Berbamine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.36745
C3 complement component 3 0.196121
SAMD4A sterile alpha motif domain containing 4A 0.0924121
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.091048
LRMDA leucine rich melanocyte differentiation associated 0.0688462
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0654585
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0653412
TNS1 tensin 1 0.0644922
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0640099
IGF2 insulin-like growth factor 2 0.0639527
FNDC3B fibronectin type III domain containing 3B 0.0578574
PLEC plectin 0.0568905
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0562634
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.056175
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0558471
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.055042
SMAD3 SMAD family member 3 0.0528699
ZMIZ1 zinc finger, MIZ-type containing 1 0.0525088
ATXN1 ataxin 1 0.0513667
VEGFA vascular endothelial growth factor A 0.0497671
MYH9 myosin, heavy chain 9, non-muscle 0.0491131
TNS3 tensin 3 0.0487897
SRRM2 serine/arginine repetitive matrix 2 0.0479995
EXT1 exostosin glycosyltransferase 1 0.0479234
VMP1 vacuole membrane protein 1 0.0459877
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0437731
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0432929
KRT8 keratin 8, type II 0.0432301
SVIL supervillin 0.0430503
PTK2 protein tyrosine kinase 2 0.0418706
FAT1 FAT atypical cadherin 1 0.0416982
APLP2 amyloid beta (A4) precursor-like protein 2 0.0415528
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0411817
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0394791
PPARD peroxisome proliferator-activated receptor delta 0.0388158
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0373623
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0364404
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0358364
CAMTA1 calmodulin binding transcription activator 1 0.0350865
RPL3 ribosomal protein L3 0.0349816
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0343803
MSI2 musashi RNA-binding protein 2 0.034311
EIF4B eukaryotic translation initiation factor 4B 0.0333243
SH3PXD2A SH3 and PX domains 2A 0.0322513
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0314908
JAG1 jagged 1 0.0309066
RBM19 RNA binding motif protein 19 0.0301772
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0300688
COL7A1 collagen, type VII, alpha 1 0.0298656
HSPA8 heat shock 70kDa protein 8 0.0292927
RUNX1 runt-related transcription factor 1 0.0290217
PHF3 PHD finger protein 3 0.0289345
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0288009
SKI SKI proto-oncogene 0.028541
SEPTIN9 septin 9 0.0281354
SHB Src homology 2 domain containing adaptor protein B 0.0280788
EPAS1 endothelial PAS domain protein 1 0.0276816
DOCK4 dedicator of cytokinesis 4 0.0273578
FNIP1 folliculin interacting protein 1 0.0272955
FOXO3 forkhead box O3 0.0270237
MTSS1 metastasis suppressor 1 0.0268824
IGFBP1 insulin-like growth factor binding protein 1 0.0262651
TRIO trio Rho guanine nucleotide exchange factor 0.0261824
RBM33 RNA binding motif protein 33 0.0260722
EEF2 eukaryotic translation elongation factor 2 0.0256674
ABTB3 ankyrin repeat and BTB domain containing 3 0.0255219
IQSEC1 IQ motif and Sec7 domain 1 0.0255217
ADARB1 adenosine deaminase, RNA-specific, B1 0.0250427
TOP1 topoisomerase (DNA) I 0.0250185
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0250055
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0248971
PRRC2A proline-rich coiled-coil 2A 0.0247411
NCOR2 nuclear receptor corepressor 2 0.024716
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0244416
MED13L mediator complex subunit 13-like 0.0244299
NKD1 naked cuticle homolog 1 (Drosophila) 0.0243041
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0242311
ZNF638 zinc finger protein 638 0.0241436
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0240245
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0239583
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0239305
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0238523
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0237819
DNAH17 dynein, axonemal, heavy chain 17 0.0237731
FLNA filamin A, alpha 0.023678
NACA nascent polypeptide-associated complex alpha subunit 0.0235214
TLE4 transducin-like enhancer of split 4 0.0234455
MCL1 myeloid cell leukemia 1 0.0232263
HDAC4 histone deacetylase 4 0.0232089
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0231734
CEMIP2 cell migration inducing hyaluronidase 2 0.0230445
ABAT 4-aminobutyrate aminotransferase 0.0229152
PRKCA protein kinase C, alpha 0.0225615
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0223648
DTNA dystrobrevin, alpha 0.0222852
PRELID2 PRELI domain containing 2 0.0222494
ANKH ANKH inorganic pyrophosphate transport regulator 0.0220574
PLXDC2 plexin domain containing 2 0.0218227
