Berbamine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.231631
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.168355
FNDC3B fibronectin type III domain containing 3B 0.0855625
CXCL8 chemokine (C-X-C motif) ligand 8 0.082223
NRG1 neuregulin 1 0.0672281
EXT1 exostosin glycosyltransferase 1 0.0643122
NAMPT nicotinamide phosphoribosyltransferase 0.0620613
TRIO trio Rho guanine nucleotide exchange factor 0.0565796
TMEM165 transmembrane protein 165 0.0506957
HIPK2 homeodomain interacting protein kinase 2 0.0492699
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0476849
BIRC6 baculoviral IAP repeat containing 6 0.0459943
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0448456
OGA O-GlcNAcase 0.0445258
P4HB prolyl 4-hydroxylase, beta polypeptide 0.043197
RICTOR RPTOR independent companion of MTOR, complex 2 0.0426787
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0425377
SMOX spermine oxidase 0.0415576
TMED9 transmembrane emp24 protein transport domain containing 9 0.0404644
EFNA5 ephrin-A5 0.0395705
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0390847
TMEM263 transmembrane protein 263 0.0388067
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.038317
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0374432
AOPEP aminopeptidase O (putative) 0.0369424
PRRC2C proline-rich coiled-coil 2C 0.0358552
AKAP9 A kinase (PRKA) anchor protein 9 0.0357703
AHRR aryl-hydrocarbon receptor repressor 0.0341686
DOCK5 dedicator of cytokinesis 5 0.0340064
SEC31A SEC31 homolog A (S. cerevisiae) 0.0338652
VMP1 vacuole membrane protein 1 0.0336978
FAM20C family with sequence similarity 20, member C 0.03363
AEBP2 AE binding protein 2 0.0334077
CD109 CD109 molecule 0.0331472
STC2 stanniocalcin 2 0.0330807
RUNX2 runt-related transcription factor 2 0.0330551
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0328971
NIPBL Nipped-B homolog (Drosophila) 0.0327201
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0325838
ETV6 ets variant 6 0.0319465
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0318814
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0317764
KMT2C lysine (K)-specific methyltransferase 2C 0.0316086
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0315573
HDLBP high density lipoprotein binding protein 0.0313368
TENT2 terminal nucleotidyltransferase 2 0.0312815
RBM39 RNA binding motif protein 39 0.0311659
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0308762
SUCO SUN domain containing ossification factor 0.0307744
TBC1D22A TBC1 domain family, member 22A 0.0305757
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0305505
FBXW11 F-box and WD repeat domain containing 11 0.0303459
FRY furry homolog (Drosophila) 0.0302895
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0300184
MYH9 myosin, heavy chain 9, non-muscle 0.0294438
SOS1 son of sevenless homolog 1 (Drosophila) 0.0290134
MCTP2 multiple C2 domains, transmembrane 2 0.0288257
SEC23A Sec23 homolog A (S. cerevisiae) 0.0285074
CADM1 cell adhesion molecule 1 0.0284097
CCNL1 cyclin L1 0.0283642
HELZ helicase with zinc finger 0.02786
RPS21 ribosomal protein S21 0.0276252
PDE4D phosphodiesterase 4D, cAMP-specific 0.0275969
GLIS3 GLIS family zinc finger 3 0.0275083
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0274513
NEK7 NIMA-related kinase 7 0.0273776
ANKRD11 ankyrin repeat domain 11 0.0271408
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0270713
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0267604
MAPK8 mitogen-activated protein kinase 8 0.0267241
RAB1A RAB1A, member RAS oncogene family 0.0267101
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0264879
DSCAM Down syndrome cell adhesion molecule 0.026134
FNBP1 formin binding protein 1 0.0254762
UBE2H ubiquitin-conjugating enzyme E2H 0.0253769
DENND5B DENN/MADD domain containing 5B 0.0250945
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0250825
COG6 component of oligomeric golgi complex 6 0.0249869
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0249418
AHR aryl hydrocarbon receptor 0.0247919
VEGFA vascular endothelial growth factor A 0.0247898
ZCCHC7 zinc finger, CCHC domain containing 7 0.0247785
GOLT1B golgi transport 1B 0.0245921
BASP1 brain abundant, membrane attached signal protein 1 0.024581
ACBD3 acyl-CoA binding domain containing 3 0.0245132
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0241671
SOD2 superoxide dismutase 2, mitochondrial 0.0240956
PRKCA protein kinase C, alpha 0.0240289
YBX3 Y box binding protein 3 0.0239881
LAMB3 laminin, beta 3 0.0239597
TTC3 tetratricopeptide repeat domain 3 0.0237333
WDR26 WD repeat domain 26 0.0236883
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0236372
KDM5A lysine (K)-specific demethylase 5A 0.0236186
CDC73 cell division cycle 73 0.0234537
PMM2 phosphomannomutase 2 0.0234527
SHB Src homology 2 domain containing adaptor protein B 0.0234297
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0234104
