Berbamine (dihydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VGF VGF nerve growth factor inducible 0.140094
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0958579
NDRG1 N-myc downstream regulated 1 0.0907381
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0762474
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0654422
NALF1 NALCN channel auxiliary factor 1 0.0646793
CHD7 chromodomain helicase DNA binding protein 7 0.0551085
GRB10 growth factor receptor-bound protein 10 0.0531138
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0494557
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0482588
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0457872
CENPF centromere protein F, 350/400kDa 0.0447065
DTNA dystrobrevin, alpha 0.0427638
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0419724
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0417095
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0412229
HMGB3 high mobility group box 3 0.0411047
IGFBP5 insulin-like growth factor binding protein 5 0.040152
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0384652
PSD3 pleckstrin and Sec7 domain containing 3 0.0383654
XPO1 exportin 1 0.0361937
MSI2 musashi RNA-binding protein 2 0.0342221
CA8 carbonic anhydrase VIII 0.0338504
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.033495
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0331963
CHGB chromogranin B 0.0316868
KDM3A lysine (K)-specific demethylase 3A 0.0313417
AFF1 AF4/FMR2 family, member 1 0.0313047
DGKD diacylglycerol kinase, delta 130kDa 0.0306919
MBNL2 muscleblind-like splicing regulator 2 0.0306752
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0305372
CADM1 cell adhesion molecule 1 0.0303563
ZNF292 zinc finger protein 292 0.0299719
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.029512
ERRFI1 ERBB receptor feedback inhibitor 1 0.02948
GPC6 glypican 6 0.0290857
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0277985
TRIO trio Rho guanine nucleotide exchange factor 0.0277418
NUP58 nucleoporin 58 0.0275045
SINHCAF SIN3-HDAC complex associated factor 0.0273563
MYEF2 myelin expression factor 2 0.0269175
MYH9 myosin, heavy chain 9, non-muscle 0.026858
NBAS neuroblastoma amplified sequence 0.0266051
ESRRG estrogen-related receptor gamma 0.0265654
RORA RAR-related orphan receptor A 0.0259552
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0257809
FKBP9 FK506 binding protein 9, 63 kDa 0.0256584
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0255824
RPL3 ribosomal protein L3 0.0253116
TPD52 tumor protein D52 0.0251901
PTK2 protein tyrosine kinase 2 0.025165
MED13L mediator complex subunit 13-like 0.0242516
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0241379
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0234094
AUTS2 autism susceptibility candidate 2 0.0233528
DENND1A DENN/MADD domain containing 1A 0.0233526
NUMA1 nuclear mitotic apparatus protein 1 0.0232158
WDR45B WD repeat domain 45B 0.0228916
ARB2A ARB2 cotranscriptional regulator A 0.0228515
ADGRL3 adhesion G protein-coupled receptor L3 0.0225141
LIFR leukemia inhibitory factor receptor alpha 0.022463
NFIA nuclear factor I/A 0.022463
FAM13A family with sequence similarity 13, member A 0.0224621
STRN3 striatin, calmodulin binding protein 3 0.0224496
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0223177
PHF21A PHD finger protein 21A 0.0222635
PIAS2 protein inhibitor of activated STAT, 2 0.0221153
CCNY cyclin Y 0.0218491
PEG10 paternally expressed 10 0.0217169
BCL2 B-cell CLL/lymphoma 2 0.0216592
TSPYL2 TSPY-like 2 0.0215255
VEGFA vascular endothelial growth factor A 0.0214021
TOP2B topoisomerase (DNA) II beta 180kDa 0.0212395
PCBP3 poly(rC) binding protein 3 0.0210702
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0210093
TENM1 teneurin transmembrane protein 1 0.0209345
SPTBN1 spectrin, beta, non-erythrocytic 1 0.020847
YEATS2 YEATS domain containing 2 0.0208057
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0207852
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0207055
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0205977
PDE10A phosphodiesterase 10A 0.0205534
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0204446
LSAMP limbic system-associated membrane protein 0.020343
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0202023
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0201768
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0201491
LMNB1 lamin B1 0.0196636
NELL1 NEL-like 1 (chicken) 0.01965
NUF2 NUF2, NDC80 kinetochore complex component 0.0194728
GRAMD4 GRAM domain containing 4 0.019471
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0193629
IQSEC1 IQ motif and Sec7 domain 1 0.019351
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0191574
CCNL1 cyclin L1 0.0191427
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0189468
