Berbamine (dihydrochloride)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.242958
NDRG1 N-myc downstream regulated 1 0.104876
PSD3 pleckstrin and Sec7 domain containing 3 0.0748139
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0712869
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0675302
ANXA2 annexin A2 0.0559421
CD109 CD109 molecule 0.0534076
ZNF292 zinc finger protein 292 0.0445464
ERRFI1 ERBB receptor feedback inhibitor 1 0.0444328
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0402485
EIF4H eukaryotic translation initiation factor 4H 0.0359032
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0350372
IER3 immediate early response 3 0.0337107
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0336799
CEMIP cell migration inducing protein, hyaluronan binding 0.0335945
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0326118
WSB1 WD repeat and SOCS box containing 1 0.0322558
PDE4D phosphodiesterase 4D, cAMP-specific 0.0303074
MCTP2 multiple C2 domains, transmembrane 2 0.0300692
ANGPTL4 angiopoietin-like 4 0.0298597
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0292152
ADM adrenomedullin 0.0290879
KDM4B lysine (K)-specific demethylase 4B 0.0283963
SBF2 SET binding factor 2 0.0281655
DDIT4 DNA-damage-inducible transcript 4 0.0278841
FAM13A family with sequence similarity 13, member A 0.0274454
EGFR epidermal growth factor receptor 0.0271993
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0271517
FGFR1 fibroblast growth factor receptor 1 0.0268443
NAV2 neuron navigator 2 0.0259208
KMT2E lysine (K)-specific methyltransferase 2E 0.0258592
MAML2 mastermind-like 2 (Drosophila) 0.0258535
ESYT2 extended synaptotagmin-like protein 2 0.0257043
ANO6 anoctamin 6 0.0256591
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0255101
FNDC3B fibronectin type III domain containing 3B 0.0251006
WWTR1 WW domain containing transcription regulator 1 0.0248445
LMNA lamin A/C 0.0246728
TRIO trio Rho guanine nucleotide exchange factor 0.0243543
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0242199
ZNF395 zinc finger protein 395 0.0242021
KDM3A lysine (K)-specific demethylase 3A 0.0240555
MYOF myoferlin 0.0240432
LOC112694756 uncharaterized LOC112694756 0.023708
CAVIN1 caveolae associated protein 1 0.023541
CCDC88A coiled-coil domain containing 88A 0.0234378
SRRM2 serine/arginine repetitive matrix 2 0.0227765
OGA O-GlcNAcase 0.0226402
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.0220656
GOLGB1 golgin B1 0.0219608
TMEM178B transmembrane protein 178B 0.0218684
BZW1 basic leucine zipper and W2 domains 1 0.0218132
MORF4L2 mortality factor 4 like 2 0.0217897
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0217179
ALCAM activated leukocyte cell adhesion molecule 0.0210618
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0210463
BZW2 basic leucine zipper and W2 domains 2 0.0209698
TRA2A transformer 2 alpha homolog (Drosophila) 0.0206784
GLS2 glutaminase 2 (liver, mitochondrial) 0.0206777
RRBP1 ribosome binding protein 1 0.0205436
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.020264
SNAP25 synaptosomal-associated protein, 25kDa 0.020241
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0199387
LCORL ligand dependent nuclear receptor corepressor-like 0.0197842
ZMYND8 zinc finger, MYND-type containing 8 0.0196135
TPT1 tumor protein, translationally-controlled 1 0.019526
LRRC23 leucine rich repeat containing 23 0.0195195
MEF2A myocyte enhancer factor 2A 0.0193249
USP3 ubiquitin specific peptidase 3 0.0188958
RPL30 ribosomal protein L30 0.0186613
RTN4 reticulon 4 0.0185956
FLNA filamin A, alpha 0.0185566
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.018387
SNX14 sorting nexin 14 0.0181151
CDC73 cell division cycle 73 0.0180474
AKAP9 A kinase (PRKA) anchor protein 9 0.0179128
RSRP1 arginine/serine-rich protein 1 0.0178398
GYS1 glycogen synthase 1 (muscle) 0.0178214
ARRDC3 arrestin domain containing 3 0.0177625
MBD5 methyl-CpG binding domain protein 5 0.0177582
SEC24D SEC24 family member D 0.0176888
SEC31A SEC31 homolog A (S. cerevisiae) 0.0175988
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0175021
YEATS2 YEATS domain containing 2 0.0174946
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0174411
LOXL2 lysyl oxidase-like 2 0.0174021
RERE arginine-glutamic acid dipeptide (RE) repeats 0.017357
SCFD2 sec1 family domain containing 2 0.0172079
AFDN afadin, adherens junction formation factor 0.0171638
HMGA2 high mobility group AT-hook 2 0.0171236
RASA3 RAS p21 protein activator 3 0.0169463
DGKD diacylglycerol kinase, delta 130kDa 0.0169162
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0168127
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0167215
CEP250 centrosomal protein 250kDa 0.0166832
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0165377
SFXN1 sideroflexin 1 0.016444
AMZ1 archaelysin family metallopeptidase 1 0.0161636
ANKRD10 ankyrin repeat domain 10 0.0161214
