Berbamine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.138282
NDRG1 N-myc downstream regulated 1 0.135581
FNDC3B fibronectin type III domain containing 3B 0.128262
GRB10 growth factor receptor-bound protein 10 0.11606
PTMA prothymosin, alpha 0.10406
TMSB10 thymosin beta 10 0.0794961
MYH9 myosin, heavy chain 9, non-muscle 0.0793387
LAMB3 laminin, beta 3 0.0731744
FAM13A family with sequence similarity 13, member A 0.0709623
PLEC plectin 0.0675728
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0672162
ZFAND3 zinc finger, AN1-type domain 3 0.0647749
FLNB filamin B, beta 0.0626232
HLA-B major histocompatibility complex, class I, B 0.0614586
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0607612
RNF145 ring finger protein 145 0.0598097
DSCAM Down syndrome cell adhesion molecule 0.0561904
RBM39 RNA binding motif protein 39 0.0560698
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0549049
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0541798
PTK2 protein tyrosine kinase 2 0.0532569
KMT2E lysine (K)-specific methyltransferase 2E 0.0525869
ZSWIM6 zinc finger, SWIM-type containing 6 0.0525009
SAMD4A sterile alpha motif domain containing 4A 0.0518729
RBM25 RNA binding motif protein 25 0.0515108
NAV2 neuron navigator 2 0.0503703
SETD5 SET domain containing 5 0.050062
PDLIM5 PDZ and LIM domain 5 0.0496626
COPA coatomer protein complex, subunit alpha 0.0486486
TSC22D2 TSC22 domain family, member 2 0.048638
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0475141
ZNF292 zinc finger protein 292 0.0468361
VEGFA vascular endothelial growth factor A 0.0456159
PRRC2C proline-rich coiled-coil 2C 0.04554
TRIO trio Rho guanine nucleotide exchange factor 0.04534
RPL35A ribosomal protein L35a 0.0450899
CCNL1 cyclin L1 0.0446506
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0444795
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0442148
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0437798
UBC ubiquitin C 0.043621
PGK1 phosphoglycerate kinase 1 0.0427638
HELZ helicase with zinc finger 0.0424932
ENO2 enolase 2 (gamma, neuronal) 0.0418888
GPBP1 GC-rich promoter binding protein 1 0.0417234
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0416786
YTHDC1 YTH domain containing 1 0.0415984
MARCHF6 membrane associated ring-CH-type finger 6 0.0413289
SEC23A Sec23 homolog A (S. cerevisiae) 0.0412617
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0404911
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0403558
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0402216
ARID4B AT rich interactive domain 4B (RBP1-like) 0.039884
RCOR1 REST corepressor 1 0.0396712
PPARD peroxisome proliferator-activated receptor delta 0.0395961
SMAD3 SMAD family member 3 0.0388687
ANKRD17 ankyrin repeat domain 17 0.0385864
TUFT1 tuftelin 1 0.0384553
GOLGA4 golgin A4 0.038392
SPAG9 sperm associated antigen 9 0.0379282
LIMCH1 LIM and calponin homology domains 1 0.0375247
PLAU plasminogen activator, urokinase 0.0373903
CD109 CD109 molecule 0.0370502
CALR calreticulin 0.036657
TMED9 transmembrane emp24 protein transport domain containing 9 0.0365373
ANKRD11 ankyrin repeat domain 11 0.0364959
AKAP13 A kinase (PRKA) anchor protein 13 0.0360567
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0357296
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0357031
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0356928
FNIP1 folliculin interacting protein 1 0.0350689
NAMPT nicotinamide phosphoribosyltransferase 0.0349295
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0340361
EIF1 eukaryotic translation initiation factor 1 0.0335341
CDC73 cell division cycle 73 0.0329183
LPP LIM domain containing preferred translocation partner in lipoma 0.0328535
KRT7 keratin 7, type II 0.0324799
ACTG1 actin gamma 1 0.0323391
TENT2 terminal nucleotidyltransferase 2 0.0322472
CERT1 ceramide transporter 1 0.0321159
TRA2B transformer 2 beta homolog (Drosophila) 0.031842
NKTR natural killer cell triggering receptor 0.0314425
CCNY cyclin Y 0.0312687
KDM3A lysine (K)-specific demethylase 3A 0.0311394
OGA O-GlcNAcase 0.0308734
KDM6A lysine (K)-specific demethylase 6A 0.0305096
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0305026
HSPA8 heat shock 70kDa protein 8 0.0303108
ANKHD1 ankyrin repeat and KH domain containing 1 0.0301331
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0300652
SEC24D SEC24 family member D 0.0297682
VMP1 vacuole membrane protein 1 0.0297027
ACBD3 acyl-CoA binding domain containing 3 0.0296296
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0293982
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0292635
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0291725
RLF rearranged L-myc fusion 0.0288375
KMT2C lysine (K)-specific methyltransferase 2C 0.0287358
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0286743
PDIA4 protein disulfide isomerase family A, member 4 0.0286626

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.242476
