Berbamine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.14854
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.136176
TRIO trio Rho guanine nucleotide exchange factor 0.135289
PLEC plectin 0.120261
FLNB filamin B, beta 0.118698
MEF2A myocyte enhancer factor 2A 0.117506
MTSS1 metastasis suppressor 1 0.11079
TGM2 transglutaminase 2 0.106803
PODXL podocalyxin-like 0.0955388
MSN moesin 0.094408
MYH9 myosin, heavy chain 9, non-muscle 0.0852785
RAI14 retinoic acid induced 14 0.0841929
CEMIP cell migration inducing protein, hyaluronan binding 0.0812286
KIAA1217 KIAA1217 0.0766644
RICTOR RPTOR independent companion of MTOR, complex 2 0.0747406
APLP2 amyloid beta (A4) precursor-like protein 2 0.0746181
NAV2 neuron navigator 2 0.0734569
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0721353
NCOR2 nuclear receptor corepressor 2 0.0716739
BLCAP bladder cancer associated protein 0.0669673
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0659746
NAMPT nicotinamide phosphoribosyltransferase 0.0639848
HSPG2 heparan sulfate proteoglycan 2 0.0585267
PRELID2 PRELI domain containing 2 0.0561779
EFHD2 EF-hand domain family, member D2 0.0556587
CLU clusterin 0.052936
ZNF292 zinc finger protein 292 0.0528857
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0522979
OGA O-GlcNAcase 0.0519417
EZR ezrin 0.0517379
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0517256
LAMA5 laminin, alpha 5 0.0514133
FNIP1 folliculin interacting protein 1 0.0510592
PTK2 protein tyrosine kinase 2 0.049957
KMT2E lysine (K)-specific methyltransferase 2E 0.0478299
ESYT2 extended synaptotagmin-like protein 2 0.0473804
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0466987
PGK1 phosphoglycerate kinase 1 0.0459689
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0457345
TNIP1 TNFAIP3 interacting protein 1 0.0454263
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0447427
FNDC3B fibronectin type III domain containing 3B 0.0446081
MYO10 myosin X 0.0442279
DIDO1 death inducer-obliterator 1 0.043107
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.042724
SH3PXD2A SH3 and PX domains 2A 0.0420586
EPHA2 EPH receptor A2 0.0417643
ITCH itchy E3 ubiquitin protein ligase 0.0417512
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0413784
TPM3 tropomyosin 3 0.0410314
RNF145 ring finger protein 145 0.0406972
ANKH ANKH inorganic pyrophosphate transport regulator 0.0397698
AKAP13 A kinase (PRKA) anchor protein 13 0.0394788
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0379395
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0376152
CEP250 centrosomal protein 250kDa 0.0373357
MBNL2 muscleblind-like splicing regulator 2 0.0370367
UBA6 ubiquitin-like modifier activating enzyme 6 0.036972
KIF16B kinesin family member 16B 0.0364552
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0364026
SULF1 sulfatase 1 0.0357246
MYOF myoferlin 0.034882
KDM6A lysine (K)-specific demethylase 6A 0.0348584
YAP1 Yes-associated protein 1 0.0346577
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0345244
SMAD3 SMAD family member 3 0.0342457
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0342101
YEATS2 YEATS domain containing 2 0.0336494
TMEM165 transmembrane protein 165 0.0333638
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0329557
PCBP2 poly(rC) binding protein 2 0.0328966
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0325004
DSTN destrin (actin depolymerizing factor) 0.0319829
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0310973
GRB10 growth factor receptor-bound protein 10 0.0307745
GOLGA4 golgin A4 0.0307734
DOK5 docking protein 5 0.03072
GATA6 GATA binding protein 6 0.0306564
SRRM2 serine/arginine repetitive matrix 2 0.0302778
ARHGAP29 Rho GTPase activating protein 29 0.0300765
MEGF6 multiple EGF-like-domains 6 0.029584
PCDH1 protocadherin 1 0.029351
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0290374
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0290366
ANXA11 annexin A11 0.0288633
ECPAS Ecm29 proteasome adaptor and scaffold 0.0288398
KDM7A lysine (K)-specific demethylase 7A 0.0287009
ITGB4 integrin, beta 4 0.028647
ARRDC3 arrestin domain containing 3 0.0282546
OSBPL6 oxysterol binding protein-like 6 0.0281843
HELZ helicase with zinc finger 0.0280878
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0278687
MACF1 microtubule-actin crosslinking factor 1 0.02777
DSCAM Down syndrome cell adhesion molecule 0.0275147
PPARG peroxisome proliferator-activated receptor gamma 0.0273594
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0272019
MCL1 myeloid cell leukemia 1 0.0271547
RNF19B ring finger protein 19B 0.0271165
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0270078
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0268202

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.272083
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.117187
