Berberine (chloride hydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0988757
CXCL8 chemokine (C-X-C motif) ligand 8 0.0904953
FNDC3B fibronectin type III domain containing 3B 0.0762559
MYH9 myosin, heavy chain 9, non-muscle 0.0709377
SOD2 superoxide dismutase 2, mitochondrial 0.0617848
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0609248
TRIO trio Rho guanine nucleotide exchange factor 0.0607451
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0607025
ZFAND3 zinc finger, AN1-type domain 3 0.0589692
SPAG9 sperm associated antigen 9 0.0577243
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0573306
POTEF POTE ankyrin domain family, member F 0.050874
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0506371
ASPH aspartate beta-hydroxylase 0.0498107
NAMPT nicotinamide phosphoribosyltransferase 0.0492791
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0478531
DDIT4 DNA-damage-inducible transcript 4 0.0465358
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0464187
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0454226
ICAM1 intercellular adhesion molecule 1 0.0444852
MBNL2 muscleblind-like splicing regulator 2 0.0439649
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0437406
SUCO SUN domain containing ossification factor 0.0436131
G0S2 G0/G1 switch 2 0.0417903
PTK2 protein tyrosine kinase 2 0.0413508
JAK1 Janus kinase 1 0.0412724
ANKRD11 ankyrin repeat domain 11 0.0411837
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.039618
ANKRD33B ankyrin repeat domain 33B 0.0389901
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0383108
FMNL2 formin-like 2 0.0382218
SMAD3 SMAD family member 3 0.0372549
RBM39 RNA binding motif protein 39 0.0367863
TXNRD1 thioredoxin reductase 1 0.0362126
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0352928
QKI QKI, KH domain containing, RNA binding 0.0349619
ADAM17 ADAM metallopeptidase domain 17 0.0348943
APP amyloid beta (A4) precursor protein 0.0346546
COG5 component of oligomeric golgi complex 5 0.0342289
ZCCHC7 zinc finger, CCHC domain containing 7 0.0342196
WAC WW domain containing adaptor with coiled-coil 0.0341543
NRIP1 nuclear receptor interacting protein 1 0.0340797
NRP2 neuropilin 2 0.0339538
ANXA5 annexin A5 0.0336767
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0335309
RAB1A RAB1A, member RAS oncogene family 0.0334602
TFG TRK-fused gene 0.0330992
CRY1 cryptochrome circadian clock 1 0.0318561
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0316161
RHEB Ras homolog enriched in brain 0.0315592
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0315438
HELZ helicase with zinc finger 0.0311741
ADAM9 ADAM metallopeptidase domain 9 0.0308375
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0307892
IFRD1 interferon-related developmental regulator 1 0.0307033
PLK2 polo-like kinase 2 0.0306316
FAT1 FAT atypical cadherin 1 0.0303747
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0303645
DENND2B DENN domain containing 2B 0.0302931
HMGB2 high mobility group box 2 0.0299323
UBE2H ubiquitin-conjugating enzyme E2H 0.0297244
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.029624
COPA coatomer protein complex, subunit alpha 0.0294566
ATP13A3 ATPase type 13A3 0.0294029
KYNU kynureninase 0.0293984
HBP1 HMG-box transcription factor 1 0.0293234
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0291868
DENND4A DENN/MADD domain containing 4A 0.0291864
RBM33 RNA binding motif protein 33 0.0290776
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.029058
KMT2C lysine (K)-specific methyltransferase 2C 0.0289897
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0286846
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0286597
USP3 ubiquitin specific peptidase 3 0.0286091
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0285955
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0284315
WASL Wiskott-Aldrich syndrome-like 0.0283122
RAD21 RAD21 homolog (S. pombe) 0.0281969
TPM3 tropomyosin 3 0.028077
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0279768
CHD1 chromodomain helicase DNA binding protein 1 0.0278783
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0278288
VMP1 vacuole membrane protein 1 0.0277889
RAB10 RAB10, member RAS oncogene family 0.027605
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0276049
WDR43 WD repeat domain 43 0.0275527
CXCL2 chemokine (C-X-C motif) ligand 2 0.0273979
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0273921
ANXA1 annexin A1 0.0271249
NAP1L4 nucleosome assembly protein 1-like 4 0.0270071
RPS2 ribosomal protein S2 0.0270065
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0267628
FXR1 fragile X mental retardation, autosomal homolog 1 0.0266736
TLE4 transducin-like enhancer of split 4 0.0266083
TSC22D2 TSC22 domain family, member 2 0.0264792
ARRDC3 arrestin domain containing 3 0.0263372
