Berbamine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.232664
CPED1 cadherin-like and PC-esterase domain containing 1 0.0659004
TPT1 tumor protein, translationally-controlled 1 0.0597162
RPL23 ribosomal protein L23 0.0566848
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0548737
ZFAND3 zinc finger, AN1-type domain 3 0.0514187
CAMTA1 calmodulin binding transcription activator 1 0.0486845
KMT2C lysine (K)-specific methyltransferase 2C 0.0478135
HDAC9 histone deacetylase 9 0.044657
NCEH1 neutral cholesterol ester hydrolase 1 0.0443375
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0427381
SREBF2 sterol regulatory element binding transcription factor 2 0.0422849
DSCAM Down syndrome cell adhesion molecule 0.0420439
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0414803
SAMD4A sterile alpha motif domain containing 4A 0.0405028
RPL35A ribosomal protein L35a 0.0393274
SLC38A2 solute carrier family 38, member 2 0.0377919
PGK1 phosphoglycerate kinase 1 0.0366936
RBM39 RNA binding motif protein 39 0.0365299
AHI1 Abelson helper integration site 1 0.0360243
TMSB10 thymosin beta 10 0.0357874
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0355689
ANKRD11 ankyrin repeat domain 11 0.0346318
NBEA neurobeachin 0.0338311
ATOSA atos homolog A 0.0338104
SMYD3 SET and MYND domain containing 3 0.0335837
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0332443
ANKRD17 ankyrin repeat domain 17 0.0331081
ASXL1 additional sex combs like transcriptional regulator 1 0.0330156
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0327209
ANKRD12 ankyrin repeat domain 12 0.0326518
EXT1 exostosin glycosyltransferase 1 0.0324059
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0320094
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0316799
EVI5 ecotropic viral integration site 5 0.0316603
QKI QKI, KH domain containing, RNA binding 0.0315509
TNPO1 transportin 1 0.0310908
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0307711
GLI2 GLI family zinc finger 2 0.030606
KMT2E lysine (K)-specific methyltransferase 2E 0.0301201
TTC28 tetratricopeptide repeat domain 28 0.0297367
WSB1 WD repeat and SOCS box containing 1 0.0295528
EFNA5 ephrin-A5 0.029426
PUM2 pumilio RNA-binding family member 2 0.0293652
KDM3A lysine (K)-specific demethylase 3A 0.0290272
FDPS farnesyl diphosphate synthase 0.0286684
ITGA10 integrin, alpha 10 0.0282259
PNISR PNN-interacting serine/arginine-rich protein 0.0281552
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0280928
SETD5 SET domain containing 5 0.0280638
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0279311
KIAA1958 KIAA1958 0.0276512
TMEM41B transmembrane protein 41B 0.0273755
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0272398
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0269285
NKTR natural killer cell triggering receptor 0.0261008
ECT2 epithelial cell transforming 2 0.0258483
PTK2 protein tyrosine kinase 2 0.025624
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0256132
SRSF11 serine/arginine-rich splicing factor 11 0.0253193
EIF4A2 eukaryotic translation initiation factor 4A2 0.0252333
NFE2L2 nuclear factor, erythroid 2-like 2 0.0249894
PLXNA1 plexin A1 0.0246141
GLS2 glutaminase 2 (liver, mitochondrial) 0.0244488
EXOC4 exocyst complex component 4 0.0242391
SFPQ splicing factor proline/glutamine-rich 0.0241058
CTIF CBP80/20-dependent translation initiation factor 0.0240932
ACACA acetyl-CoA carboxylase alpha 0.0240801
TCERG1 transcription elongation regulator 1 0.0237203
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0233649
ERBIN erbb2 interacting protein 0.0233548
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0232983
NAV2 neuron navigator 2 0.0232361
KAT6A K(lysine) acetyltransferase 6A 0.0232279
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.0230413
TNRC6B trinucleotide repeat containing 6B 0.0229338
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0226948
ANKHD1 ankyrin repeat and KH domain containing 1 0.0226927
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0226578
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0226022
ZNF638 zinc finger protein 638 0.022597
SPPL3 signal peptide peptidase like 3 0.0223275
LPP LIM domain containing preferred translocation partner in lipoma 0.0222889
CREBBP CREB binding protein 0.0222814
PTPRG protein tyrosine phosphatase, receptor type, G 0.0221791
FBXO11 F-box protein 11 0.0221722
PMM2 phosphomannomutase 2 0.0221596
PYGB phosphorylase, glycogen; brain 0.0221389
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0220707
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0220147
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0219835
CCNY cyclin Y 0.0219276
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0218195
SEC63 SEC63 homolog (S. cerevisiae) 0.0216967
DUSP6 dual specificity phosphatase 6 0.0214905
MYL12B myosin, light chain 12B, regulatory 0.0214879
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0214854
RNF145 ring finger protein 145 0.0214213
