Berbamine (dihydrochloride)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.224828
VIM vimentin 0.194672
IGFBP3 insulin-like growth factor binding protein 3 0.185614
CXCL8 chemokine (C-X-C motif) ligand 8 0.126128
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0800306
B2M beta-2-microglobulin 0.0782332
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0771198
TRIO trio Rho guanine nucleotide exchange factor 0.0762897
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0752734
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0727867
F3 coagulation factor III (thromboplastin, tissue factor) 0.0695423
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0686774
COL1A1 collagen, type I, alpha 1 0.0665771
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0648708
ERRFI1 ERBB receptor feedback inhibitor 1 0.063288
ANXA5 annexin A5 0.0578648
PKM pyruvate kinase, muscle 0.0564357
ASPH aspartate beta-hydroxylase 0.0544279
RASAL2 RAS protein activator like 2 0.0527084
FN1 fibronectin 1 0.051304
AKAP12 A kinase (PRKA) anchor protein 12 0.0506844
PCBP2 poly(rC) binding protein 2 0.0495982
COL1A2 collagen, type I, alpha 2 0.0495437
FAM13A family with sequence similarity 13, member A 0.0491882
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0490384
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0489724
CALU calumenin 0.0487161
KLF7 Kruppel-like factor 7 (ubiquitous) 0.048279
ARRDC3 arrestin domain containing 3 0.0471832
ERBIN erbb2 interacting protein 0.0471287
RTN4 reticulon 4 0.0458354
JMJD1C jumonji domain containing 1C 0.0440429
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0431951
DLG1 discs, large homolog 1 (Drosophila) 0.0425327
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0417249
MAP1B microtubule-associated protein 1B 0.0412783
NCOR1 nuclear receptor corepressor 1 0.0412731
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.040737
MAP4 microtubule-associated protein 4 0.040713
ATP13A3 ATPase type 13A3 0.0401525
DDIT4 DNA-damage-inducible transcript 4 0.0396309
SEPTIN7 septin 7 0.0390231
RAP1B RAP1B, member of RAS oncogene family 0.0386455
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0379991
POTEF POTE ankyrin domain family, member F 0.0379658
UGCG UDP-glucose ceramide glucosyltransferase 0.0375483
KTN1 kinectin 1 (kinesin receptor) 0.0372276
ENO1 enolase 1, (alpha) 0.0371416
SEPTIN9 septin 9 0.0370256
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0368375
EGFR epidermal growth factor receptor 0.0367475
SRRM2 serine/arginine repetitive matrix 2 0.0361296
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0360761
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0360447
FNDC3B fibronectin type III domain containing 3B 0.0360224
PDIA3 protein disulfide isomerase family A, member 3 0.0357682
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.035711
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0352436
KIF13A kinesin family member 13A 0.0342292
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0341725
TENT2 terminal nucleotidyltransferase 2 0.0341034
COPA coatomer protein complex, subunit alpha 0.0337778
DST dystonin 0.0331842
RSRC2 arginine/serine-rich coiled-coil 2 0.0331495
FOSL1 FOS-like antigen 1 0.0329148
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0324466
MYOF myoferlin 0.0321068
RAB8B RAB8B, member RAS oncogene family 0.031997
HELZ helicase with zinc finger 0.0318611
NAMPT nicotinamide phosphoribosyltransferase 0.0317781
PDIA6 protein disulfide isomerase family A, member 6 0.0316207
RIOK3 RIO kinase 3 0.0314734
WDR41 WD repeat domain 41 0.0313897
RPS12 ribosomal protein S12 0.0313464
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.031002
CLASP1 cytoplasmic linker associated protein 1 0.0308882
ADM adrenomedullin 0.0308495
RAB1A RAB1A, member RAS oncogene family 0.0306156
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0302403
CLIC4 chloride intracellular channel 4 0.0302173
RND3 Rho family GTPase 3 0.0301015
CDK6 cyclin-dependent kinase 6 0.0299921
FLNA filamin A, alpha 0.0299444
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0299413
EMP1 epithelial membrane protein 1 0.0294922
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.029436
ANKRD11 ankyrin repeat domain 11 0.0293348
PTMA prothymosin, alpha 0.0292002
OPTN optineurin 0.0291096
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0289879
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0289059
CALD1 caldesmon 1 0.0289056
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0287779
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0287211
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0286132
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0285307
PACS1 phosphofurin acidic cluster sorting protein 1 0.0285043
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0284461
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0283629
ZC3H11A zinc finger CCCH-type containing 11A 0.0283332

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.198667
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127104
