Berbamine (dihydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.317022
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.169555
NAV2 neuron navigator 2 0.153078
PLEC plectin 0.143753
CDH13 cadherin 13 0.109898
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.105042
KRT18 keratin 18, type I 0.102384
MAML2 mastermind-like 2 (Drosophila) 0.0839221
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0816117
VCL vinculin 0.0724676
HDAC4 histone deacetylase 4 0.0683429
EEF2 eukaryotic translation elongation factor 2 0.0591755
CDK6 cyclin-dependent kinase 6 0.0500907
LOC112694756 uncharaterized LOC112694756 0.0496434
MYH9 myosin, heavy chain 9, non-muscle 0.0493283
ACTN1 actinin, alpha 1 0.0492969
INTS6 integrator complex subunit 6 0.0489414
ANO1 anoctamin 1, calcium activated chloride channel 0.0487128
LDHA lactate dehydrogenase A 0.0468196
ITGB4 integrin, beta 4 0.0463293
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0443437
AKAP12 A kinase (PRKA) anchor protein 12 0.0441127
ADGRL2 adhesion G protein-coupled receptor L2 0.0440461
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0438012
FLNA filamin A, alpha 0.0426275
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0424512
ANXA2 annexin A2 0.0417751
KRT8 keratin 8, type II 0.0413913
RAD51B RAD51 paralog B 0.0408934
CEMIP cell migration inducing protein, hyaluronan binding 0.0397856
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0392931
CCND1 cyclin D1 0.0386875
ITGA6 integrin, alpha 6 0.0372627
ACTN4 actinin, alpha 4 0.0366306
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0357159
SRRM2 serine/arginine repetitive matrix 2 0.0356134
MED13 mediator complex subunit 13 0.0352801
EZR ezrin 0.0352477
SDK1 sidekick cell adhesion molecule 1 0.0344976
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0341028
SKAP1 src kinase associated phosphoprotein 1 0.0340086
PDE4D phosphodiesterase 4D, cAMP-specific 0.0338429
MSI2 musashi RNA-binding protein 2 0.033841
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0334814
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0327265
TPM4 tropomyosin 4 0.0325461
KIZ kizuna centrosomal protein 0.0313649
GMDS GDP-mannose 4,6-dehydratase 0.0309728
EIF4H eukaryotic translation initiation factor 4H 0.0307388
CMIP c-Maf inducing protein 0.0305422
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.030468
MRPS6 mitochondrial ribosomal protein S6 0.0296961
DST dystonin 0.0296425
RPS4X ribosomal protein S4, X-linked 0.0287453
NPAS2 neuronal PAS domain protein 2 0.0283964
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0280428
IGFBP3 insulin-like growth factor binding protein 3 0.0280105
LPP LIM domain containing preferred translocation partner in lipoma 0.0279618
MYOF myoferlin 0.027827
RPL35A ribosomal protein L35a 0.0274599
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0266819
TMSB4X thymosin beta 4, X-linked 0.0265677
FLNB filamin B, beta 0.0265556
ZBTB20 zinc finger and BTB domain containing 20 0.026495
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0261586
TPI1 triosephosphate isomerase 1 0.0259381
SPATA13 spermatogenesis associated 13 0.0258208
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.025587
RNF213 ring finger protein 213 0.02536
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0253573
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0252573
ANXA3 annexin A3 0.0252518
TNIK TRAF2 and NCK interacting kinase 0.0252098
MTCL1 microtubule crosslinking factor 1 0.0251352
WWOX WW domain containing oxidoreductase 0.0248845
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.0248228
TNS4 tensin 4 0.0241273
NCOR2 nuclear receptor corepressor 2 0.0240829
IGF1R insulin-like growth factor 1 receptor 0.0239483
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0237826
CD46 CD46 molecule, complement regulatory protein 0.0237317
JAG1 jagged 1 0.0230284
RPL3 ribosomal protein L3 0.0226333
NTSR1 neurotensin receptor 1 (high affinity) 0.0222378
PRRC2A proline-rich coiled-coil 2A 0.022215
CTBP2 C-terminal binding protein 2 0.0221466
TMEM163 transmembrane protein 163 0.0219436
MCL1 myeloid cell leukemia 1 0.0216175
EXOC4 exocyst complex component 4 0.0214215
LMNA lamin A/C 0.0210492
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0208735
DYNC2I1 dynein 2 intermediate chain 1 0.0207614
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0206539
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.020609
SLC38A2 solute carrier family 38, member 2 0.0205968
PDGFA platelet-derived growth factor alpha polypeptide 0.0205918
LRMDA leucine rich melanocyte differentiation associated 0.0204593
TBC1D5 TBC1 domain family, member 5 0.0204517
LASP1 LIM and SH3 protein 1 0.0202749
EPHA2 EPH receptor A2 0.0200627

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.249714
RPS6 ribosomal protein S6 -0.0880041
