Berbamine (dihydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.105502
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0907888
MAML2 mastermind-like 2 (Drosophila) 0.0824153
LOC112694756 uncharaterized LOC112694756 0.0711706
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0647752
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0595153
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.057651
NFIA nuclear factor I/A 0.0535308
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0510335
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0467006
CEMIP cell migration inducing protein, hyaluronan binding 0.0453815
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.044357
SDK1 sidekick cell adhesion molecule 1 0.0440871
HDLBP high density lipoprotein binding protein 0.0437567
FLNA filamin A, alpha 0.0413323
KRT18 keratin 18, type I 0.0393087
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0383426
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0381375
EIF4H eukaryotic translation initiation factor 4H 0.0367647
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0365747
MPRIP myosin phosphatase Rho interacting protein 0.0322782
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0322772
MACC1 metastasis associated in colon cancer 1 0.0321911
MYOF myoferlin 0.0315534
MED13L mediator complex subunit 13-like 0.0312829
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0294404
KIAA1671 KIAA1671 0.0292747
NDRG1 N-myc downstream regulated 1 0.0292308
FNDC3B fibronectin type III domain containing 3B 0.0290978
RPL3 ribosomal protein L3 0.0290898
FAT1 FAT atypical cadherin 1 0.028902
OSBPL10 oxysterol binding protein-like 10 0.0286155
ZNF207 zinc finger protein 207 0.0285763
TRA2A transformer 2 alpha homolog (Drosophila) 0.0278076
DSPP dentin sialophosphoprotein 0.0275807
BCL2L1 BCL2-like 1 0.0273011
MYH14 myosin, heavy chain 14, non-muscle 0.027276
ITGB4 integrin, beta 4 0.0269799
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0262719
FXR1 fragile X mental retardation, autosomal homolog 1 0.0258252
BIRC6 baculoviral IAP repeat containing 6 0.0255153
ZMYND8 zinc finger, MYND-type containing 8 0.0251835
ARHGAP12 Rho GTPase activating protein 12 0.0251425
LPP LIM domain containing preferred translocation partner in lipoma 0.0249424
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0247804
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0243795
CTBP2 C-terminal binding protein 2 0.0237461
CUX1 cut-like homeobox 1 0.0236747
TRIO trio Rho guanine nucleotide exchange factor 0.0236051
XPO1 exportin 1 0.0234484
MTMR3 myotubularin related protein 3 0.023394
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0231141
PDIA3 protein disulfide isomerase family A, member 3 0.0230519
ADAM19 ADAM metallopeptidase domain 19 0.0225993
JUP junction plakoglobin 0.0225667
EHBP1 EH domain binding protein 1 0.0224781
TMCC1 transmembrane and coiled-coil domain family 1 0.0224118
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0224089
MBNL2 muscleblind-like splicing regulator 2 0.0223522
NOP58 NOP58 ribonucleoprotein 0.022214
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0221259
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 0.0220874
CCNY cyclin Y 0.0219814
FRMD5 FERM domain containing 5 0.0218482
CHD1 chromodomain helicase DNA binding protein 1 0.0217906
OSER1 oxidative stress responsive serine-rich 1 0.021628
NCOR2 nuclear receptor corepressor 2 0.0213858
ANXA2 annexin A2 0.0213732
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0213408
CCDC200 coiled-coil domain containing 200 0.0212693
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0211811
MYO1B myosin IB 0.0211424
DIDO1 death inducer-obliterator 1 0.0209757
DLG1 discs, large homolog 1 (Drosophila) 0.0208953
KMT2E lysine (K)-specific methyltransferase 2E 0.0207663
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.020547
MSI2 musashi RNA-binding protein 2 0.0204717
MKRN1 makorin ring finger protein 1 0.0204701
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0204651
TMEM123 transmembrane protein 123 0.0203268
MYO18A myosin XVIIIA 0.0201839
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0201643
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0200388
SRRM2 serine/arginine repetitive matrix 2 0.0199485
ANO1 anoctamin 1, calcium activated chloride channel 0.0197012
EZR ezrin 0.0197003
KDM7A lysine (K)-specific demethylase 7A 0.0194864
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0194344
GMDS GDP-mannose 4,6-dehydratase 0.0194269
CEP250 centrosomal protein 250kDa 0.0193265
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0191888
DOCK4 dedicator of cytokinesis 4 0.0191661
EEF2 eukaryotic translation elongation factor 2 0.0190803
GTF2IRD1 GTF2I repeat domain containing 1 0.0189896
RBM33 RNA binding motif protein 33 0.0189518
