Berberine (chloride hydrate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.0574563
INTS6 integrator complex subunit 6 0.0434339
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0292403
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0276038
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0274718
NAP1L1 nucleosome assembly protein 1-like 1 0.0271393
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0244686
ZSWIM6 zinc finger, SWIM-type containing 6 0.0230774
DENND5A DENN/MADD domain containing 5A 0.0184695
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0170803
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0163476
ZNF638 zinc finger protein 638 0.0160294
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.015875
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0150749
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0135967
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0135307
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0130748
ADIPOR2 adiponectin receptor 2 0.0124794
CANX calnexin 0.0123518
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.011404
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.011349
AHRR aryl-hydrocarbon receptor repressor 0.0107451
NRDC nardilysin convertase 0.0106824
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0106453
PDLIM5 PDZ and LIM domain 5 0.0106011
KMT2E lysine (K)-specific methyltransferase 2E 0.00999035
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.00997839
FBXL17 F-box and leucine-rich repeat protein 17 0.00995931
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.00994703
RPS12 ribosomal protein S12 0.0098495
DSCAM Down syndrome cell adhesion molecule 0.00956292
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00953942
EGLN3 egl-9 family hypoxia-inducible factor 3 0.00948882
TBCA tubulin folding cofactor A 0.00938202
NALF1 NALCN channel auxiliary factor 1 0.00936893
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0091707
SMC6 structural maintenance of chromosomes 6 0.00893446
DNAH14 dynein, axonemal, heavy chain 14 0.00888627
ASPH aspartate beta-hydroxylase 0.00870246
FXR1 fragile X mental retardation, autosomal homolog 1 0.00868484
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.00865733
INTS4 integrator complex subunit 4 0.00864293
LRRC23 leucine rich repeat containing 23 0.00857617
DUSP16 dual specificity phosphatase 16 0.00843032
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.00829261
SERTAD2 SERTA domain containing 2 0.00824389
DCAF8 DDB1 and CUL4 associated factor 8 0.00816432
CLPTM1L CLPTM1-like 0.00805704
MMS22L MMS22-like, DNA repair protein 0.00799294
HSPH1 heat shock 105kDa/110kDa protein 1 0.00797158
CREM cAMP responsive element modulator 0.00794994
BCHE butyrylcholinesterase 0.00788715
APLP2 amyloid beta (A4) precursor-like protein 2 0.00787213
KIF21A kinesin family member 21A 0.0078442
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.00775317
BIRC3 baculoviral IAP repeat containing 3 0.00769566
PPME1 protein phosphatase methylesterase 1 0.00764524
YBX3 Y box binding protein 3 0.00762982
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.00761842
HOMER1 homer scaffolding protein 1 0.00758598
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00757298
MCF2L MCF.2 cell line derived transforming sequence-like 0.00756613
SFPQ splicing factor proline/glutamine-rich 0.00753397
RYK receptor-like tyrosine kinase 0.00740316
EXT1 exostosin glycosyltransferase 1 0.00735752
TTC3 tetratricopeptide repeat domain 3 0.00727011
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0072652
AEBP2 AE binding protein 2 0.00724239
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00715517
TRAPPC8 trafficking protein particle complex 8 0.00709887
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.00704951
RIMS2 regulating synaptic membrane exocytosis 2 0.00695799
PTPRD protein tyrosine phosphatase, receptor type, D 0.00689795
CSRNP2 cysteine-serine-rich nuclear protein 2 0.00688125
FGFR1 fibroblast growth factor receptor 1 0.00687743
RPL37A ribosomal protein L37a 0.00680886
ANKRD13C ankyrin repeat domain 13C 0.00679759
PTPRM protein tyrosine phosphatase, receptor type, M 0.00679429
RPL31 ribosomal protein L31 0.0067833
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.00673927
LGALS12 lectin, galactoside-binding, soluble, 12 0.00672855
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.00670735
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.00669066
CFAP44 cilia and flagella associated protein 44 0.00666102
NIPBL Nipped-B homolog (Drosophila) 0.00661475
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00659136
RCOR1 REST corepressor 1 0.00659012
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.00658832
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0065812
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.00651265
FLNB filamin B, beta 0.00646357
SAMD4A sterile alpha motif domain containing 4A 0.0064532
RPS6 ribosomal protein S6 0.00645041
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00644451
CFAP70 cilia and flagella associated protein 70 0.00641714
