Berbamine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SRRM2 serine/arginine repetitive matrix 2 0.0947263
LMO7 LIM domain 7 0.0877562
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0701456
FAT1 FAT atypical cadherin 1 0.0623396
CEMIP cell migration inducing protein, hyaluronan binding 0.0616642
VEGFA vascular endothelial growth factor A 0.0541766
MPRIP myosin phosphatase Rho interacting protein 0.0539006
KRT8 keratin 8, type II 0.0494799
TNS4 tensin 4 0.049166
ZFAND3 zinc finger, AN1-type domain 3 0.0433453
PLEC plectin 0.0399283
ABHD2 abhydrolase domain containing 2 0.039661
NCOR2 nuclear receptor corepressor 2 0.0381059
CTBP2 C-terminal binding protein 2 0.037141
RPL35A ribosomal protein L35a 0.0368947
RNF43 ring finger protein 43 0.0365667
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0355044
ATXN1 ataxin 1 0.0348687
ANKRD11 ankyrin repeat domain 11 0.0342083
FNBP4 formin binding protein 4 0.0340781
MYH9 myosin, heavy chain 9, non-muscle 0.0337691
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0334916
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0328444
RPS6 ribosomal protein S6 0.0327133
AKAP9 A kinase (PRKA) anchor protein 9 0.031726
ITGA6 integrin, alpha 6 0.0314837
BTBD9 BTB (POZ) domain containing 9 0.0314225
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0306515
RPL9 ribosomal protein L9 0.0301886
ENO2 enolase 2 (gamma, neuronal) 0.0301528
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0301399
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0299871
PTEN phosphatase and tensin homolog 0.0299138
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0291979
NUMA1 nuclear mitotic apparatus protein 1 0.0290635
RPLP2 ribosomal protein, large, P2 0.028914
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0287337
RPS8 ribosomal protein S8 0.0284924
RPS23 ribosomal protein S23 0.0283274
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0280021
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0275938
TPT1 tumor protein, translationally-controlled 1 0.0274706
FLNB filamin B, beta 0.0264907
DSCAM Down syndrome cell adhesion molecule 0.0263727
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0260891
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0260157
N4BP2L2 NEDD4 binding protein 2-like 2 0.0260139
DNM2 dynamin 2 0.0259743
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.025913
RNF145 ring finger protein 145 0.0258472
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0258072
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0257892
NEBL nebulette 0.025536
WSB1 WD repeat and SOCS box containing 1 0.0254706
RPS29 ribosomal protein S29 0.0253981
CMIP c-Maf inducing protein 0.0253576
TRIM2 tripartite motif containing 2 0.0250721
EIF4B eukaryotic translation initiation factor 4B 0.0249711
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0249329
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0248165
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0247505
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0247468
TTC17 tetratricopeptide repeat domain 17 0.0246806
TMSB10 thymosin beta 10 0.0246456
VMP1 vacuole membrane protein 1 0.024611
SFPQ splicing factor proline/glutamine-rich 0.0245329
RPS12 ribosomal protein S12 0.0244631
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0237936
RBM25 RNA binding motif protein 25 0.0237923
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0236815
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0236285
MACF1 microtubule-actin crosslinking factor 1 0.0232965
TNRC18 trinucleotide repeat containing 18 0.0232878
EFNA5 ephrin-A5 0.0229974
OGA O-GlcNAcase 0.022879
SAMD4A sterile alpha motif domain containing 4A 0.0228742
HSPG2 heparan sulfate proteoglycan 2 0.0228466
ACTG1 actin gamma 1 0.022623
MON2 MON2 homolog (S. cerevisiae) 0.0226005
ARID1B AT rich interactive domain 1B (SWI1-like) 0.022588
HDAC4 histone deacetylase 4 0.0225364
ESRP1 epithelial splicing regulatory protein 1 0.0224766
ANXA11 annexin A11 0.0223901
PTK2 protein tyrosine kinase 2 0.0222512
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0221523
MYO5B myosin VB 0.0221211
BLCAP bladder cancer associated protein 0.0219749
PRRC2C proline-rich coiled-coil 2C 0.0219317
DHFR dihydrofolate reductase 0.0219113
MED13 mediator complex subunit 13 0.0218996
KMT2C lysine (K)-specific methyltransferase 2C 0.0218035
MINK1 misshapen-like kinase 1 0.021777
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0217655
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0217344
GSK3B glycogen synthase kinase 3 beta 0.0215737
KMT2D lysine (K)-specific methyltransferase 2D 0.021568
AGRN agrin 0.0214652
AKAP13 A kinase (PRKA) anchor protein 13 0.0214408
RPL11 ribosomal protein L11 0.0214133
SHB Src homology 2 domain containing adaptor protein B 0.0213614

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.292451
