Berbamine (dihydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.079441
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0402504
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0341258
CD109 CD109 molecule 0.0340597
FLNA filamin A, alpha 0.0318505
PDIA3 protein disulfide isomerase family A, member 3 0.0290557
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.027606
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0275886
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0269805
SEC23A Sec23 homolog A (S. cerevisiae) 0.0261805
HMGB3 high mobility group box 3 0.024901
HILPDA hypoxia inducible lipid droplet-associated 0.0245339
WDFY1 WD repeat and FYVE domain containing 1 0.0236463
LOC112694756 uncharaterized LOC112694756 0.0235209
EIF4H eukaryotic translation initiation factor 4H 0.0231187
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0225179
BIRC6 baculoviral IAP repeat containing 6 0.0220938
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0216894
RNF145 ring finger protein 145 0.0214928
SOD2 superoxide dismutase 2, mitochondrial 0.020682
PLEC plectin 0.0204838
MIS18BP1 MIS18 binding protein 1 0.0200383
UBA6 ubiquitin-like modifier activating enzyme 6 0.0199114
AFDN afadin, adherens junction formation factor 0.0194245
SRP54 signal recognition particle 54kDa 0.019281
XPO1 exportin 1 0.0192269
WDR26 WD repeat domain 26 0.0191864
SMOX spermine oxidase 0.0190489
AHR aryl hydrocarbon receptor 0.0188945
WDR45B WD repeat domain 45B 0.0186616
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.018659
HELZ helicase with zinc finger 0.0185039
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0182509
SEC31A SEC31 homolog A (S. cerevisiae) 0.0181588
KMT2E lysine (K)-specific methyltransferase 2E 0.0180917
RPL3 ribosomal protein L3 0.0179557
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0178877
EPS8 epidermal growth factor receptor pathway substrate 8 0.01781
NUP58 nucleoporin 58 0.0175864
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0173857
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0173749
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0172324
SIRT1 sirtuin 1 0.0172007
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0170733
CLTC clathrin, heavy chain (Hc) 0.0170345
RAB1A RAB1A, member RAS oncogene family 0.0167437
FXR1 fragile X mental retardation, autosomal homolog 1 0.0166876
HLA-C major histocompatibility complex, class I, C 0.0164989
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0163589
DDIT4 DNA-damage-inducible transcript 4 0.0163445
SEC24C SEC24 family member C 0.0162133
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.016112
TBC1D22A TBC1 domain family, member 22A 0.0160846
NEK7 NIMA-related kinase 7 0.0160675
IRAK3 interleukin-1 receptor-associated kinase 3 0.0159365
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0157847
RPS2 ribosomal protein S2 0.0156865
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0155954
CDC73 cell division cycle 73 0.0155895
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.015585
ARRDC3 arrestin domain containing 3 0.0155128
MLEC malectin 0.0153684
MARCHF7 membrane associated ring-CH-type finger 7 0.0153116
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0152987
RAB6A RAB6A, member RAS oncogene family 0.0152181
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0151536
TFG TRK-fused gene 0.015018
KDM3B lysine (K)-specific demethylase 3B 0.0149104
CALR calreticulin 0.0148447
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0147816
GDNF glial cell derived neurotrophic factor 0.0146842
NDEL1 nudE neurodevelopment protein 1-like 1 0.014566
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0144875
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0144824
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0144202
TRA2A transformer 2 alpha homolog (Drosophila) 0.0143742
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0143701
ADD3 adducin 3 (gamma) 0.014361
SLAIN2 SLAIN motif family, member 2 0.0142011
RNMT RNA (guanine-7-) methyltransferase 0.0141517
FAT1 FAT atypical cadherin 1 0.0138951
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0138923
ATXN2L ataxin 2-like 0.0137446
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0136845
GATAD2B GATA zinc finger domain containing 2B 0.013627
GOLT1B golgi transport 1B 0.0134505
TENT2 terminal nucleotidyltransferase 2 0.0133426
RSRP1 arginine/serine-rich protein 1 0.0132339
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.01321
SURF4 surfeit 4 0.0131601
PRRC1 proline-rich coiled-coil 1 0.0131411
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0129278
ACADVL acyl-CoA dehydrogenase, very long chain 0.0128278
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.012778
AHCTF1 AT hook containing transcription factor 1 0.0127545
SHB Src homology 2 domain containing adaptor protein B 0.0127456
