Berbamine (dihydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.1914
LSAMP limbic system-associated membrane protein 0.101386
FMN1 formin 1 0.0852825
MSI2 musashi RNA-binding protein 2 0.0835972
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0723097
SREBF2 sterol regulatory element binding transcription factor 2 0.0678792
NLGN1 neuroligin 1 0.064702
PRELID2 PRELI domain containing 2 0.0612758
SEPTIN9 septin 9 0.058971
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0579531
SLC39A11 solute carrier family 39, member 11 0.0561883
IGFBP3 insulin-like growth factor binding protein 3 0.0555427
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0536755
FLNA filamin A, alpha 0.0526918
NRG3 neuregulin 3 0.0520436
FMNL2 formin-like 2 0.0519496
LINGO2 leucine rich repeat and Ig domain containing 2 0.0516077
CTTN cortactin 0.0501055
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0490334
SMYD3 SET and MYND domain containing 3 0.0469485
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0451894
PLEC plectin 0.0450178
PTPRM protein tyrosine phosphatase, receptor type, M 0.0448124
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0444804
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.043971
IGF1R insulin-like growth factor 1 receptor 0.0436154
EIF4H eukaryotic translation initiation factor 4H 0.0435783
PDIA3 protein disulfide isomerase family A, member 3 0.0427609
JMJD1C jumonji domain containing 1C 0.0424248
NOTCH2 notch 2 0.040776
CANX calnexin 0.0398926
PTK2 protein tyrosine kinase 2 0.0394045
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0384958
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0384701
KAZN kazrin, periplakin interacting protein 0.0381676
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0380322
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0366561
CDH13 cadherin 13 0.0361337
MMP12 matrix metallopeptidase 12 0.0360781
RAD51B RAD51 paralog B 0.0359556
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.035692
ANKRD17 ankyrin repeat domain 17 0.0354719
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0348327
CEP250 centrosomal protein 250kDa 0.0345529
CTBP2 C-terminal binding protein 2 0.0341361
MAML3 mastermind-like 3 (Drosophila) 0.0340318
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0333145
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.032786
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0327422
SEC31A SEC31 homolog A (S. cerevisiae) 0.0325088
BIRC6 baculoviral IAP repeat containing 6 0.0324153
ANKRD11 ankyrin repeat domain 11 0.0318775
TNNC1 troponin C type 1 (slow) 0.0318619
TAS2R14 taste receptor, type 2, member 14 0.0318218
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0316439
PTPRG protein tyrosine phosphatase, receptor type, G 0.0316259
NBAS neuroblastoma amplified sequence 0.0314888
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0313344
CLTC clathrin, heavy chain (Hc) 0.0309778
AFF1 AF4/FMR2 family, member 1 0.0307888
AFF4 AF4/FMR2 family, member 4 0.0306857
PCBP2 poly(rC) binding protein 2 0.0306272
HELZ helicase with zinc finger 0.0305215
CAMTA1 calmodulin binding transcription activator 1 0.0303443
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0302456
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0300635
FHIT fragile histidine triad 0.0300548
CDK13 cyclin-dependent kinase 13 0.0296768
RPL3 ribosomal protein L3 0.0295656
EHBP1 EH domain binding protein 1 0.0295085
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0293231
TRA2A transformer 2 alpha homolog (Drosophila) 0.029268
SPTBN1 spectrin, beta, non-erythrocytic 1 0.029261
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0290257
LRMDA leucine rich melanocyte differentiation associated 0.0289377
CADM1 cell adhesion molecule 1 0.0288173
KMT2C lysine (K)-specific methyltransferase 2C 0.0288085
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0288038
USP34 ubiquitin specific peptidase 34 0.0287846
TMEM51 transmembrane protein 51 0.0287278
RSRP1 arginine/serine-rich protein 1 0.0285509
YEATS2 YEATS domain containing 2 0.0284955
STAG2 stromal antigen 2 0.0281383
PEX5L peroxisomal biogenesis factor 5-like 0.0279918
TNIK TRAF2 and NCK interacting kinase 0.0277373
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.027563
EP300 E1A binding protein p300 0.0275502
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0272592
ATXN2 ataxin 2 0.0271564
CHD1 chromodomain helicase DNA binding protein 1 0.0270406
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0269716
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.026957
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0265799
CTSD cathepsin D 0.0265597
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.026288
ZFAND3 zinc finger, AN1-type domain 3 0.0261556
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0260513