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0232887
CARD16 caspase recruitment domain family, member 16 0.0232592

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.221455
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188878
ASPH aspartate beta-hydroxylase -0.147153
VIM vimentin -0.116338
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0829238
ENO1 enolase 1, (alpha) -0.0826066
S100A6 S100 calcium binding protein A6 -0.0676048
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0661592
FTH1 ferritin, heavy polypeptide 1 -0.0637959
FTL ferritin, light polypeptide -0.0572332
PLIN2 perilipin 2 -0.0495898
CENPF centromere protein F, 350/400kDa -0.0482427
WWTR1 WW domain containing transcription regulator 1 -0.0476588
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0458956
IGFBP3 insulin-like growth factor binding protein 3 -0.0452233
RPS6 ribosomal protein S6 -0.0449274
S100A10 S100 calcium binding protein A10 -0.0422091
MKI67 marker of proliferation Ki-67 -0.0409376
RPL37A ribosomal protein L37a -0.0401537
RPS27 ribosomal protein S27 -0.0382714
RPS29 ribosomal protein S29 -0.0374383
MAP1B microtubule-associated protein 1B -0.0371385
LTBP1 latent transforming growth factor beta binding protein 1 -0.0345275
IFI27 interferon, alpha-inducible protein 27 -0.0335022
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0327902
RPL31 ribosomal protein L31 -0.0324328
IFI6 interferon, alpha-inducible protein 6 -0.0321077
PTMA prothymosin, alpha -0.0314295
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0313484
RPS8 ribosomal protein S8 -0.0313246
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0307036
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0305216
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0301142
PKM pyruvate kinase, muscle -0.0301054
KPNB1 karyopherin (importin) beta 1 -0.0297543
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.029213
SVIL supervillin -0.0288452
POTEF POTE ankyrin domain family, member F -0.0282333
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0279328
RPS14 ribosomal protein S14 -0.0275317
B2M beta-2-microglobulin -0.0273917
MBNL1 muscleblind-like splicing regulator 1 -0.0270516
KTN1 kinectin 1 (kinesin receptor) -0.0245274
RPS12 ribosomal protein S12 -0.0243993
MUSK muscle, skeletal, receptor tyrosine kinase -0.0243515
FDPS farnesyl diphosphate synthase -0.0243205
TSC22D1 TSC22 domain family, member 1 -0.0241463
PALLD palladin, cytoskeletal associated protein -0.0238446
ISG15 ISG15 ubiquitin-like modifier -0.0238051
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0237593
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0237389
LDHA lactate dehydrogenase A -0.0237208
IFIH1 interferon induced with helicase C domain 1 -0.0233022
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0231396
SEPTIN7 septin 7 -0.0229836
RPS2 ribosomal protein S2 -0.0227098
ETV1 ets variant 1 -0.02234
RACK1 receptor for activated C kinase 1 -0.0222152
HSPB1 heat shock 27kDa protein 1 -0.0222099
TPM4 tropomyosin 4 -0.0216619
RPS27A ribosomal protein S27a -0.0216183
IFITM1 interferon induced transmembrane protein 1 -0.0215875
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0214192
ANXA2 annexin A2 -0.0208889
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0207919
RPL37 ribosomal protein L37 -0.0204263
FHL2 four and a half LIM domains 2 -0.0204186
RPS24 ribosomal protein S24 -0.0199934
RPS25 ribosomal protein S25 -0.019847
MYO10 myosin X -0.0196813
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0194863
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0193322
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0192113
TLN1 talin 1 -0.0190823
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0190054
RPL38 ribosomal protein L38 -0.0189793
RPLP1 ribosomal protein, large, P1 -0.0187427
RAB10 RAB10, member RAS oncogene family -0.0184791
VDAC1 voltage-dependent anion channel 1 -0.0184299
SFRP1 secreted frizzled-related protein 1 -0.0182542
TUBA1B tubulin, alpha 1b -0.0182109
LAMB1 laminin, beta 1 -0.0180255
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0179747
AKAP12 A kinase (PRKA) anchor protein 12 -0.0178742
NT5E 5'-nucleotidase, ecto (CD73) -0.017813
RHOBTB3 Rho-related BTB domain containing 3 -0.0177321
BPTF bromodomain PHD finger transcription factor -0.0176936
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0176488
HILPDA hypoxia inducible lipid droplet-associated -0.0175492
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0174488
TMEM156 transmembrane protein 156 -0.0173905
TRIP11 thyroid hormone receptor interactor 11 -0.0173026
VCAN versican -0.0172197
SLK STE20-like kinase -0.0171793
RPL10A ribosomal protein L10a -0.0170509
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0169556
CTSB cathepsin B -0.0169138
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0168985
AHNAK AHNAK nucleoprotein -0.0168917
RPS13 ribosomal protein S13 -0.0167663