Berbamine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.156033
LPIN1 lipin 1 0.137965
MSI2 musashi RNA-binding protein 2 0.120752
NRG1 neuregulin 1 0.108923
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0872079
ACTG1 actin gamma 1 0.0843886
SRRM2 serine/arginine repetitive matrix 2 0.0823623
NALF1 NALCN channel auxiliary factor 1 0.080237
SEPTIN9 septin 9 0.0766596
GPC5 glypican 5 0.0730691
TRIB2 tribbles pseudokinase 2 0.0713011
COL1A1 collagen, type I, alpha 1 0.0697327
AOPEP aminopeptidase O (putative) 0.0598561
RNF213 ring finger protein 213 0.0589778
PRRC2B proline-rich coiled-coil 2B 0.0570862
PRKCA protein kinase C, alpha 0.0567105
TMSB10 thymosin beta 10 0.0558495
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0556012
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0540605
PRRC2C proline-rich coiled-coil 2C 0.0521075
RPL35A ribosomal protein L35a 0.0519495
EIF1 eukaryotic translation initiation factor 1 0.050581
DLC1 DLC1 Rho GTPase activating protein 0.0505681
RAD51B RAD51 paralog B 0.0491212
CEMIP cell migration inducing protein, hyaluronan binding 0.0488424
RPL23 ribosomal protein L23 0.0485383
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.047577
MAML2 mastermind-like 2 (Drosophila) 0.0475041
ZMIZ1 zinc finger, MIZ-type containing 1 0.0474587
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0472112
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0459675
SMAD6 SMAD family member 6 0.0458351
THSD4 thrombospondin, type I, domain containing 4 0.0457779
UNC5C unc-5 homolog C (C. elegans) 0.0456944
AHNAK AHNAK nucleoprotein 0.0449432
LOC112694756 uncharaterized LOC112694756 0.043725
ANKRD11 ankyrin repeat domain 11 0.0428393
RPS20 ribosomal protein S20 0.0428155
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0417292
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0415154
ZNF804A zinc finger protein 804A 0.0414586
SMAD3 SMAD family member 3 0.0413228
AUTS2 autism susceptibility candidate 2 0.0409243
TPT1 tumor protein, translationally-controlled 1 0.0404345
RPL34 ribosomal protein L34 0.0402365
NCOR2 nuclear receptor corepressor 2 0.0383561
COL3A1 collagen, type III, alpha 1 0.0382234
ZNF609 zinc finger protein 609 0.0377506
NACA nascent polypeptide-associated complex alpha subunit 0.0376827
NUMA1 nuclear mitotic apparatus protein 1 0.0373531
MYH9 myosin, heavy chain 9, non-muscle 0.0366653
CBX5 chromobox homolog 5 0.0365082
PTMA prothymosin, alpha 0.0364865
UNC5B unc-5 homolog B (C. elegans) 0.036293
GSE1 Gse1 coiled-coil protein 0.0360263
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0358555
CUX1 cut-like homeobox 1 0.035604
KPNB1 karyopherin (importin) beta 1 0.0354964
UBAP2L ubiquitin associated protein 2-like 0.0352653
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0347848
COL18A1 collagen, type XVIII, alpha 1 0.0346785
HDLBP high density lipoprotein binding protein 0.0342605
MAP4 microtubule-associated protein 4 0.0334387
RHOA ras homolog family member A 0.0332742
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0331888
ANKRD10 ankyrin repeat domain 10 0.0331406
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0328795
CPED1 cadherin-like and PC-esterase domain containing 1 0.0328151
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.032815
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0327723
TIMP3 TIMP metallopeptidase inhibitor 3 0.0325153
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0324185
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0322722
TCF12 transcription factor 12 0.0321875
PRKD1 protein kinase D1 0.0320422
RPL13A ribosomal protein L13a 0.0319044
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0317387
DPH6 diphthamine biosynthesis 6 0.0317115
ANXA2 annexin A2 0.0316763
CADM2 cell adhesion molecule 2 0.0316115
HSPA8 heat shock 70kDa protein 8 0.0315983
KCNIP4 Kv channel interacting protein 4 0.0314261
LSAMP limbic system-associated membrane protein 0.0310702
RPTOR regulatory associated protein of MTOR, complex 1 0.0309874
YEATS2 YEATS domain containing 2 0.0309607
DHFR dihydrofolate reductase 0.0309099
MEF2D myocyte enhancer factor 2D 0.0308993
USP9X ubiquitin specific peptidase 9, X-linked 0.0305313
ATRNL1 attractin-like 1 0.0302485
RPL19 ribosomal protein L19 0.0298873
CALU calumenin 0.0297787
EWSR1 EWS RNA-binding protein 1 0.0297666
VCAN versican 0.0297405
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0296883
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0295615
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0294846
PGK1 phosphoglycerate kinase 1 0.029414
CENPF centromere protein F, 350/400kDa 0.0293358
DNAH14 dynein, axonemal, heavy chain 14 0.0291696
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0290331

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.183087
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0996173
