Berbamine (dihydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.15263
LAMB3 laminin, beta 3 0.106886
RPS3 ribosomal protein S3 0.100913
LPP LIM domain containing preferred translocation partner in lipoma 0.0867883
SET SET nuclear proto-oncogene 0.0858576
EEF2 eukaryotic translation elongation factor 2 0.075846
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0680782
PRRC2A proline-rich coiled-coil 2A 0.065098
RPS12 ribosomal protein S12 0.0628388
CALD1 caldesmon 1 0.0622568
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0604509
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0599211
FMNL2 formin-like 2 0.059691
EIF4H eukaryotic translation initiation factor 4H 0.0594999
SRRM2 serine/arginine repetitive matrix 2 0.0560407
WDR43 WD repeat domain 43 0.0549778
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0546478
NDRG1 N-myc downstream regulated 1 0.0546076
MYH9 myosin, heavy chain 9, non-muscle 0.0543478
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0530357
CHD1 chromodomain helicase DNA binding protein 1 0.0529018
OGA O-GlcNAcase 0.0528938
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0524931
RPL3 ribosomal protein L3 0.0524454
NUP58 nucleoporin 58 0.0520329
ANO6 anoctamin 6 0.0501982
BHLHE40 basic helix-loop-helix family, member e40 0.0497561
TRIO trio Rho guanine nucleotide exchange factor 0.0497505
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0494217
PTMA prothymosin, alpha 0.0490033
WAC WW domain containing adaptor with coiled-coil 0.0481884
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0479498
PRRC2C proline-rich coiled-coil 2C 0.0478376
RBM26 RNA binding motif protein 26 0.0454257
CALR calreticulin 0.0453762
MACF1 microtubule-actin crosslinking factor 1 0.0451229
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0446515
SFPQ splicing factor proline/glutamine-rich 0.0443809
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0439715
RPL7 ribosomal protein L7 0.0434367
MCL1 myeloid cell leukemia 1 0.0429582
ACTN1 actinin, alpha 1 0.0429229
TTR transthyretin 0.042842
EIF4B eukaryotic translation initiation factor 4B 0.0426893
ZNF292 zinc finger protein 292 0.0426536
RSRC2 arginine/serine-rich coiled-coil 2 0.0425625
CAMTA1 calmodulin binding transcription activator 1 0.0421932
RACK1 receptor for activated C kinase 1 0.0421247
FHL2 four and a half LIM domains 2 0.0418144
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0403685
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0403164
FNDC3B fibronectin type III domain containing 3B 0.0396358
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0392956
BIRC6 baculoviral IAP repeat containing 6 0.039277
ATP13A3 ATPase type 13A3 0.0388778
HSPA8 heat shock 70kDa protein 8 0.0387492
NCKAP1 NCK-associated protein 1 0.0382709
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0377589
SBF2 SET binding factor 2 0.0376701
VCL vinculin 0.0371874
PIAS2 protein inhibitor of activated STAT, 2 0.0371013
CUL3 cullin 3 0.0370453
PCBP2 poly(rC) binding protein 2 0.0369652
KDM6A lysine (K)-specific demethylase 6A 0.0365089
CLTC clathrin, heavy chain (Hc) 0.0359546
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0356756
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0355954
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0355724
RPS2 ribosomal protein S2 0.0355087
KIF5B kinesin family member 5B 0.0352176
ASXL1 additional sex combs like transcriptional regulator 1 0.0350972
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0346045
GAPVD1 GTPase activating protein and VPS9 domains 1 0.0342692
RPL37A ribosomal protein L37a 0.0335365
NAMPT nicotinamide phosphoribosyltransferase 0.0335302
FOXO3 forkhead box O3 0.0335003
CEP250 centrosomal protein 250kDa 0.0331325
RPS17 ribosomal protein S17 0.0330884
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0328473
SAMD4A sterile alpha motif domain containing 4A 0.0324492
KMT2E lysine (K)-specific methyltransferase 2E 0.0324235
YTHDC1 YTH domain containing 1 0.0320557
CELF1 CUGBP, Elav-like family member 1 0.0320414
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0320179
ANKRD11 ankyrin repeat domain 11 0.0319277
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0317076
USP9X ubiquitin specific peptidase 9, X-linked 0.0315844
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0314655
SRSF11 serine/arginine-rich splicing factor 11 0.0314131
BIRC2 baculoviral IAP repeat containing 2 0.0312019
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0311993
FAM91A1 family with sequence similarity 91, member A1 0.0311988
SMTN smoothelin 0.0309184
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0309077
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0307237
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.030703
YBX1 Y box binding protein 1 0.0306077
PDIA6 protein disulfide isomerase family A, member 6 0.0305669
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0303484
USP24 ubiquitin specific peptidase 24 0.0303281

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181391
