Berbamine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEP250 centrosomal protein 250kDa 0.053979
DSCAM Down syndrome cell adhesion molecule 0.0534798
ZNF292 zinc finger protein 292 0.0477242
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0443928
ARL15 ADP-ribosylation factor-like 15 0.042733
NUMA1 nuclear mitotic apparatus protein 1 0.0425759
SMAD3 SMAD family member 3 0.0399361
SMYD3 SET and MYND domain containing 3 0.0397689
RPL23 ribosomal protein L23 0.0381949
SRRM2 serine/arginine repetitive matrix 2 0.0378743
SQSTM1 sequestosome 1 0.0378014
MYH9 myosin, heavy chain 9, non-muscle 0.0375839
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0368363
PRRC2B proline-rich coiled-coil 2B 0.0365994
NCEH1 neutral cholesterol ester hydrolase 1 0.0361465
MPRIP myosin phosphatase Rho interacting protein 0.0360789
GOLGB1 golgin B1 0.0357933
VMP1 vacuole membrane protein 1 0.0346856
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0338616
TBC1D5 TBC1 domain family, member 5 0.0322268
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0317624
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0306117
BRD2 bromodomain containing 2 0.029442
SETD5 SET domain containing 5 0.0293727
NF1 neurofibromin 1 0.0286612
SON SON DNA binding protein 0.0285541
ZNF609 zinc finger protein 609 0.0280165
FNDC3B fibronectin type III domain containing 3B 0.0271642
GLS2 glutaminase 2 (liver, mitochondrial) 0.0270005
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0269167
APLP2 amyloid beta (A4) precursor-like protein 2 0.0269156
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0267449
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0265911
TBC1D22A TBC1 domain family, member 22A 0.0264746
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0263743
TENT2 terminal nucleotidyltransferase 2 0.0262963
ZBTB25 zinc finger and BTB domain containing 25 0.0258033
STK24 serine/threonine kinase 24 0.025643
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0247065
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0246475
CELF1 CUGBP, Elav-like family member 1 0.0243385
ANKRD11 ankyrin repeat domain 11 0.0242985
ARHGAP26 Rho GTPase activating protein 26 0.0240793
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0238105
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0236624
YBX3 Y box binding protein 3 0.0236295
IARS1 isoleucyl-tRNA synthetase 1 0.0234336
FNIP1 folliculin interacting protein 1 0.0232976
TRA2A transformer 2 alpha homolog (Drosophila) 0.023284
NCOA6 nuclear receptor coactivator 6 0.0230271
GARS1 glycyl-tRNA synthetase 1 0.0228322
RABGAP1 RAB GTPase activating protein 1 0.02269
BIRC3 baculoviral IAP repeat containing 3 0.022596
NUP58 nucleoporin 58 0.0225541
EIF1 eukaryotic translation initiation factor 1 0.0225298
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0223834
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0220944
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0219896
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0217502
RAD18 RAD18 E3 ubiquitin protein ligase 0.0216746
RB1CC1 RB1-inducible coiled-coil 1 0.0216312
ATM ATM serine/threonine kinase 0.0214373
NAMPT nicotinamide phosphoribosyltransferase 0.0213236
EXOC6B exocyst complex component 6B 0.0212864
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0212737
YAP1 Yes-associated protein 1 0.0207203
RBM39 RNA binding motif protein 39 0.0206333
ERGIC3 ERGIC and golgi 3 0.0204856
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0204
ZFAND6 zinc finger, AN1-type domain 6 0.020378
MAPK14 mitogen-activated protein kinase 14 0.0203642
GNS glucosamine (N-acetyl)-6-sulfatase 0.0200753
CCDC14 coiled-coil domain containing 14 0.0200631
TM9SF4 transmembrane 9 superfamily protein member 4 0.0200593
BCAS3 breast carcinoma amplified sequence 3 0.0196816
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0195442
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0194472
TXNIP thioredoxin interacting protein 0.0194354
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0193687
BIRC6 baculoviral IAP repeat containing 6 0.0193403
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0193317
C2ORF42 chromosome 2 open reading frame 42 0.0193245
KDM6A lysine (K)-specific demethylase 6A 0.0193223
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0192492
PRRC2C proline-rich coiled-coil 2C 0.0191655
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0191595
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0191505
KTN1 kinectin 1 (kinesin receptor) 0.0191163
RBM33 RNA binding motif protein 33 0.0191088
KIAA1958 KIAA1958 0.019076
OSMR oncostatin M receptor 0.0190541
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.0189865
HLA-B major histocompatibility complex, class I, B 0.0189544
PRPF8 pre-mRNA processing factor 8 0.0189069
SBF2 SET binding factor 2 0.0188294
MTMR3 myotubularin related protein 3 0.018815
EPS8 epidermal growth factor receptor pathway substrate 8 0.0187101
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0186792
