Berbamine (dihydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.143018
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.134265
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.130196
PDE4B phosphodiesterase 4B, cAMP-specific 0.129899
CPED1 cadherin-like and PC-esterase domain containing 1 0.125354
GNPDA1 glucosamine-6-phosphate deaminase 1 0.125041
VCL vinculin 0.120349
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.114914
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.112086
LOC112694756 uncharaterized LOC112694756 0.109713
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0973215
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0957608
DLG1 discs, large homolog 1 (Drosophila) 0.0922191
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0853542
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0848951
FOXP1 forkhead box P1 0.0793509
LPP LIM domain containing preferred translocation partner in lipoma 0.0780239
ANKRD11 ankyrin repeat domain 11 0.075888
SSBP2 single-stranded DNA binding protein 2 0.0753577
NFIA nuclear factor I/A 0.0703949
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0699142
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0676804
ACTG1 actin gamma 1 0.061267
HDLBP high density lipoprotein binding protein 0.0595217
PLXNA1 plexin A1 0.0580195
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0562043
PDGFC platelet derived growth factor C 0.0546136
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0536996
CAMKMT calmodulin-lysine N-methyltransferase 0.0528484
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0511858
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0508671
SLC38A2 solute carrier family 38, member 2 0.0505731
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0497595
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.048838
SRRM2 serine/arginine repetitive matrix 2 0.0481543
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0480978
CLIC4 chloride intracellular channel 4 0.0479895
GARS1 glycyl-tRNA synthetase 1 0.0468068
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0463918
MSI2 musashi RNA-binding protein 2 0.0423057
NBEA neurobeachin 0.0421317
CALR calreticulin 0.0416485
EVI5 ecotropic viral integration site 5 0.041622
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0404466
EIF4H eukaryotic translation initiation factor 4H 0.0403256
TJP1 tight junction protein 1 0.0401611
IARS1 isoleucyl-tRNA synthetase 1 0.0400775
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0400636
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0392235
LOXL3 lysyl oxidase-like 3 0.0382713
PRDM16 PR domain containing 16 0.0369909
CALU calumenin 0.0367814
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0359094
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0357043
RBM39 RNA binding motif protein 39 0.035299
ENOSF1 enolase superfamily member 1 0.0351413
NT5C2 5'-nucleotidase, cytosolic II 0.0351185
HLA-C major histocompatibility complex, class I, C 0.03498
PNISR PNN-interacting serine/arginine-rich protein 0.034889
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0345895
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0345788
KPNB1 karyopherin (importin) beta 1 0.0345118
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0343254
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0338172
KIF5B kinesin family member 5B 0.0334302
AMOTL2 angiomotin like 2 0.0331642
CLIP1 CAP-GLY domain containing linker protein 1 0.0324768
CD47 CD47 molecule 0.0324579
HJURP Holliday junction recognition protein 0.0324422
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0323996
IGF1R insulin-like growth factor 1 receptor 0.0321584
RRBP1 ribosome binding protein 1 0.0316076
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0315898
MYOF myoferlin 0.0313142
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0311373
PREPL prolyl endopeptidase-like 0.0311084
GNAS GNAS complex locus 0.0310485
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0309276
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0307576
ZNF207 zinc finger protein 207 0.0307496
CTIF CBP80/20-dependent translation initiation factor 0.0307427
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0303829
ZMIZ1 zinc finger, MIZ-type containing 1 0.0302048
TMSB4X thymosin beta 4, X-linked 0.0301154
EFNA5 ephrin-A5 0.0300405
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0300182
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0293331
SEC63 SEC63 homolog (S. cerevisiae) 0.0292352
EPS8 epidermal growth factor receptor pathway substrate 8 0.0289584
GATA6 GATA binding protein 6 0.0288207
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0288206
RPL34 ribosomal protein L34 0.0287308
NARS1 asparaginyl-tRNA synthetase 1 0.0287001
ELOVL5 ELOVL fatty acid elongase 5 0.0286945
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0284622
