Berberine (chloride hydrate)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.329765
COL6A3 collagen, type VI, alpha 3 0.121442
CXCL8 chemokine (C-X-C motif) ligand 8 0.085648
CD44 CD44 molecule (Indian blood group) 0.0660431
ATP13A3 ATPase type 13A3 0.0624837
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0582043
ELL2 elongation factor, RNA polymerase II, 2 0.0531147
ARRDC3 arrestin domain containing 3 0.0506377
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0450415
ERRFI1 ERBB receptor feedback inhibitor 1 0.0448678
FTH1 ferritin, heavy polypeptide 1 0.0407083
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0396595
DOCK5 dedicator of cytokinesis 5 0.0354559
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0353597
MYH9 myosin, heavy chain 9, non-muscle 0.0352969
WWTR1 WW domain containing transcription regulator 1 0.0345348
ESYT2 extended synaptotagmin-like protein 2 0.033177
SMAD3 SMAD family member 3 0.031693
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0294943
MTSS1 metastasis suppressor 1 0.0293251
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0284959
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0282459
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0276115
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0275222
ZNF292 zinc finger protein 292 0.0270648
LDHA lactate dehydrogenase A 0.0248983
ANKH ANKH inorganic pyrophosphate transport regulator 0.0248539
FBXL13 F-box and leucine-rich repeat protein 13 0.0246127
HMGA2 high mobility group AT-hook 2 0.0246104
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0234277
KDM7A lysine (K)-specific demethylase 7A 0.0233568
PTK2 protein tyrosine kinase 2 0.0231615
UBA6 ubiquitin-like modifier activating enzyme 6 0.023096
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0229267
ECE1 endothelin converting enzyme 1 0.0228376
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0224844
APP amyloid beta (A4) precursor protein 0.0221405
VEGFC vascular endothelial growth factor C 0.0211595
KDM2A lysine (K)-specific demethylase 2A 0.020359
PDIA3 protein disulfide isomerase family A, member 3 0.0203096
ADAM17 ADAM metallopeptidase domain 17 0.0202839
YEATS2 YEATS domain containing 2 0.0201313
SPAG9 sperm associated antigen 9 0.0200623
FMNL2 formin-like 2 0.0195783
FBN1 fibrillin 1 0.0195663
NOTCH2 notch 2 0.0195203
ARHGAP29 Rho GTPase activating protein 29 0.0194818
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0194678
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0194341
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0194186
KMT2E lysine (K)-specific methyltransferase 2E 0.0193872
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0191599
ADAM9 ADAM metallopeptidase domain 9 0.019125
NAV2 neuron navigator 2 0.0189887
ANTXR2 anthrax toxin receptor 2 0.0189844
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0189234
TNIP1 TNFAIP3 interacting protein 1 0.0187288
KMT2C lysine (K)-specific methyltransferase 2C 0.0186847
VEGFA vascular endothelial growth factor A 0.0182615
KIF1B kinesin family member 1B 0.0178816
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0176232
CLIC4 chloride intracellular channel 4 0.0175714
RASA2 RAS p21 protein activator 2 0.0175681
HSPA8 heat shock 70kDa protein 8 0.0174362
RPL3 ribosomal protein L3 0.0174067
FAT1 FAT atypical cadherin 1 0.0172728
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0171445
FNBP1L formin binding protein 1-like 0.0170689
POTEF POTE ankyrin domain family, member F 0.0169193
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0168194
BHLHE40 basic helix-loop-helix family, member e40 0.0166713
MRTFA myocardin related transcription factor A 0.0165985
LOXL2 lysyl oxidase-like 2 0.0165168
PKM pyruvate kinase, muscle 0.0164488
VIRMA vir like m6A methyltransferase associated 0.0162688
VMP1 vacuole membrane protein 1 0.0161292
STC1 stanniocalcin 1 0.0159571
AFAP1 actin filament associated protein 1 0.0159456
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.015917
ANXA5 annexin A5 0.0159025
SQLE squalene epoxidase 0.0158903
RNF145 ring finger protein 145 0.0154547
BZW1 basic leucine zipper and W2 domains 1 0.0154166
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0153042
PICALM phosphatidylinositol binding clathrin assembly protein 0.0152827
TRIO trio Rho guanine nucleotide exchange factor 0.0152427
FCHSD2 FCH and double SH3 domains 2 0.0151398
COL4A1 collagen, type IV, alpha 1 0.0150662
PDE10A phosphodiesterase 10A 0.0150593
PCM1 pericentriolar material 1 0.0150444
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0150072
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0149774
PDIA6 protein disulfide isomerase family A, member 6 0.0148041
ASPH aspartate beta-hydroxylase 0.0146296
AXL AXL receptor tyrosine kinase 0.0146169
SHB Src homology 2 domain containing adaptor protein B 0.0145602