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0992513
IGF2 insulin-like growth factor 2 -0.0965093
RPS2 ribosomal protein S2 -0.0854952
ITPRID2 ITPR interacting domain containing 2 -0.0659067
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0654874
PTPRD protein tyrosine phosphatase, receptor type, D -0.0643814
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0630306
KMT2E lysine (K)-specific methyltransferase 2E -0.061759
MEIS2 Meis homeobox 2 -0.061102
FNDC3A fibronectin type III domain containing 3A -0.0581566
FNBP1 formin binding protein 1 -0.0553965
PLAT plasminogen activator, tissue -0.0549732
TLE4 transducin-like enhancer of split 4 -0.0535804
SLIT2 slit homolog 2 (Drosophila) -0.0497886
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0490659
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0484412
TPST1 tyrosylprotein sulfotransferase 1 -0.0481381
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.04784
PCBP2 poly(rC) binding protein 2 -0.047689
SLITRK6 SLIT and NTRK-like family, member 6 -0.0467554
ZMYM2 zinc finger, MYM-type 2 -0.0463838
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0451632
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0447064
PIAS1 protein inhibitor of activated STAT, 1 -0.044177
NEK7 NIMA-related kinase 7 -0.0435035
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0432584
ZNF207 zinc finger protein 207 -0.0395736
TAOK1 TAO kinase 1 -0.0389356
VCL vinculin -0.0377436
NPEPPS aminopeptidase puromycin sensitive -0.0369398
MBTD1 mbt domain containing 1 -0.0365357
MBNL2 muscleblind-like splicing regulator 2 -0.0360944
MXI1 MAX interactor 1, dimerization protein -0.0349283
MYO9A myosin IXA -0.0347349
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0342109
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0340165
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.033936
RYBP RING1 and YY1 binding protein -0.0339025
CSNK1A1 casein kinase 1, alpha 1 -0.0336754
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0334559
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0332362
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0328662
SNX14 sorting nexin 14 -0.0328371
SRP54 signal recognition particle 54kDa -0.0324756
SPAG9 sperm associated antigen 9 -0.0323424
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0321668
HELZ helicase with zinc finger -0.0321214
PAPOLA poly(A) polymerase alpha -0.0320538
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0320403
ERBIN erbb2 interacting protein -0.0316012
PDE10A phosphodiesterase 10A -0.0315549
PCM1 pericentriolar material 1 -0.0313653
AKAP9 A kinase (PRKA) anchor protein 9 -0.0309243
PUM2 pumilio RNA-binding family member 2 -0.0309197
NOP58 NOP58 ribonucleoprotein -0.0307087
MED13 mediator complex subunit 13 -0.0305643
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0304627
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0303815
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0303587
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0303255
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0301874
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -0.0300374
KMT2C lysine (K)-specific methyltransferase 2C -0.0298751
NCAM2 neural cell adhesion molecule 2 -0.0298024
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0296062
ANKRD28 ankyrin repeat domain 28 -0.029403
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0293712
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0290861
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0287889
GLG1 golgi glycoprotein 1 -0.0287167
GNAS GNAS complex locus -0.0286896
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0285424
THBS1 thrombospondin 1 -0.0285194
MTDH metadherin -0.028445
NIPBL Nipped-B homolog (Drosophila) -0.0282691
ARHGAP5 Rho GTPase activating protein 5 -0.0276841
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0276642
RTN4 reticulon 4 -0.0273346
POTEF POTE ankyrin domain family, member F -0.0271718
SIK2 salt-inducible kinase 2 -0.0271076
GLCCI1 glucocorticoid induced 1 -0.026839
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0268336
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0268275
PRPF4B pre-mRNA processing factor 4B -0.0261616
DNMBP dynamin binding protein -0.0259206
TLN1 talin 1 -0.0259036
KTN1 kinectin 1 (kinesin receptor) -0.0258916
CLTC clathrin, heavy chain (Hc) -0.0256517
AQR aquarius intron-binding spliceosomal factor -0.0255848
MEF2A myocyte enhancer factor 2A -0.0253828
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0251963
ATOSA atos homolog A -0.0251762
HIP1 huntingtin interacting protein 1 -0.024951
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0248968
RIOK3 RIO kinase 3 -0.024882
ANO6 anoctamin 6 -0.0247749
UBE3A ubiquitin protein ligase E3A -0.024277
RAB30 RAB30, member RAS oncogene family -0.0241738