Berbamine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HLA-B major histocompatibility complex, class I, B 0.115476
NAMPT nicotinamide phosphoribosyltransferase 0.112737
ADM adrenomedullin 0.110209
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.096619
FN1 fibronectin 1 0.0712618
NDRG1 N-myc downstream regulated 1 0.0710423
EIF1 eukaryotic translation initiation factor 1 0.0618588
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.060285
MT2A metallothionein 2A 0.0602436
UGCG UDP-glucose ceramide glucosyltransferase 0.0586124
TPT1 tumor protein, translationally-controlled 1 0.0576766
MYH9 myosin, heavy chain 9, non-muscle 0.0546535
PGK1 phosphoglycerate kinase 1 0.0545574
ATP13A3 ATPase type 13A3 0.0544768
OGA O-GlcNAcase 0.0541228
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0532599
MT1X metallothionein 1X 0.0513529
ELL2 elongation factor, RNA polymerase II, 2 0.0501096
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0494928
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0484229
SFTPA2 surfactant protein A2 0.0474508
VEGFA vascular endothelial growth factor A 0.0461981
BASP1 brain abundant, membrane attached signal protein 1 0.0454862
RBM39 RNA binding motif protein 39 0.0409894
WSB1 WD repeat and SOCS box containing 1 0.0401915
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0391099
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0381935
RPL35A ribosomal protein L35a 0.0380989
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0350004
HLA-A major histocompatibility complex, class I, A 0.0343562
ZFAND3 zinc finger, AN1-type domain 3 0.0341085
NPEPPS aminopeptidase puromycin sensitive 0.0338116
TENT5A terminal nucleotidyltransferase 5A 0.0337762
SRRM2 serine/arginine repetitive matrix 2 0.0337713
BTG1 B-cell translocation gene 1, anti-proliferative 0.0318879
PPARD peroxisome proliferator-activated receptor delta 0.0317448
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0298698
ZMIZ1 zinc finger, MIZ-type containing 1 0.0296683
GLIS3 GLIS family zinc finger 3 0.0293794
CCNL1 cyclin L1 0.0293278
NUMA1 nuclear mitotic apparatus protein 1 0.0292192
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.027412
RB1CC1 RB1-inducible coiled-coil 1 0.0273969
PRRC2C proline-rich coiled-coil 2C 0.0268305
PHIP pleckstrin homology domain interacting protein 0.0260577
TSC22D2 TSC22 domain family, member 2 0.0246343
SDC4 syndecan 4 0.0242138
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0240505
RBM6 RNA binding motif protein 6 0.0239219
DENND5A DENN/MADD domain containing 5A 0.0239021
AFDN afadin, adherens junction formation factor 0.0237484
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0230485
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0228073
SBF2 SET binding factor 2 0.0227323
FUS FUS RNA binding protein 0.0226501
VMP1 vacuole membrane protein 1 0.0225391
RPS21 ribosomal protein S21 0.0225244
SMAD3 SMAD family member 3 0.0220813
INSIG1 insulin induced gene 1 0.0219866
AMPD3 adenosine monophosphate deaminase 3 0.0219561
MSN moesin 0.0217866
HLA-C major histocompatibility complex, class I, C 0.0216766
FAM20C family with sequence similarity 20, member C 0.0213492
CEP95 centrosomal protein 95kDa 0.0210421
TMSB10 thymosin beta 10 0.0207769
CSDE1 cold shock domain containing E1, RNA-binding 0.0207647
TMEM41B transmembrane protein 41B 0.0204701
CEP250 centrosomal protein 250kDa 0.0202066
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0200092
RAB6A RAB6A, member RAS oncogene family 0.0199462
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0196952
TOP1 topoisomerase (DNA) I 0.0196377
BRD2 bromodomain containing 2 0.0195806
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0194631
SF1 splicing factor 1 0.0194105
INHBA inhibin, beta A 0.0194071
ZFP36L1 ZFP36 ring finger protein-like 1 0.019337
YEATS2 YEATS domain containing 2 0.0192906
USP9X ubiquitin specific peptidase 9, X-linked 0.0192252
RPL11 ribosomal protein L11 0.0191704
RNF213 ring finger protein 213 0.0189941
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0189898
KDM6A lysine (K)-specific demethylase 6A 0.0189636
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0188429
YTHDC1 YTH domain containing 1 0.0187058
SMAP1 small ArfGAP 1 0.01869
RASA2 RAS p21 protein activator 2 0.0185263
ZNF292 zinc finger protein 292 0.0184779
BRWD3 bromodomain and WD repeat domain containing 3 0.018332
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0182015
BCLAF1 BCL2-associated transcription factor 1 0.0181576
RBMX RNA binding motif protein, X-linked 0.0178955
EIF3L eukaryotic translation initiation factor 3, subunit L 0.0178769
EIF4H eukaryotic translation initiation factor 4H 0.0178701
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0176632
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0174071
RNF145 ring finger protein 145 0.0173877
