Berbamine (dihydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.145612
NDRG1 N-myc downstream regulated 1 0.104147
IGFBP3 insulin-like growth factor binding protein 3 0.0893646
DDIT4 DNA-damage-inducible transcript 4 0.08229
PLEC plectin 0.0816887
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0815778
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0762804
EZR ezrin 0.0731742
EMP1 epithelial membrane protein 1 0.0728301
NPEPPS aminopeptidase puromycin sensitive 0.0712857
ANXA2 annexin A2 0.069138
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0678248
PTMA prothymosin, alpha 0.0615301
LOC102724023 ES1 protein homolog, mitochondrial 0.0594355
TPM4 tropomyosin 4 0.0586516
LDHA lactate dehydrogenase A 0.0581783
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.057258
TMSB4X thymosin beta 4, X-linked 0.0560879
TSC22D2 TSC22 domain family, member 2 0.055055
TMEM123 transmembrane protein 123 0.0514229
FN1 fibronectin 1 0.0507013
JUP junction plakoglobin 0.0506532
SVIL supervillin 0.0492943
LMO7 LIM domain 7 0.0484789
TPI1 triosephosphate isomerase 1 0.048259
PLAU plasminogen activator, urokinase 0.0465562
ERRFI1 ERBB receptor feedback inhibitor 1 0.04623
UGCG UDP-glucose ceramide glucosyltransferase 0.0458314
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0444443
LAMB3 laminin, beta 3 0.0436626
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0429086
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0425727
RPL35A ribosomal protein L35a 0.0425227
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0414595
KRT19 keratin 19, type I 0.0404194
KDM2A lysine (K)-specific demethylase 2A 0.0403231
DAPK1 death-associated protein kinase 1 0.0401875
KDM3A lysine (K)-specific demethylase 3A 0.0395788
PGK1 phosphoglycerate kinase 1 0.0393975
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0387792
HMGA1 high mobility group AT-hook 1 0.0384392
RIOK3 RIO kinase 3 0.0379303
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0376829
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0370943
ESYT2 extended synaptotagmin-like protein 2 0.0367877
DLG1 discs, large homolog 1 (Drosophila) 0.036773
TRIO trio Rho guanine nucleotide exchange factor 0.0365921
WDR45B WD repeat domain 45B 0.0361775
MAML2 mastermind-like 2 (Drosophila) 0.0357508
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0350298
NIBAN2 niban apoptosis regulator 2 0.034975
KDM5B lysine (K)-specific demethylase 5B 0.0347631
BACE2 beta-site APP-cleaving enzyme 2 0.0339775
CD47 CD47 molecule 0.033912
USP3 ubiquitin specific peptidase 3 0.0337446
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0336321
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0335136
UBE2H ubiquitin-conjugating enzyme E2H 0.0326638
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0322571
CLMN calmin (calponin-like, transmembrane) 0.0322245
F3 coagulation factor III (thromboplastin, tissue factor) 0.0319662
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0318084
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0317611
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0306838
CD2AP CD2-associated protein 0.0306391
ITGB4 integrin, beta 4 0.030539
SLMAP sarcolemma associated protein 0.0304103
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0303307
WFDC2 WAP four-disulfide core domain 2 0.0297172
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0296896
LGALS3 lectin, galactoside-binding, soluble, 3 0.0296588
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.029404
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0293872
MEF2A myocyte enhancer factor 2A 0.0293479
MORF4L2 mortality factor 4 like 2 0.0289587
PKM pyruvate kinase, muscle 0.0287549
FMNL2 formin-like 2 0.028493
GNAS GNAS complex locus 0.0284617
GRID1 glutamate receptor, ionotropic, delta 1 0.0282903
RLF rearranged L-myc fusion 0.0274745
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0271288
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0270539
ASS1 argininosuccinate synthase 1 0.0266507
HBP1 HMG-box transcription factor 1 0.0265814
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0265633
SKAP2 src kinase associated phosphoprotein 2 0.0264709
SOX4 SRY (sex determining region Y)-box 4 0.0261577
RYK receptor-like tyrosine kinase 0.026071
ARF4 ADP-ribosylation factor 4 0.0259132
TMOD3 tropomodulin 3 (ubiquitous) 0.0256655
LOC112694756 uncharaterized LOC112694756 0.0256481
SULF2 sulfatase 2 0.0249938
ANXA1 annexin A1 0.0247099
RAB6A RAB6A, member RAS oncogene family 0.0246932
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0246636
LPP LIM domain containing preferred translocation partner in lipoma 0.02459
PARD3 par-3 family cell polarity regulator 0.024231
FAM13A family with sequence similarity 13, member A 0.0241817