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0213417
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0211651

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.222663
PKM pyruvate kinase, muscle -0.136976
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0791393
S100A6 S100 calcium binding protein A6 -0.0715496
LDHA lactate dehydrogenase A -0.0650558
CCND1 cyclin D1 -0.0594996
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0592053
PTMA prothymosin, alpha -0.0572408
TPM4 tropomyosin 4 -0.0567048
RPLP0 ribosomal protein, large, P0 -0.0551104
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0546107
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0533527
POTEF POTE ankyrin domain family, member F -0.0526358
ACTG1 actin gamma 1 -0.0525795
PFN1 profilin 1 -0.0506777
RPS8 ribosomal protein S8 -0.0502334
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0500503
ENO1 enolase 1, (alpha) -0.0487175
PDE4B phosphodiesterase 4B, cAMP-specific -0.0459596
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0459039
S100A4 S100 calcium binding protein A4 -0.0445721
EEF2 eukaryotic translation elongation factor 2 -0.0441086
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0430368
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0426208
GLI3 GLI family zinc finger 3 -0.0413262
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0386787
BMP10 bone morphogenetic protein 10 -0.0381042
RPL28 ribosomal protein L28 -0.0367274
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0363665
TMSB4X thymosin beta 4, X-linked -0.0352866
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0346977
LOC102724023 ES1 protein homolog, mitochondrial -0.0341779
RPS6 ribosomal protein S6 -0.0336976
DSTN destrin (actin depolymerizing factor) -0.0322855
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0322625
RHOA ras homolog family member A -0.0322139
RPLP1 ribosomal protein, large, P1 -0.0319063
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0313663
HSPB1 heat shock 27kDa protein 1 -0.0311075
RPS27 ribosomal protein S27 -0.0309155
CERT1 ceramide transporter 1 -0.0307722
TRERF1 transcriptional regulating factor 1 -0.0303716
MKI67 marker of proliferation Ki-67 -0.0299116
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0296199
PDE4D phosphodiesterase 4D, cAMP-specific -0.0290511
RPS2 ribosomal protein S2 -0.0290298
RPS13 ribosomal protein S13 -0.0290172
TUBB4B tubulin, beta 4B class IVb -0.0277895
ARL4C ADP-ribosylation factor-like 4C -0.0268145
SEPTIN7 septin 7 -0.0265787
DPYD dihydropyrimidine dehydrogenase -0.0265584
ITGA6 integrin, alpha 6 -0.0265287
DIAPH3 diaphanous-related formin 3 -0.0264642
SERBP1 SERPINE1 mRNA binding protein 1 -0.0264158
S100A9 S100 calcium binding protein A9 -0.0262021
FOXP1 forkhead box P1 -0.0260903
GCLM glutamate-cysteine ligase, modifier subunit -0.0254477
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.02542
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0253454
ATAD2 ATPase family, AAA domain containing 2 -0.0253002
S100A10 S100 calcium binding protein A10 -0.0251924
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0250319
B2M beta-2-microglobulin -0.0248737
VDAC1 voltage-dependent anion channel 1 -0.0245914
RPL3 ribosomal protein L3 -0.0245077
TUBA1B tubulin, alpha 1b -0.0243835
BLTP3B bridge-like lipid transfer protein family member 3B -0.0243425
RPL37A ribosomal protein L37a -0.0235665
HEG1 heart development protein with EGF-like domains 1 -0.0234259
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0226644
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0224313
RPL7 ribosomal protein L7 -0.0223977
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0220665
AHNAK AHNAK nucleoprotein -0.0216606
PDIA3 protein disulfide isomerase family A, member 3 -0.0215574
HDGF hepatoma-derived growth factor -0.021482
TOP2A topoisomerase (DNA) II alpha 170kDa -0.021364
FAT1 FAT atypical cadherin 1 -0.0211985
YBX1 Y box binding protein 1 -0.0209251
RPL27A ribosomal protein L27a -0.0209191
RPL13A ribosomal protein L13a -0.0208945
EMP3 epithelial membrane protein 3 -0.020838
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0208108
MBNL1 muscleblind-like splicing regulator 1 -0.0204402
ARHGAP25 Rho GTPase activating protein 25 -0.0204066
RPL39 ribosomal protein L39 -0.0202558
ADAM10 ADAM metallopeptidase domain 10 -0.0200451
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.019959
SOX9 SRY (sex determining region Y)-box 9 -0.0195797
SCARB2 scavenger receptor class B, member 2 -0.019535
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -0.01946
ATXN1 ataxin 1 -0.0194253
TUBB tubulin, beta class I -0.0193883
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0192351
RPL7A ribosomal protein L7a -0.019228
TPR translocated promoter region, nuclear basket protein -0.0191843
HMGB1 high mobility group box 1 -0.0190224
SBF2 SET binding factor 2 -0.0189342
TPM3 tropomyosin 3 -0.0189328
MYO5A myosin VA (heavy chain 12, myoxin) -0.0188705