Berbamine (dihydrochloride)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.115735
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.109345
TRPS1 trichorhinophalangeal syndrome I 0.0917415
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0884134
THBS1 thrombospondin 1 0.0805451
FNDC3B fibronectin type III domain containing 3B 0.0607699
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0479619
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0463861
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0457699
ZNF608 zinc finger protein 608 0.045192
DST dystonin 0.0434916
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0418486
TRIO trio Rho guanine nucleotide exchange factor 0.0396919
DSCAM Down syndrome cell adhesion molecule 0.0395155
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0382504
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0374471
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0374338
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0372602
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0371249
EMP1 epithelial membrane protein 1 0.035341
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0349573
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0349139
NCOA2 nuclear receptor coactivator 2 0.034749
USP9X ubiquitin specific peptidase 9, X-linked 0.0342482
SMC4 structural maintenance of chromosomes 4 0.0339682
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0338512
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0330065
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0325104
ZSWIM6 zinc finger, SWIM-type containing 6 0.0323248
MYO10 myosin X 0.0319603
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0318214
STAG2 stromal antigen 2 0.0312901
NTM neurotrimin 0.0308862
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0305691
SAMD4A sterile alpha motif domain containing 4A 0.030484
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0304661
CSDE1 cold shock domain containing E1, RNA-binding 0.0302786
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0299116
MYOF myoferlin 0.0298349
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0294987
OGA O-GlcNAcase 0.0289722
AFF4 AF4/FMR2 family, member 4 0.028971
TSC22D2 TSC22 domain family, member 2 0.0288027
SRPK2 SRSF protein kinase 2 0.0286726
SFPQ splicing factor proline/glutamine-rich 0.028633
USP25 ubiquitin specific peptidase 25 0.0286109
BZW1 basic leucine zipper and W2 domains 1 0.0285873
EIF4H eukaryotic translation initiation factor 4H 0.0285496
PCDH17 protocadherin 17 0.0283131
TTC28 tetratricopeptide repeat domain 28 0.0282406
ZEB2 zinc finger E-box binding homeobox 2 0.0280376
SHROOM3 shroom family member 3 0.027838
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0273748
RASAL2 RAS protein activator like 2 0.0266999
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0264942
PRKD1 protein kinase D1 0.0264818
CKAP5 cytoskeleton associated protein 5 0.0264359
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0262977
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0259713
CENPE centromere protein E, 312kDa 0.0257046
RCOR1 REST corepressor 1 0.0255565
FAM171B family with sequence similarity 171, member B 0.0254672
SND1 staphylococcal nuclease and tudor domain containing 1 0.0245343
ZNF217 zinc finger protein 217 0.024169
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0241144
PHF3 PHD finger protein 3 0.0238764
SCFD1 sec1 family domain containing 1 0.0233454
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0233006
NDRG1 N-myc downstream regulated 1 0.023292
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0232907
SRP72 signal recognition particle 72kDa 0.0232387
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0231627
USP53 ubiquitin specific peptidase 53 0.0230567
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0229997
GASK1B golgi associated kinase 1B 0.0229117
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0227717
GLO1 glyoxalase I 0.02274
CUL4B cullin 4B 0.0225375
SESN1 sestrin 1 0.0222509
CHD1 chromodomain helicase DNA binding protein 1 0.0219675
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0219136
RARS1 arginyl-tRNA synthetase 1 0.0218664
MARCHF7 membrane associated ring-CH-type finger 7 0.0218278
CLTC clathrin, heavy chain (Hc) 0.0216563
CERT1 ceramide transporter 1 0.0214703
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0213703
FLNA filamin A, alpha 0.0213295
KIF11 kinesin family member 11 0.0211312
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0210107
LIN28B lin-28 homolog B (C. elegans) 0.0206943
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0204166
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0203523
ITPRID2 ITPR interacting domain containing 2 0.0202182
ATP5F1A ATP synthase F1 subunit alpha 0.0201245
PAXBP1 PAX3 and PAX7 binding protein 1 0.0200797
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0200675
DYM dymeclin 0.0200227
