Berbamine (dihydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.271783
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.107337
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0761906
SEPTIN9 septin 9 0.0723149
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0697539
VCL vinculin 0.0665505
THSD4 thrombospondin, type I, domain containing 4 0.0662175
PLEC plectin 0.0647517
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.061052
LOC112694756 uncharaterized LOC112694756 0.0563865
HSPG2 heparan sulfate proteoglycan 2 0.05347
SRRM2 serine/arginine repetitive matrix 2 0.0532026
TRIO trio Rho guanine nucleotide exchange factor 0.0527168
EGFR epidermal growth factor receptor 0.052407
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0465363
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0451089
MCL1 myeloid cell leukemia 1 0.0439791
MYH9 myosin, heavy chain 9, non-muscle 0.0436482
ANKRD11 ankyrin repeat domain 11 0.0436056
SLC35F3 solute carrier family 35, member F3 0.0419857
FOSL1 FOS-like antigen 1 0.0398535
RNF220 ring finger protein 220 0.0397049
MACF1 microtubule-actin crosslinking factor 1 0.0393062
DST dystonin 0.0387686
TNS3 tensin 3 0.0342204
EGR1 early growth response 1 0.0339797
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0329484
CMIP c-Maf inducing protein 0.032732
COL18A1 collagen, type XVIII, alpha 1 0.0316306
PRRC2A proline-rich coiled-coil 2A 0.0311496
FLNA filamin A, alpha 0.0308761
EIF4H eukaryotic translation initiation factor 4H 0.0289679
NCOR2 nuclear receptor corepressor 2 0.0286022
KTN1 kinectin 1 (kinesin receptor) 0.0285732
MSN moesin 0.0285603
UBASH3B ubiquitin associated and SH3 domain containing B 0.0282335
NHSL1 NHS-like 1 0.0281174
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0280571
ATXN1 ataxin 1 0.0277497
ANGPTL4 angiopoietin-like 4 0.0275236
EEF2 eukaryotic translation elongation factor 2 0.0274606
TPM1 tropomyosin 1 (alpha) 0.027312
INTS6 integrator complex subunit 6 0.0271074
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0261966
HMGA2 high mobility group AT-hook 2 0.0258444
L1CAM L1 cell adhesion molecule 0.025118
MYO1E myosin IE 0.024668
RNF213 ring finger protein 213 0.0246264
RAD51B RAD51 paralog B 0.0241747
SDK1 sidekick cell adhesion molecule 1 0.0239414
SAMD4B sterile alpha motif domain containing 4B 0.023749
GSE1 Gse1 coiled-coil protein 0.0233788
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0233459
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.023307
CTBP2 C-terminal binding protein 2 0.0230829
STEAP3 STEAP family member 3, metalloreductase 0.0230202
RPL3 ribosomal protein L3 0.0226488
GRK5 G protein-coupled receptor kinase 5 0.0224353
DOCK1 dedicator of cytokinesis 1 0.0224086
HDAC4 histone deacetylase 4 0.0220921
MAP3K10 mitogen-activated protein kinase kinase kinase 10 0.0216152
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0215225
NAV2 neuron navigator 2 0.021317
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.021101
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0204194
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0203349
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0201654
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0200139
VEGFA vascular endothelial growth factor A 0.0198229
TNRC18 trinucleotide repeat containing 18 0.0195149
MTCL1 microtubule crosslinking factor 1 0.0192411
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0192143
STC2 stanniocalcin 2 0.0191605
AHNAK2 AHNAK nucleoprotein 2 0.0191154
FANK1 fibronectin type III and ankyrin repeat domains 1 0.0190435
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0190261
LAMA5 laminin, alpha 5 0.0189493
WDR27 WD repeat domain 27 0.0189142
ACTG1 actin gamma 1 0.0187086
LPP LIM domain containing preferred translocation partner in lipoma 0.0185917
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.018549
ZDHHC14 zinc finger, DHHC-type containing 14 0.018511
FHL2 four and a half LIM domains 2 0.0184479
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0184161
MYO10 myosin X 0.0176377
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0175074
CCDC57 coiled-coil domain containing 57 0.017283
MSRB3 methionine sulfoxide reductase B3 0.0172674
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0169745
MYOF myoferlin 0.016928
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0168984
ACTN1 actinin, alpha 1 0.0165793
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.016458
PTK2 protein tyrosine kinase 2 0.0159549
SESN2 sestrin 2 0.0158649
IGF1R insulin-like growth factor 1 receptor 0.0158625
MAML3 mastermind-like 3 (Drosophila) 0.0157772
PRDM16 PR domain containing 16 0.0157638
WNK1 WNK lysine deficient protein kinase 1 0.0155767
HSPA8 heat shock 70kDa protein 8 0.0155637

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.258865
