Berbamine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.119304
DSCAM Down syndrome cell adhesion molecule 0.111235
SRRM2 serine/arginine repetitive matrix 2 0.108655
SAMD4A sterile alpha motif domain containing 4A 0.101691
LMO7 LIM domain 7 0.099083
MBNL2 muscleblind-like splicing regulator 2 0.0969502
SPATA13 spermatogenesis associated 13 0.0927318
EXT1 exostosin glycosyltransferase 1 0.0851986
AKAP13 A kinase (PRKA) anchor protein 13 0.0806393
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0796055
HLA-B major histocompatibility complex, class I, B 0.0791566
EZR ezrin 0.0789588
EPHB2 EPH receptor B2 0.0761967
SMAD3 SMAD family member 3 0.0728628
CCNL1 cyclin L1 0.0701253
TRIO trio Rho guanine nucleotide exchange factor 0.0674475
EPS8 epidermal growth factor receptor pathway substrate 8 0.0665229
N4BP2L2 NEDD4 binding protein 2-like 2 0.0653013
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0648386
P4HB prolyl 4-hydroxylase, beta polypeptide 0.061833
MYH9 myosin, heavy chain 9, non-muscle 0.060788
SHB Src homology 2 domain containing adaptor protein B 0.060359
SPTBN1 spectrin, beta, non-erythrocytic 1 0.059705
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0545233
MLPH melanophilin 0.0542167
FNDC3B fibronectin type III domain containing 3B 0.0537177
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0535346
IRS2 insulin receptor substrate 2 0.0531802
HLA-A major histocompatibility complex, class I, A 0.0519543
COPA coatomer protein complex, subunit alpha 0.0518773
MSI2 musashi RNA-binding protein 2 0.050912
RNF213 ring finger protein 213 0.0507687
IRF1 interferon regulatory factor 1 0.0507008
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0495347
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0493057
PADI1 peptidyl arginine deiminase, type I 0.0490744
TUFT1 tuftelin 1 0.0470488
VMP1 vacuole membrane protein 1 0.0463338
FAT1 FAT atypical cadherin 1 0.0461562
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0458545
SQSTM1 sequestosome 1 0.0454771
BCL2L1 BCL2-like 1 0.0450133
MPRIP myosin phosphatase Rho interacting protein 0.044888
SERINC5 serine incorporator 5 0.0438347
CTBP2 C-terminal binding protein 2 0.0435064
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.043429
ANXA2 annexin A2 0.0431732
ZNF292 zinc finger protein 292 0.0428581
AFF1 AF4/FMR2 family, member 1 0.0425116
ATXN1 ataxin 1 0.0422637
MYO10 myosin X 0.0416158
EPSTI1 epithelial stromal interaction 1 (breast) 0.0415788
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0415186
EGLN3 egl-9 family hypoxia-inducible factor 3 0.041337
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0409089
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0401348
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0396426
SYNE2 spectrin repeat containing, nuclear envelope 2 0.039498
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0393526
ABHD2 abhydrolase domain containing 2 0.0391248
OARD1 O-acyl-ADP-ribose deacylase 1 0.0385554
RHOBTB3 Rho-related BTB domain containing 3 0.0385521
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0384703
UBAC2 UBA domain containing 2 0.0376843
MTUS1 microtubule associated tumor suppressor 1 0.0375511
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.037221
FNIP1 folliculin interacting protein 1 0.0366176
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.036397
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0361316
ETNK1 ethanolamine kinase 1 0.0355175
EIF1 eukaryotic translation initiation factor 1 0.0351987
DHFR dihydrofolate reductase 0.0351867
PHF3 PHD finger protein 3 0.035116
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0349978
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0347277
SEC31A SEC31 homolog A (S. cerevisiae) 0.0347057
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0344616
PGK1 phosphoglycerate kinase 1 0.033958
TOX3 TOX high mobility group box family member 3 0.0338215
STAT2 signal transducer and activator of transcription 2, 113kDa 0.0337775
CEMIP2 cell migration inducing hyaluronidase 2 0.033625
EGR1 early growth response 1 0.0336207
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0330593
TRIM25 tripartite motif containing 25 0.0320191
HLA-C major histocompatibility complex, class I, C 0.0318842
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0315608
KAZN kazrin, periplakin interacting protein 0.0314867
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0310077
NCOR2 nuclear receptor corepressor 2 0.0309773
BCLAF1 BCL2-associated transcription factor 1 0.0308668
GOLPH3L golgi phosphoprotein 3-like 0.030838
UBAP1 ubiquitin associated protein 1 0.0307578
CMIP c-Maf inducing protein 0.0307034
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0306133
AHI1 Abelson helper integration site 1 0.0303535
MACC1 metastasis associated in colon cancer 1 0.0302493
COPG1 coatomer protein complex, subunit gamma 1 0.0301192
SETD5 SET domain containing 5 0.0299985
RBM33 RNA binding motif protein 33 0.0298105
KRT8 keratin 8, type II 0.0297432

