Berbamine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

136 genes differentially expressed following the Berbamine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.196577
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.194407
BTBD9 BTB (POZ) domain containing 9 0.147988
VMP1 vacuole membrane protein 1 0.147242
ELOVL5 ELOVL fatty acid elongase 5 0.128478
DSCAM Down syndrome cell adhesion molecule 0.125193
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.116211
GRB10 growth factor receptor-bound protein 10 0.113352
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0916649
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0889949
DST dystonin 0.0854241
EEF2 eukaryotic translation elongation factor 2 0.0846287
VCL vinculin 0.0763347
EFNA5 ephrin-A5 0.0747564
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0737409
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0729709
RORA RAR-related orphan receptor A 0.0715122
PGK1 phosphoglycerate kinase 1 0.06975
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0673034
DOCK5 dedicator of cytokinesis 5 0.0666689
GLIS3 GLIS family zinc finger 3 0.0651283
RBM39 RNA binding motif protein 39 0.0649926
SPAG9 sperm associated antigen 9 0.063989
USP34 ubiquitin specific peptidase 34 0.0635849
LMO7 LIM domain 7 0.0624433
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0607561
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0603306
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0602772
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0563488
PDE10A phosphodiesterase 10A 0.0518413
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0506736
PTMA prothymosin, alpha 0.0496082
AOPEP aminopeptidase O (putative) 0.0490369
TPT1 tumor protein, translationally-controlled 1 0.0475474
PRKCA protein kinase C, alpha 0.0454961
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0452304
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0451908
TXNRD1 thioredoxin reductase 1 0.0413569
ASPH aspartate beta-hydroxylase 0.0403819
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0330378
TMSB10 thymosin beta 10 0.0317395
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0298251
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0294431
SBF2 SET binding factor 2 0.024192
OGA O-GlcNAcase 0.0238723
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0233235
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0228324
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0205989
GPC6 glypican 6 0.0176541
ELL2 elongation factor, RNA polymerase II, 2 0.0166773
SMAD3 SMAD family member 3 0.0165895
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0152644
MT2A metallothionein 2A 0.014443
KTN1 kinectin 1 (kinesin receptor) 0.0125949
PRKD3 protein kinase D3 0.0110532
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.00990064
LAMA4 laminin, alpha 4 0.00683943
TRIO trio Rho guanine nucleotide exchange factor 0.00635916
SAMD4A sterile alpha motif domain containing 4A 0.00569497
RPL35A ribosomal protein L35a 0.0056295
CDH13 cadherin 13 0.00536958
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00481599
JMJD1C jumonji domain containing 1C 0.00477717
RIGI RNA sensor RIG-I 0.0025425
MAML2 mastermind-like 2 (Drosophila) 0.00135842

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.149855
FN1 fibronectin 1 -0.139059
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.137106
RPL23 ribosomal protein L23 -0.123615
PALM2AKAP2 PALM2 and AKAP2 fusion -0.117997
KMT2C lysine (K)-specific methyltransferase 2C -0.106428
VIM vimentin -0.100686
RNF213 ring finger protein 213 -0.0963122
MYO1E myosin IE -0.0920775
NDRG1 N-myc downstream regulated 1 -0.0910869
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0843124
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0785428
PDLIM5 PDZ and LIM domain 5 -0.074735
MON2 MON2 homolog (S. cerevisiae) -0.0742286
THSD4 thrombospondin, type I, domain containing 4 -0.0688545
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0677432
IGFBP5 insulin-like growth factor binding protein 5 -0.0677308
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0664208
CD44 CD44 molecule (Indian blood group) -0.0632725
IGF2 insulin-like growth factor 2 -0.0627079
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0616179
NPAS2 neuronal PAS domain protein 2 -0.0614708
SLTM SAFB-like, transcription modulator -0.0604645
SRPK2 SRSF protein kinase 2 -0.0496973
FNDC3B fibronectin type III domain containing 3B -0.0496633
RPS16 ribosomal protein S16 -0.0490798
AKAP12 A kinase (PRKA) anchor protein 12 -0.048704
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0486521
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0462645
ATXN1 ataxin 1 -0.0420056
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0417362
TPM4 tropomyosin 4 -0.0408127
RAD51B RAD51 paralog B -0.0396498
SETD5 SET domain containing 5 -0.0377704
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0340807
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0337038
NALF1 NALCN channel auxiliary factor 1 -0.0336187
RPS6 ribosomal protein S6 -0.0333866
EXT1 exostosin glycosyltransferase 1 -0.0323194
MYOF myoferlin -0.0301629
COL5A2 collagen, type V, alpha 2 -0.0286829
ZBTB20 zinc finger and BTB domain containing 20 -0.0258521
B2M beta-2-microglobulin -0.0229973
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0228241
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.022789
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0227332
PRRC2C proline-rich coiled-coil 2C -0.0219536
PDE4D phosphodiesterase 4D, cAMP-specific -0.020776
TCF12 transcription factor 12 -0.0204623
MYO6 myosin VI -0.020282
PARD3 par-3 family cell polarity regulator -0.0198712
PTK2 protein tyrosine kinase 2 -0.0191233
RPS3 ribosomal protein S3 -0.0168095
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0166143
SMYD3 SET and MYND domain containing 3 -0.0162265
FNDC3A fibronectin type III domain containing 3A -0.0159209
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0140607
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0136196
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0126946
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0100052
DOCK4 dedicator of cytokinesis 4 -0.00975268
KMT2E lysine (K)-specific methyltransferase 2E -0.00884805
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.00863899
BBX bobby sox homolog (Drosophila) -0.00843189
LDHA lactate dehydrogenase A -0.00765577
APP amyloid beta (A4) precursor protein -0.00690285
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00633431
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.00460731
MAML3 mastermind-like 3 (Drosophila) -0.00380818
OSMR oncostatin M receptor -0.00311634
FTL ferritin, light polypeptide -6.0106E-4