Berbamine_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.159568
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0870242
CCN2 cellular communication network factor 2 0.0745472
ZBTB20 zinc finger and BTB domain containing 20 0.0712925
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0684993
RPL23 ribosomal protein L23 0.0651002
SRRM2 serine/arginine repetitive matrix 2 0.0641426
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0639637
EIF1 eukaryotic translation initiation factor 1 0.0624169
HSPA8 heat shock 70kDa protein 8 0.0539788
EIF4A2 eukaryotic translation initiation factor 4A2 0.0539402
ERRFI1 ERBB receptor feedback inhibitor 1 0.0538802
HLA-A major histocompatibility complex, class I, A 0.0538312
ATP11A ATPase, class VI, type 11A 0.0536559
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0510648
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0510092
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.050049
AHNAK AHNAK nucleoprotein 0.0492116
ASPH aspartate beta-hydroxylase 0.047368
RPL11 ribosomal protein L11 0.0460186
TPM3 tropomyosin 3 0.0460072
NACA nascent polypeptide-associated complex alpha subunit 0.0459342
EEF2 eukaryotic translation elongation factor 2 0.0454236
PGK1 phosphoglycerate kinase 1 0.0446801
RPL35A ribosomal protein L35a 0.0428384
AKAP12 A kinase (PRKA) anchor protein 12 0.0412777
H1-0 H1.0 linker histone 0.041056
GASK1B golgi associated kinase 1B 0.0409675
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0395585
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0392573
MED13L mediator complex subunit 13-like 0.0391875
OGA O-GlcNAcase 0.0388671
YEATS2 YEATS domain containing 2 0.0378115
PTMA prothymosin, alpha 0.0375776
RPS12 ribosomal protein S12 0.0373092
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0369694
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0365721
BRD2 bromodomain containing 2 0.0359514
RPS3 ribosomal protein S3 0.0357118
LOC112694756 uncharaterized LOC112694756 0.034232
TPT1 tumor protein, translationally-controlled 1 0.0338447
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0328516
MMP12 matrix metallopeptidase 12 0.0327847
RPL4 ribosomal protein L4 0.0325115
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0325038
PLEC plectin 0.032333
CPOX coproporphyrinogen oxidase 0.0322797
RPS19 ribosomal protein S19 0.032102
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.031962
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0319024
SLC38A2 solute carrier family 38, member 2 0.0317403
AXIN2 axin 2 0.0316554
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0316404
CAMTA1 calmodulin binding transcription activator 1 0.0312422
ZNF217 zinc finger protein 217 0.0306441
RPL19 ribosomal protein L19 0.0302317
RPS21 ribosomal protein S21 0.0301138
RPL26 ribosomal protein L26 0.0298853
NEK7 NIMA-related kinase 7 0.0296815
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0288176
EXOC6B exocyst complex component 6B 0.0286804
RPL12 ribosomal protein L12 0.0285714
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0281655
UBC ubiquitin C 0.0278633
CELF2 CUGBP, Elav-like family member 2 0.0277322
PDIA6 protein disulfide isomerase family A, member 6 0.027533
NCKAP1 NCK-associated protein 1 0.0269542
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0267063
EIF4H eukaryotic translation initiation factor 4H 0.0266968
FAT1 FAT atypical cadherin 1 0.0264521
PRRC2A proline-rich coiled-coil 2A 0.0264272
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0262985
BCAS3 breast carcinoma amplified sequence 3 0.0261147
SQSTM1 sequestosome 1 0.0261073
EZR ezrin 0.026106
SON SON DNA binding protein 0.0260952
KLHL24 kelch-like family member 24 0.0250552
HDLBP high density lipoprotein binding protein 0.0248896
CLPTM1L CLPTM1-like 0.0248476
RPS13 ribosomal protein S13 0.0248382
MAT2A methionine adenosyltransferase II, alpha 0.0247957
PTBP1 polypyrimidine tract binding protein 1 0.0247951
PDCD6 programmed cell death 6 0.0247183
RPS23 ribosomal protein S23 0.0246624
DIDO1 death inducer-obliterator 1 0.0246091
NCOR2 nuclear receptor corepressor 2 0.0246007
MYH9 myosin, heavy chain 9, non-muscle 0.0245865
FUS FUS RNA binding protein 0.0244891
PUM2 pumilio RNA-binding family member 2 0.0244018
ADAR adenosine deaminase, RNA-specific 0.0241111
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0240544
NUMA1 nuclear mitotic apparatus protein 1 0.0234465
GARS1 glycyl-tRNA synthetase 1 0.023378
SMYD3 SET and MYND domain containing 3 0.023335
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0231021
CAMKMT calmodulin-lysine N-methyltransferase 0.0222952
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0222188
PARD6B par-6 family cell polarity regulator beta 0.0221295
TRIO trio Rho guanine nucleotide exchange factor 0.0221137
RPS16 ribosomal protein S16 0.0220084

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.234467
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.205593