IGFBP3 insulin-like growth factor binding protein 3 -0.189877
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182043
S100A6 S100 calcium binding protein A6 -0.094374
FTH1 ferritin, heavy polypeptide 1 -0.0850447
ENO1 enolase 1, (alpha) -0.0728244
DSPP dentin sialophosphoprotein -0.0708515
TMSB4X thymosin beta 4, X-linked -0.0707207
LMO7 LIM domain 7 -0.0699243
RPLP1 ribosomal protein, large, P1 -0.0677935
IFI27 interferon, alpha-inducible protein 27 -0.065618
S100A10 S100 calcium binding protein A10 -0.0622436
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0607522
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0508738
MAP1B microtubule-associated protein 1B -0.0504022
TXNRD1 thioredoxin reductase 1 -0.0504016
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0487477
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0477139
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0469786
LDHA lactate dehydrogenase A -0.0467359
FBXO32 F-box protein 32 -0.0453538
RPS6 ribosomal protein S6 -0.0447026
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0425569
ANXA2 annexin A2 -0.040734
KRT19 keratin 19, type I -0.0373121
DSG2 desmoglein 2 -0.0368383
CSTB cystatin B (stefin B) -0.0360214
AHNAK AHNAK nucleoprotein -0.0347213
EPCAM epithelial cell adhesion molecule -0.0344073
MSMO1 methylsterol monooxygenase 1 -0.0343062
IFITM3 interferon induced transmembrane protein 3 -0.0339831
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0335776
CCND1 cyclin D1 -0.0326371
POTEF POTE ankyrin domain family, member F -0.0313738
VGLL3 vestigial-like family member 3 -0.0309754
TXNIP thioredoxin interacting protein -0.0301036
IFI6 interferon, alpha-inducible protein 6 -0.0297595
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.029751
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0289865
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0289106
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0288809
CAPN2 calpain 2, (m/II) large subunit -0.0286823
LGALS1 lectin, galactoside-binding, soluble, 1 -0.028412
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0283774
EGFR epidermal growth factor receptor -0.0283252
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0279259
RPS27 ribosomal protein S27 -0.0273095
SOX4 SRY (sex determining region Y)-box 4 -0.0269572
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0264816
VIM vimentin -0.0263104
STEAP4 STEAP family member 4 -0.026226
CD2AP CD2-associated protein -0.0262129
LOC112694756 uncharaterized LOC112694756 -0.0260105
MX1 MX dynamin-like GTPase 1 -0.0259132
F3 coagulation factor III (thromboplastin, tissue factor) -0.0258323
BZW1 basic leucine zipper and W2 domains 1 -0.0258231
STAT1 signal transducer and activator of transcription 1, 91kDa -0.02562
FTL ferritin, light polypeptide -0.0255067
TPM4 tropomyosin 4 -0.0252892
YBX1 Y box binding protein 1 -0.0249608
MX2 MX dynamin-like GTPase 2 -0.024388
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0242112
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0228435
TFPI2 tissue factor pathway inhibitor 2 -0.0224719
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0222672
SP100 SP100 nuclear antigen -0.0220901
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0216811
SVIL supervillin -0.0213894
KPNB1 karyopherin (importin) beta 1 -0.0213247
TACSTD2 tumor-associated calcium signal transducer 2 -0.0209435
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0209178
SQSTM1 sequestosome 1 -0.0206142
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0206013
CAVIN1 caveolae associated protein 1 -0.0205224
MACC1 metastasis associated in colon cancer 1 -0.0203643
NR3C2 nuclear receptor subfamily 3, group C, member 2 -0.0202877
SYT1 synaptotagmin I -0.0202716
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0200685
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0200628
NRP1 neuropilin 1 -0.019912
CTSS cathepsin S -0.0198068
ARF1 ADP-ribosylation factor 1 -0.0198007
ZBTB20 zinc finger and BTB domain containing 20 -0.0194192
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0190306
RAB27B RAB27B, member RAS oncogene family -0.0188607
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0185322
ERBIN erbb2 interacting protein -0.0184061
SQLE squalene epoxidase -0.0180847
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0179459
BTG1 B-cell translocation gene 1, anti-proliferative -0.0178479
RRBP1 ribosome binding protein 1 -0.0178424
DPP4 dipeptidyl-peptidase 4 -0.0177776
BHLHE40 basic helix-loop-helix family, member e40 -0.0177297
RPL30 ribosomal protein L30 -0.0176169
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0175651
RPL12 ribosomal protein L12 -0.0175489
S100A11 S100 calcium binding protein A11 -0.0174055
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0172539
PGBD5 piggyBac transposable element derived 5 -0.0171262
ASPH aspartate beta-hydroxylase -0.0168969