TFG TRK-fused gene 0.018861
ARCN1 archain 1 0.0188245
FRAS1 Fraser extracellular matrix complex subunit 1 0.0187353
RUNX2 runt-related transcription factor 2 0.0186892
XRN2 5'-3' exoribonuclease 2 0.0186796

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.31416
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180658
TMSB10 thymosin beta 10 -0.171262
B2M beta-2-microglobulin -0.115681
RPLP1 ribosomal protein, large, P1 -0.0825236
RPS6 ribosomal protein S6 -0.0823264
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0819159
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0775776
CST3 cystatin C -0.0757805
RPL12 ribosomal protein L12 -0.0736529
KRT8 keratin 8, type II -0.0670385
RPS21 ribosomal protein S21 -0.0654092
EIF1 eukaryotic translation initiation factor 1 -0.0635359
RPL19 ribosomal protein L19 -0.0628806
RPLP2 ribosomal protein, large, P2 -0.0627018
RPL28 ribosomal protein L28 -0.0617934
RPS19 ribosomal protein S19 -0.0610248
FTH1 ferritin, heavy polypeptide 1 -0.0597269
RPL23 ribosomal protein L23 -0.0592159
CCNL1 cyclin L1 -0.057389
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0501025
LOC102724023 ES1 protein homolog, mitochondrial -0.0487942
TPT1 tumor protein, translationally-controlled 1 -0.0479919
RPS8 ribosomal protein S8 -0.0472499
S100A10 S100 calcium binding protein A10 -0.0472125
RPS3 ribosomal protein S3 -0.0459391
RPL32 ribosomal protein L32 -0.0451573
RPL31 ribosomal protein L31 -0.0449105
MKI67 marker of proliferation Ki-67 -0.0439459
RPS12 ribosomal protein S12 -0.0433879
PTMA prothymosin, alpha -0.0428643
RPL37A ribosomal protein L37a -0.0426528
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0410897
RPL13A ribosomal protein L13a -0.0407142
AREG amphiregulin -0.0405873
ZNF292 zinc finger protein 292 -0.0405221
RPL35A ribosomal protein L35a -0.0401962
RPS13 ribosomal protein S13 -0.0390159
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0386034
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0377117
RPS17 ribosomal protein S17 -0.0367531
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0365439
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0362816
H3-3B H3.3 histone B -0.0362133
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0353576
ATP5F1E ATP synthase F1 subunit epsilon -0.0352555
RPL36 ribosomal protein L36 -0.0350284
NAV2 neuron navigator 2 -0.033988
RPS5 ribosomal protein S5 -0.0336234
CENPF centromere protein F, 350/400kDa -0.033524
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0328889
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0326241
MT2A metallothionein 2A -0.0320594
BHLHE40 basic helix-loop-helix family, member e40 -0.0310989
LRRC58 leucine rich repeat containing 58 -0.0309739
RPS15 ribosomal protein S15 -0.0307642
RPLP0 ribosomal protein, large, P0 -0.0306128
CLDN4 claudin 4 -0.0303006
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0302946
CBX3 chromobox homolog 3 -0.0302569
VEGFA vascular endothelial growth factor A -0.0302251
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0300472
GPHN gephyrin -0.0299088
RBM25 RNA binding motif protein 25 -0.0297631
HLA-B major histocompatibility complex, class I, B -0.0295455
POTEF POTE ankyrin domain family, member F -0.0294697
IER3 immediate early response 3 -0.0291895
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0289323
RPS27A ribosomal protein S27a -0.0289135
VIM vimentin -0.0289082
RPL35 ribosomal protein L35 -0.0288018
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0285083
EEF1G eukaryotic translation elongation factor 1 gamma -0.0284596
RPS29 ribosomal protein S29 -0.0280761
RPS11 ribosomal protein S11 -0.0280307
RPL26 ribosomal protein L26 -0.0278352
RPL18 ribosomal protein L18 -0.0278023
RPL8 ribosomal protein L8 -0.0269173
RPS16 ribosomal protein S16 -0.0264713
H2AC6 H2A clustered histone 6 -0.0259705
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0256145
IFIH1 interferon induced with helicase C domain 1 -0.0253975
FUS FUS RNA binding protein -0.0252578
SKAP2 src kinase associated phosphoprotein 2 -0.0250698
IFITM3 interferon induced transmembrane protein 3 -0.0248498
RPS27 ribosomal protein S27 -0.0247882
RPL37 ribosomal protein L37 -0.0246327
EIF5B eukaryotic translation initiation factor 5B -0.0245716
TXNRD1 thioredoxin reductase 1 -0.0242225
HMGB1 high mobility group box 1 -0.0238429
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0236704
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0232456
EGR1 early growth response 1 -0.0231571
YBX1 Y box binding protein 1 -0.0231463
DIAPH1 diaphanous-related formin 1 -0.0230471
ACTG1 actin gamma 1 -0.0228904
PNISR PNN-interacting serine/arginine-rich protein -0.0228422
SLC38A1 solute carrier family 38, member 1 -0.0225488
ZFP36 ZFP36 ring finger protein -0.0224737
RAD21 RAD21 homolog (S. pombe) -0.0222952