KLHL28 kelch-like family member 28 0.0125828
CALU calumenin 0.012582
ATL2 atlastin GTPase 2 0.0125779
CTBP2 C-terminal binding protein 2 0.0125665

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.387688
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.212868
MT2A metallothionein 2A -0.203876
FN1 fibronectin 1 -0.142414
ASPH aspartate beta-hydroxylase -0.131538
TMSB10 thymosin beta 10 -0.131381
NRG1 neuregulin 1 -0.124304
FTL ferritin, light polypeptide -0.10188
B2M beta-2-microglobulin -0.0912199
HLA-B major histocompatibility complex, class I, B -0.0851512
IFI27 interferon, alpha-inducible protein 27 -0.0808741
HMGA2 high mobility group AT-hook 2 -0.0690094
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0598112
TMEM156 transmembrane protein 156 -0.0582795
CCNL1 cyclin L1 -0.0572609
MAP1B microtubule-associated protein 1B -0.0549189
TMSB4X thymosin beta 4, X-linked -0.0532451
S100A6 S100 calcium binding protein A6 -0.0523805
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0513474
SYT1 synaptotagmin I -0.0499894
SOX4 SRY (sex determining region Y)-box 4 -0.0498741
LOC102724023 ES1 protein homolog, mitochondrial -0.0479781
ITGA1 integrin, alpha 1 -0.0478186
IFI6 interferon, alpha-inducible protein 6 -0.0468746
EXT1 exostosin glycosyltransferase 1 -0.046483
POTEF POTE ankyrin domain family, member F -0.0464416
PTMA prothymosin, alpha -0.0461851
VEGFA vascular endothelial growth factor A -0.0440377
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0438666
SFTPA2 surfactant protein A2 -0.0438422
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0436936
KLHL5 kelch-like family member 5 -0.0428945
IFI16 interferon, gamma-inducible protein 16 -0.0417878
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0409967
DUSP6 dual specificity phosphatase 6 -0.0407082
SQSTM1 sequestosome 1 -0.0399288
PDE4D phosphodiesterase 4D, cAMP-specific -0.0383861
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0378223
ACTG1 actin gamma 1 -0.0372479
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0372411
VCL vinculin -0.0371461
S100A10 S100 calcium binding protein A10 -0.0366559
EGR1 early growth response 1 -0.0366383
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0363608
VIM vimentin -0.036141
RPS21 ribosomal protein S21 -0.0361158
RPLP1 ribosomal protein, large, P1 -0.036056
S100A9 S100 calcium binding protein A9 -0.035337
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0352456
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0347917
ETV1 ets variant 1 -0.0341839
FTH1 ferritin, heavy polypeptide 1 -0.0339955
AHI1 Abelson helper integration site 1 -0.0339853
TPT1 tumor protein, translationally-controlled 1 -0.0338286
RPS19 ribosomal protein S19 -0.0335724
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0325644
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0325522
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0324082
PGK1 phosphoglycerate kinase 1 -0.0323406
YBX3 Y box binding protein 3 -0.0323055
IFIH1 interferon induced with helicase C domain 1 -0.0319843
SMAD3 SMAD family member 3 -0.0309501
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0308161
LTBP1 latent transforming growth factor beta binding protein 1 -0.0307274
HMGA1 high mobility group AT-hook 1 -0.0307191
RPS8 ribosomal protein S8 -0.0306909
NTN4 netrin 4 -0.0304457
ARHGAP5 Rho GTPase activating protein 5 -0.0304343
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0299103
PTK2 protein tyrosine kinase 2 -0.0299037
RPL38 ribosomal protein L38 -0.0298048
ENO1 enolase 1, (alpha) -0.0294947
ZBTB20 zinc finger and BTB domain containing 20 -0.0294334
RPS27A ribosomal protein S27a -0.0292502
RSF1 remodeling and spacing factor 1 -0.0288281
LY6E lymphocyte antigen 6 complex, locus E -0.0282792
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0281761
RPL35A ribosomal protein L35a -0.0281509
IFI44L interferon-induced protein 44-like -0.0278526
RANBP17 RAN binding protein 17 -0.0278152
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0277591
ANKRD28 ankyrin repeat domain 28 -0.0276897
TXNIP thioredoxin interacting protein -0.0274596
OSMR oncostatin M receptor -0.0273379
RPL28 ribosomal protein L28 -0.0272257
AEBP2 AE binding protein 2 -0.0271687
LDHA lactate dehydrogenase A -0.0269707
HLA-A major histocompatibility complex, class I, A -0.0266614
RPL12 ribosomal protein L12 -0.0265419
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0263336
NRP1 neuropilin 1 -0.0262216
CBX3 chromobox homolog 3 -0.0259241
BPTF bromodomain PHD finger transcription factor -0.0255958
SEPTIN9 septin 9 -0.0255468
TTC28 tetratricopeptide repeat domain 28 -0.025388
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0253628
AREG amphiregulin -0.025245
RPS6 ribosomal protein S6 -0.0251909
SMYD3 SET and MYND domain containing 3 -0.0250262
DNAH14 dynein, axonemal, heavy chain 14 -0.0247192