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0982907
CD44 CD44 molecule (Indian blood group) -0.088256
VCL vinculin -0.0857564
PALLD palladin, cytoskeletal associated protein -0.0775278
LMO7 LIM domain 7 -0.0715666
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0643154
SAMD9 sterile alpha motif domain containing 9 -0.0529001
S100A10 S100 calcium binding protein A10 -0.0524071
RIGI RNA sensor RIG-I -0.0518465
ALCAM activated leukocyte cell adhesion molecule -0.0484652
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0482794
PDLIM5 PDZ and LIM domain 5 -0.0473079
FOXO1 forkhead box O1 -0.0467486
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0464548
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0441648
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0425937
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0420478
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0420126
LDHA lactate dehydrogenase A -0.0417194
DPYD dihydropyrimidine dehydrogenase -0.0399821
MBNL1 muscleblind-like splicing regulator 1 -0.0378281
CAV1 caveolin 1, caveolae protein, 22kDa -0.0367206
NEK7 NIMA-related kinase 7 -0.0361596
INTS6 integrator complex subunit 6 -0.0352842
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0350963
RPLP1 ribosomal protein, large, P1 -0.0330187
EGR1 early growth response 1 -0.0328355
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0322082
MORF4L2 mortality factor 4 like 2 -0.0320564
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0320084
IFI6 interferon, alpha-inducible protein 6 -0.031375
RPS24 ribosomal protein S24 -0.0311979
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0309403
RASAL2 RAS protein activator like 2 -0.0297472
CAVIN1 caveolae associated protein 1 -0.0293859
ARF1 ADP-ribosylation factor 1 -0.0289389
MKI67 marker of proliferation Ki-67 -0.0285892
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0284682
ANXA2 annexin A2 -0.0282727
TXNRD1 thioredoxin reductase 1 -0.0279353
RAB10 RAB10, member RAS oncogene family -0.0278989
WNT2B wingless-type MMTV integration site family, member 2B -0.0278338
PITPNB phosphatidylinositol transfer protein, beta -0.0276753
OSMR oncostatin M receptor -0.0275396
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0273652
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0272474
IFITM3 interferon induced transmembrane protein 3 -0.0264979
SP100 SP100 nuclear antigen -0.0264875
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.026187
ZNFX1 zinc finger, NFX1-type containing 1 -0.0258876
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0257444
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0255131
MTAP methylthioadenosine phosphorylase -0.025498
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0254831
SULF2 sulfatase 2 -0.0254694
FBXO11 F-box protein 11 -0.0251024
THBD thrombomodulin -0.0247357
VDAC1 voltage-dependent anion channel 1 -0.0247002
STAU1 staufen double-stranded RNA binding protein 1 -0.0242766
IFIH1 interferon induced with helicase C domain 1 -0.02409
RPS8 ribosomal protein S8 -0.0233948
ANKHD1 ankyrin repeat and KH domain containing 1 -0.023329
TSC22D1 TSC22 domain family, member 1 -0.0232268
PTMA prothymosin, alpha -0.0232185
S100A11 S100 calcium binding protein A11 -0.0220228
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0219568
FAM107B family with sequence similarity 107, member B -0.0219422
EMP1 epithelial membrane protein 1 -0.0216591
S100A6 S100 calcium binding protein A6 -0.0214504
ANKRD28 ankyrin repeat domain 28 -0.0214052
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0211022
TJP1 tight junction protein 1 -0.0210118
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0210112
RPL34 ribosomal protein L34 -0.0210097
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0207337
SETX senataxin -0.0206091
NIPBL Nipped-B homolog (Drosophila) -0.0204682
IER3 immediate early response 3 -0.0204261
IFITM1 interferon induced transmembrane protein 1 -0.020253
AGO2 argonaute RISC catalytic component 2 -0.0200562
SLC38A2 solute carrier family 38, member 2 -0.0199934
CORO2A coronin, actin binding protein, 2A -0.0199141
RPLP0 ribosomal protein, large, P0 -0.0198459
MYO1E myosin IE -0.0197432
BMAL2 basic helix-loop-helix ARNT like 2 -0.0196931
CUL4B cullin 4B -0.0196487
RPS27A ribosomal protein S27a -0.0195264
LUZP1 leucine zipper protein 1 -0.0194325
FNDC3A fibronectin type III domain containing 3A -0.0193116
RAB7A RAB7A, member RAS oncogene family -0.0193058
RRBP1 ribosome binding protein 1 -0.0192971
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0192335
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0189088
RPL39 ribosomal protein L39 -0.0188986
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0185049
RAD21 RAD21 homolog (S. pombe) -0.0182199
RCOR1 REST corepressor 1 -0.0180817
ARHGAP5 Rho GTPase activating protein 5 -0.0177388