| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Berberine (chloride hydrate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Berberine (chloride hydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.258035 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.191742 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.131123 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.130823 |
| ASPH | aspartate beta-hydroxylase | 0.122873 |
| CD44 | CD44 molecule (Indian blood group) | 0.115836 |
| HMGA2 | high mobility group AT-hook 2 | 0.106703 |
| COL6A3 | collagen, type VI, alpha 3 | 0.10605 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.101603 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.100536 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.10011 |
| COL5A1 | collagen, type V, alpha 1 | 0.0988217 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0965659 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0837025 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0826845 |
| AHNAK | AHNAK nucleoprotein | 0.0809162 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0808096 |
| DST | dystonin | 0.0799423 |
| MYO10 | myosin X | 0.0770006 |
| SEPTIN9 | septin 9 | 0.0678826 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0655433 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.065242 |
| NAV1 | neuron navigator 1 | 0.0643563 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0640047 |
| AXL | AXL receptor tyrosine kinase | 0.0637988 |
| VEGFA | vascular endothelial growth factor A | 0.0623811 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0620615 |
| GLIS3 | GLIS family zinc finger 3 | 0.0587694 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0585081 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0568315 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0553288 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0519129 |
| SMAD3 | SMAD family member 3 | 0.0518328 |
| CDCP1 | CUB domain containing protein 1 | 0.0515071 |
| RUNX1 | runt-related transcription factor 1 | 0.0514603 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0480216 |
| PTK2 | protein tyrosine kinase 2 | 0.0462409 |
| MSN | moesin | 0.0457908 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0456514 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0454094 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0444462 |
| PKM | pyruvate kinase, muscle | 0.0444053 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.044347 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0441743 |
| RAI14 | retinoic acid induced 14 | 0.0423948 |
| TPM3 | tropomyosin 3 | 0.0422349 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0421671 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0417014 |
| FLNB | filamin B, beta | 0.0415373 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0412598 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0408212 |
| DNMBP | dynamin binding protein | 0.0404005 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0400411 |
| ENO1 | enolase 1, (alpha) | 0.0398394 |
| CLIC4 | chloride intracellular channel 4 | 0.0396214 |
| DOCK5 | dedicator of cytokinesis 5 | 0.039474 |
| ATXN1 | ataxin 1 | 0.0391942 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0389776 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0381957 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0381065 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0381 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0380637 |
| ZNF638 | zinc finger protein 638 | 0.0376342 |
| PCBP3 | poly(rC) binding protein 3 | 0.0371198 |
| PRKCA | protein kinase C, alpha | 0.0371057 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0369705 |
| MLPH | melanophilin | 0.0350585 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0347402 |
| MAP1B | microtubule-associated protein 1B | 0.03428 |
| FAM13A | family with sequence similarity 13, member A | 0.0337482 |
| PRELID2 | PRELI domain containing 2 | 0.0333768 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0328865 |
| TNS1 | tensin 1 | 0.0326742 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0314683 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0311112 |
| SVIL | supervillin | 0.029539 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0285916 |
| USP34 | ubiquitin specific peptidase 34 | 0.0285145 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0284884 |
| VEGFC | vascular endothelial growth factor C | 0.0282516 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0279766 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.027578 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0275566 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0273987 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0271577 |
| SET | SET nuclear proto-oncogene | 0.0270565 |
| MTSS1 | metastasis suppressor 1 | 0.0269099 |
| RIN2 | Ras and Rab interactor 2 | 0.0267672 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0267375 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0263889 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0263243 |
| RPL3 | ribosomal protein L3 | 0.02611 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0260526 |
| RPS6 | ribosomal protein S6 | 0.025994 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0254508 |
| YEATS2 | YEATS domain containing 2 | 0.0254073 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0254 |