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0145584
NBAS neuroblastoma amplified sequence 0.0145083
ITCH itchy E3 ubiquitin protein ligase 0.0144793
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0144395

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.151634
NDRG1 N-myc downstream regulated 1 -0.150001
TMSB10 thymosin beta 10 -0.139488
TIMP3 TIMP metallopeptidase inhibitor 3 -0.13603
COL1A1 collagen, type I, alpha 1 -0.129078
TGFBI transforming growth factor, beta-induced, 68kDa -0.114168
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0900153
CDH13 cadherin 13 -0.0793808
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0784522
EXT1 exostosin glycosyltransferase 1 -0.0774219
FN1 fibronectin 1 -0.0624986
MT2A metallothionein 2A -0.0622538
CALD1 caldesmon 1 -0.0614337
FTL ferritin, light polypeptide -0.0610867
VCL vinculin -0.0559974
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0555415
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0527732
HLA-B major histocompatibility complex, class I, B -0.0503743
ACTG1 actin gamma 1 -0.0488771
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0461293
PDE4D phosphodiesterase 4D, cAMP-specific -0.0450438
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0435265
PSD3 pleckstrin and Sec7 domain containing 3 -0.0432348
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0406207
TPT1 tumor protein, translationally-controlled 1 -0.0395218
RPL35A ribosomal protein L35a -0.0384756
COL6A2 collagen, type VI, alpha 2 -0.0379841
RPL23 ribosomal protein L23 -0.0376564
GARS1 glycyl-tRNA synthetase 1 -0.0362289
RPS8 ribosomal protein S8 -0.0341843
PDLIM5 PDZ and LIM domain 5 -0.03392
PTMA prothymosin, alpha -0.0327864
ENO1 enolase 1, (alpha) -0.0323181
RPS19 ribosomal protein S19 -0.0309069
IER3 immediate early response 3 -0.02912
COL5A1 collagen, type V, alpha 1 -0.0286347
CADM1 cell adhesion molecule 1 -0.0285297
STC2 stanniocalcin 2 -0.0284669
S100A9 S100 calcium binding protein A9 -0.0279057
LOX lysyl oxidase -0.0274459
COL6A1 collagen, type VI, alpha 1 -0.0273866
IFI6 interferon, alpha-inducible protein 6 -0.0271071
IARS1 isoleucyl-tRNA synthetase 1 -0.0270056
NALF1 NALCN channel auxiliary factor 1 -0.0269186
COL1A2 collagen, type I, alpha 2 -0.0268156
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0266174
ADAM12 ADAM metallopeptidase domain 12 -0.0258964
SQSTM1 sequestosome 1 -0.0255109
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0254035
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0248146
GLIS3 GLIS family zinc finger 3 -0.0243037
DGKI diacylglycerol kinase, iota -0.0242343
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.024179
HDAC9 histone deacetylase 9 -0.0238886
RPS3 ribosomal protein S3 -0.0238869
RACK1 receptor for activated C kinase 1 -0.0234445
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0234224
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0232375
RRBP1 ribosome binding protein 1 -0.0231029
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0225323
SEC61G Sec61 gamma subunit -0.0224189
NEK10 NIMA-related kinase 10 -0.0223274
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0221621
COL8A1 collagen, type VIII, alpha 1 -0.0221043
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0219635
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0218677
FOXP1 forkhead box P1 -0.0217261
HM13 histocompatibility (minor) 13 -0.021192
PRSS23 protease, serine, 23 -0.0208341
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0206419
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0206296
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0206069
ATF4 activating transcription factor 4 -0.0205123
RPS27A ribosomal protein S27a -0.020475
LMNA lamin A/C -0.0204242
RBPMS RNA binding protein with multiple splicing -0.0203747
RPL9 ribosomal protein L9 -0.0202652
EGR1 early growth response 1 -0.0202313
CNTN5 contactin 5 -0.0201845
WSB1 WD repeat and SOCS box containing 1 -0.0200229
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0198632
MYO1E myosin IE -0.019673
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0196165
TPI1 triosephosphate isomerase 1 -0.0196042
PALLD palladin, cytoskeletal associated protein -0.0195483
ENO2 enolase 2 (gamma, neuronal) -0.0194213
CUX1 cut-like homeobox 1 -0.0194023
PTPRF protein tyrosine phosphatase, receptor type, F -0.0192531
INHBA inhibin, beta A -0.0191666
RPL37A ribosomal protein L37a -0.0191153
LMO4 LIM domain only 4 -0.0188603
PRELID2 PRELI domain containing 2 -0.0187102
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0185565
DPYD dihydropyrimidine dehydrogenase -0.0185344
TARS1 threonyl-tRNA synthetase 1 -0.0185229
CMIP c-Maf inducing protein -0.0184179
MYDGF myeloid-derived growth factor -0.0183016
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0182547
FRMD4A FERM domain containing 4A -0.0179528
KDM4B lysine (K)-specific demethylase 4B -0.0179527