Berberine (chloride hydrate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.099197
HMGA2 high mobility group AT-hook 2 0.0665859
RASAL2 RAS protein activator like 2 0.0635889
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0628908
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0541698
EFNA5 ephrin-A5 0.0531451
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0529647
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0468451
ABTB3 ankyrin repeat and BTB domain containing 3 0.0435209
PSD3 pleckstrin and Sec7 domain containing 3 0.0418072
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0399266
TRIO trio Rho guanine nucleotide exchange factor 0.0387468
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0382289
GLS2 glutaminase 2 (liver, mitochondrial) 0.0352337
AKAP13 A kinase (PRKA) anchor protein 13 0.0342996
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0329982
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0316907
SAMD4A sterile alpha motif domain containing 4A 0.0310279
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0280449
FMNL2 formin-like 2 0.0280394
EGFR epidermal growth factor receptor 0.027725
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0276501
TGFA transforming growth factor, alpha 0.0267603
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0262685
EFNB2 ephrin-B2 0.0261555
BMP6 bone morphogenetic protein 6 0.0253349
ZSWIM6 zinc finger, SWIM-type containing 6 0.0248798
DOCK5 dedicator of cytokinesis 5 0.0248601
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0239981
PELI1 pellino E3 ubiquitin protein ligase 1 0.0232774
LAMA4 laminin, alpha 4 0.0232675
NDRG1 N-myc downstream regulated 1 0.0229057
TSC22D2 TSC22 domain family, member 2 0.0220884
SFPQ splicing factor proline/glutamine-rich 0.0216536
NRIP1 nuclear receptor interacting protein 1 0.0216269
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0213676
GREB1L growth regulation by estrogen in breast cancer-like 0.0211057
PDLIM5 PDZ and LIM domain 5 0.0209984
CD44 CD44 molecule (Indian blood group) 0.0207875
MBNL1 muscleblind-like splicing regulator 1 0.0205257
RAB10 RAB10, member RAS oncogene family 0.0202328
TMEM164 transmembrane protein 164 0.019588
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0195726
ARHGAP42 Rho GTPase activating protein 42 0.0194691
BCL2L1 BCL2-like 1 0.0194251
AKAP12 A kinase (PRKA) anchor protein 12 0.0193681
BCAR3 breast cancer anti-estrogen resistance 3 0.018592
WWC1 WW and C2 domain containing 1 0.018313
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0179506
ERBIN erbb2 interacting protein 0.0176744
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0175913
TGM2 transglutaminase 2 0.0170179
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0169838
APLP2 amyloid beta (A4) precursor-like protein 2 0.0168464
SON SON DNA binding protein 0.0168132
SAMD9 sterile alpha motif domain containing 9 0.015977
TPM3 tropomyosin 3 0.0159389
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0155129
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0154165
MSN moesin 0.0152415
FER fer (fps/fes related) tyrosine kinase 0.0150408
SGMS2 sphingomyelin synthase 2 0.0149616
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0146504
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0141595
THRB thyroid hormone receptor, beta 0.0140716
SMAD3 SMAD family member 3 0.013746
FLNB filamin B, beta 0.0136634
CAB39 calcium binding protein 39 0.0135826
HIPK2 homeodomain interacting protein kinase 2 0.0135519
GIGYF2 GRB10 interacting GYF protein 2 0.0130855
NABP1 nucleic acid binding protein 1 0.0130509
AHRR aryl-hydrocarbon receptor repressor 0.0129424
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0129322
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0129156
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0127485
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0126352
RPS2 ribosomal protein S2 0.0123984
TNIK TRAF2 and NCK interacting kinase 0.0123763
GRAMD2B GRAM domain containing 2B 0.0122503
SACK1B scaffolding CK1 anchoring protein B 0.0121289
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0119659
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0118238
KIAA1549L KIAA1549-like 0.0117517
VGLL3 vestigial-like family member 3 0.0117509
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0116637
EXOC6B exocyst complex component 6B 0.0116623
CAPRIN2 caprin family member 2 0.0115447
IRS2 insulin receptor substrate 2 0.0115167
DUSP4 dual specificity phosphatase 4 0.0113812
CHD1 chromodomain helicase DNA binding protein 1 0.0112173
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.011205
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0110941
GDA guanine deaminase 0.0109811
ARHGAP29 Rho GTPase activating protein 29 0.0109779
ZMIZ1 zinc finger, MIZ-type containing 1 0.010922