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.111975
SMC4 structural maintenance of chromosomes 4 -0.110807
PDE4D phosphodiesterase 4D, cAMP-specific -0.105982
VIM vimentin -0.0944507
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0694948
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0673243
AREG amphiregulin -0.06605
CENPF centromere protein F, 350/400kDa -0.060449
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0580474
VDAC1 voltage-dependent anion channel 1 -0.0497804
YAP1 Yes-associated protein 1 -0.0494827
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0478767
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0462532
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0413694
PCDH7 protocadherin 7 -0.041309
KIF18B kinesin family member 18B -0.0387687
LOC102724023 ES1 protein homolog, mitochondrial -0.0372512
TMEM41B transmembrane protein 41B -0.0367823
MBNL1 muscleblind-like splicing regulator 1 -0.0363671
RTN4 reticulon 4 -0.0362263
ZNF804A zinc finger protein 804A -0.0356882
TUBA1B tubulin, alpha 1b -0.035538
USP34 ubiquitin specific peptidase 34 -0.0354331
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.035347
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0352938
MKI67 marker of proliferation Ki-67 -0.035116
DIAPH3 diaphanous-related formin 3 -0.0341337
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.033206
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0331086
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0329002
NDC80 NDC80 kinetochore complex component -0.032558
JMJD1C jumonji domain containing 1C -0.0325525
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0321677
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.03205
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0320443
CIP2A cellular inhibitor of PP2A -0.031511
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0310545
FBXO11 F-box protein 11 -0.0307779
ANXA1 annexin A1 -0.0306939
KTN1 kinectin 1 (kinesin receptor) -0.0301889
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0291789
ANKRD28 ankyrin repeat domain 28 -0.0291787
BIRC3 baculoviral IAP repeat containing 3 -0.0291554
ENO1 enolase 1, (alpha) -0.0290258
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0284102
CENPE centromere protein E, 312kDa -0.0283607
GPHN gephyrin -0.0283386
TPX2 TPX2, microtubule-associated -0.0279978
GNAS GNAS complex locus -0.0271246
BCHE butyrylcholinesterase -0.026578
NAV3 neuron navigator 3 -0.026449
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0261604
CCDC88A coiled-coil domain containing 88A -0.0261421
LDHA lactate dehydrogenase A -0.0260731
NEGR1 neuronal growth regulator 1 -0.0258389
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0257317
TPR translocated promoter region, nuclear basket protein -0.0255302
DTNA dystrobrevin, alpha -0.0254923
NCEH1 neutral cholesterol ester hydrolase 1 -0.0249837
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0245361
DLC1 DLC1 Rho GTPase activating protein -0.0241663
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0238531
DCAF7 DDB1 and CUL4 associated factor 7 -0.0237522
SGO2 shugoshin 2 -0.0235863
CCSER1 coiled-coil serine-rich protein 1 -0.0235135
PEG10 paternally expressed 10 -0.0234167
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0232961
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0232651
DST dystonin -0.0228121
ATAD2 ATPase family, AAA domain containing 2 -0.0221751
PCBP2 poly(rC) binding protein 2 -0.0220046
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0218133
RASAL2 RAS protein activator like 2 -0.0217959
TUBB4B tubulin, beta 4B class IVb -0.0215963
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0212927
IMMT inner membrane protein, mitochondrial -0.0210932
STIL SCL/TAL1 interrupting locus -0.0208914
KIF11 kinesin family member 11 -0.02082
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0207362
TPM4 tropomyosin 4 -0.020574
CSMD3 CUB and Sushi multiple domains 3 -0.0204873
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.020365
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -0.0202574
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0201537
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0201198
EIF5B eukaryotic translation initiation factor 5B -0.0197568
EDARADD EDAR-associated death domain -0.0197501
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0194798
SMC3 structural maintenance of chromosomes 3 -0.0193086
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0192254
PDE4B phosphodiesterase 4B, cAMP-specific -0.0192004
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0190508
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0189211
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0188614
FAM177A1 family with sequence similarity 177, member A1 -0.0187383
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0187223
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0187108
LMAN1 lectin, mannose-binding, 1 -0.0186341