Berberine (chloride hydrate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.130242
FNDC3B fibronectin type III domain containing 3B 0.109985
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0936083
IGFBP3 insulin-like growth factor binding protein 3 0.0880363
FTH1 ferritin, heavy polypeptide 1 0.0824774
SPAG9 sperm associated antigen 9 0.081581
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0792383
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0762647
ADAM9 ADAM metallopeptidase domain 9 0.0629976
ERRFI1 ERBB receptor feedback inhibitor 1 0.059965
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0572574
APLP2 amyloid beta (A4) precursor-like protein 2 0.0555421
AKAP12 A kinase (PRKA) anchor protein 12 0.0543775
PDIA3 protein disulfide isomerase family A, member 3 0.0541668
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0527982
BIRC3 baculoviral IAP repeat containing 3 0.0491329
POTEF POTE ankyrin domain family, member F 0.0488572
LMO7 LIM domain 7 0.0488148
CXCL8 chemokine (C-X-C motif) ligand 8 0.0461722
ELL2 elongation factor, RNA polymerase II, 2 0.0461103
FAM13A family with sequence similarity 13, member A 0.043661
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0431276
HELZ helicase with zinc finger 0.0408958
KMT2E lysine (K)-specific methyltransferase 2E 0.0408805
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.039841
AKAP13 A kinase (PRKA) anchor protein 13 0.0390133
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0389345
EFNA5 ephrin-A5 0.0388233
HILPDA hypoxia inducible lipid droplet-associated 0.0384777
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0381803
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0377462
RIMKLB ribosomal modification protein rimK-like family member B 0.0366767
KDM5B lysine (K)-specific demethylase 5B 0.0363408
UBA6 ubiquitin-like modifier activating enzyme 6 0.0359904
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0354273
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.034463
CCNL1 cyclin L1 0.0344304
FNBP1L formin binding protein 1-like 0.0340268
RCOR1 REST corepressor 1 0.0340212
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.033981
MYO1B myosin IB 0.0337754
BRD2 bromodomain containing 2 0.0336673
PCBP2 poly(rC) binding protein 2 0.0336047
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0333844
PPARD peroxisome proliferator-activated receptor delta 0.0332128
KYNU kynureninase 0.0326596
EZR ezrin 0.0323151
NAMPT nicotinamide phosphoribosyltransferase 0.0321461
STRN3 striatin, calmodulin binding protein 3 0.0314793
WSB1 WD repeat and SOCS box containing 1 0.0313795
GRB10 growth factor receptor-bound protein 10 0.0313184
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0311306
CCNY cyclin Y 0.0306618
FXR1 fragile X mental retardation, autosomal homolog 1 0.0303029
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0302653
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0298158
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0298136
ZSWIM6 zinc finger, SWIM-type containing 6 0.0295418
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0292914
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.028699
VEGFA vascular endothelial growth factor A 0.0286457
UBASH3B ubiquitin associated and SH3 domain containing B 0.028397
SGMS2 sphingomyelin synthase 2 0.0280618
DST dystonin 0.0278162
TFG TRK-fused gene 0.0277016
RIOK3 RIO kinase 3 0.0276851
MEF2A myocyte enhancer factor 2A 0.0276154
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0275544
RAB1A RAB1A, member RAS oncogene family 0.0274437
USP3 ubiquitin specific peptidase 3 0.027125
PHF3 PHD finger protein 3 0.0270945
LDHA lactate dehydrogenase A 0.027075
WAC WW domain containing adaptor with coiled-coil 0.0265417
SUCO SUN domain containing ossification factor 0.0262857
SRP54 signal recognition particle 54kDa 0.0261166
AREG amphiregulin 0.0260762
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0260132
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0259479
PDZD8 PDZ domain containing 8 0.025895
UBC ubiquitin C 0.0256021
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0255516
ANXA1 annexin A1 0.0254789
EPS8 epidermal growth factor receptor pathway substrate 8 0.0254519
COPA coatomer protein complex, subunit alpha 0.0252679
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0252312
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.024987
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0249127
BCAR3 breast cancer anti-estrogen resistance 3 0.0246153
HOOK2 hook microtubule-tethering protein 2 0.0242187
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0242185
NUP58 nucleoporin 58 0.0240805
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0238172
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.023797
DSCAM Down syndrome cell adhesion molecule 0.0237148
