Berberine (chloride hydrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.127155
AKAP12 A kinase (PRKA) anchor protein 12 0.110158
COL6A3 collagen, type VI, alpha 3 0.094004
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0766647
CXCL8 chemokine (C-X-C motif) ligand 8 0.0657246
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0496748
ERRFI1 ERBB receptor feedback inhibitor 1 0.0487884
SBF2 SET binding factor 2 0.0343888
B2M beta-2-microglobulin 0.029319
ANTXR2 anthrax toxin receptor 2 0.0291673
ASPH aspartate beta-hydroxylase 0.028909
FAM20C family with sequence similarity 20, member C 0.0276625
BACE2 beta-site APP-cleaving enzyme 2 0.0276197
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0264199
MON2 MON2 homolog (S. cerevisiae) 0.0261543
INHBA inhibin, beta A 0.0247309
VEGFC vascular endothelial growth factor C 0.0215682
DST dystonin 0.0211438
FAM13A family with sequence similarity 13, member A 0.020763
HMGA2 high mobility group AT-hook 2 0.0201327
CD44 CD44 molecule (Indian blood group) 0.0198142
CLMP CXADR-like membrane protein 0.0194822
MMP12 matrix metallopeptidase 12 0.0188984
RAI14 retinoic acid induced 14 0.0187289
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.018515
EGFR epidermal growth factor receptor 0.01835
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0179232
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0177437
HILPDA hypoxia inducible lipid droplet-associated 0.0177035
CENPF centromere protein F, 350/400kDa 0.0176817
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0174194
KIAA1549L KIAA1549-like 0.0172484
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0170286
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0167399
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0165665
GRAMD1B GRAM domain containing 1B 0.0165197
CALD1 caldesmon 1 0.0164367
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0163994
ZNF841 zinc finger protein 841 0.0163694
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0162776
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.01576
ATF7IP activating transcription factor 7 interacting protein 0.0146479
TXNRD1 thioredoxin reductase 1 0.0145555
MARCHF7 membrane associated ring-CH-type finger 7 0.0145161
RLF rearranged L-myc fusion 0.0144879
RNF24 ring finger protein 24 0.0142487
CADM1 cell adhesion molecule 1 0.0142457
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0141483
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0141375
CERT1 ceramide transporter 1 0.0140651
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0140429
KMT2C lysine (K)-specific methyltransferase 2C 0.0139052
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0138694
TMEM39A transmembrane protein 39A 0.01383
NF1 neurofibromin 1 0.0135953
NALF1 NALCN channel auxiliary factor 1 0.0135832
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0135783
PRSS23 protease, serine, 23 0.0134602
RAD50 RAD50 homolog (S. cerevisiae) 0.0134485
NRIP1 nuclear receptor interacting protein 1 0.0134209
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.0133571
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0132649
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0132346
COL23A1 collagen, type XXIII, alpha 1 0.013164
NPC1 Niemann-Pick disease, type C1 0.0131253
SASH1 SAM and SH3 domain containing 1 0.013124
TPM3 tropomyosin 3 0.013091
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.0130624
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.013008
CEP350 centrosomal protein 350kDa 0.0130002
MYO10 myosin X 0.0129798
CEMIP cell migration inducing protein, hyaluronan binding 0.012967
CARD16 caspase recruitment domain family, member 16 0.0128647
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0126208
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0124317
PYGL phosphorylase, glycogen, liver 0.012345
TRIP11 thyroid hormone receptor interactor 11 0.0123201
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0122764
SCRN1 secernin 1 0.0121777
TMEM87A transmembrane protein 87A 0.0121057
CLEC1B C-type lectin domain family 1, member B 0.0121025
TERF2IP telomeric repeat binding factor 2, interacting protein 0.0120835
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0120647
AVL9 AVL9 homolog (S. cerevisiase) 0.0118646
ANXA5 annexin A5 0.0118274
KPNB1 karyopherin (importin) beta 1 0.0117375
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0116355
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0116214
CALU calumenin 0.0115643
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0115597
DNMBP dynamin binding protein 0.0114818
ZNF146 zinc finger protein 146 0.0114171
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0113799
TBC1D15 TBC1 domain family, member 15 0.0113628
SENP6 SUMO1/sentrin specific peptidase 6 0.0113074
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0112395