ASXL1 additional sex combs like transcriptional regulator 1 0.0173196
RICTOR RPTOR independent companion of MTOR, complex 2 0.0172278
RLF rearranged L-myc fusion 0.0171454

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.282105
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149553
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.114684
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.112868
LDHA lactate dehydrogenase A -0.105402
SOD2 superoxide dismutase 2, mitochondrial -0.105277
VCL vinculin -0.10109
ENO1 enolase 1, (alpha) -0.0992925
IGFBP3 insulin-like growth factor binding protein 3 -0.0839225
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0816645
FRMD4A FERM domain containing 4A -0.0801337
PLIN2 perilipin 2 -0.0722618
HDAC9 histone deacetylase 9 -0.0713352
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.070884
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0701865
ANXA2 annexin A2 -0.0642788
CD44 CD44 molecule (Indian blood group) -0.0603242
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0597602
FTH1 ferritin, heavy polypeptide 1 -0.0574213
UBC ubiquitin C -0.0569684
SQSTM1 sequestosome 1 -0.0562455
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0561699
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0549103
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0546635
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0531693
TPM1 tropomyosin 1 (alpha) -0.0519383
MYOF myoferlin -0.0518757
EXT1 exostosin glycosyltransferase 1 -0.0515182
ASPH aspartate beta-hydroxylase -0.0512391
PKM pyruvate kinase, muscle -0.049725
DST dystonin -0.0496807
RPS27A ribosomal protein S27a -0.0489191
CANX calnexin -0.0488663
VCAN versican -0.0475457
RPS12 ribosomal protein S12 -0.0470205
PALLD palladin, cytoskeletal associated protein -0.0423068
INTS6 integrator complex subunit 6 -0.0411871
KTN1 kinectin 1 (kinesin receptor) -0.0410104
AKAP12 A kinase (PRKA) anchor protein 12 -0.0403922
GPC6 glypican 6 -0.0400663
RPLP1 ribosomal protein, large, P1 -0.039603
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0380188
AHNAK AHNAK nucleoprotein -0.035872
PDE4D phosphodiesterase 4D, cAMP-specific -0.0356722
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.035659
FTL ferritin, light polypeptide -0.0345195
TGFBI transforming growth factor, beta-induced, 68kDa -0.0338518
MORF4L2 mortality factor 4 like 2 -0.0333207
EGFR epidermal growth factor receptor -0.0331419
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0330604
LAMP2 lysosomal-associated membrane protein 2 -0.0329417
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0323881
VDAC1 voltage-dependent anion channel 1 -0.031991
HMGA2 high mobility group AT-hook 2 -0.0317657
IER3 immediate early response 3 -0.0312847
THBS1 thrombospondin 1 -0.0311875
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0310154
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0309082
DIAPH2 diaphanous-related formin 2 -0.030585
PDIA3 protein disulfide isomerase family A, member 3 -0.030252
WWOX WW domain containing oxidoreductase -0.0300442
RIGI RNA sensor RIG-I -0.0298104
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0294977
RHOBTB3 Rho-related BTB domain containing 3 -0.0294882
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.029188
RPS6 ribosomal protein S6 -0.0288922
GOLGB1 golgin B1 -0.0288791
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.027935
TENM2 teneurin transmembrane protein 2 -0.0279131
PSD3 pleckstrin and Sec7 domain containing 3 -0.0277909
NAV1 neuron navigator 1 -0.0276332
SEPTIN9 septin 9 -0.0268046
CTSD cathepsin D -0.0267733
SFRP1 secreted frizzled-related protein 1 -0.0267274
PTMA prothymosin, alpha -0.0267019
TPM4 tropomyosin 4 -0.026307
CDH13 cadherin 13 -0.0261204
CALR calreticulin -0.0259889
SOX9 SRY (sex determining region Y)-box 9 -0.0251251
EPAS1 endothelial PAS domain protein 1 -0.0247129
YBX1 Y box binding protein 1 -0.0246794
PHF3 PHD finger protein 3 -0.0240542
HLA-E major histocompatibility complex, class I, E -0.0239346
PDE10A phosphodiesterase 10A -0.0238429
HMGB1 high mobility group box 1 -0.0238369
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0237153
EFNA5 ephrin-A5 -0.0236712
COL8A1 collagen, type VIII, alpha 1 -0.0234981
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0233675
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0227235
RUNX1 runt-related transcription factor 1 -0.022517
BBX bobby sox homolog (Drosophila) -0.0224374
RPS2 ribosomal protein S2 -0.022425
IFIH1 interferon induced with helicase C domain 1 -0.0220802
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0220058
ARFGEF3 ARFGEF family member 3 -0.0217721
TSC22D1 TSC22 domain family, member 1 -0.0216852
SAMD9 sterile alpha motif domain containing 9 -0.0216063
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0214166
MBNL2 muscleblind-like splicing regulator 2 -0.0211715