Berberine (chloride hydrate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.160853
PM20D1 peptidase M20 domain containing 1 0.149328
AKAP12 A kinase (PRKA) anchor protein 12 0.107476
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0745822
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0744364
POTEF POTE ankyrin domain family, member F 0.0645669
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0557597
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0548673
RBM39 RNA binding motif protein 39 0.0520115
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0515485
FTH1 ferritin, heavy polypeptide 1 0.0514071
ZFAND3 zinc finger, AN1-type domain 3 0.0513831
SMOC1 SPARC related modular calcium binding 1 0.0499574
ERRFI1 ERBB receptor feedback inhibitor 1 0.0468078
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0458766
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.04551
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0449457
TPM3 tropomyosin 3 0.0442846
CCNL1 cyclin L1 0.0437086
PDIA3 protein disulfide isomerase family A, member 3 0.0433816
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0431932
COPA coatomer protein complex, subunit alpha 0.0426121
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0413197
FGB fibrinogen beta chain 0.0404452
TRA2A transformer 2 alpha homolog (Drosophila) 0.0403883
ZSWIM6 zinc finger, SWIM-type containing 6 0.0395635
WAC WW domain containing adaptor with coiled-coil 0.0395241
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0388124
RNF145 ring finger protein 145 0.0386932
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0365837
PCBP2 poly(rC) binding protein 2 0.0365592
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0363863
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0361761
KIF5B kinesin family member 5B 0.0359492
GLS2 glutaminase 2 (liver, mitochondrial) 0.0359138
MCL1 myeloid cell leukemia 1 0.0354499
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0343897
RBM25 RNA binding motif protein 25 0.0342226
PDLIM5 PDZ and LIM domain 5 0.0336125
KTN1 kinectin 1 (kinesin receptor) 0.0323002
PDIA6 protein disulfide isomerase family A, member 6 0.0322312
SLC38A2 solute carrier family 38, member 2 0.0321324
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0321286
TFG TRK-fused gene 0.0318017
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0317703
WDR43 WD repeat domain 43 0.0314418
ZNF207 zinc finger protein 207 0.0313577
TFPI2 tissue factor pathway inhibitor 2 0.0311395
ELL2 elongation factor, RNA polymerase II, 2 0.0309189
FNDC3B fibronectin type III domain containing 3B 0.0302964
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0298279
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0296168
YBX1 Y box binding protein 1 0.0294405
WWOX WW domain containing oxidoreductase 0.0293457
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0287962
PRRC2C proline-rich coiled-coil 2C 0.0282106
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0281157
KMT2E lysine (K)-specific methyltransferase 2E 0.0278847
BRD2 bromodomain containing 2 0.027676
CALR calreticulin 0.027642
RICTOR RPTOR independent companion of MTOR, complex 2 0.0273383
CHD1 chromodomain helicase DNA binding protein 1 0.0272355
PUM1 pumilio RNA-binding family member 1 0.0270669
AKAP13 A kinase (PRKA) anchor protein 13 0.0270568
PUM2 pumilio RNA-binding family member 2 0.0267975
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0266998
NOP58 NOP58 ribonucleoprotein 0.0266994
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0266283
PARD3 par-3 family cell polarity regulator 0.0264988
NUP58 nucleoporin 58 0.0263905
BCLAF1 BCL2-associated transcription factor 1 0.0263229
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0259335
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0257441
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0256431
YBX3 Y box binding protein 3 0.0254128
UGCG UDP-glucose ceramide glucosyltransferase 0.0250992
VEZT vezatin, adherens junctions transmembrane protein 0.0249547
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0247064
ZNF292 zinc finger protein 292 0.0245661
MORF4L2 mortality factor 4 like 2 0.024416
ALCAM activated leukocyte cell adhesion molecule 0.0242158
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0240941
SFPQ splicing factor proline/glutamine-rich 0.0240462
GOLGA4 golgin A4 0.0239983
APLP2 amyloid beta (A4) precursor-like protein 2 0.0238858
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0233761
SRP54 signal recognition particle 54kDa 0.0233463
FXR1 fragile X mental retardation, autosomal homolog 1 0.023241
DSCAM Down syndrome cell adhesion molecule 0.0232012
RCOR1 REST corepressor 1 0.0230837
HELZ helicase with zinc finger 0.0230136
CSNK1A1 casein kinase 1, alpha 1 0.0230101
UBA6 ubiquitin-like modifier activating enzyme 6 0.0224323
FTO fat mass and obesity associated 0.0224117
AHR aryl hydrocarbon receptor 0.0223178
SPAG9 sperm associated antigen 9 0.0221442