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.229748
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.219048
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.144653
NPSR1 neuropeptide S receptor 1 -0.108735
AHNAK AHNAK nucleoprotein -0.084532
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0844844
LDHA lactate dehydrogenase A -0.0840309
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0818851
FTH1 ferritin, heavy polypeptide 1 -0.0818044
ANXA2 annexin A2 -0.0809917
ENO1 enolase 1, (alpha) -0.0710763
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0661563
PTMA prothymosin, alpha -0.0655264
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0625858
TPM4 tropomyosin 4 -0.0593594
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0589777
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0569148
EPCAM epithelial cell adhesion molecule -0.0562051
RPLP0 ribosomal protein, large, P0 -0.0561686
PIGR polymeric immunoglobulin receptor -0.0542401
TXNIP thioredoxin interacting protein -0.0541922
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0523586
S100A6 S100 calcium binding protein A6 -0.0490991
MLEC malectin -0.0459581
VCL vinculin -0.045063
PDIA3 protein disulfide isomerase family A, member 3 -0.0443787
MYO1E myosin IE -0.0443435
DSPP dentin sialophosphoprotein -0.0440225
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0417855
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0399862
TMEM123 transmembrane protein 123 -0.0395078
CANX calnexin -0.0390046
KLF6 Kruppel-like factor 6 -0.038464
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0369115
PPARG peroxisome proliferator-activated receptor gamma -0.0352599
FERMT1 fermitin family member 1 -0.0340138
MUC17 mucin 17, cell surface associated -0.0331951
KRT19 keratin 19, type I -0.0324278
PSD3 pleckstrin and Sec7 domain containing 3 -0.0320441
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0319253
EREG epiregulin -0.0315511
LOC112694756 uncharaterized LOC112694756 -0.0313149
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0307394
YBX1 Y box binding protein 1 -0.0302951
MXI1 MAX interactor 1, dimerization protein -0.0296739
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0289696
FAM13A family with sequence similarity 13, member A -0.0284834
ARHGAP5 Rho GTPase activating protein 5 -0.0283951
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0283223
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0273481
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0264601
CBX3 chromobox homolog 3 -0.0260441
NDRG1 N-myc downstream regulated 1 -0.0255823
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0252158
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0250658
CCND1 cyclin D1 -0.025061
NRN1 neuritin 1 -0.0244889
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0244562
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0243855
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0243744
RPL12 ribosomal protein L12 -0.0243738
DSG2 desmoglein 2 -0.0242523
S100A10 S100 calcium binding protein A10 -0.0240775
HILPDA hypoxia inducible lipid droplet-associated -0.0240725
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0239549
JUN jun proto-oncogene -0.0236468
ARF1 ADP-ribosylation factor 1 -0.0233619
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0232897
PKP2 plakophilin 2 -0.0229559
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0226052
SLC35F3 solute carrier family 35, member F3 -0.02243
GNAS GNAS complex locus -0.022352
LOC102724023 ES1 protein homolog, mitochondrial -0.0223199
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0223195
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0222745
PERP PERP, TP53 apoptosis effector -0.0221939
HDAC2 histone deacetylase 2 -0.0221935
FNBP1L formin binding protein 1-like -0.0220725
CDC42SE2 CDC42 small effector 2 -0.0219704
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0218306
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0217774
EZR ezrin -0.021458
PCDH9 protocadherin 9 -0.0213141
FTL ferritin, light polypeptide -0.0212804
CENPF centromere protein F, 350/400kDa -0.0209033
KIF5B kinesin family member 5B -0.020868
FAM162A family with sequence similarity 162, member A -0.020846
PTBP3 polypyrimidine tract binding protein 3 -0.0204411
LIMA1 LIM domain and actin binding 1 -0.0203166
BZW1 basic leucine zipper and W2 domains 1 -0.0202634
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0200431
TXN2 thioredoxin 2 -0.0199628
TSC22D1 TSC22 domain family, member 1 -0.0198139
MT1X metallothionein 1X -0.0194699
DLG1 discs, large homolog 1 (Drosophila) -0.0192587
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0191476
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0189658
PFN1 profilin 1 -0.0188739
TPI1 triosephosphate isomerase 1 -0.0187836