein L26 -0.056245
MAML3 mastermind-like 3 (Drosophila) -0.0556379
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0549949
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0546186
COL4A5 collagen, type IV, alpha 5 -0.0543888
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0528492
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0526621
FTL ferritin, light polypeptide -0.0524802
RPS6 ribosomal protein S6 -0.0523183
KYNU kynureninase -0.0503873
RPS3 ribosomal protein S3 -0.0501021
PCBP2 poly(rC) binding protein 2 -0.0486482
RPL12 ribosomal protein L12 -0.0480355
AHNAK AHNAK nucleoprotein -0.0467479
RAD51B RAD51 paralog B -0.0467238
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.046005
GRAMD1B GRAM domain containing 1B -0.0449157
RPL31 ribosomal protein L31 -0.0438436
LIMCH1 LIM and calponin homology domains 1 -0.0437856
INTS6 integrator complex subunit 6 -0.0422155
LSAMP limbic system-associated membrane protein -0.0419803
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0419584
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0418147
PDIA4 protein disulfide isomerase family A, member 4 -0.0416303
ENO1 enolase 1, (alpha) -0.0401941
PTPRM protein tyrosine phosphatase, receptor type, M -0.0399494
RPS19 ribosomal protein S19 -0.0396857
ZNF638 zinc finger protein 638 -0.0395143
SET SET nuclear proto-oncogene -0.0389489
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0387279
PRELID2 PRELI domain containing 2 -0.0381812
CADM2 cell adhesion molecule 2 -0.0358145
SMOC1 SPARC related modular calcium binding 1 -0.0354229
RPLP2 ribosomal protein, large, P2 -0.0351948
HDAC4 histone deacetylase 4 -0.0350984
AUTS2 autism susceptibility candidate 2 -0.0340423
FMNL2 formin-like 2 -0.0335163
RPS8 ribosomal protein S8 -0.0335089
PCBP3 poly(rC) binding protein 3 -0.0334396
RPL4 ribosomal protein L4 -0.0330858
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0328333
PDLIM5 PDZ and LIM domain 5 -0.0327733
DST dystonin -0.0327208
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0326353
RPLP1 ribosomal protein, large, P1 -0.0321924
RPL36 ribosomal protein L36 -0.0321592
ANTXR1 anthrax toxin receptor 1 -0.0318041
RPS27 ribosomal protein S27 -0.0312079
DENND1A DENN/MADD domain containing 1A -0.0310876
NT5C2 5'-nucleotidase, cytosolic II -0.0310524
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0303618
RPS29 ribosomal protein S29 -0.030196
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0300236
SQSTM1 sequestosome 1 -0.0299954
EEF1G eukaryotic translation elongation factor 1 gamma -0.0295903
CTIF CBP80/20-dependent translation initiation factor -0.0294462
RPL5 ribosomal protein L5 -0.0289476
VMP1 vacuole membrane protein 1 -0.0286827
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0283683
EFNA5 ephrin-A5 -0.0283122
RPS4X ribosomal protein S4, X-linked -0.0281869
PDE7B phosphodiesterase 7B -0.0279554
CANX calnexin -0.0274124
MBD5 methyl-CpG binding domain protein 5 -0.0273289
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0270516
RPL28 ribosomal protein L28 -0.0270111
RPL35 ribosomal protein L35 -0.0268532
CTBP2 C-terminal binding protein 2 -0.0267614
PKM pyruvate kinase, muscle -0.0265382
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0252897
GIGYF2 GRB10 interacting GYF protein 2 -0.0251769
VCL vinculin -0.0250367
RPL37 ribosomal protein L37 -0.0247075
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0245192
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.024462
FLNB filamin B, beta -0.0244551
RPS2 ribosomal protein S2 -0.0243954
RBM25 RNA binding motif protein 25 -0.024368