Berbamine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.207274
NDRG1 N-myc downstream regulated 1 0.134174
MT2A metallothionein 2A 0.119179
IGFBP3 insulin-like growth factor binding protein 3 0.0899355
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0836819
TGFBI transforming growth factor, beta-induced, 68kDa 0.0782029
NRXN3 neurexin 3 0.0754686
NAMPT nicotinamide phosphoribosyltransferase 0.0674009
AKAP9 A kinase (PRKA) anchor protein 9 0.0664848
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0606948
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0580797
MT1X metallothionein 1X 0.0569117
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0567197
FNIP1 folliculin interacting protein 1 0.0515077
ELL2 elongation factor, RNA polymerase II, 2 0.051168
VEGFA vascular endothelial growth factor A 0.0508398
IL6 interleukin 6 0.0478509
GOLGA4 golgin A4 0.04648
TENT5A terminal nucleotidyltransferase 5A 0.0461162
FAM13A family with sequence similarity 13, member A 0.0455794
ARRDC3 arrestin domain containing 3 0.0443883
CLEC1B C-type lectin domain family 1, member B 0.0421039
ZCCHC7 zinc finger, CCHC domain containing 7 0.0417202
RNF145 ring finger protein 145 0.0404523
PRELID2 PRELI domain containing 2 0.0398043
UGCG UDP-glucose ceramide glucosyltransferase 0.0393371
VEGFC vascular endothelial growth factor C 0.0380962
EFNA5 ephrin-A5 0.0374606
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0370058
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.03671
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0365267
RICTOR RPTOR independent companion of MTOR, complex 2 0.0363229
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0355568
BACE2 beta-site APP-cleaving enzyme 2 0.0355256
ATP13A3 ATPase type 13A3 0.0345052
TMEM165 transmembrane protein 165 0.033951
SHB Src homology 2 domain containing adaptor protein B 0.0337435
ANKRD11 ankyrin repeat domain 11 0.033284
TMF1 TATA element modulatory factor 1 0.0329479
NF1 neurofibromin 1 0.0327533
TGFB1 transforming growth factor, beta 1 0.0327252
ZNF638 zinc finger protein 638 0.0325494
SEPTIN9 septin 9 0.0323385
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.032161
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0320136
CYB5R3 cytochrome b5 reductase 3 0.0317486
SKIC3 SKI3 subunit of superkiller complex 0.0314718
CADM1 cell adhesion molecule 1 0.0314506
COG6 component of oligomeric golgi complex 6 0.0310064
GOLGB1 golgin B1 0.0307694
NCOR2 nuclear receptor corepressor 2 0.0306552
KMT2E lysine (K)-specific methyltransferase 2E 0.0303337
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0302523
RUNX1 runt-related transcription factor 1 0.0299414
FTH1 ferritin, heavy polypeptide 1 0.0296993
CXCL8 chemokine (C-X-C motif) ligand 8 0.029684
YBX1 Y box binding protein 1 0.0292462
RAB6A RAB6A, member RAS oncogene family 0.0290214
RPL35A ribosomal protein L35a 0.0289152
ARHGAP35 Rho GTPase activating protein 35 0.0288631
SRSF11 serine/arginine-rich splicing factor 11 0.0288555
ERRFI1 ERBB receptor feedback inhibitor 1 0.0288466
TPT1 tumor protein, translationally-controlled 1 0.0283922
EGFR epidermal growth factor receptor 0.0283257
WSB1 WD repeat and SOCS box containing 1 0.0281205
SNX13 sorting nexin 13 0.0279539
COL6A1 collagen, type VI, alpha 1 0.0277308
EIF1 eukaryotic translation initiation factor 1 0.0276142
MARCHF6 membrane associated ring-CH-type finger 6 0.0276001
RASAL2 RAS protein activator like 2 0.0274434
ADM adrenomedullin 0.027074
COG5 component of oligomeric golgi complex 5 0.0265782
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0265674
RPL23 ribosomal protein L23 0.0265669
NALF1 NALCN channel auxiliary factor 1 0.0264573
EPAS1 endothelial PAS domain protein 1 0.0264197
FAM13B family with sequence similarity 13, member B 0.0263624
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0253238
LOC112694756 uncharaterized LOC112694756 0.0252872
SETD5 SET domain containing 5 0.0252088
SRRM2 serine/arginine repetitive matrix 2 0.0249794
CA9 carbonic anhydrase IX 0.024852
ELP2 elongator acetyltransferase complex subunit 2 0.0246837
OPTN optineurin 0.0246475
MYH9 myosin, heavy chain 9, non-muscle 0.0246147
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0241753
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0241518
AHR aryl hydrocarbon receptor 0.0239939
AVL9 AVL9 homolog (S. cerevisiase) 0.0238893
FOSL1 FOS-like antigen 1 0.023665
ARB2A ARB2 cotranscriptional regulator A 0.0236338
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.0234931
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0234017
PLEC plectin 0.0232887
TRA2A transformer 2 alpha homolog (Drosophila) 0.0231388
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0228223
TBC1D22A TBC1 domain family, member 22A 0.0219377
ITCH itchy E3 ubiquitin protein ligase 0.0218618
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0218495