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0239632
KIAA1671 KIAA1671 0.0238084

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.302075
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.132741
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0983972
WWC1 WW and C2 domain containing 1 -0.0822596
RPS27A ribosomal protein S27a -0.0806645
LAMA4 laminin, alpha 4 -0.0731196
RPS6 ribosomal protein S6 -0.0703125
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0702981
PCLO piccolo presynaptic cytomatrix protein -0.0700963
LAMC2 laminin, gamma 2 -0.0685601
UBC ubiquitin C -0.0683096
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0663155
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0659182
TPT1 tumor protein, translationally-controlled 1 -0.0654068
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0645995
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0643713
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0620374
DSG2 desmoglein 2 -0.0594353
RPS3 ribosomal protein S3 -0.0585179
VCL vinculin -0.0584019
VMP1 vacuole membrane protein 1 -0.0579969
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.057582
OSMR oncostatin M receptor -0.0570431
THBS1 thrombospondin 1 -0.0558224
MACF1 microtubule-actin crosslinking factor 1 -0.0544122
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0541265
ACTG1 actin gamma 1 -0.0498731
NRIP1 nuclear receptor interacting protein 1 -0.047968
SENP5 SUMO1/sentrin specific peptidase 5 -0.0470479
MT2A metallothionein 2A -0.0469974
MKI67 marker of proliferation Ki-67 -0.0469809
POTEF POTE ankyrin domain family, member F -0.0469174
RPS12 ribosomal protein S12 -0.0463334
KRT8 keratin 8, type II -0.0455063
DIAPH3 diaphanous-related formin 3 -0.0452541
BCAR3 breast cancer anti-estrogen resistance 3 -0.0449834
NCEH1 neutral cholesterol ester hydrolase 1 -0.0446152
CANX calnexin -0.0445622
ARHGAP26 Rho GTPase activating protein 26 -0.0442332
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0438774
SENP6 SUMO1/sentrin specific peptidase 6 -0.04381
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0436076
RPL23 ribosomal protein L23 -0.0431475
RPL26 ribosomal protein L26 -0.0430489
SMYD3 SET and MYND domain containing 3 -0.04277
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0424787
RPL12 ribosomal protein L12 -0.0421374
RPS8 ribosomal protein S8 -0.0418814
SMC4 structural maintenance of chromosomes 4 -0.0413062
IL1RAP interleukin 1 receptor accessory protein -0.0410952
RPL37A ribosomal protein L37a -0.0410584
BCL2L1 BCL2-like 1 -0.0407575
FAF1 Fas (TNFRSF6) associated factor 1 -0.0407376
GOLGB1 golgin B1 -0.0404537
KRT17 keratin 17, type I -0.0403626
APLP2 amyloid beta (A4) precursor-like protein 2 -0.040264
ZBTB20 zinc finger and BTB domain containing 20 -0.0398736
RPS2 ribosomal protein S2 -0.0397168
GOLGA4 golgin A4 -0.0396354
IL6ST interleukin 6 signal transducer -0.039624
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0395903
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0381084
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0379396
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0379386
NF1 neurofibromin 1 -0.0377079
RPL9 ribosomal protein L9 -0.0375642
RAD51B RAD51 paralog B -0.0368489
PLAT plasminogen activator, tissue -0.0366912
GPHN gephyrin -0.0360976
MUC4 mucin 4, cell surface associated -0.0357329
STK24 serine/threonine kinase 24 -0.0356975
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0354457
RPL19 ribosomal protein L19 -0.0347743
FHIT fragile histidine triad -0.0345784
PLSCR1 phospholipid scramblase 1 -0.034025
ACTN4 actinin, alpha 4 -0.0339603
RPS29 ribosomal protein S29 -0.033785
RPS23 ribosomal protein S23 -0.0335861
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0333043
ATAD2 ATPase family, AAA domain containing 2 -0.0330601
ZC3H13 zinc finger CCCH-type containing 13 -0.0329525
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0325829
RPS13 ribosomal protein S13 -0.0324869
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0321736
ANKRD12 ankyrin repeat domain 12 -0.0319054
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0317543
LATS2 large tumor suppressor kinase 2 -0.0316606
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0315676
TGM2 transglutaminase 2 -0.0315022
RPS15 ribosomal protein S15 -0.0308831
ARL15 ADP-ribosylation factor-like 15 -0.030564
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0305216
RPL37 ribosomal protein L37 -0.0303871
TMSB10 thymosin beta 10 -0.0303308
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.030173
RASAL2 RAS protein activator like 2 -0.030084
RPL31 ribosomal protein L31 -0.0299474
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0298389
ARB2A ARB2 cotranscriptional regulator A -0.0296876
RPL32 ribosomal protein L32 -0.0294512