EIF4H eukaryotic translation initiation factor 4H 0.0183163
BABAM2 BRISC and BRCA1 A complex member 2 0.0182585

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.302427
VIM vimentin -0.192197
LDHA lactate dehydrogenase A -0.119869
TMSB10 thymosin beta 10 -0.105778
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0921619
PTMA prothymosin, alpha -0.0844434
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0700621
ANXA2 annexin A2 -0.0619655
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0519611
GNAS GNAS complex locus -0.0517565
HILPDA hypoxia inducible lipid droplet-associated -0.0513346
CANX calnexin -0.0512338
TPT1 tumor protein, translationally-controlled 1 -0.0475505
PRKCA protein kinase C, alpha -0.0469476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0461338
HMGA2 high mobility group AT-hook 2 -0.0452837
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0433468
BASP1 brain abundant, membrane attached signal protein 1 -0.0415534
ANXA1 annexin A1 -0.0411738
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0377176
IGF2 insulin-like growth factor 2 -0.036845
CD44 CD44 molecule (Indian blood group) -0.0361872
SLC38A2 solute carrier family 38, member 2 -0.0329864
CAV1 caveolin 1, caveolae protein, 22kDa -0.0325125
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0321231
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0313681
RPLP0 ribosomal protein, large, P0 -0.0308219
IER3 immediate early response 3 -0.0305902
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0303914
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0300636
MAP4 microtubule-associated protein 4 -0.0293905
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0291098
NDRG1 N-myc downstream regulated 1 -0.0288556
ENO1 enolase 1, (alpha) -0.028854
SEPTIN7 septin 7 -0.0286876
FTH1 ferritin, heavy polypeptide 1 -0.0285172
VCL vinculin -0.028468
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0279151
MACF1 microtubule-actin crosslinking factor 1 -0.0277984
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0274307
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0272979
VDAC1 voltage-dependent anion channel 1 -0.0271702
RPS3 ribosomal protein S3 -0.027036
TPM4 tropomyosin 4 -0.0269947
RAI14 retinoic acid induced 14 -0.0266356
NPAS2 neuronal PAS domain protein 2 -0.0265032
BPTF bromodomain PHD finger transcription factor -0.0261716
ZBTB20 zinc finger and BTB domain containing 20 -0.0260672
RPS8 ribosomal protein S8 -0.0259903
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0256246
SH3KBP1 SH3-domain kinase binding protein 1 -0.0255267
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0251956
MYO9A myosin IXA -0.0251772
ITGA6 integrin, alpha 6 -0.025003
S100A10 S100 calcium binding protein A10 -0.0249095
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0248683
NAP1L1 nucleosome assembly protein 1-like 1 -0.0245712
ADM adrenomedullin -0.0241347
UBB ubiquitin B -0.0236992
RAI1 retinoic acid induced 1 -0.0236728
DST dystonin -0.0236332
DNER delta/notch-like EGF repeat containing -0.0235883
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0235693
RHEB Ras homolog enriched in brain -0.023457
WWOX WW domain containing oxidoreductase -0.0233154
MBNL1 muscleblind-like splicing regulator 1 -0.0232714
BTG1 B-cell translocation gene 1, anti-proliferative -0.0232442
CENPF centromere protein F, 350/400kDa -0.0231526
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.022724
NT5E 5'-nucleotidase, ecto (CD73) -0.0227182
IPO7 importin 7 -0.022649
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0226343
CFH complement factor H -0.0224462
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0224223
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0222623
PARD3 par-3 family cell polarity regulator -0.0220388
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0219089
LMAN1 lectin, mannose-binding, 1 -0.0218525
PODXL podocalyxin-like -0.0217978
AKAP12 A kinase (PRKA) anchor protein 12 -0.0217049
TUBA1B tubulin, alpha 1b -0.0216323
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0214722
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0213779
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0212941
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.021282
CALR calreticulin -0.0211634
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0211558
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0209528
THBS1 thrombospondin 1 -0.0208748
SPDL1 spindle apparatus coiled-coil protein 1 -0.0206337
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0203764
GPC6 glypican 6 -0.0202597
CAVIN1 caveolae associated protein 1 -0.0201976
PFN1 profilin 1 -0.0201333
CCAR1 cell division cycle and apoptosis regulator 1 -0.0196878
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0195984
TRIO trio Rho guanine nucleotide exchange factor -0.0195873
PTK2 protein tyrosine kinase 2 -0.0194137
ARHGAP18 Rho GTPase activating protein 18 -0.01901
TBCA tubulin folding cofactor A -0.0189264