Berberine (chloride hydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.171054
ASPH aspartate beta-hydroxylase 0.132513
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.125398
EGLN1 egl-9 family hypoxia-inducible factor 1 0.113606
AKAP12 A kinase (PRKA) anchor protein 12 0.098074
CD109 CD109 molecule 0.0947167
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0856677
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0780878
IGFBP3 insulin-like growth factor binding protein 3 0.0772728
PRELID2 PRELI domain containing 2 0.0769753
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0767012
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0744705
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0722013
ESYT2 extended synaptotagmin-like protein 2 0.0710774
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0699684
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0681819
PDIA4 protein disulfide isomerase family A, member 4 0.0657239
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0649542
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0634533
TAC4 tachykinin 4 (hemokinin) 0.0622185
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0617453
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0616633
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0543818
CANX calnexin 0.0531148
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0522183
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0518088
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0513023
PDIA3 protein disulfide isomerase family A, member 3 0.0503813
KMT2E lysine (K)-specific methyltransferase 2E 0.050205
FMNL2 formin-like 2 0.0486331
CHSY1 chondroitin sulfate synthase 1 0.0484508
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0473154
FNDC3B fibronectin type III domain containing 3B 0.0450134
NBAS neuroblastoma amplified sequence 0.0442682
ANXA5 annexin A5 0.0441158
TIMP3 TIMP metallopeptidase inhibitor 3 0.0439662
ZNF292 zinc finger protein 292 0.04252
TPR translocated promoter region, nuclear basket protein 0.0424193
DST dystonin 0.0420768
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0418928
CLMN calmin (calponin-like, transmembrane) 0.0418755
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0408283
ZNF638 zinc finger protein 638 0.0403737
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0387478
PHF21A PHD finger protein 21A 0.0387085
KDM5B lysine (K)-specific demethylase 5B 0.0382013
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0363103
ERRFI1 ERBB receptor feedback inhibitor 1 0.0357295
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0352836
LEF1 lymphoid enhancer-binding factor 1 0.0346128
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0346016
CTTNBP2 cortactin binding protein 2 0.0337465
FBXO32 F-box protein 32 0.0335924
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0332689
ENO1 enolase 1, (alpha) 0.0328789
ARRDC3 arrestin domain containing 3 0.0326585
MAML3 mastermind-like 3 (Drosophila) 0.0325509
ZMYND8 zinc finger, MYND-type containing 8 0.0324351
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0324074
HILPDA hypoxia inducible lipid droplet-associated 0.0321844
SMYD3 SET and MYND domain containing 3 0.0320546
NLGN1 neuroligin 1 0.0314818
UHMK1 U2AF homology motif (UHM) kinase 1 0.0309163
SSBP3 single stranded DNA binding protein 3 0.0309136
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0305635
VGLL4 vestigial-like family member 4 0.0302198
YEATS2 YEATS domain containing 2 0.0299544
AHNAK AHNAK nucleoprotein 0.0296027
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0294885
CALU calumenin 0.028351
HOOK2 hook microtubule-tethering protein 2 0.0282533
ARFGEF3 ARFGEF family member 3 0.0280602
PTPRG protein tyrosine phosphatase, receptor type, G 0.0277123
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0276852
BHLHE40 basic helix-loop-helix family, member e40 0.0276797
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0273725
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0272828
KMT2C lysine (K)-specific methyltransferase 2C 0.0270253
MIMS1 mitochondrial inner membrane scaffold 1 0.0269251
IFRD1 interferon-related developmental regulator 1 0.0268239
BACE2 beta-site APP-cleaving enzyme 2 0.02676
ETV3 ets variant 3 0.0267207
PGK1 phosphoglycerate kinase 1 0.026389
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0262655
RNMT RNA (guanine-7-) methyltransferase 0.0261794
EXOC4 exocyst complex component 4 0.0257351
ANKRD36 ankyrin repeat domain 36 0.0255693
CEP170 centrosomal protein 170kDa 0.0253813
NDRG1 N-myc downstream regulated 1 0.0250585
PKM pyruvate kinase, muscle 0.0247353
INSIG1 insulin induced gene 1 0.0240993
SSBP2 single-stranded DNA binding protein 2 0.0239843
FAM162A family with sequence similarity 162, member A 0.0236943
SUCO SUN domain containing ossification factor 0.0236095
FRMD6 FERM domain containing 6 0.0236073
RNF150 ring finger protein 150 0.0229609