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.188839
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.151365
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.10127
B2M beta-2-microglobulin -0.0988097
NPSR1 neuropeptide S receptor 1 -0.0820658
IFNGR1 interferon gamma receptor 1 -0.0780293
INTS6 integrator complex subunit 6 -0.0726387
EPCAM epithelial cell adhesion molecule -0.068028
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.064377
ENO1 enolase 1, (alpha) -0.057914
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0547863
PLSCR2 phospholipid scramblase 2 -0.0513485
XAF1 XIAP associated factor 1 -0.0500153
STS steroid sulfatase (microsomal), isozyme S -0.0499941
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0499758
IFI6 interferon, alpha-inducible protein 6 -0.0455658
DSPP dentin sialophosphoprotein -0.0450667
PERP PERP, TP53 apoptosis effector -0.0435751
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0433223
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0413235
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0401841
CLTC clathrin, heavy chain (Hc) -0.0386875
FNDC3A fibronectin type III domain containing 3A -0.0380829
POF1B premature ovarian failure, 1B -0.0371448
RPS2 ribosomal protein S2 -0.0369282
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0367025
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0366076
EFNB2 ephrin-B2 -0.0364923
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.034735
NCOA7 nuclear receptor coactivator 7 -0.034276
GCLC glutamate-cysteine ligase, catalytic subunit -0.0340876
ZDHHC20 zinc finger, DHHC-type containing 20 -0.03405
CEP350 centrosomal protein 350kDa -0.033759
ASPH aspartate beta-hydroxylase -0.0334827
LCN2 lipocalin 2 -0.032732
SAMD9 sterile alpha motif domain containing 9 -0.0322024
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0320919
APOL1 apolipoprotein L, 1 -0.0319531
SH3GLB1 SH3-domain GRB2-like endophilin B1 -0.0315311
PRELID2 PRELI domain containing 2 -0.0301605
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0291557
VWA8 von Willebrand factor A domain containing 8 -0.0278963
NDRG1 N-myc downstream regulated 1 -0.0276978
MUC20 mucin 20, cell surface associated -0.0275561
LIMA1 LIM domain and actin binding 1 -0.0274621
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0273835
SAMD12 sterile alpha motif domain containing 12 -0.0272753
PDIA3 protein disulfide isomerase family A, member 3 -0.0271473
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0271262
PTMA prothymosin, alpha -0.0270473
SDC4 syndecan 4 -0.026826
PTBP3 polypyrimidine tract binding protein 3 -0.0267091
AREG amphiregulin -0.0265212
SPIDR scaffolding protein involved in DNA repair -0.0264661
MT2A metallothionein 2A -0.0262952
KRT19 keratin 19, type I -0.025813
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -0.0252906
NIPBL Nipped-B homolog (Drosophila) -0.0252648
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0249873
ZC3H13 zinc finger CCCH-type containing 13 -0.0246468
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0244223
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0241845
RAB2A RAB2A, member RAS oncogene family -0.0240248
S100A9 S100 calcium binding protein A9 -0.0238384
RPS6 ribosomal protein S6 -0.0235602
NCOR1 nuclear receptor corepressor 1 -0.023402
RYBP RING1 and YY1 binding protein -0.0232931
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0232591
RPL38 ribosomal protein L38 -0.0229358
CST3 cystatin C -0.0228106
SENP5 SUMO1/sentrin specific peptidase 5 -0.022781
PAPOLA poly(A) polymerase alpha -0.0226851
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0225902
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 -0.0225006
ARRDC3 arrestin domain containing 3 -0.0223096
XPO1 exportin 1 -0.0222622
MICU2 mitochondrial calcium uptake 2 -0.0222338
FTL ferritin, light polypeptide -0.0222194
IFI27 interferon, alpha-inducible protein 27 -0.0219815
FMN1 formin 1 -0.0218291
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0217925
SEC62 SEC62 homolog (S. cerevisiae) -0.0217826
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0217439
SSH2 slingshot protein phosphatase 2 -0.0214448
GOLM2 golgi membrane protein 2 -0.0214353
LDHA lactate dehydrogenase A -0.0213895
SKP1 S-phase kinase-associated protein 1 -0.0212568
RPL12 ribosomal protein L12 -0.0211792
ARHGAP26 Rho GTPase activating protein 26 -0.0211062
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.02087
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -0.0207924
TRIM56 tripartite motif containing 56 -0.0207448
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -0.0207376
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.020645
PPARA peroxisome proliferator-activated receptor alpha -0.0204582
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0204298
IER3 immediate early response 3 -0.020418
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0202653
KDM3A lysine (K)-specific demethylase 3A -0.020213
DSG2 desmoglein 2 -0.0201946