Berberine (chloride hydrate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.16191
ERRFI1 ERBB receptor feedback inhibitor 1 0.112905
GRAMD1B GRAM domain containing 1B 0.107487
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0671661
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0603623
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0513325
TAS2R14 taste receptor, type 2, member 14 0.0482243
THSD4 thrombospondin, type I, domain containing 4 0.0474715
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0470282
PDE4D phosphodiesterase 4D, cAMP-specific 0.0444113
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0397482
ZNF638 zinc finger protein 638 0.0392003
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0382379
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0381594
EXOC4 exocyst complex component 4 0.038158
IGF1R insulin-like growth factor 1 receptor 0.0365653
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0354966
PRKCE protein kinase C, epsilon 0.0339303
AFF3 AF4/FMR2 family, member 3 0.0338922
PDE10A phosphodiesterase 10A 0.033868
ZFAND3 zinc finger, AN1-type domain 3 0.0328724
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0321423
RIMS2 regulating synaptic membrane exocytosis 2 0.0318475
TPM3 tropomyosin 3 0.0315633
HMGA2 high mobility group AT-hook 2 0.0304971
ELL2 elongation factor, RNA polymerase II, 2 0.0296744
MCL1 myeloid cell leukemia 1 0.0292903
ATP11A ATPase, class VI, type 11A 0.0290862
SMYD3 SET and MYND domain containing 3 0.0290724
FMNL2 formin-like 2 0.0287425
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0285312
PRELID2 PRELI domain containing 2 0.0278121
MACF1 microtubule-actin crosslinking factor 1 0.0272905
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0268601
YAP1 Yes-associated protein 1 0.0264952
NF1 neurofibromin 1 0.0261669
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0261587
DST dystonin 0.0261235
RERE arginine-glutamic acid dipeptide (RE) repeats 0.025989
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0259105
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0253842
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0247666
WWOX WW domain containing oxidoreductase 0.0244166
WDR70 WD repeat domain 70 0.0243859
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0242566
RICTOR RPTOR independent companion of MTOR, complex 2 0.0241793
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0241782
ZBTB20 zinc finger and BTB domain containing 20 0.023904
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0237091
AHNAK AHNAK nucleoprotein 0.0235181
EXOC6B exocyst complex component 6B 0.0234818
TBC1D5 TBC1 domain family, member 5 0.0233963
PDLIM5 PDZ and LIM domain 5 0.0232641
RAD51B RAD51 paralog B 0.0228105
TRIO trio Rho guanine nucleotide exchange factor 0.0224409
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0219044
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0217762
USP34 ubiquitin specific peptidase 34 0.0212799
RABGAP1L RAB GTPase activating protein 1-like 0.021187
TXNRD1 thioredoxin reductase 1 0.020975
RBM39 RNA binding motif protein 39 0.0209382
NABP1 nucleic acid binding protein 1 0.0205353
PTK2 protein tyrosine kinase 2 0.0204847
ANKRD36 ankyrin repeat domain 36 0.0203594
WNK1 WNK lysine deficient protein kinase 1 0.0203471
DNAH14 dynein, axonemal, heavy chain 14 0.0203401
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0202377
OSMR oncostatin M receptor 0.0200553
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0195622
PYGL phosphorylase, glycogen, liver 0.0194595
ANO6 anoctamin 6 0.0193611
PHF3 PHD finger protein 3 0.0192345
CCDC91 coiled-coil domain containing 91 0.0188127
SENP6 SUMO1/sentrin specific peptidase 6 0.0186947
MED13L mediator complex subunit 13-like 0.0186432
DOCK5 dedicator of cytokinesis 5 0.0182692
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0181338
VMP1 vacuole membrane protein 1 0.0180476
DOCK1 dedicator of cytokinesis 1 0.0180437
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0175598
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0175296
DSPP dentin sialophosphoprotein 0.0171935
JMJD1C jumonji domain containing 1C 0.0171501
AEBP2 AE binding protein 2 0.0170931
LRPPRC leucine-rich pentatricopeptide repeat containing 0.016933
HSPA8 heat shock 70kDa protein 8 0.0168898
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0168135
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0167883
MYH9 myosin, heavy chain 9, non-muscle 0.0166882
BICD1 bicaudal D homolog 1 (Drosophila) 0.0166533
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0163447
JAK1 Janus kinase 1 0.0163009
EHBP1 EH domain binding protein 1 0.0162055
PATJ PATJ crumbs cell polarity complex component 0.0161172
MBD5 methyl-CpG binding domain protein 5 0.0159773