HOMER1 homer scaffolding protein 1 0.0228558
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0226443
STRIP2 striatin interacting protein 2 0.0226161
IL1RAP interleukin 1 receptor accessory protein 0.0225175

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.311339
FMN1 formin 1 -0.201299
EGR1 early growth response 1 -0.124564
VIM vimentin -0.101095
TMSB10 thymosin beta 10 -0.0988689
VCL vinculin -0.0838494
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0752449
HLA-B major histocompatibility complex, class I, B -0.0610167
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0606829
COL19A1 collagen, type XIX, alpha 1 -0.0606386
PTCHD4 patched domain containing 4 -0.0572161
ACTG1 actin gamma 1 -0.0557251
CALD1 caldesmon 1 -0.0492593
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0480108
CUX1 cut-like homeobox 1 -0.0439658
ENO2 enolase 2 (gamma, neuronal) -0.039222
ZFYVE16 zinc finger, FYVE domain containing 16 -0.0391487
TAGLN2 transgelin 2 -0.0378083
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0358614
MT2A metallothionein 2A -0.0353476
ACTN1 actinin, alpha 1 -0.0335642
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0331598
WWTR1 WW domain containing transcription regulator 1 -0.0327702
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0327339
EHBP1 EH domain binding protein 1 -0.0322777
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.032153
PTMA prothymosin, alpha -0.0320362
MBNL2 muscleblind-like splicing regulator 2 -0.0310105
S100A6 S100 calcium binding protein A6 -0.0308226
RPS19 ribosomal protein S19 -0.0307265
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0307002
CYTH3 cytohesin 3 -0.0305292
IFI6 interferon, alpha-inducible protein 6 -0.0288198
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.028373
TLE4 transducin-like enhancer of split 4 -0.027537
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0275003
SON SON DNA binding protein -0.0273518
FHL2 four and a half LIM domains 2 -0.0267009
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0263585
NPC1 Niemann-Pick disease, type C1 -0.026221
PDLIM5 PDZ and LIM domain 5 -0.02613
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0260834
RTN4 reticulon 4 -0.0260217
LIMA1 LIM domain and actin binding 1 -0.0260074
FTL ferritin, light polypeptide -0.0259481
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0256782
S100A9 S100 calcium binding protein A9 -0.0256041
PHC2 polyhomeotic homolog 2 (Drosophila) -0.025359
ADNP activity-dependent neuroprotector homeobox -0.0248428
RHOJ ras homolog family member J -0.024782
PAX3 paired box 3 -0.0247514
FAM193A family with sequence similarity 193, member A -0.0247312
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0243212
TPI1 triosephosphate isomerase 1 -0.0237446
PNLIPRP3 pancreatic lipase-related protein 3 -0.0236344
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0236296
LAMB1 laminin, beta 1 -0.0233364
AKAP6 A kinase (PRKA) anchor protein 6 -0.0231467
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0230874
RAB7A RAB7A, member RAS oncogene family -0.023038
MITF microphthalmia-associated transcription factor -0.0230231
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0224231
CSNK1A1 casein kinase 1, alpha 1 -0.0221927
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0219164
TM4SF1 transmembrane 4 L six family member 1 -0.0217954
CABIN1 calcineurin binding protein 1 -0.0214727
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0213816
PFN1 profilin 1 -0.0213352
NAV1 neuron navigator 1 -0.0212376
AHCYL2 adenosylhomocysteinase-like 2 -0.0211256
CTSD cathepsin D -0.0210763
RPL37A ribosomal protein L37a -0.0210686
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0207575
PI15 peptidase inhibitor 15 -0.0206065
RPS3 ribosomal protein S3 -0.0205769
UBE2H ubiquitin-conjugating enzyme E2H -0.0200923
CD63 CD63 molecule -0.0200889
CAPZB capping protein (actin filament) muscle Z-line, beta -0.020059
ZNF644 zinc finger protein 644 -0.0200461
LOC112694756 uncharaterized LOC112694756 -0.0199697
MYO1E myosin IE -0.0198447
ERBIN erbb2 interacting protein -0.0198241
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0194893
CDK13 cyclin-dependent kinase 13 -0.0192299
TCF12 transcription factor 12 -0.0191383
RPLP2 ribosomal protein, large, P2 -0.0191259
ATF6 activating transcription factor 6 -0.0191084
RPL36 ribosomal protein L36 -0.019089
POU2F1 POU class 2 homeobox 1 -0.0190447
CYB5R3 cytochrome b5 reductase 3 -0.0186853
ANKRD17 ankyrin repeat domain 17 -0.0186713
SEM1 SEM1 26S proteasome subunit -0.0186459
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0186451
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0186219
ANKRD28 ankyrin repeat domain 28 -0.0184219
TPT1 tumor protein, translationally-controlled 1 -0.0184201
RPS23 ribosomal protein S23 -0.0180639
RPS24 ribosomal protein S24 -0.0180546
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0180089
PRKD1 protein kinase D1 -0.017937