ACTG1 actin gamma 1 -0.119201
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0984787
ZNF438 zinc finger protein 438 -0.0973389
NAV3 neuron navigator 3 -0.0905868
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0774344
RPS6 ribosomal protein S6 -0.0720796
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0601689
EXT1 exostosin glycosyltransferase 1 -0.0570148
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0566554
POTEF POTE ankyrin domain family, member F -0.0561765
UPP1 uridine phosphorylase 1 -0.0551065
ANTXR2 anthrax toxin receptor 2 -0.0530099
EGR1 early growth response 1 -0.0509618
RPL7A ribosomal protein L7a -0.0507535
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0504836
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0468235
FUS FUS RNA binding protein -0.0465928
RPL8 ribosomal protein L8 -0.0460966
C2CD2 C2 calcium-dependent domain containing 2 -0.0457627
NABP1 nucleic acid binding protein 1 -0.0452556
RPL28 ribosomal protein L28 -0.0448663
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0431594
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.041147
FRMD4A FERM domain containing 4A -0.0407961
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0405116
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0400956
TXNRD1 thioredoxin reductase 1 -0.0393052
IFI16 interferon, gamma-inducible protein 16 -0.0387843
IARS1 isoleucyl-tRNA synthetase 1 -0.0385746
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.0377733
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0370294
FUBP3 far upstream element (FUSE) binding protein 3 -0.0364294
FKBP15 FK506 binding protein 15, 133kDa -0.0360236
SHANK1 SH3 and multiple ankyrin repeat domains 1 -0.0352541
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0348089
FAF1 Fas (TNFRSF6) associated factor 1 -0.0338983
ARHGAP22 Rho GTPase activating protein 22 -0.0328351
RPLP2 ribosomal protein, large, P2 -0.0314602
PFN1 profilin 1 -0.0314355
HMGA1 high mobility group AT-hook 1 -0.0313704
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.031081
RPL38 ribosomal protein L38 -0.0307841
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0302326
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0298517
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0298421
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0296176
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0295706
TMSB10 thymosin beta 10 -0.0293229
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0288526
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0288027
RRBP1 ribosome binding protein 1 -0.028629
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.028579
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0285696
UBXN4 UBX domain protein 4 -0.0281373
RBBP6 retinoblastoma binding protein 6 -0.0277147
AK1 adenylate kinase 1 -0.0276511
PDIA3 protein disulfide isomerase family A, member 3 -0.0273784
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0267829
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0265003
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0257154
ZBTB38 zinc finger and BTB domain containing 38 -0.0254291
CSNK1E casein kinase 1, epsilon -0.0252822
MON2 MON2 homolog (S. cerevisiae) -0.0252133
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0251417
RAB7A RAB7A, member RAS oncogene family -0.0249999
ZNF638 zinc finger protein 638 -0.0247635
DGKH diacylglycerol kinase, eta -0.0244668
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0244167
LY6E lymphocyte antigen 6 complex, locus E -0.024391
PKM pyruvate kinase, muscle -0.0241318
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0241215
FTL ferritin, light polypeptide -0.0240094
GPHN gephyrin -0.0238717
STAU2 staufen double-stranded RNA binding protein 2 -0.0238435
RPLP1 ribosomal protein, large, P1 -0.0236932
RPS15 ribosomal protein S15 -0.0236201
SPRY4 sprouty homolog 4 (Drosophila) -0.0233126
RPLP0 ribosomal protein, large, P0 -0.0232856
AHI1 Abelson helper integration site 1 -0.0231849
LARS1 leucyl-tRNA synthetase 1 -0.022917
G0S2 G0/G1 switch 2 -0.0229103
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0226397
TAOK1 TAO kinase 1 -0.0225461
AAK1 AP2 associated kinase 1 -0.0224715
RPL39 ribosomal protein L39 -0.0223964
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0220753
MX2 MX dynamin-like GTPase 2 -0.022016
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0219424
FNDC3A fibronectin type III domain containing 3A -0.0218993
CASP4 caspase 4, apoptosis-related cysteine peptidase -0.0217146
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0215725
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0214242
HLA-A major histocompatibility complex, class I, A -0.0213994
CD44 CD44 molecule (Indian blood group) -0.0213835
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.0212972
DLC1 DLC1 Rho GTPase activating protein -0.0211645
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0210373
S100A11 S100 calcium binding protein A11 -0.0209043
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0208816