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0159055
PRH1 proline-rich protein HaeIII subfamily 1 0.0158982
FNDC3B fibronectin type III domain containing 3B 0.0158844
CAPRIN2 caprin family member 2 0.0157819
UBAP2L ubiquitin associated protein 2-like 0.015717

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.284182
TMSB10 thymosin beta 10 -0.13924
PTMA prothymosin, alpha -0.1173
VIM vimentin -0.0970212
TPI1 triosephosphate isomerase 1 -0.0941739
RPS3 ribosomal protein S3 -0.086415
RPL23 ribosomal protein L23 -0.068227
RPS8 ribosomal protein S8 -0.0619478
RPL37 ribosomal protein L37 -0.0547132
RPL35A ribosomal protein L35a -0.0545456
RPLP1 ribosomal protein, large, P1 -0.0519615
TFPI2 tissue factor pathway inhibitor 2 -0.0518097
PFN1 profilin 1 -0.0517186
RPS21 ribosomal protein S21 -0.0510952
RPL12 ribosomal protein L12 -0.0491665
MT2A metallothionein 2A -0.0473447
RPS12 ribosomal protein S12 -0.0472373
RPS19 ribosomal protein S19 -0.0472325
RPL37A ribosomal protein L37a -0.0461679
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0450109
ACTG1 actin gamma 1 -0.0446547
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0437795
RPL26 ribosomal protein L26 -0.0432831
FTL ferritin, light polypeptide -0.0425118
MYL12B myosin, light chain 12B, regulatory -0.0412644
RPS27 ribosomal protein S27 -0.0387783
RPS4X ribosomal protein S4, X-linked -0.0379102
RPL32 ribosomal protein L32 -0.0371828
RPLP0 ribosomal protein, large, P0 -0.0363954
RPL36 ribosomal protein L36 -0.0363684
EGR1 early growth response 1 -0.0363289
TPT1 tumor protein, translationally-controlled 1 -0.0358394
RPL8 ribosomal protein L8 -0.0356944
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0356645
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0347407
RPL19 ribosomal protein L19 -0.0336863
CSDE1 cold shock domain containing E1, RNA-binding -0.0335383
RPS29 ribosomal protein S29 -0.0333068
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0332852
RPLP2 ribosomal protein, large, P2 -0.0322341
RPS15 ribosomal protein S15 -0.0320263
NAP1L1 nucleosome assembly protein 1-like 1 -0.0313596
EIF1 eukaryotic translation initiation factor 1 -0.0312504
RPL11 ribosomal protein L11 -0.0308981
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0305513
EEF2 eukaryotic translation elongation factor 2 -0.030355
RPL34 ribosomal protein L34 -0.0303003
LOC102724023 ES1 protein homolog, mitochondrial -0.0298304
RPL31 ribosomal protein L31 -0.0296142
HLA-B major histocompatibility complex, class I, B -0.0284586
RPS6 ribosomal protein S6 -0.0282332
RPL5 ribosomal protein L5 -0.0278226
RACK1 receptor for activated C kinase 1 -0.0276695
EIF5B eukaryotic translation initiation factor 5B -0.0274796
RPS14 ribosomal protein S14 -0.0266815
RPS17 ribosomal protein S17 -0.0266265
RPS27A ribosomal protein S27a -0.0264484
ATP5F1E ATP synthase F1 subunit epsilon -0.0264259
RPS10 ribosomal protein S10 -0.0262911
RPL9 ribosomal protein L9 -0.0261011
GSTP1 glutathione S-transferase pi 1 -0.0257215
LDHB lactate dehydrogenase B -0.0256507
UBC ubiquitin C -0.024887
NACA nascent polypeptide-associated complex alpha subunit -0.0248525
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0247387
HMGA1 high mobility group AT-hook 1 -0.0246691
RPL28 ribosomal protein L28 -0.0242899
RPL18 ribosomal protein L18 -0.0240578
RPL35 ribosomal protein L35 -0.0238537
H3-3B H3.3 histone B -0.0232502
IFI6 interferon, alpha-inducible protein 6 -0.0231797
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0227608
OAZ1 ornithine decarboxylase antizyme 1 -0.0223113
KRT18 keratin 18, type I -0.0220614
RPS24 ribosomal protein S24 -0.0212323
S100A11 S100 calcium binding protein A11 -0.0210459
TUBA1B tubulin, alpha 1b -0.0208742
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0205786
CBX3 chromobox homolog 3 -0.0204921
B2M beta-2-microglobulin -0.0204849
RPS23 ribosomal protein S23 -0.0200203
RPS13 ribosomal protein S13 -0.0199442
RPL36A ribosomal protein L36a -0.0197029
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0196436
KPNB1 karyopherin (importin) beta 1 -0.0194669
TPM2 tropomyosin 2 (beta) -0.019211
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0190156
GPX4 glutathione peroxidase 4 -0.0187802
RPS25 ribosomal protein S25 -0.018693
TAGLN2 transgelin 2 -0.0186367
AHCYL1 adenosylhomocysteinase-like 1 -0.0185204
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0184076
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0183324
S100A6 S100 calcium binding protein A6 -0.0178259
PTPRF protein tyrosine phosphatase, receptor type, F -0.0173015
RPL30 ribosomal protein L30 -0.0172365
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0169133
PA2G4 proliferation-associated 2G4, 38kDa -0.0168191
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0167552
RPL13A ribosomal protein L13a -0.0166692