MT2A metallothionein 2A -0.114307
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.103184
TMSB10 thymosin beta 10 -0.0717245
SMYD3 SET and MYND domain containing 3 -0.0714118
TGFBI transforming growth factor, beta-induced, 68kDa -0.065794
SDC4 syndecan 4 -0.0643042
ZMYND8 zinc finger, MYND-type containing 8 -0.0541698
PRELID2 PRELI domain containing 2 -0.0541343
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0534109
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0526425
CANX calnexin -0.0521432
HMGA2 high mobility group AT-hook 2 -0.050704
COG6 component of oligomeric golgi complex 6 -0.0506874
RAD51B RAD51 paralog B -0.0502043
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0495266
MT1X metallothionein 1X -0.0460762
CALR calreticulin -0.0443356
BTBD9 BTB (POZ) domain containing 9 -0.0441398
HLA-B major histocompatibility complex, class I, B -0.043802
WDPCP WD repeat containing planar cell polarity effector -0.0427312
STC1 stanniocalcin 1 -0.0424884
AHNAK AHNAK nucleoprotein -0.0410921
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0397741
SOD2 superoxide dismutase 2, mitochondrial -0.0397415
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0380949
FNIP1 folliculin interacting protein 1 -0.0380718
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0380101
ALK anaplastic lymphoma receptor tyrosine kinase -0.0374998
TPT1 tumor protein, translationally-controlled 1 -0.0368177
PTGES2 prostaglandin E synthase 2 -0.0357595
LOX lysyl oxidase -0.0354941
CA12 carbonic anhydrase XII -0.0353562
ELL2 elongation factor, RNA polymerase II, 2 -0.0351748
TMEM263 transmembrane protein 263 -0.0351199
COL6A1 collagen, type VI, alpha 1 -0.034878
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0339528
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.033576
RPL34 ribosomal protein L34 -0.033245
PDE4D phosphodiesterase 4D, cAMP-specific -0.0332289
PDCD6IP programmed cell death 6 interacting protein -0.0326971
ZBTB20 zinc finger and BTB domain containing 20 -0.0316738
BBS9 Bardet-Biedl syndrome 9 -0.0314893
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0310298
JPH2 junctophilin 2 -0.0305676
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0305289
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0303941
MORF4L2 mortality factor 4 like 2 -0.0302327
ANKRD17 ankyrin repeat domain 17 -0.0300229
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0294265
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0294196
ZC3H13 zinc finger CCCH-type containing 13 -0.0293786
GOLGB1 golgin B1 -0.0289552
NFX1 nuclear transcription factor, X-box binding 1 -0.0286192
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0284462
GPR107 G protein-coupled receptor 107 -0.0279074
SPDYA speedy/RINGO cell cycle regulator family member A -0.0278045
CEMIP cell migration inducing protein, hyaluronan binding -0.0277119
PDLIM5 PDZ and LIM domain 5 -0.0275939
AGO3 argonaute RISC catalytic component 3 -0.0273724
PRRC1 proline-rich coiled-coil 1 -0.0273316
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0269716
COG5 component of oligomeric golgi complex 5 -0.0269446
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0269039
EXOC4 exocyst complex component 4 -0.0267771
COL6A2 collagen, type VI, alpha 2 -0.0266858
PDIA4 protein disulfide isomerase family A, member 4 -0.0263964
HIPK2 homeodomain interacting protein kinase 2 -0.026387
FAM13B family with sequence similarity 13, member B -0.0262996
NSD3 nuclear receptor binding SET domain protein 3 -0.0259976
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0259317
SUB1 SUB1 homolog (S. cerevisiae) -0.025656
HDLBP high density lipoprotein binding protein -0.0254709
NDFIP1 Nedd4 family interacting protein 1 -0.0253899
STAG2 stromal antigen 2 -0.0253433
FTL ferritin, light polypeptide -0.0249218
TTC3 tetratricopeptide repeat domain 3 -0.0248137
VEZT vezatin, adherens junctions transmembrane protein -0.0244586
HPCAL1 hippocalcin-like 1 -0.024119
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0241066
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0240418
PMM2 phosphomannomutase 2 -0.0240043
CSMD2 CUB and Sushi multiple domains 2 -0.0238673
XPO1 exportin 1 -0.0238143
RPL35A ribosomal protein L35a -0.0237506
SCLT1 sodium channel and clathrin linker 1 -0.0237455
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.0237318
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0237081
ELP4 elongator acetyltransferase complex subunit 4 -0.0236626
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0232574
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -0.0232061
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0230513
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0229592
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0229229
STK17A serine/threonine kinase 17a -0.0228308
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0227771
APOLD1 apolipoprotein L domain containing 1 -0.0227531
MAPK8 mitogen-activated protein kinase 8 -0.0227478
SETD5 SET domain containing 5 -0.0226411