| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Berberine (chloride hydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Berberine (chloride hydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0944977 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0859987 |
| KYNU | kynureninase | 0.0726239 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0682458 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0658404 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.065579 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0637957 |
| RIGI | RNA sensor RIG-I | 0.0624564 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0581539 |
| RBM39 | RNA binding motif protein 39 | 0.0580928 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0569682 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0565343 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0561483 |
| ASPH | aspartate beta-hydroxylase | 0.0554735 |
| MYO10 | myosin X | 0.0545613 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0539477 |
| EGFR | epidermal growth factor receptor | 0.0532675 |
| SMYD3 | SET and MYND domain containing 3 | 0.0529029 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0523884 |
| DST | dystonin | 0.0520373 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0519056 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0505647 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0505346 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0501822 |
| FAT1 | FAT atypical cadherin 1 | 0.049377 |
| PDE10A | phosphodiesterase 10A | 0.0485609 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0477388 |
| VCL | vinculin | 0.0472831 |
| ANO6 | anoctamin 6 | 0.0472188 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.046521 |
| PAPOLA | poly(A) polymerase alpha | 0.0465115 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0460163 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0445582 |
| EFNA5 | ephrin-A5 | 0.0443179 |
| VMP1 | vacuole membrane protein 1 | 0.0442279 |
| SMAD3 | SMAD family member 3 | 0.0439755 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0437916 |
| NABP1 | nucleic acid binding protein 1 | 0.0437911 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.043641 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0433927 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0418234 |
| ANXA2 | annexin A2 | 0.041623 |
| MED13L | mediator complex subunit 13-like | 0.0415976 |
| CD44 | CD44 molecule (Indian blood group) | 0.0414425 |
| ATP13A3 | ATPase type 13A3 | 0.0413059 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0412148 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0410371 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0403598 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0402645 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0395517 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0393645 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0393268 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0393033 |
| APP | amyloid beta (A4) precursor protein | 0.0392348 |
| HMGA2 | high mobility group AT-hook 2 | 0.0391728 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0385775 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0381127 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0379148 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0369941 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.036979 |
| OXR1 | oxidation resistance 1 | 0.036607 |
| TES | testin LIM domain protein | 0.0364547 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0363849 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0361396 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0361157 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0358537 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0356704 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0354763 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.035417 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.03505 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0347562 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0344704 |
| TOX3 | TOX high mobility group box family member 3 | 0.034198 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0339621 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.033946 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.0336224 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0335879 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0333863 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0333108 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.033164 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.033124 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0330433 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0329636 |
| CWF19L2 | CWF19-like 2, cell cycle control (S. pombe) | 0.0329622 |
| YTHDC1 | YTH domain containing 1 | 0.0326938 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0322951 |
| EHBP1 | EH domain binding protein 1 | 0.0322121 |
| ANXA5 | annexin A5 | 0.031966 |
| ECT2 | epithelial cell transforming 2 | 0.0312793 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0311944 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0311798 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0310862 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0310337 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0309573 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0309221 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0308056 |
| RASA2 | RAS p21 protein activator 2 | 0.0306135 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0306128 |
| WWOX | WW domain containing oxidoreductase | 0.0305092 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.030429 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.26367 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.138172 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.127069 |
| ATOSA | atos homolog A | -0.125612 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.108902 |
| KRT17 | keratin 17, type I | -0.0919959 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0896904 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0884596 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0873026 |
| LAMC2 | laminin, gamma 2 | -0.0768259 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0706059 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0704358 |
| ANTXR2 | anthrax toxin receptor 2 | -0.068494 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0673963 |
| STC1 | stanniocalcin 1 | -0.0631072 |
| LMO7 | LIM domain 7 | -0.0627349 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.060765 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.060585 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.06044 |
| SVIL | supervillin | -0.0604252 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0585965 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0583145 |
| LAMB3 | laminin, beta 3 | -0.0582799 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0569238 |
| RAI14 | retinoic acid induced 14 | -0.0551294 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0545347 |
| CSTB | cystatin B (stefin B) | -0.0537161 |
| ABHD17C | abhydrolase domain containing 17C | -0.052646 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0516053 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0512093 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0497068 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0492857 |
| MUC16 | mucin 16, cell surface associated | -0.0482298 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0480814 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.047231 |
| CLMP | CXADR-like membrane protein | -0.0458633 |
| RPL19 | ribosomal protein L19 | -0.0454529 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0448319 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0434511 |
| FOXO3 | forkhead box O3 | -0.043224 |
| RCOR1 | REST corepressor 1 | -0.0428809 |
| S100A9 | S100 calcium binding protein A9 | -0.0425041 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0420148 |
| NDRG1 | N-myc downstream regulated 1 | -0.0417791 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0416966 |
| ITGB4 | integrin, beta 4 | -0.0415 |
| GPC6 | glypican 6 | -0.0412091 |
| MCL1 | myeloid cell leukemia 1 | -0.0411583 |
| TMSB10 | thymosin beta 10 | -0.0410349 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0407887 |
| BTBD10 | BTB (POZ) domain containing 10 | -0.0403551 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0392814 |
| CCNI | cyclin I | -0.0387368 |
| THOC2 | THO complex 2 | -0.0381092 |
| IRS2 | insulin receptor substrate 2 | -0.0379991 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0379212 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.037536 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0370501 |
| HLA-B | major histocompatibility complex, class I, B | -0.037028 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0368789 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0367674 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.036463 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | -0.0360754 |
| NHSL1 | NHS-like 1 | -0.0359463 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0356735 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0355297 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0354467 |
| SBF2 | SET binding factor 2 | -0.03535 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0352848 |
| RREB1 | ras responsive element binding protein 1 | -0.0347192 |
| RBM47 | RNA binding motif protein 47 | -0.0343882 |
| DIAPH1 | diaphanous-related formin 1 | -0.034338 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0337821 |
| KLF6 | Kruppel-like factor 6 | -0.0335931 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0335794 |
| WASF2 | WAS protein family, member 2 | -0.0335422 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0334707 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0333873 |
| USP53 | ubiquitin specific peptidase 53 | -0.0332328 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0330359 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0328579 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0328483 |
| FTL | ferritin, light polypeptide | -0.0323571 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0322687 |
| VIM | vimentin | -0.0320384 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0318191 |
| CDK14 | cyclin-dependent kinase 14 | -0.0316426 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0314998 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.03133 |
| RAD51B | RAD51 paralog B | -0.0313249 |
| RPLP1 | ribosomal protein, large, P1 | -0.0312964 |
| H3-3B | H3.3 histone B | -0.0312737 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0312449 |
| CA2 | carbonic anhydrase II | -0.0312095 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0311384 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0310712 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.031068 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.0309126 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0307851 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0303112 |
