Berberine (chloride hydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.179897
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.103269
AKAP12 A kinase (PRKA) anchor protein 12 0.102694
DSPP dentin sialophosphoprotein 0.0681181
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0569466
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0568868
SVIL supervillin 0.0545121
TF transferrin 0.0537903
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0514314
JMJD1C jumonji domain containing 1C 0.0504686
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.048157
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0471516
TNS1 tensin 1 0.0464869
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0444131
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0428804
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0399528
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0392839
EHBP1 EH domain binding protein 1 0.0366996
ELL2 elongation factor, RNA polymerase II, 2 0.0355659
ENKUR enkurin, TRPC channel interacting protein 0.0353205
TXNRD1 thioredoxin reductase 1 0.0329543
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0323804
DOCK5 dedicator of cytokinesis 5 0.0314898
GK glycerol kinase 0.0310729
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0303546
FNDC3B fibronectin type III domain containing 3B 0.0293885
CANX calnexin 0.029017
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0287157
APLP2 amyloid beta (A4) precursor-like protein 2 0.0286736
VMP1 vacuole membrane protein 1 0.0285255
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0283378
WWC2 WW and C2 domain containing 2 0.0282285
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0277141
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0268362
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0267948
RUNX1 runt-related transcription factor 1 0.0266845
NAP1L1 nucleosome assembly protein 1-like 1 0.026582
SOS1 son of sevenless homolog 1 (Drosophila) 0.0261743
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0258934
CP ceruloplasmin (ferroxidase) 0.0257868
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0255388
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0252716
NGLY1 N-glycanase 1 0.023992
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0238768
DNAH5 dynein, axonemal, heavy chain 5 0.0238459
AFDN afadin, adherens junction formation factor 0.0237599
DNAH17 dynein, axonemal, heavy chain 17 0.0232013
RAI14 retinoic acid induced 14 0.0229211
FBXO42 F-box protein 42 0.0226841
ARHGAP21 Rho GTPase activating protein 21 0.0226706
MAML2 mastermind-like 2 (Drosophila) 0.0225789
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0225678
FAM13A family with sequence similarity 13, member A 0.0223951
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0222839
RBM39 RNA binding motif protein 39 0.0221385
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0215845
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0215122
MBNL2 muscleblind-like splicing regulator 2 0.0213299
TMEM181 transmembrane protein 181 0.020836
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0206558
NUP58 nucleoporin 58 0.0203773
SCARB2 scavenger receptor class B, member 2 0.0202892
CRY1 cryptochrome circadian clock 1 0.0202367
ANXA5 annexin A5 0.0198159
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0196955
ESYT2 extended synaptotagmin-like protein 2 0.0196625
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0196281
IL1RAP interleukin 1 receptor accessory protein 0.0195715
MBNL1 muscleblind-like splicing regulator 1 0.0194959
AFF1 AF4/FMR2 family, member 1 0.0190825
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0188079
MTSS1 metastasis suppressor 1 0.018707
SLC38A2 solute carrier family 38, member 2 0.0187012
RPL3 ribosomal protein L3 0.0185587
IPO7 importin 7 0.0184968
GPBP1 GC-rich promoter binding protein 1 0.018469
KCMF1 potassium channel modulatory factor 1 0.0184216
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0183645
ZNF638 zinc finger protein 638 0.0183238
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0183061
TRIO trio Rho guanine nucleotide exchange factor 0.01819
TMX4 thioredoxin-related transmembrane protein 4 0.0181208
RPS2 ribosomal protein S2 0.0179786
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0179577
PER2 period circadian clock 2 0.0178997
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0178778
SET SET nuclear proto-oncogene 0.0177902
EIF4B eukaryotic translation initiation factor 4B 0.0174487
ZNF292 zinc finger protein 292 0.01733
OPTN optineurin 0.0173039
PAWR PRKC, apoptosis, WT1, regulator 0.0172117
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0171806
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0166815
SMAD3 SMAD family member 3 0.0165765
SAMD4A sterile alpha motif domain containing 4A 0.0165638
