Berberine (chloride hydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.173707
EXT1 exostosin glycosyltransferase 1 0.135234
DTNA dystrobrevin, alpha 0.124916
SAMD3 sterile alpha motif domain containing 3 0.0856707
ERRFI1 ERBB receptor feedback inhibitor 1 0.0834873
RPS6 ribosomal protein S6 0.082202
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0704664
PRKG1 protein kinase, cGMP-dependent, type I 0.0680719
PBX3 pre-B-cell leukemia homeobox 3 0.0572639
SDCCAG8 serologically defined colon cancer antigen 8 0.0537105
POTEF POTE ankyrin domain family, member F 0.0504769
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0488655
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.047924
NAV3 neuron navigator 3 0.0461163
ESM1 endothelial cell-specific molecule 1 0.0441735
KIAA1217 KIAA1217 0.0435239
MARCHF4 membrane associated ring-CH-type finger 4 0.0434586
ENKUR enkurin, TRPC channel interacting protein 0.0425419
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0423664
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0413187
LIMA1 LIM domain and actin binding 1 0.0410689
DSCAM Down syndrome cell adhesion molecule 0.0403318
VIM vimentin 0.0378952
NAP1L1 nucleosome assembly protein 1-like 1 0.0368197
CXCL8 chemokine (C-X-C motif) ligand 8 0.036451
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0364338
HDAC9 histone deacetylase 9 0.0355528
ASPH aspartate beta-hydroxylase 0.0343757
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0340708
USP34 ubiquitin specific peptidase 34 0.0328216
PHACTR1 phosphatase and actin regulator 1 0.0321446
ITGA6 integrin, alpha 6 0.0320574
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0320282
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0309197
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.030115
DOCK4 dedicator of cytokinesis 4 0.0298379
ZNF638 zinc finger protein 638 0.0292164
UBA6 ubiquitin-like modifier activating enzyme 6 0.0291178
MYO10 myosin X 0.0290982
RPS2 ribosomal protein S2 0.0289149
C2CD2 C2 calcium-dependent domain containing 2 0.0286612
CALD1 caldesmon 1 0.0275548
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.027025
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0267195
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0266653
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0258802
SAMD4A sterile alpha motif domain containing 4A 0.0256698
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0251725
NTM neurotrimin 0.0249125
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0245884
PIBF1 progesterone immunomodulatory binding factor 1 0.0241944
ENO1 enolase 1, (alpha) 0.0236952
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0235697
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0232179
FER fer (fps/fes related) tyrosine kinase 0.0230973
GPHN gephyrin 0.0229087
ARHGAP21 Rho GTPase activating protein 21 0.0218251
EFNA5 ephrin-A5 0.0217167
ANTXR2 anthrax toxin receptor 2 0.0215005
BZW1 basic leucine zipper and W2 domains 1 0.0211715
ARFGEF3 ARFGEF family member 3 0.0210052
RND3 Rho family GTPase 3 0.020796
SET SET nuclear proto-oncogene 0.0207603
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0205973
TPM3 tropomyosin 3 0.0205636
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0201997
HAS2 hyaluronan synthase 2 0.0199417
LIMCH1 LIM and calponin homology domains 1 0.0195224
ZEB1 zinc finger E-box binding homeobox 1 0.0195066
BPTF bromodomain PHD finger transcription factor 0.0193027
EIF5B eukaryotic translation initiation factor 5B 0.0189849
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0187659
HEG1 heart development protein with EGF-like domains 1 0.0186907
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0186361
GRAMD1B GRAM domain containing 1B 0.0184572
ZCCHC7 zinc finger, CCHC domain containing 7 0.0184164
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0182693
RABGAP1L RAB GTPase activating protein 1-like 0.0180837
NALF1 NALCN channel auxiliary factor 1 0.0178407
PACS1 phosphofurin acidic cluster sorting protein 1 0.0175773
DGKI diacylglycerol kinase, iota 0.0175254
KDM7A lysine (K)-specific demethylase 7A 0.0173472
MAP2K1 mitogen-activated protein kinase kinase 1 0.0173115
MSN moesin 0.0169084
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0167626
ARHGAP18 Rho GTPase activating protein 18 0.0165317
KTN1 kinectin 1 (kinesin receptor) 0.0157046
SPATS2 spermatogenesis associated, serine-rich 2 0.0155675
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0155568
ADTRP androgen-dependent TFPI-regulating protein 0.0151874
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0150242
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0149533
PTPRD protein tyrosine phosphatase, receptor type, D 0.0144695
TTC3 tetratricopeptide repeat domain 3 0.0144104
HSPA8 heat shock 70kDa protein 8 0.0142839
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0142666