CTBP2 C-terminal binding protein 2 0.028409
PTEN phosphatase and tensin homolog 0.0283024
NAP1L1 nucleosome assembly protein 1-like 1 0.0282723
ATXN2L ataxin 2-like 0.0280708
MATR3 matrin 3 0.0279971

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.157142
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.130621
RPS2 ribosomal protein S2 -0.0864509
PTMA prothymosin, alpha -0.0787786
RPS6 ribosomal protein S6 -0.0784232
PKM pyruvate kinase, muscle -0.0741537
ADAM10 ADAM metallopeptidase domain 10 -0.0718352
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0533034
BRD2 bromodomain containing 2 -0.0497338
ANXA1 annexin A1 -0.0464561
USP34 ubiquitin specific peptidase 34 -0.0443804
RPL12 ribosomal protein L12 -0.0430393
EML4 echinoderm microtubule associated protein like 4 -0.0430163
RPS8 ribosomal protein S8 -0.039183
MACROD2 MACRO domain containing 2 -0.0390222
POTEF POTE ankyrin domain family, member F -0.0366181
RPL37A ribosomal protein L37a -0.0346187
IFI16 interferon, gamma-inducible protein 16 -0.0342739
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0342643
PRRC2C proline-rich coiled-coil 2C -0.0330012
RPL21 ribosomal protein L21 -0.0329804
ECPAS Ecm29 proteasome adaptor and scaffold -0.03261
CCNL1 cyclin L1 -0.0325751
HSPA8 heat shock 70kDa protein 8 -0.031966
RPL26 ribosomal protein L26 -0.0306446
DENND4A DENN/MADD domain containing 4A -0.0304765
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0296758
RPL9 ribosomal protein L9 -0.0294508
UBC ubiquitin C -0.0287934
FER fer (fps/fes related) tyrosine kinase -0.0285984
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0284668
RPL19 ribosomal protein L19 -0.0277574
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0275172
RPS3 ribosomal protein S3 -0.0270153
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0269689
RPLP2 ribosomal protein, large, P2 -0.0269617
H1-4 H1.4 linker histone, cluster member -0.026818
EXT1 exostosin glycosyltransferase 1 -0.0261267
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0258741
RPS29 ribosomal protein S29 -0.025392
NCKAP1 NCK-associated protein 1 -0.0253652
ZBTB10 zinc finger and BTB domain containing 10 -0.0252336
RPS17 ribosomal protein S17 -0.0251571
RPL7A ribosomal protein L7a -0.0249343
RPS18 ribosomal protein S18 -0.0248126
RPL38 ribosomal protein L38 -0.0243907
BMP10 bone morphogenetic protein 10 -0.0242574
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0240618
RSRC1 arginine/serine-rich coiled-coil 1 -0.0238257
BTBD9 BTB (POZ) domain containing 9 -0.0237995
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0233646
TAOK1 TAO kinase 1 -0.0230897
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0228805
RPS12 ribosomal protein S12 -0.0225178
RPS23 ribosomal protein S23 -0.0223919
GPHN gephyrin -0.0223627
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0221112
BMP2K BMP2 inducible kinase -0.0220717
ZFAND6 zinc finger, AN1-type domain 6 -0.0219763
RUNX1 runt-related transcription factor 1 -0.0218978
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0218147
SETD5 SET domain containing 5 -0.0218009
RB1CC1 RB1-inducible coiled-coil 1 -0.0217218
S100A11 S100 calcium binding protein A11 -0.0216523
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.021593
BIRC3 baculoviral IAP repeat containing 3 -0.0215926
SMNDC1 survival motor neuron domain containing 1 -0.021238
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0210755
METTL15 methyltransferase like 15 -0.0210603
MBD5 methyl-CpG binding domain protein 5 -0.0209088
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0208685
SQSTM1 sequestosome 1 -0.0208111
S100A10 S100 calcium binding protein A10 -0.0207821
PAPOLA poly(A) polymerase alpha -0.0207101
RPS15 ribosomal protein S15 -0.0206914
FTL ferritin, light polypeptide -0.0202972
RPL7 ribosomal protein L7 -0.0200507
BRD4 bromodomain containing 4 -0.0199831
VMP1 vacuole membrane protein 1 -0.0197479
RPL32 ribosomal protein L32 -0.0197427
RAB10 RAB10, member RAS oncogene family -0.0195687
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0195259
KLF3 Kruppel-like factor 3 (basic) -0.0194105
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0193147
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.019255
RPL36 ribosomal protein L36 -0.0192004
CLU clusterin -0.0191639
FOXJ3 forkhead box J3 -0.0190843
NIPBL Nipped-B homolog (Drosophila) -0.0189552
SPAG9 sperm associated antigen 9 -0.0188973
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0188901
RPS13 ribosomal protein S13 -0.018883
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0188416
MYO9A myosin IXA -0.0187649
ZBTB20 zinc finger and BTB domain containing 20 -0.0187157
BBS9 Bardet-Biedl syndrome 9 -0.0185376
RPS10 ribosomal protein S10 -0.0184662
IRS1 insulin receptor substrate 1 -0.0184342
B2M beta-2-microglobulin -0.0181135
NAMPT nicotinamide phosphoribosyltransferase -0.0180122