PDLIM5 PDZ and LIM domain 5 0.0261084
RASA2 RAS p21 protein activator 2 0.0256674
SBF2 SET binding factor 2 0.0256182
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0251912

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.193809
IGFBP3 insulin-like growth factor binding protein 3 -0.169022
VIM vimentin -0.167204
TMSB10 thymosin beta 10 -0.14863
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.1423
HLA-B major histocompatibility complex, class I, B -0.128643
CP ceruloplasmin (ferroxidase) -0.105023
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0944917
MT2A metallothionein 2A -0.0849457
FTL ferritin, light polypeptide -0.0819761
NDRG1 N-myc downstream regulated 1 -0.0742243
APOL1 apolipoprotein L, 1 -0.0642398
TPT1 tumor protein, translationally-controlled 1 -0.0617769
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0586002
B2M beta-2-microglobulin -0.0574276
CCL2 chemokine (C-C motif) ligand 2 -0.057062
RPL35A ribosomal protein L35a -0.0561258
PLIN2 perilipin 2 -0.0547977
CTSD cathepsin D -0.0526154
HLA-C major histocompatibility complex, class I, C -0.0503384
ARL4C ADP-ribosylation factor-like 4C -0.0491528
RAI14 retinoic acid induced 14 -0.0447924
IFI16 interferon, gamma-inducible protein 16 -0.0442991
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0440786
CKAP4 cytoskeleton-associated protein 4 -0.0430431
CA12 carbonic anhydrase XII -0.0421731
RRBP1 ribosome binding protein 1 -0.042159
ZMYND8 zinc finger, MYND-type containing 8 -0.0419676
IFI6 interferon, alpha-inducible protein 6 -0.0405406
S100A6 S100 calcium binding protein A6 -0.0403033
IFITM3 interferon induced transmembrane protein 3 -0.0389622
CD82 CD82 molecule -0.0380485
TFPI2 tissue factor pathway inhibitor 2 -0.0378941
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0372816
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0370357
HM13 histocompatibility (minor) 13 -0.0370304
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0364605
CD63 CD63 molecule -0.0360725
TSHZ2 teashirt zinc finger homeobox 2 -0.0354503
HLA-A major histocompatibility complex, class I, A -0.034873
PFN1 profilin 1 -0.0344383
LOXL2 lysyl oxidase-like 2 -0.0341098
RPL23 ribosomal protein L23 -0.0335387
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0335009
S100A11 S100 calcium binding protein A11 -0.0331889
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0330312
CBX3 chromobox homolog 3 -0.0327509
CD44 CD44 molecule (Indian blood group) -0.0324997
MRPS6 mitochondrial ribosomal protein S6 -0.0324162
TM4SF1 transmembrane 4 L six family member 1 -0.0323441
RPL12 ribosomal protein L12 -0.0313895
IFI27 interferon, alpha-inducible protein 27 -0.0310553
RPS19 ribosomal protein S19 -0.0310057
LAMB3 laminin, beta 3 -0.0309936
GPC6 glypican 6 -0.0308861
CDCP1 CUB domain containing protein 1 -0.0308493
ADM adrenomedullin -0.0291478
GCC2 GRIP and coiled-coil domain containing 2 -0.0289836
OSMR oncostatin M receptor -0.0282611
PDE4D phosphodiesterase 4D, cAMP-specific -0.0281848
IFITM1 interferon induced transmembrane protein 1 -0.0279731
HLA-E major histocompatibility complex, class I, E -0.0278508
TPM1 tropomyosin 1 (alpha) -0.0277291
CLMP CXADR-like membrane protein -0.0275472
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0273439
CALD1 caldesmon 1 -0.027147
P3H2 prolyl 3-hydroxylase 2 -0.0269258
SERF2 small EDRK-rich factor 2 -0.0266964
BNC2 basonuclin 2 -0.026641
RPL34 ribosomal protein L34 -0.0266036
ANXA4 annexin A4 -0.0265811
RPL37A ribosomal protein L37a -0.026516
EHBP1 EH domain binding protein 1 -0.0262962
OXR1 oxidation resistance 1 -0.0262653
RTN4 reticulon 4 -0.0260878
RPL9 ribosomal protein L9 -0.0259683
IFIH1 interferon induced with helicase C domain 1 -0.0258501
CUX1 cut-like homeobox 1 -0.0255139
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0252344
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0252177
TUBA1B tubulin, alpha 1b -0.0251364
PRRC2C proline-rich coiled-coil 2C -0.0251159
KPNB1 karyopherin (importin) beta 1 -0.0250407
RPS13 ribosomal protein S13 -0.0250084
VCL vinculin -0.0246454
FN1 fibronectin 1 -0.0245844
LITAF lipopolysaccharide-induced TNF factor -0.0245418
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0244023
CYBA cytochrome b-245, alpha polypeptide -0.0243638
MMP7 matrix metallopeptidase 7 -0.0243208
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0243142
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0241536
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0240088
NUCB2 nucleobindin 2 -0.0238586
RNASET2 ribonuclease T2 -0.0235795
CMIP c-Maf inducing protein -0.0235465
TMEM165 transmembrane protein 165 -0.0233906
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0233588
SQLE squalene epoxidase -0.0232907
LOC102724023 ES1 protein homolog, mitochondrial -0.0231499