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0165467
IGFBP3 insulin-like growth factor binding protein 3 0.0165358
PKP4 plakophilin 4 0.0165063
ANO6 anoctamin 6 0.0163121
FAT1 FAT atypical cadherin 1 0.0162933

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.201268
IGF2 insulin-like growth factor 2 -0.170877
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.153705
APOA2 apolipoprotein A-II -0.147515
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137556
TPT1 tumor protein, translationally-controlled 1 -0.112207
TMSB10 thymosin beta 10 -0.10883
APOB apolipoprotein B -0.108168
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0964005
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0738211
FN1 fibronectin 1 -0.070674
TM4SF1 transmembrane 4 L six family member 1 -0.0704331
FTL ferritin, light polypeptide -0.063575
VCL vinculin -0.061912
C3 complement component 3 -0.0617976
GPC3 glypican 3 -0.0580595
RPS24 ribosomal protein S24 -0.0562641
RPL23 ribosomal protein L23 -0.0549245
RPS19 ribosomal protein S19 -0.0533153
ITGAV integrin, alpha V -0.0489087
RPS21 ribosomal protein S21 -0.0479751
PDLIM5 PDZ and LIM domain 5 -0.047088
RPL35A ribosomal protein L35a -0.0450738
ZBTB20 zinc finger and BTB domain containing 20 -0.0432836
RPL11 ribosomal protein L11 -0.0427679
IGFBP1 insulin-like growth factor binding protein 1 -0.0418595
EXT1 exostosin glycosyltransferase 1 -0.0414436
AMBP alpha-1-microglobulin/bikunin precursor -0.0409267
RPLP0 ribosomal protein, large, P0 -0.0406176
RPL12 ribosomal protein L12 -0.0405221
RPLP2 ribosomal protein, large, P2 -0.0397845
AHSG alpha-2-HS-glycoprotein -0.0395831
RPLP1 ribosomal protein, large, P1 -0.0385623
IFI6 interferon, alpha-inducible protein 6 -0.0368176
DST dystonin -0.0366211
RPL34 ribosomal protein L34 -0.0365497
ACTG1 actin gamma 1 -0.0356597
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0354041
PTCHD4 patched domain containing 4 -0.0351007
APOE apolipoprotein E -0.0339329
RPS23 ribosomal protein S23 -0.0333043
RPS5 ribosomal protein S5 -0.0321193
EGR1 early growth response 1 -0.0320869
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0313747
RPS27A ribosomal protein S27a -0.0313123
FAM107B family with sequence similarity 107, member B -0.0304422
HMGA1 high mobility group AT-hook 1 -0.0295689
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0293298
KRT18 keratin 18, type I -0.0290179
SDC4 syndecan 4 -0.028808
RPL38 ribosomal protein L38 -0.0285666
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0285007
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0284238
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0284018
A2M alpha-2-macroglobulin -0.0281103
RPS25 ribosomal protein S25 -0.0279439
RPS13 ribosomal protein S13 -0.02792
NPAS2 neuronal PAS domain protein 2 -0.0278579
IFITM1 interferon induced transmembrane protein 1 -0.0276171
S100A9 S100 calcium binding protein A9 -0.0275438
INTS6 integrator complex subunit 6 -0.027357
APOA1 apolipoprotein A-I -0.026749
RPL37A ribosomal protein L37a -0.0261857
CAPZB capping protein (actin filament) muscle Z-line, beta -0.026054
PTMA prothymosin, alpha -0.0256472
STAU1 staufen double-stranded RNA binding protein 1 -0.0254238
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0252268
PFN1 profilin 1 -0.0251839
RPL28 ribosomal protein L28 -0.0249048
LPP LIM domain containing preferred translocation partner in lipoma -0.0243441
TMEM123 transmembrane protein 123 -0.0239719
RPL32 ribosomal protein L32 -0.0237172
RPS14 ribosomal protein S14 -0.0236441
RPS12 ribosomal protein S12 -0.023495
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0234299
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0232615
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0232612
GNAS GNAS complex locus -0.0232054
LOC112694756 uncharaterized LOC112694756 -0.023025
ISG15 ISG15 ubiquitin-like modifier -0.0229973
RPL36 ribosomal protein L36 -0.0227589
LYZ lysozyme -0.0226361
ATP5F1E ATP synthase F1 subunit epsilon -0.0225971
ATXN1 ataxin 1 -0.0225686
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0225449
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0225229
TRIM26 tripartite motif containing 26 -0.0224414
DOCK4 dedicator of cytokinesis 4 -0.0222264
CTSB cathepsin B -0.0220138
PTPRF protein tyrosine phosphatase, receptor type, F -0.021736
RNF213 ring finger protein 213 -0.0217141
LRMDA leucine rich melanocyte differentiation associated -0.021702
RPL27 ribosomal protein L27 -0.0216894
H1-0 H1.0 linker histone -0.0214035
IER3 immediate early response 3 -0.0213513
RPS29 ribosomal protein S29 -0.0213335
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0212806
B2M beta-2-microglobulin -0.0212155
MT1X metallothionein 1X -0.0212121
HLA-B major histocompatibility complex, class I, B -0.0212003