| EGFR | epidermal growth factor receptor | 0.0253745 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.025085 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0250795 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.333898 |
| TMSB10 | thymosin beta 10 | -0.160934 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.136902 |
| FN1 | fibronectin 1 | -0.121005 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0960752 |
| ACTG1 | actin gamma 1 | -0.0927108 |
| PTMA | prothymosin, alpha | -0.0901107 |
| IGF2 | insulin-like growth factor 2 | -0.0787864 |
| VCL | vinculin | -0.0740498 |
| VIM | vimentin | -0.064623 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0624767 |
| LOX | lysyl oxidase | -0.0557535 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0458874 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0458647 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0418131 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0379042 |
| EGR1 | early growth response 1 | -0.0371289 |
| TNNC1 | troponin C type 1 (slow) | -0.0354936 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.035281 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0332407 |
| IER3 | immediate early response 3 | -0.0327783 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0305799 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0302786 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.029929 |
| RPL35A | ribosomal protein L35a | -0.029442 |
| COL1A1 | collagen, type I, alpha 1 | -0.0283639 |
| S100A10 | S100 calcium binding protein A10 | -0.0278415 |
| RPL34 | ribosomal protein L34 | -0.0276407 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0272694 |
| HDLBP | high density lipoprotein binding protein | -0.0271769 |
| TMEM263 | transmembrane protein 263 | -0.0268654 |
| SPAG9 | sperm associated antigen 9 | -0.0263584 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0261532 |
| FLNA | filamin A, alpha | -0.0257804 |
| TUBB | tubulin, beta class I | -0.0253068 |
| RRBP1 | ribosome binding protein 1 | -0.0235715 |
| OSMR | oncostatin M receptor | -0.0231969 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0231759 |
| RAD21 | RAD21 homolog (S. pombe) | -0.022717 |
| FTL | ferritin, light polypeptide | -0.0227004 |
| CAVIN1 | caveolae associated protein 1 | -0.0224897 |
| RPS24 | ribosomal protein S24 | -0.0221023 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0215527 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0211788 |
| ARF1 | ADP-ribosylation factor 1 | -0.0207977 |
| RPS19 | ribosomal protein S19 | -0.0204441 |
| NABP1 | nucleic acid binding protein 1 | -0.0202525 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.020189 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0200403 |
| WDR45B | WD repeat domain 45B | -0.0198005 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0196781 |
| CENPE | centromere protein E, 312kDa | -0.0195529 |
| H3-3B | H3.3 histone B | -0.0194116 |
| MORF4L2 | mortality factor 4 like 2 | -0.0193838 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0191402 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0190745 |
| PALLD | palladin, cytoskeletal associated protein | -0.0187845 |
| GLG1 | golgi glycoprotein 1 | -0.0186556 |
| RPLP2 | ribosomal protein, large, P2 | -0.0184511 |
| CCNI | cyclin I | -0.0183686 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0181914 |
| MT2A | metallothionein 2A | -0.018049 |
| SEC24D | SEC24 family member D | -0.0179915 |
| FSTL1 | follistatin-like 1 | -0.0177768 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0175643 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0174321 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.017331 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0173021 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0172801 |
| LAMB3 | laminin, beta 3 | -0.0171711 |
| RPS21 | ribosomal protein S21 | -0.0171414 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.016896 |
| TPX2 | TPX2, microtubule-associated | -0.0167408 |
| INHBA | inhibin, beta A | -0.0167253 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0163123 |
| RPL32 | ribosomal protein L32 | -0.0162813 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.016005 |
| MT1X | metallothionein 1X | -0.0158959 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0158543 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0156252 |
| SGO2 | shugoshin 2 | -0.0156197 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0154528 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0152125 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0151369 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0151272 |
| RPLP1 | ribosomal protein, large, P1 | -0.0150161 |
| ASTN2 | astrotactin 2 | -0.0150153 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.0148616 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.014839 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0148135 |
| NUP98 | nucleoporin 98kDa | -0.0147989 |
| CD109 | CD109 molecule | -0.0147118 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0146365 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0145947 |
| GOLT1B | golgi transport 1B | -0.0144302 |
| RPS13 | ribosomal protein S13 | -0.01437 |
| LMNA | lamin A/C | -0.0142942 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0141982 |
| RPL6 | ribosomal protein L6 | -0.014155 |
| GANAB | glucosidase, alpha; neutral AB | -0.0140989 |