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0111759
ARHGAP32 Rho GTPase activating protein 32 0.0111085
ANO6 anoctamin 6 0.0110953
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.0110328

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.385932
TMSB10 thymosin beta 10 -0.153312
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.138247
FTL ferritin, light polypeptide -0.122453
PTMA prothymosin, alpha -0.108196
VIM vimentin -0.100796
SDK1 sidekick cell adhesion molecule 1 -0.0666832
RPS27A ribosomal protein S27a -0.0634707
VCL vinculin -0.0620684
TPT1 tumor protein, translationally-controlled 1 -0.0560206
UBC ubiquitin C -0.055893
NDRG1 N-myc downstream regulated 1 -0.0545425
RPL37A ribosomal protein L37a -0.0522575
HLA-B major histocompatibility complex, class I, B -0.049702
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0476358
RPL23 ribosomal protein L23 -0.0438528
PKM pyruvate kinase, muscle -0.0425746
RPL28 ribosomal protein L28 -0.0412669
ENO1 enolase 1, (alpha) -0.0408305
RPS13 ribosomal protein S13 -0.0394988
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.038389
ANKRD11 ankyrin repeat domain 11 -0.0377455
MT2A metallothionein 2A -0.0373524
KDM4B lysine (K)-specific demethylase 4B -0.0370689
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0363424
RPLP2 ribosomal protein, large, P2 -0.0356554
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0353264
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.035268
INTS6 integrator complex subunit 6 -0.0344935
EEF2 eukaryotic translation elongation factor 2 -0.0343234
RPL9 ribosomal protein L9 -0.0342748
RPL35A ribosomal protein L35a -0.0338596
RPS23 ribosomal protein S23 -0.0337549
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0337066
ZSWIM6 zinc finger, SWIM-type containing 6 -0.032475
CALR calreticulin -0.0320591
MT1X metallothionein 1X -0.0316297
RPS19 ribosomal protein S19 -0.0309522
FUS FUS RNA binding protein -0.0303342
MCL1 myeloid cell leukemia 1 -0.0295858
ENO2 enolase 2 (gamma, neuronal) -0.0294279
RPS25 ribosomal protein S25 -0.0291681
FLNA filamin A, alpha -0.0287188
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.028437
RPS8 ribosomal protein S8 -0.0284294
RPL27A ribosomal protein L27a -0.0282651
FN1 fibronectin 1 -0.0280138
STK17A serine/threonine kinase 17a -0.0277478
CREB5 cAMP responsive element binding protein 5 -0.0274538
S100A6 S100 calcium binding protein A6 -0.027274
RPS3 ribosomal protein S3 -0.027263
RPS11 ribosomal protein S11 -0.0270645
ACTG1 actin gamma 1 -0.0261427
RPL11 ribosomal protein L11 -0.0258209
TGFBI transforming growth factor, beta-induced, 68kDa -0.0258038
SEC61G Sec61 gamma subunit -0.0257071
RPS17 ribosomal protein S17 -0.025554
RPS24 ribosomal protein S24 -0.0254025
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0248005
RPS12 ribosomal protein S12 -0.0246187
RACK1 receptor for activated C kinase 1 -0.0245224
TRA2A transformer 2 alpha homolog (Drosophila) -0.0245062
BRD2 bromodomain containing 2 -0.0242957
PDE4D phosphodiesterase 4D, cAMP-specific -0.0241306
LOC112694756 uncharaterized LOC112694756 -0.0237516
ATXN1 ataxin 1 -0.0233134
HLA-C major histocompatibility complex, class I, C -0.0229567
PDLIM5 PDZ and LIM domain 5 -0.0226477
WDR1 WD repeat domain 1 -0.0225144
WSB1 WD repeat and SOCS box containing 1 -0.0223254
RPLP1 ribosomal protein, large, P1 -0.0223039
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0219803
PRDX1 peroxiredoxin 1 -0.0218857
RPL36 ribosomal protein L36 -0.0217991
RPL12 ribosomal protein L12 -0.0213888
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0211745
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0210759
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0209998
EIF1 eukaryotic translation initiation factor 1 -0.0209156
ALCAM activated leukocyte cell adhesion molecule -0.0209152
TPI1 triosephosphate isomerase 1 -0.0208503
GLS2 glutaminase 2 (liver, mitochondrial) -0.0207746
GARS1 glycyl-tRNA synthetase 1 -0.0204975
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0204833
IGFBP5 insulin-like growth factor binding protein 5 -0.0204092
RPL34 ribosomal protein L34 -0.0203827
MYH9 myosin, heavy chain 9, non-muscle -0.020094
ACTN4 actinin, alpha 4 -0.0200592
RPL38 ribosomal protein L38 -0.0200519
NAP1L1 nucleosome assembly protein 1-like 1 -0.0200224
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0196889
P4HB prolyl 4-hydroxylase, beta polypeptide -0.019586
LDHA lactate dehydrogenase A -0.0195793
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0193427
RPL19 ribosomal protein L19 -0.0192012
S100A9 S100 calcium binding protein A9 -0.0191983
SQSTM1 sequestosome 1 -0.0191012
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0189499
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0188485
RPS16 ribosomal protein S16 -0.0187724