JMJD1C jumonji domain containing 1C 0.0142121
RSL1D1 ribosomal L1 domain containing 1 0.014206
RNMT RNA (guanine-7-) methyltransferase 0.0141013
EXOC2 exocyst complex component 2 0.0138406

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.299938
TMSB10 thymosin beta 10 -0.106646
GPC6 glypican 6 -0.0711132
FNDC3B fibronectin type III domain containing 3B -0.0643342
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0624389
VCL vinculin -0.0619723
ACTG1 actin gamma 1 -0.0549633
FTL ferritin, light polypeptide -0.0505307
PTMA prothymosin, alpha -0.0458052
PDE4D phosphodiesterase 4D, cAMP-specific -0.0437321
TRIO trio Rho guanine nucleotide exchange factor -0.0421289
RTN4 reticulon 4 -0.0414417
SMAD3 SMAD family member 3 -0.0376307
CD44 CD44 molecule (Indian blood group) -0.0363814
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0325688
FN1 fibronectin 1 -0.0321087
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0311712
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0310514
RPL23 ribosomal protein L23 -0.0300302
RPS21 ribosomal protein S21 -0.0298866
RPS23 ribosomal protein S23 -0.0298464
TPT1 tumor protein, translationally-controlled 1 -0.0291693
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0290963
ALCAM activated leukocyte cell adhesion molecule -0.0287697
CTSB cathepsin B -0.0286376
ANXA2 annexin A2 -0.0286266
RPLP2 ribosomal protein, large, P2 -0.0283863
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0282622
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0279058
UBC ubiquitin C -0.0275882
RBM39 RNA binding motif protein 39 -0.0274868
LPP LIM domain containing preferred translocation partner in lipoma -0.0272943
FLNA filamin A, alpha -0.0257348
PTCHD4 patched domain containing 4 -0.0257219
RIGI RNA sensor RIG-I -0.0256832
TNNC1 troponin C type 1 (slow) -0.0256443
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0256024
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0256007
MYOF myoferlin -0.0250372
NDRG1 N-myc downstream regulated 1 -0.0249339
CD109 CD109 molecule -0.024255
TRPS1 trichorhinophalangeal syndrome I -0.0238776
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0237137
DIAPH3 diaphanous-related formin 3 -0.0235378
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0232378
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0231139
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0230194
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0229581
BNC2 basonuclin 2 -0.0227063
ATXN1 ataxin 1 -0.0227019
WAC WW domain containing adaptor with coiled-coil -0.022525
EGR1 early growth response 1 -0.022502
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0220372
LOC112694756 uncharaterized LOC112694756 -0.0219397
RPS24 ribosomal protein S24 -0.0217299
KLF6 Kruppel-like factor 6 -0.0215364
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0212872
ZFAND3 zinc finger, AN1-type domain 3 -0.0211341
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0210267
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0209172
RPL32 ribosomal protein L32 -0.0208058
H1-0 H1.0 linker histone -0.0206725
RPS27A ribosomal protein S27a -0.0205571
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0204646
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0202937
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0202159
UGCG UDP-glucose ceramide glucosyltransferase -0.020076
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0199622
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0198251
RPS19 ribosomal protein S19 -0.019748
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0195724
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0194185
SBF2 SET binding factor 2 -0.0193941
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0193571
RPS13 ribosomal protein S13 -0.0193346
HMGA1 high mobility group AT-hook 1 -0.0192812
NLGN1 neuroligin 1 -0.0189421
MED13L mediator complex subunit 13-like -0.0189344
RPL38 ribosomal protein L38 -0.0188471
ZNF217 zinc finger protein 217 -0.0184648
RPL35A ribosomal protein L35a -0.0180829
SLC38A2 solute carrier family 38, member 2 -0.0180085
MT2A metallothionein 2A -0.0178991
GNAS GNAS complex locus -0.0178611
RPL34 ribosomal protein L34 -0.0178062
ZNF292 zinc finger protein 292 -0.0176758
RAD21 RAD21 homolog (S. pombe) -0.0172483
MAP1B microtubule-associated protein 1B -0.017238
FRMD6 FERM domain containing 6 -0.0168601
CUL3 cullin 3 -0.0168312
OSMR oncostatin M receptor -0.0166077
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0165825
MARCHF6 membrane associated ring-CH-type finger 6 -0.0165824
RPL19 ribosomal protein L19 -0.0165761
TM4SF1 transmembrane 4 L six family member 1 -0.0165383
ZMYM2 zinc finger, MYM-type 2 -0.0163534
RPL36A ribosomal protein L36a -0.0163017
INTS6 integrator complex subunit 6 -0.0162752
TSC22D1 TSC22 domain family, member 1 -0.0162464
RPL27A ribosomal protein L27a -0.0162445