RAB1A RAB1A, member RAS oncogene family 0.0220928
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0219956
FNBP1L formin binding protein 1-like 0.0219867
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0218236

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.301579
VIM vimentin -0.107845
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0781315
TMSB10 thymosin beta 10 -0.0739701
GRAMD1B GRAM domain containing 1B -0.0634065
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0608758
BICC1 BicC family RNA binding protein 1 -0.0588785
IER3 immediate early response 3 -0.0562068
THSD4 thrombospondin, type I, domain containing 4 -0.0512295
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0508964
ACTG1 actin gamma 1 -0.0504377
CAVIN1 caveolae associated protein 1 -0.0503095
HDAC9 histone deacetylase 9 -0.0398703
CMIP c-Maf inducing protein -0.038862
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0368586
TXNRD1 thioredoxin reductase 1 -0.0359453
FLNB filamin B, beta -0.0348378
TPT1 tumor protein, translationally-controlled 1 -0.0339862
ANGPTL4 angiopoietin-like 4 -0.031496
BABAM2 BRISC and BRCA1 A complex member 2 -0.0312209
PYGL phosphorylase, glycogen, liver -0.0311286
EGFR epidermal growth factor receptor -0.030667
STC1 stanniocalcin 1 -0.0296992
SOX4 SRY (sex determining region Y)-box 4 -0.0276614
ZMYND8 zinc finger, MYND-type containing 8 -0.0274226
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0263473
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.026087
AGO2 argonaute RISC catalytic component 2 -0.0258665
TRIO trio Rho guanine nucleotide exchange factor -0.0257878
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0255182
TPM4 tropomyosin 4 -0.0254559
ZFHX3 zinc finger homeobox 3 -0.0252144
SVIL supervillin -0.0246249
EGR1 early growth response 1 -0.0244765
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0241528
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0233925
C15ORF48 chromosome 15 open reading frame 48 -0.0232569
DGKD diacylglycerol kinase, delta 130kDa -0.0232237
STC2 stanniocalcin 2 -0.0227556
VDAC1 voltage-dependent anion channel 1 -0.0225919
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0222081
OSMR oncostatin M receptor -0.0219568
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0211051
RPL36 ribosomal protein L36 -0.0210949
SEPTIN10 septin 10 -0.0204199
PTPRF protein tyrosine phosphatase, receptor type, F -0.0203074
ACTN1 actinin, alpha 1 -0.0202634
TM4SF1 transmembrane 4 L six family member 1 -0.0202533
NPC1 Niemann-Pick disease, type C1 -0.0199198
IGF1R insulin-like growth factor 1 receptor -0.0196805
FOXP1 forkhead box P1 -0.019627
NTN4 netrin 4 -0.0190822
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0190184
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0183238
KIFC3 kinesin family member C3 -0.0182808
CD44 CD44 molecule (Indian blood group) -0.0182403
SQSTM1 sequestosome 1 -0.0180891
PTMA prothymosin, alpha -0.0180626
ATG7 autophagy related 7 -0.0178735
SMAD3 SMAD family member 3 -0.0178503
MAML3 mastermind-like 3 (Drosophila) -0.0178404
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0178283
NAV3 neuron navigator 3 -0.017584
AK1 adenylate kinase 1 -0.0175812
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0174655
EFNA5 ephrin-A5 -0.0173845
FTL ferritin, light polypeptide -0.0172692
RIN2 Ras and Rab interactor 2 -0.017216
DNMBP dynamin binding protein -0.0171288
RPS3 ribosomal protein S3 -0.0171256
RPS27A ribosomal protein S27a -0.0170935
NCEH1 neutral cholesterol ester hydrolase 1 -0.0168856
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0168055
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0167768
RPL31 ribosomal protein L31 -0.0165709
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0163311
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0162302
DOCK4 dedicator of cytokinesis 4 -0.0161783
IGFBP4 insulin-like growth factor binding protein 4 -0.0160844
SLC35F3 solute carrier family 35, member F3 -0.0159696
CUX1 cut-like homeobox 1 -0.0158459
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0157599
LARP1 La ribonucleoprotein domain family, member 1 -0.0156544
CFLAR CASP8 and FADD-like apoptosis regulator -0.0155232
DPYSL2 dihydropyrimidinase-like 2 -0.0154393
LOC112694756 uncharaterized LOC112694756 -0.0153888
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0152892
ZBTB20 zinc finger and BTB domain containing 20 -0.0152813
ATXN3 ataxin 3 -0.0147429
CHD9 chromodomain helicase DNA binding protein 9 -0.0146778
RPS8 ribosomal protein S8 -0.0146136
HMOX1 heme oxygenase 1 -0.0145224
TMEM131 transmembrane protein 131 -0.0144712
NEBL nebulette -0.0144266
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0144001
KAZN kazrin, periplakin interacting protein -0.0143638
SSH2 slingshot protein phosphatase 2 -0.0142695
DOCK5 dedicator of cytokinesis 5 -0.0140964
RHOA ras homolog family member A -0.013913
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0138298