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0624438
RPS2 ribosomal protein S2 -0.0614961
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.055141
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0534451
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0496518
TPT1 tumor protein, translationally-controlled 1 -0.0473477
GOLGA4 golgin A4 -0.0461722
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0461362
SETD5 SET domain containing 5 -0.0403715
SCAF11 SR-related CTD-associated factor 11 -0.0358853
NKTR natural killer cell triggering receptor -0.0353272
PCLO piccolo presynaptic cytomatrix protein -0.0343748
RPL26 ribosomal protein L26 -0.0341247
RBM39 RNA binding motif protein 39 -0.0335878
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0329843
AKAP9 A kinase (PRKA) anchor protein 9 -0.0329646
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0328536
SYT1 synaptotagmin I -0.0328292
RPS24 ribosomal protein S24 -0.0327649
RPS23 ribosomal protein S23 -0.0318491
SBF2 SET binding factor 2 -0.0309524
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0306338
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0302509
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0300266
JMJD1C jumonji domain containing 1C -0.0298192
DIAPH3 diaphanous-related formin 3 -0.0298165
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0293569
RPL12 ribosomal protein L12 -0.0292979
TXNIP thioredoxin interacting protein -0.0287666
SPAG9 sperm associated antigen 9 -0.0281336
RPL32 ribosomal protein L32 -0.0279987
COG5 component of oligomeric golgi complex 5 -0.0278154
RPL36A ribosomal protein L36a -0.0277637
RPS5 ribosomal protein S5 -0.0276698
ESYT2 extended synaptotagmin-like protein 2 -0.0276464
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0274513
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0274074
EIF1 eukaryotic translation initiation factor 1 -0.0272571
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0267479
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0267415
RPLP2 ribosomal protein, large, P2 -0.0266803
CLTC clathrin, heavy chain (Hc) -0.0260311
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0260103
RPS15 ribosomal protein S15 -0.0259634
COPB1 coatomer protein complex, subunit beta 1 -0.025844
OXR1 oxidation resistance 1 -0.0258198
TTC3 tetratricopeptide repeat domain 3 -0.025527
OGA O-GlcNAcase -0.0255032
RPLP1 ribosomal protein, large, P1 -0.0253766
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0252057
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0252021
PUM2 pumilio RNA-binding family member 2 -0.0250458
VMP1 vacuole membrane protein 1 -0.0249612
PAPOLA poly(A) polymerase alpha -0.0248333
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0242539
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.024229
SENP5 SUMO1/sentrin specific peptidase 5 -0.02412
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0241189
RPLP0 ribosomal protein, large, P0 -0.0239122
GOLGB1 golgin B1 -0.0238724
BRD4 bromodomain containing 4 -0.0238545
RPS25 ribosomal protein S25 -0.0237689
ANO6 anoctamin 6 -0.0235739
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0234492
UBXN4 UBX domain protein 4 -0.0234238
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -0.0234166
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0232311
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0231497
LMO7 LIM domain 7 -0.0230065
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0229948
RPL38 ribosomal protein L38 -0.0229674
VGLL4 vestigial-like family member 4 -0.0229484
KMT2E lysine (K)-specific methyltransferase 2E -0.0229335
GAN gigaxonin -0.0228687
FAF1 Fas (TNFRSF6) associated factor 1 -0.0228204
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.022733
RPS8 ribosomal protein S8 -0.0226424
CBFB core-binding factor, beta subunit -0.0224528
RFWD3 ring finger and WD repeat domain 3 -0.0224513
RPL7 ribosomal protein L7 -0.0224294
GLG1 golgi glycoprotein 1 -0.0223227
STAU1 staufen double-stranded RNA binding protein 1 -0.0220221
RPL28 ribosomal protein L28 -0.0219832
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0218432
ATP5F1B ATP synthase F1 subunit beta -0.021672
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0216433
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0216076
GOLT1B golgi transport 1B -0.0216026
NIPBL Nipped-B homolog (Drosophila) -0.0215132
USP34 ubiquitin specific peptidase 34 -0.0214817
HELZ helicase with zinc finger -0.0213888
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0211618
GCC2 GRIP and coiled-coil domain containing 2 -0.0211101
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0209843
SMC5 structural maintenance of chromosomes 5 -0.0207741
WASF2 WAS protein family, member 2 -0.0205753
ITCH itchy E3 ubiquitin protein ligase -0.0205742
RPS16 ribosomal protein S16 -0.0205649