EPAS1 endothelial PAS domain protein 1 0.0235171
PAPOLA poly(A) polymerase alpha 0.0233472
YTHDC1 YTH domain containing 1 0.0232991
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0232249
GCLC glutamate-cysteine ligase, catalytic subunit 0.0231388
MORF4L2 mortality factor 4 like 2 0.0230768

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.241503
TMSB10 thymosin beta 10 -0.19987
HLA-B major histocompatibility complex, class I, B -0.117349
LAMB3 laminin, beta 3 -0.111478
PTMA prothymosin, alpha -0.10011
TPT1 tumor protein, translationally-controlled 1 -0.0994399
B2M beta-2-microglobulin -0.0776377
RPLP1 ribosomal protein, large, P1 -0.0765637
ISG15 ISG15 ubiquitin-like modifier -0.0730757
RPL23 ribosomal protein L23 -0.072579
RPL35A ribosomal protein L35a -0.0639688
VIM vimentin -0.0618805
ACTG1 actin gamma 1 -0.059966
RPL19 ribosomal protein L19 -0.058672
EIF1 eukaryotic translation initiation factor 1 -0.0580442
LAMC2 laminin, gamma 2 -0.0561192
KRT19 keratin 19, type I -0.0555341
MT1X metallothionein 1X -0.0554141
IFI27 interferon, alpha-inducible protein 27 -0.0551573
C15ORF48 chromosome 15 open reading frame 48 -0.0518289
MMP7 matrix metallopeptidase 7 -0.0517285
RPS29 ribosomal protein S29 -0.0495789
RPS8 ribosomal protein S8 -0.0494893
TMSB4X thymosin beta 4, X-linked -0.0492332
RPS21 ribosomal protein S21 -0.0490083
RPS19 ribosomal protein S19 -0.048066
KLF6 Kruppel-like factor 6 -0.0480581
RPL34 ribosomal protein L34 -0.0478047
RPS3 ribosomal protein S3 -0.0447984
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0440352
PLAUR plasminogen activator, urokinase receptor -0.0424041
CP ceruloplasmin (ferroxidase) -0.0418883
TM4SF1 transmembrane 4 L six family member 1 -0.0407696
IFI6 interferon, alpha-inducible protein 6 -0.0399743
RPL9 ribosomal protein L9 -0.0397941
S100A6 S100 calcium binding protein A6 -0.0389307
RPS14 ribosomal protein S14 -0.0385042
S100A10 S100 calcium binding protein A10 -0.0362761
RPS27A ribosomal protein S27a -0.0360438
RPS23 ribosomal protein S23 -0.0357575
RPL37A ribosomal protein L37a -0.0356645
RPS24 ribosomal protein S24 -0.0354988
RPL11 ribosomal protein L11 -0.0347468
SLC38A1 solute carrier family 38, member 1 -0.0333333
EGR1 early growth response 1 -0.0324956
MAML2 mastermind-like 2 (Drosophila) -0.0324316
HLA-E major histocompatibility complex, class I, E -0.0321509
RPS25 ribosomal protein S25 -0.0311703
RPS27 ribosomal protein S27 -0.0302726
RPL31 ribosomal protein L31 -0.0300043
RPL12 ribosomal protein L12 -0.0292519
RPL37 ribosomal protein L37 -0.0288878
RPLP2 ribosomal protein, large, P2 -0.0287535
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0287224
RPL36AL ribosomal protein L36a-like -0.028619
IFITM1 interferon induced transmembrane protein 1 -0.028262
FTL ferritin, light polypeptide -0.0279923
RPS6 ribosomal protein S6 -0.0279237
S100A11 S100 calcium binding protein A11 -0.0278207
RACK1 receptor for activated C kinase 1 -0.0277594
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0277069
RPL36 ribosomal protein L36 -0.0275233
RPS12 ribosomal protein S12 -0.0270015
IFITM3 interferon induced transmembrane protein 3 -0.0269368
CNRIP1 cannabinoid receptor interacting protein 1 -0.0269172
ANXA2 annexin A2 -0.0267371
RPS17 ribosomal protein S17 -0.026611
RPL26 ribosomal protein L26 -0.0261465
ZMYND8 zinc finger, MYND-type containing 8 -0.0259551
ADAM8 ADAM metallopeptidase domain 8 -0.0250117
MUC4 mucin 4, cell surface associated -0.024659
OSMR oncostatin M receptor -0.0245994
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0245484
GCC2 GRIP and coiled-coil domain containing 2 -0.0242008
RIN2 Ras and Rab interactor 2 -0.0241809
LMNA lamin A/C -0.0239138
RPLP0 ribosomal protein, large, P0 -0.0236426
PDE4D phosphodiesterase 4D, cAMP-specific -0.0233739
PLAT plasminogen activator, tissue -0.0231543
RPS16 ribosomal protein S16 -0.0230784
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0228819
RPL18 ribosomal protein L18 -0.0227336
CAPN2 calpain 2, (m/II) large subunit -0.0225347
RPL32 ribosomal protein L32 -0.0221705
IER3 immediate early response 3 -0.0220467
HLA-C major histocompatibility complex, class I, C -0.021561
NCKAP5 NCK-associated protein 5 -0.0215314
RRBP1 ribosome binding protein 1 -0.0214928
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0211317
TMEM165 transmembrane protein 165 -0.0211278
RPL38 ribosomal protein L38 -0.0209554
PTPRF protein tyrosine phosphatase, receptor type, F -0.02069
LY6E lymphocyte antigen 6 complex, locus E -0.0206755
RPL27 ribosomal protein L27 -0.0205595
RPL5 ribosomal protein L5 -0.0202343
RAD51B RAD51 paralog B -0.0201605
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0199556
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0195927
RPL28 ribosomal protein L28 -0.0195277
RNF213 ring finger protein 213 -0.0194441