NRDC nardilysin convertase 0.0108965
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0108684
KLF5 Kruppel-like factor 5 (intestinal) 0.0108661
HDAC9 histone deacetylase 9 0.0108567
GSK3B glycogen synthase kinase 3 beta 0.0108295

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.185432
PTMA prothymosin, alpha -0.14316
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.136115
LAMB3 laminin, beta 3 -0.129331
VIM vimentin -0.1284
IGFBP3 insulin-like growth factor binding protein 3 -0.120583
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11694
TMSB10 thymosin beta 10 -0.116762
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.107502
BAIAP2L1 BAI1-associated protein 2-like 1 -0.101554
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0947913
LMTK2 lemur tyrosine kinase 2 -0.0947755
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0917469
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.082121
B2M beta-2-microglobulin -0.0760954
FTL ferritin, light polypeptide -0.0701324
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0699646
FTH1 ferritin, heavy polypeptide 1 -0.0677961
RAB1A RAB1A, member RAS oncogene family -0.0666733
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0662208
RPS13 ribosomal protein S13 -0.0638097
LMO7 LIM domain 7 -0.0628363
RPLP2 ribosomal protein, large, P2 -0.0614287
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.060245
RPL34 ribosomal protein L34 -0.0602304
RPL35A ribosomal protein L35a -0.0594356
EZR ezrin -0.0585034
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0579605
S100A10 S100 calcium binding protein A10 -0.0562562
KLK10 kallikrein-related peptidase 10 -0.0562026
EIF1 eukaryotic translation initiation factor 1 -0.055764
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0553969
UBC ubiquitin C -0.0550802
RPL37A ribosomal protein L37a -0.0537382
RPS25 ribosomal protein S25 -0.0531813
ACTG1 actin gamma 1 -0.0531709
PTPRR protein tyrosine phosphatase, receptor type, R -0.0525928
RPS8 ribosomal protein S8 -0.0517607
ANXA2 annexin A2 -0.0514049
SQSTM1 sequestosome 1 -0.0509971
PGK1 phosphoglycerate kinase 1 -0.0507641
RPL31 ribosomal protein L31 -0.0505575
TPM4 tropomyosin 4 -0.0497481
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0490531
GCC2 GRIP and coiled-coil domain containing 2 -0.0479631
SDC4 syndecan 4 -0.0474508
RPLP1 ribosomal protein, large, P1 -0.0473988
KDM3A lysine (K)-specific demethylase 3A -0.0455523
RIOK3 RIO kinase 3 -0.0446765
WSB1 WD repeat and SOCS box containing 1 -0.0446006
GNAS GNAS complex locus -0.0444049
RPS27A ribosomal protein S27a -0.0441454
HMGA1 high mobility group AT-hook 1 -0.0439772
EGR1 early growth response 1 -0.0439164
RPS6 ribosomal protein S6 -0.0436873
FAM107B family with sequence similarity 107, member B -0.0434072
TXNRD1 thioredoxin reductase 1 -0.0428913
RPS23 ribosomal protein S23 -0.042721
RPL7A ribosomal protein L7a -0.0417456
RPS21 ribosomal protein S21 -0.0414374
GOLGA4 golgin A4 -0.0410464
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0409452
SKAP2 src kinase associated phosphoprotein 2 -0.0409008
IER3 immediate early response 3 -0.0407016
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0406059
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0403935
MXD1 MAX dimerization protein 1 -0.0403774
SEC31A SEC31 homolog A (S. cerevisiae) -0.0398992
RPL36A ribosomal protein L36a -0.0398616
RPL11 ribosomal protein L11 -0.039422
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0392484
S100A6 S100 calcium binding protein A6 -0.0390734
EMP1 epithelial membrane protein 1 -0.039072
JMJD1C jumonji domain containing 1C -0.0390271
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0389691
RPL8 ribosomal protein L8 -0.038295
HLA-E major histocompatibility complex, class I, E -0.0382371
RPS29 ribosomal protein S29 -0.0381733
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0378468
RPS3 ribosomal protein S3 -0.0377414
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0377092
MCL1 myeloid cell leukemia 1 -0.0376015
CALU calumenin -0.0364366
RPS27 ribosomal protein S27 -0.0351741
TM4SF1 transmembrane 4 L six family member 1 -0.0349033
MTDH metadherin -0.0347545
SP100 SP100 nuclear antigen -0.0345942
UPP1 uridine phosphorylase 1 -0.0342636
KDM5B lysine (K)-specific demethylase 5B -0.0341451
KRT18 keratin 18, type I -0.0341204
TMEM263 transmembrane protein 263 -0.033609
RPL26 ribosomal protein L26 -0.0330347
ZNF292 zinc finger protein 292 -0.032732
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0325752
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0324186
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0321007
RPS24 ribosomal protein S24 -0.0320418
RPL19 ribosomal protein L19 -0.0319216
RPL28 ribosomal protein L28 -0.031887
RPL30 ribosomal protein L30 -0.0316169