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0216425

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.217235
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.206256
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.140339
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112977
SDC4 syndecan 4 -0.0861402
ENO1 enolase 1, (alpha) -0.0861396
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0842303
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0787601
VIM vimentin -0.0761726
VCL vinculin -0.0756999
AHNAK AHNAK nucleoprotein -0.0746057
TMSB10 thymosin beta 10 -0.0727396
PTMA prothymosin, alpha -0.067436
GRB10 growth factor receptor-bound protein 10 -0.0642622
TPM4 tropomyosin 4 -0.0637028
CALU calumenin -0.0578371
COL1A2 collagen, type I, alpha 2 -0.0548423
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0508162
ACTG1 actin gamma 1 -0.0505336
PRSS23 protease, serine, 23 -0.0496152
CANX calnexin -0.04878
LOX lysyl oxidase -0.0468545
IGFBP5 insulin-like growth factor binding protein 5 -0.0445926
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0438058
COL3A1 collagen, type III, alpha 1 -0.0418256
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0412093
COL1A1 collagen, type I, alpha 1 -0.0395543
RAB1A RAB1A, member RAS oncogene family -0.0381934
SPAG9 sperm associated antigen 9 -0.0375584
ANXA2 annexin A2 -0.036074
HDLBP high density lipoprotein binding protein -0.0341761
RAD21 RAD21 homolog (S. pombe) -0.0337945
WAC WW domain containing adaptor with coiled-coil -0.0329446
PDIA4 protein disulfide isomerase family A, member 4 -0.032299
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0321372
SOD2 superoxide dismutase 2, mitochondrial -0.0317204
PALLD palladin, cytoskeletal associated protein -0.0316575
ZFAND3 zinc finger, AN1-type domain 3 -0.0313848
KYNU kynureninase -0.0311684
TFPI2 tissue factor pathway inhibitor 2 -0.030717
RPLP1 ribosomal protein, large, P1 -0.02991
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0293654
WTAP Wilms tumor 1 associated protein -0.0285341
SEPTIN7 septin 7 -0.0281136
MAP4 microtubule-associated protein 4 -0.028089
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0280074
CAV1 caveolin 1, caveolae protein, 22kDa -0.027625
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0276065
FLNB filamin B, beta -0.0269423
CALD1 caldesmon 1 -0.0267254
FBN1 fibrillin 1 -0.0266725
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0266707
SKP1 S-phase kinase-associated protein 1 -0.0262516
RAB10 RAB10, member RAS oncogene family -0.0261864
TNNC1 troponin C type 1 (slow) -0.0260737
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0259378
BZW1 basic leucine zipper and W2 domains 1 -0.0258479
PGK1 phosphoglycerate kinase 1 -0.0255092
MACF1 microtubule-actin crosslinking factor 1 -0.0254393
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0251653
TXNIP thioredoxin interacting protein -0.0251537
PTK2 protein tyrosine kinase 2 -0.0250476
TRIO trio Rho guanine nucleotide exchange factor -0.0250183
PCYOX1 prenylcysteine oxidase 1 -0.0249868
CUL3 cullin 3 -0.0249135
PHACTR4 phosphatase and actin regulator 4 -0.0248803
HMGB2 high mobility group box 2 -0.0248152
UTRN utrophin -0.0247058
KTN1 kinectin 1 (kinesin receptor) -0.0245266
F3 coagulation factor III (thromboplastin, tissue factor) -0.0243848
UBC ubiquitin C -0.0239251
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0239153
CLTC clathrin, heavy chain (Hc) -0.0238782
MEF2A myocyte enhancer factor 2A -0.0228955
OXR1 oxidation resistance 1 -0.0228219
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0228171
MXI1 MAX interactor 1, dimerization protein -0.0227685
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0227423
UBE2H ubiquitin-conjugating enzyme E2H -0.0218073
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0217658
NIPSNAP2 nipsnap homolog 2 -0.0217166
PTGES2 prostaglandin E synthase 2 -0.0214709
MYO1E myosin IE -0.0213554
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0212835
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0212199
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0211545
RHEB Ras homolog enriched in brain -0.0210353
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0206521
CEMIP cell migration inducing protein, hyaluronan binding -0.0206099
EEF2 eukaryotic translation elongation factor 2 -0.0205567
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0204325
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0202872
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0201426
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0199212
CUL4B cullin 4B -0.0198656
JUN jun proto-oncogene -0.0198483
GLS2 glutaminase 2 (liver, mitochondrial) -0.0196821
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0196256
NAP1L1 nucleosome assembly protein 1-like 1 -0.0195477
CREBBP CREB binding protein -0.0195467