PUM2 pumilio RNA-binding family member 2 0.0200038
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.019922
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0198863

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.199393
CADM2 cell adhesion molecule 2 -0.177089
COL11A1 collagen, type XI, alpha 1 -0.176136
TMSB10 thymosin beta 10 -0.148946
RPS8 ribosomal protein S8 -0.111165
RPS16 ribosomal protein S16 -0.10467
RPS6 ribosomal protein S6 -0.0890523
MDK midkine (neurite growth-promoting factor 2) -0.0873299
COL1A2 collagen, type I, alpha 2 -0.0862788
ITGAV integrin, alpha V -0.0829944
RPL35A ribosomal protein L35a -0.0779819
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0761351
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0696586
MAP4 microtubule-associated protein 4 -0.0673225
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0658231
PFN1 profilin 1 -0.0629679
ATP5F1B ATP synthase F1 subunit beta -0.0616683
RPL23 ribosomal protein L23 -0.0586114
GNAS GNAS complex locus -0.0584539
PTMA prothymosin, alpha -0.05498
TPT1 tumor protein, translationally-controlled 1 -0.0536644
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0531743
POTEF POTE ankyrin domain family, member F -0.0515597
WSB1 WD repeat and SOCS box containing 1 -0.0479462
FBXO17 F-box protein 17 -0.0465855
SMYD3 SET and MYND domain containing 3 -0.046042
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0444236
RPS13 ribosomal protein S13 -0.0441251
RPL5 ribosomal protein L5 -0.0436265
THOC2 THO complex 2 -0.0435897
RPL37A ribosomal protein L37a -0.0431323
PGK1 phosphoglycerate kinase 1 -0.0430914
B2M beta-2-microglobulin -0.0430089
SERF2 small EDRK-rich factor 2 -0.0428182
CNRIP1 cannabinoid receptor interacting protein 1 -0.0423069
RPLP1 ribosomal protein, large, P1 -0.0422387
SYT1 synaptotagmin I -0.042204
PRRC2C proline-rich coiled-coil 2C -0.0421959
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0419495
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0415391
WASF2 WAS protein family, member 2 -0.0415214
MYL12B myosin, light chain 12B, regulatory -0.0412227
SLIT2 slit homolog 2 (Drosophila) -0.0397863
GPC3 glypican 3 -0.039672
RPL31 ribosomal protein L31 -0.0396116
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0393863
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0386458
RPL12 ribosomal protein L12 -0.038026
RPS12 ribosomal protein S12 -0.0377984
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0376234
RHOA ras homolog family member A -0.0366259
ENAH enabled homolog (Drosophila) -0.0365468
S100A9 S100 calcium binding protein A9 -0.0361765
HSPB1 heat shock 27kDa protein 1 -0.0353345
RAB2A RAB2A, member RAS oncogene family -0.0352738
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0349023
KMT2A lysine (K)-specific methyltransferase 2A -0.0348538
SNX6 sorting nexin 6 -0.034329
PCDH9 protocadherin 9 -0.0343177
UBE2K ubiquitin-conjugating enzyme E2K -0.034076
RIMS2 regulating synaptic membrane exocytosis 2 -0.0340339
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0337229
SOX2 SRY (sex determining region Y)-box 2 -0.0336531
RPS14 ribosomal protein S14 -0.0334996
PCLO piccolo presynaptic cytomatrix protein -0.0333176
S100A10 S100 calcium binding protein A10 -0.0333027
COL3A1 collagen, type III, alpha 1 -0.0328089
PARD3B par-3 family cell polarity regulator beta -0.0324468
FTL ferritin, light polypeptide -0.0323081
EXOC4 exocyst complex component 4 -0.0318879
RAD51B RAD51 paralog B -0.0316322
NAP1L1 nucleosome assembly protein 1-like 1 -0.0314333
PDE4D phosphodiesterase 4D, cAMP-specific -0.0311415
RPS3 ribosomal protein S3 -0.0310346
TENM3 teneurin transmembrane protein 3 -0.0310087
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0308182
RPLP2 ribosomal protein, large, P2 -0.029936
EIF1 eukaryotic translation initiation factor 1 -0.0297658
PHIP pleckstrin homology domain interacting protein -0.0294037
RPL36A ribosomal protein L36a -0.0292983
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0292551
YBX1 Y box binding protein 1 -0.0289765
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0289567
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.028699
RPL19 ribosomal protein L19 -0.0285815
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0285402
BPTF bromodomain PHD finger transcription factor -0.0284855
RPS24 ribosomal protein S24 -0.0284688
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0284613
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0284549
BSG basigin (Ok blood group) -0.0283672
ARHGAP24 Rho GTPase activating protein 24 -0.0283038
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0281709
ACTG1 actin gamma 1 -0.0281664
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0279966
FOXK1 forkhead box K1 -0.0276819
BRD4 bromodomain containing 4 -0.027647
RPL37 ribosomal protein L37 -0.0274804
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0274176
RPS19 ribosomal protein S19 -0.0271867