RPS16 ribosomal protein S16 -0.200955
VIM vimentin -0.142594
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.123017
PTMA prothymosin, alpha -0.111683
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.086976
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0740057
SPAG9 sperm associated antigen 9 -0.0625403
UBC ubiquitin C -0.0619502
CANX calnexin -0.0599407
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0594005
TM4SF1 transmembrane 4 L six family member 1 -0.0581332
TXNRD1 thioredoxin reductase 1 -0.0581171
OGA O-GlcNAcase -0.0554742
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0522476
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0514412
ANXA2 annexin A2 -0.0494659
RPLP0 ribosomal protein, large, P0 -0.0477408
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0474536
NAP1L1 nucleosome assembly protein 1-like 1 -0.0456031
ENO1 enolase 1, (alpha) -0.045478
TMSB10 thymosin beta 10 -0.0454301
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.044789
JMJD1C jumonji domain containing 1C -0.0445183
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0442012
TMEM123 transmembrane protein 123 -0.0438455
CD44 CD44 molecule (Indian blood group) -0.0433916
RPS24 ribosomal protein S24 -0.0433909
TMEM41B transmembrane protein 41B -0.0410996
RAP1B RAP1B, member of RAS oncogene family -0.0399978
ANLN anillin, actin binding protein -0.0393703
KDM3A lysine (K)-specific demethylase 3A -0.0387165
TM9SF3 transmembrane 9 superfamily member 3 -0.0385959
GOLGA4 golgin A4 -0.0384119
FBL fibrillarin -0.0382267
RPLP2 ribosomal protein, large, P2 -0.0362811
ZFP36 ZFP36 ring finger protein -0.0357361
MORF4L2 mortality factor 4 like 2 -0.0346885
NAMPT nicotinamide phosphoribosyltransferase -0.0336715
TPT1 tumor protein, translationally-controlled 1 -0.0334786
S100A10 S100 calcium binding protein A10 -0.0334245
H1-0 H1.0 linker histone -0.0331387
BIRC2 baculoviral IAP repeat containing 2 -0.0330033
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0326203
PGK1 phosphoglycerate kinase 1 -0.0325191
MARCHF6 membrane associated ring-CH-type finger 6 -0.0320539
RPLP1 ribosomal protein, large, P1 -0.0312476
ATP13A3 ATPase type 13A3 -0.030835
WWTR1 WW domain containing transcription regulator 1 -0.0307848
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0297981
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0297634
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0292645
RPS27A ribosomal protein S27a -0.0291425
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0290222
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0290159
KMT2A lysine (K)-specific methyltransferase 2A -0.0289217
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0289114
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.028765
TNPO1 transportin 1 -0.0287389
ZNF292 zinc finger protein 292 -0.0282199
FTL ferritin, light polypeptide -0.0282152
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0280592
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0280387
RBM39 RNA binding motif protein 39 -0.0279682
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.027963
RPL36A ribosomal protein L36a -0.0278479
RAD21 RAD21 homolog (S. pombe) -0.0276341
SUCO SUN domain containing ossification factor -0.0266677
PUM2 pumilio RNA-binding family member 2 -0.0265862
RPL12 ribosomal protein L12 -0.0265172
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0264707
PDIA4 protein disulfide isomerase family A, member 4 -0.0263046
ECT2 epithelial cell transforming 2 -0.0261287
EIF1 eukaryotic translation initiation factor 1 -0.0253898
CALR calreticulin -0.0253762
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0252918
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0252414
THOC2 THO complex 2 -0.0251376
RLF rearranged L-myc fusion -0.0250207
SETD5 SET domain containing 5 -0.0244373
NOP58 NOP58 ribonucleoprotein -0.0244124
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0243126
RPS5 ribosomal protein S5 -0.0242424
BRWD3 bromodomain and WD repeat domain containing 3 -0.0240263
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0240143
CD2AP CD2-associated protein -0.0239627
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0239491
SBF2 SET binding factor 2 -0.0237989
USP3 ubiquitin specific peptidase 3 -0.0237688
YBX1 Y box binding protein 1 -0.0237305
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0237267
RAB1A RAB1A, member RAS oncogene family -0.0237192
TPX2 TPX2, microtubule-associated -0.0237055
RSL1D1 ribosomal L1 domain containing 1 -0.0236987
RB1CC1 RB1-inducible coiled-coil 1 -0.0236885
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0235927
B2M beta-2-microglobulin -0.023469
ZNF217 zinc finger protein 217 -0.0233809
NIPBL Nipped-B homolog (Drosophila) -0.0232707
IER3 immediate early response 3 -0.0230599