TRIP12 thyroid hormone receptor interactor 12 0.0260082
CYTH3 cytohesin 3 0.0259946
PMEL premelanosome protein 0.0259563

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.211005
TMSB10 thymosin beta 10 -0.105142
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100788
RPLP1 ribosomal protein, large, P1 -0.0780033
ICAM1 intercellular adhesion molecule 1 -0.0706109
POTEF POTE ankyrin domain family, member F -0.0696383
RPS6 ribosomal protein S6 -0.0680108
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0609074
LDHA lactate dehydrogenase A -0.0596071
RPS3 ribosomal protein S3 -0.0577492
B2M beta-2-microglobulin -0.0577126
RPL23 ribosomal protein L23 -0.0560064
FTL ferritin, light polypeptide -0.0542171
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0505245
MT1X metallothionein 1X -0.0481446
S100A9 S100 calcium binding protein A9 -0.0448988
RPLP2 ribosomal protein, large, P2 -0.0448903
RPL37A ribosomal protein L37a -0.0446112
VIM vimentin -0.0443727
RPS21 ribosomal protein S21 -0.0427555
RPL12 ribosomal protein L12 -0.0402089
RPL32 ribosomal protein L32 -0.0396037
TXNRD1 thioredoxin reductase 1 -0.0347227
CCNL1 cyclin L1 -0.0339173
CBX3 chromobox homolog 3 -0.0328282
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0316391
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0314661
TFPI2 tissue factor pathway inhibitor 2 -0.0313008
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0302973
KLF6 Kruppel-like factor 6 -0.0301948
RPL19 ribosomal protein L19 -0.0286534
MATR3 matrin 3 -0.0285314
RPS27 ribosomal protein S27 -0.0279149
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.027625
RPL36 ribosomal protein L36 -0.0265749
RPL13A ribosomal protein L13a -0.0263337
CD44 CD44 molecule (Indian blood group) -0.0260199
VEGFA vascular endothelial growth factor A -0.0257518
RPS27A ribosomal protein S27a -0.0254251
MYL12B myosin, light chain 12B, regulatory -0.0253341
RPS13 ribosomal protein S13 -0.0245874
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0242554
RPL18 ribosomal protein L18 -0.0241738
RPS12 ribosomal protein S12 -0.0239895
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0239434
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0235089
TENM1 teneurin transmembrane protein 1 -0.0233305
RPS19 ribosomal protein S19 -0.0231026
FNDC3B fibronectin type III domain containing 3B -0.0224694
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0222546
RPL36A ribosomal protein L36a -0.0222372
RPL31 ribosomal protein L31 -0.0220875
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0220232
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0218016
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.021754
TOR1AIP2 torsin A interacting protein 2 -0.0216201
HLA-B major histocompatibility complex, class I, B -0.0214751
GPX4 glutathione peroxidase 4 -0.0212809
ATF4 activating transcription factor 4 -0.0212669
RHOA ras homolog family member A -0.0211802
RPS8 ribosomal protein S8 -0.0210663
S100A6 S100 calcium binding protein A6 -0.0208166
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0206393
RPL35 ribosomal protein L35 -0.0202574
SKP1 S-phase kinase-associated protein 1 -0.0202272
ENAH enabled homolog (Drosophila) -0.0201891
OAZ1 ornithine decarboxylase antizyme 1 -0.0198952
RASAL2 RAS protein activator like 2 -0.0196243
MACROD2 MACRO domain containing 2 -0.0196082
GRAMD1B GRAM domain containing 1B -0.0192597
NKTR natural killer cell triggering receptor -0.0192588
DUSP6 dual specificity phosphatase 6 -0.0192249
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.0191919
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0189621
SERF2 small EDRK-rich factor 2 -0.0189366
RPLP0 ribosomal protein, large, P0 -0.0189166
WWTR1 WW domain containing transcription regulator 1 -0.0187492
RPL37 ribosomal protein L37 -0.0185976
S100A11 S100 calcium binding protein A11 -0.0184371
RPL4 ribosomal protein L4 -0.0183364
RPL27A ribosomal protein L27a -0.018236
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0181616
RPL34 ribosomal protein L34 -0.0180831
RPS23 ribosomal protein S23 -0.017918
RPS5 ribosomal protein S5 -0.0179012
ASTN2 astrotactin 2 -0.0178969
SMC5 structural maintenance of chromosomes 5 -0.0178098
YBX3 Y box binding protein 3 -0.0178052
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0176457
RPL26 ribosomal protein L26 -0.01748
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0172656
RPL38 ribosomal protein L38 -0.0172579
PTTG1 pituitary tumor-transforming 1 -0.0171307
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0170308
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.016969
PGK1 phosphoglycerate kinase 1 -0.0168633
RPL35A ribosomal protein L35a -0.0168467
FBXL17 F-box and leucine-rich repeat protein 17 -0.0166727
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.0164687
GARS1 glycyl-tRNA synthetase 1 -0.0163642