CRLS1 cardiolipin synthase 1 0.0217409
WAC WW domain containing adaptor with coiled-coil 0.0216959

decreased expression

Symbol Name Standardized Value
GPC3 glypican 3 -0.127898
APOB apolipoprotein B -0.118575
MT2A metallothionein 2A -0.111925
TM4SF1 transmembrane 4 L six family member 1 -0.0884325
TMEM123 transmembrane protein 123 -0.0850906
EHBP1 EH domain binding protein 1 -0.0828923
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0760024
DLC1 DLC1 Rho GTPase activating protein -0.0737737
EML4 echinoderm microtubule associated protein like 4 -0.0731123
TRIM26 tripartite motif containing 26 -0.0726287
FTL ferritin, light polypeptide -0.0713796
APOA2 apolipoprotein A-II -0.065159
FBF1 Fas (TNFRSF6) binding factor 1 -0.0638775
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0637541
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0627061
CP ceruloplasmin (ferroxidase) -0.0605224
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0599609
TPT1 tumor protein, translationally-controlled 1 -0.0579459
AHSG alpha-2-HS-glycoprotein -0.0579037
VCL vinculin -0.0556876
APOE apolipoprotein E -0.0549283
RBM39 RNA binding motif protein 39 -0.05477
ENO1 enolase 1, (alpha) -0.0537052
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0533061
FRMD5 FERM domain containing 5 -0.0531833
STAU1 staufen double-stranded RNA binding protein 1 -0.0526749
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0522557
ZBTB20 zinc finger and BTB domain containing 20 -0.0520746
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0509056
RPS24 ribosomal protein S24 -0.0493168
AKAP12 A kinase (PRKA) anchor protein 12 -0.0477981
ZMYND8 zinc finger, MYND-type containing 8 -0.0464406
A2M alpha-2-macroglobulin -0.0449093
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0430222
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0425115
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0420343
NPR2 natriuretic peptide receptor 2 -0.0415602
SLC38A2 solute carrier family 38, member 2 -0.0415579
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0395748
GCC2 GRIP and coiled-coil domain containing 2 -0.039409
GNAS GNAS complex locus -0.0391095
SLC38A1 solute carrier family 38, member 1 -0.0385729
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0384439
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0382701
ARHGAP18 Rho GTPase activating protein 18 -0.0382479
RPS27A ribosomal protein S27a -0.0382077
PDIA3 protein disulfide isomerase family A, member 3 -0.0376909
LYZ lysozyme -0.0362906
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0359883
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0354493
SDC4 syndecan 4 -0.0347578
DST dystonin -0.0343763
MAML2 mastermind-like 2 (Drosophila) -0.0342415
FN1 fibronectin 1 -0.0339891
CALR calreticulin -0.0329664
IER3 immediate early response 3 -0.0325022
CPE carboxypeptidase E -0.0319633
CALD1 caldesmon 1 -0.031944
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0319292
RPLP1 ribosomal protein, large, P1 -0.0316987
PEG10 paternally expressed 10 -0.0310701
EPCAM epithelial cell adhesion molecule -0.0307163
MATN3 matrilin 3 -0.0306557
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0305022
RRBP1 ribosome binding protein 1 -0.030486
PTMA prothymosin, alpha -0.0301706
ARHGAP5 Rho GTPase activating protein 5 -0.029616
ITCH itchy E3 ubiquitin protein ligase -0.0294938
SCN1A sodium channel, voltage gated, type I alpha subunit -0.0283532
APOA1 apolipoprotein A-I -0.0282594
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0282521
GDF15 growth differentiation factor 15 -0.0276059
KPNB1 karyopherin (importin) beta 1 -0.0265858
PDGFB platelet-derived growth factor beta polypeptide -0.0265234
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0263989
PERP PERP, TP53 apoptosis effector -0.026241
ITGAV integrin, alpha V -0.0259989
AMBP alpha-1-microglobulin/bikunin precursor -0.0258869
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0258814
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0255377
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0254196
CST3 cystatin C -0.0251427
SEPTIN7 septin 7 -0.0250954
RPL34 ribosomal protein L34 -0.0249911
LMAN1 lectin, mannose-binding, 1 -0.0243094
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0242785
PLIN2 perilipin 2 -0.024217
C5 complement component 5 -0.0241968
LDHA lactate dehydrogenase A -0.0241935
RPL31 ribosomal protein L31 -0.0239483
WDR45B WD repeat domain 45B -0.0239017
SELENOP selenoprotein P -0.0234794
GLG1 golgi glycoprotein 1 -0.0228784
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0227086
PTPRM protein tyrosine phosphatase, receptor type, M -0.0222131
ADGRG6 adhesion G protein-coupled receptor G6 -0.0221758
PATJ PATJ crumbs cell polarity complex component -0.0220601
RPL12 ribosomal protein L12 -0.022033
RPS29 ribosomal protein S29 -0.0218408
EIF5B eukaryotic translation initiation factor 5B -0.0218331