EYA1 EYA transcriptional coactivator and phosphatase 1 0.016118

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.199863
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196555
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.196195
STC1 stanniocalcin 1 -0.136805
VIM vimentin -0.134073
TMSB10 thymosin beta 10 -0.133279
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.124414
COL1A1 collagen, type I, alpha 1 -0.111813
HLA-B major histocompatibility complex, class I, B -0.102727
UBC ubiquitin C -0.0999916
MT2A metallothionein 2A -0.0920634
COL1A2 collagen, type I, alpha 2 -0.0887144
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.085558
ENO1 enolase 1, (alpha) -0.078945
IFI6 interferon, alpha-inducible protein 6 -0.0778179
NRP1 neuropilin 1 -0.0768268
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0636466
CDH13 cadherin 13 -0.0619697
FTL ferritin, light polypeptide -0.057874
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0575107
POTEF POTE ankyrin domain family, member F -0.0529605
SP100 SP100 nuclear antigen -0.0513523
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0506565
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0499463
MMP2 matrix metallopeptidase 2 -0.0497793
PKM pyruvate kinase, muscle -0.048064
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0479898
HLA-A major histocompatibility complex, class I, A -0.0478954
RPS27A ribosomal protein S27a -0.046709
CALU calumenin -0.0458886
CALR calreticulin -0.0458362
IFI44L interferon-induced protein 44-like -0.0438841
TPM1 tropomyosin 1 (alpha) -0.043248
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0429556
NAV1 neuron navigator 1 -0.0422465
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0411131
COL6A1 collagen, type VI, alpha 1 -0.0394635
RAB7A RAB7A, member RAS oncogene family -0.0394435
MMP12 matrix metallopeptidase 12 -0.0386854
H1-0 H1.0 linker histone -0.0384384
GSK3B glycogen synthase kinase 3 beta -0.0364303
EGR1 early growth response 1 -0.0361679
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0358582
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0358342
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0351929
IL1B interleukin 1, beta -0.0350587
MX2 MX dynamin-like GTPase 2 -0.0338445
ASPH aspartate beta-hydroxylase -0.0333402
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0331329
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0323513
PGK1 phosphoglycerate kinase 1 -0.0318114
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0316703
GLIS3 GLIS family zinc finger 3 -0.031643
S100A6 S100 calcium binding protein A6 -0.0315865
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0311413
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0308384
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0307825
ITGA11 integrin, alpha 11 -0.0300168
PLSCR1 phospholipid scramblase 1 -0.0299141
EPSTI1 epithelial stromal interaction 1 (breast) -0.0298459
MCL1 myeloid cell leukemia 1 -0.0289636
DOCK5 dedicator of cytokinesis 5 -0.028885
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0287231
VMP1 vacuole membrane protein 1 -0.0282619
ERBIN erbb2 interacting protein -0.0281447
OSMR oncostatin M receptor -0.0280781
SOD2 superoxide dismutase 2, mitochondrial -0.0280593
C1R complement component 1, r subcomponent -0.0279883
COL5A1 collagen, type V, alpha 1 -0.0279248
INHBA inhibin, beta A -0.0277933
CCNL1 cyclin L1 -0.0275674
COL6A2 collagen, type VI, alpha 2 -0.0273119
IFI16 interferon, gamma-inducible protein 16 -0.0273053
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0271326
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0270317
IFITM3 interferon induced transmembrane protein 3 -0.0269793
RIGI RNA sensor RIG-I -0.0266774
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0265115
ITGAV integrin, alpha V -0.0265061
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0265048
NPAS2 neuronal PAS domain protein 2 -0.0264511
RPS19 ribosomal protein S19 -0.026419
LDHA lactate dehydrogenase A -0.026077
AHNAK AHNAK nucleoprotein -0.0260347
FRMD4A FERM domain containing 4A -0.0258685
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0257782
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0255885
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0251031
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0249743
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0249472
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.024885
IGFBP3 insulin-like growth factor binding protein 3 -0.0248091
CST3 cystatin C -0.0246574
SSH1 slingshot protein phosphatase 1 -0.0245431
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0241488
FTH1 ferritin, heavy polypeptide 1 -0.024101
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0238133
SCARB2 scavenger receptor class B, member 2 -0.0237125
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0236817
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0236135