SRSF5 serine/arginine-rich splicing factor 5 0.00626901
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.006259
GOLGB1 golgin B1 0.00625025
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.00624666
NRXN3 neurexin 3 0.00623066

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.183665
VIM vimentin -0.124528
NLGN1 neuroligin 1 -0.0959248
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0842228
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0786703
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0549644
TMSB10 thymosin beta 10 -0.0527385
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0515844
MMP12 matrix metallopeptidase 12 -0.0485869
ACTG1 actin gamma 1 -0.0456765
MKI67 marker of proliferation Ki-67 -0.0397334
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0370941
TMEM123 transmembrane protein 123 -0.0351341
ATP5F1B ATP synthase F1 subunit beta -0.0346206
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0338068
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.033133
CELF2 CUGBP, Elav-like family member 2 -0.0327299
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0320272
CCN2 cellular communication network factor 2 -0.0319075
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0309207
USP34 ubiquitin specific peptidase 34 -0.0304047
XPO1 exportin 1 -0.0297688
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0295815
ANXA1 annexin A1 -0.0290182
EEF2 eukaryotic translation elongation factor 2 -0.0285448
HMGA1 high mobility group AT-hook 1 -0.0273429
PCBP2 poly(rC) binding protein 2 -0.0267243
LMO7 LIM domain 7 -0.026656
SLC38A1 solute carrier family 38, member 1 -0.0264399
H1-0 H1.0 linker histone -0.0261111
EIF4B eukaryotic translation initiation factor 4B -0.0259376
RASAL2 RAS protein activator like 2 -0.0255338
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0248458
DLC1 DLC1 Rho GTPase activating protein -0.0248009
TPI1 triosephosphate isomerase 1 -0.0247264
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0246592
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0242705
MAP1B microtubule-associated protein 1B -0.024104
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0240856
ANKRD28 ankyrin repeat domain 28 -0.0238699
ECT2 epithelial cell transforming 2 -0.0236502
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0236281
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0235909
TUBB tubulin, beta class I -0.0234605
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0234419
SLC38A2 solute carrier family 38, member 2 -0.0230406
TUBA1B tubulin, alpha 1b -0.0230234
HSPB1 heat shock 27kDa protein 1 -0.0226144
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0222492
SYT1 synaptotagmin I -0.0222293
RAB1A RAB1A, member RAS oncogene family -0.0218765
TM4SF1 transmembrane 4 L six family member 1 -0.0214792
AREG amphiregulin -0.0213206
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0213072
TMEM41B transmembrane protein 41B -0.0212678
CXADR coxsackie virus and adenovirus receptor -0.0210828
EGR1 early growth response 1 -0.0210159
ADGRG6 adhesion G protein-coupled receptor G6 -0.020761
NHSL1 NHS-like 1 -0.0207055
NF1 neurofibromin 1 -0.0206742
ANKRD12 ankyrin repeat domain 12 -0.0205051
PCDH7 protocadherin 7 -0.0203704
RHOA ras homolog family member A -0.020204
MGAT4C MGAT4 family, member C -0.0201247
KIF5B kinesin family member 5B -0.0200901
PFN1 profilin 1 -0.0200659
CCND1 cyclin D1 -0.0200216
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0199412
DST dystonin -0.0196274
HDLBP high density lipoprotein binding protein -0.0194812
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0193253
LOC112694756 uncharaterized LOC112694756 -0.0188369
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.0187039
DPYD dihydropyrimidine dehydrogenase -0.0182796
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0179366
WDR43 WD repeat domain 43 -0.0178752
CLDN1 claudin 1 -0.0177613
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0176842
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0176196
STIL SCL/TAL1 interrupting locus -0.0175246
TXNRD1 thioredoxin reductase 1 -0.0174243
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0173409
CARD16 caspase recruitment domain family, member 16 -0.0171862
CMIP c-Maf inducing protein -0.0170153
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0169984
KPNB1 karyopherin (importin) beta 1 -0.0169932
VMP1 vacuole membrane protein 1 -0.0168926
SRRM2 serine/arginine repetitive matrix 2 -0.0167795
ZBTB20 zinc finger and BTB domain containing 20 -0.0167467
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0167322
CPOX coproporphyrinogen oxidase -0.0167264
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0167109
BIRC6 baculoviral IAP repeat containing 6 -0.016654
RPL8 ribosomal protein L8 -0.0166103
RPLP0 ribosomal protein, large, P0 -0.0164966
TBK1 TANK-binding kinase 1 -0.0164877
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0162617
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0162221
MARS1 methionyl-tRNA synthetase 1 -0.016106
RAB7A RAB7A, member RAS oncogene family -0.0158776