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.018905
RAD21 RAD21 homolog (S. pombe) 0.0188868
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0186502
CHD1L chromodomain helicase DNA binding protein 1-like 0.0186056

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.170347
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105589
FTL ferritin, light polypeptide -0.0831648
RPL37A ribosomal protein L37a -0.0821894
RPL26 ribosomal protein L26 -0.0811733
RPS6 ribosomal protein S6 -0.0774712
CALCA calcitonin-related polypeptide alpha -0.0772437
RPS3 ribosomal protein S3 -0.0759858
RPS8 ribosomal protein S8 -0.0737448
ACTG1 actin gamma 1 -0.0736943
RPL37 ribosomal protein L37 -0.0687619
SNAP25 synaptosomal-associated protein, 25kDa -0.0663793
RPLP1 ribosomal protein, large, P1 -0.0658996
RPS21 ribosomal protein S21 -0.0584488
MT2A metallothionein 2A -0.0568974
RPS27 ribosomal protein S27 -0.0565364
RPL31 ribosomal protein L31 -0.0533683
ATP5F1E ATP synthase F1 subunit epsilon -0.0521831
TPT1 tumor protein, translationally-controlled 1 -0.0516726
EGR1 early growth response 1 -0.0512274
RPS16 ribosomal protein S16 -0.0502854
RPS25 ribosomal protein S25 -0.0493495
FNDC3A fibronectin type III domain containing 3A -0.0471498
RPS29 ribosomal protein S29 -0.0470674
INHBA inhibin, beta A -0.0461139
ISG15 ISG15 ubiquitin-like modifier -0.0459576
RPL8 ribosomal protein L8 -0.0455111
RPL23 ribosomal protein L23 -0.0453743
RPS19 ribosomal protein S19 -0.0452423
RPS27A ribosomal protein S27a -0.0450386
PTCHD4 patched domain containing 4 -0.0428483
TMSB10 thymosin beta 10 -0.0420626
RPL35 ribosomal protein L35 -0.0417332
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0415707
STC1 stanniocalcin 1 -0.0414988
RPL38 ribosomal protein L38 -0.0412842
RPL36 ribosomal protein L36 -0.0410547
RPS17 ribosomal protein S17 -0.040595
RPS12 ribosomal protein S12 -0.0403548
RPL11 ribosomal protein L11 -0.0400582
RACK1 receptor for activated C kinase 1 -0.0398692
RPS23 ribosomal protein S23 -0.039537
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0388724
RPL30 ribosomal protein L30 -0.0387461
RPL19 ribosomal protein L19 -0.0381743
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0381528
RPL35A ribosomal protein L35a -0.0362112
RPL34 ribosomal protein L34 -0.0362023
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0361277
RPL5 ribosomal protein L5 -0.0350988
RPS5 ribosomal protein S5 -0.0346557
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0346475
RPL36AL ribosomal protein L36a-like -0.0335908
EIF1 eukaryotic translation initiation factor 1 -0.0333464
RPL7 ribosomal protein L7 -0.0333464
RPL12 ribosomal protein L12 -0.0323011
RPL7A ribosomal protein L7a -0.0320076
EIF5B eukaryotic translation initiation factor 5B -0.0315296
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0313286
TOX thymocyte selection-associated high mobility group box -0.0312971
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0312005
RPL36A ribosomal protein L36a -0.030943
RPL28 ribosomal protein L28 -0.0304999
RPL32 ribosomal protein L32 -0.0304726
SIK2 salt-inducible kinase 2 -0.03042
RPLP0 ribosomal protein, large, P0 -0.0301516
CHGA chromogranin A -0.0298371
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0295741
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0294567
IFI6 interferon, alpha-inducible protein 6 -0.0292997
SCG2 secretogranin II -0.0287039
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0281652
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0281089
RPL27 ribosomal protein L27 -0.0277759
RPS15 ribosomal protein S15 -0.0275228
RPS24 ribosomal protein S24 -0.0273354
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0272436
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0271661
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0269943
RPLP2 ribosomal protein, large, P2 -0.0268835
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0267972
PDE4D phosphodiesterase 4D, cAMP-specific -0.0264837
NDUFA4 NDUFA4, mitochondrial complex associated -0.0259991
RPS13 ribosomal protein S13 -0.0255143
FTH1 ferritin, heavy polypeptide 1 -0.0248997
THSD7A thrombospondin, type I, domain containing 7A -0.024803
RPS11 ribosomal protein S11 -0.0247871
FAF1 Fas (TNFRSF6) associated factor 1 -0.0246912
RPS14 ribosomal protein S14 -0.024633
NRG1 neuregulin 1 -0.0245843
GNAS GNAS complex locus -0.0239386
COX6C cytochrome c oxidase subunit VIc -0.0236438
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -0.023578
KPNB1 karyopherin (importin) beta 1 -0.0231856
FUS FUS RNA binding protein -0.0229658
RPL18 ribosomal protein L18 -0.0229425
B2M beta-2-microglobulin -0.022804
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0227874
WSB1 WD repeat and SOCS box containing 1 -0.0226263
BPTF bromodomain PHD finger transcription factor -0.0218839