| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Berberine (chloride hydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Berberine (chloride hydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.33718 |
| POTEF | POTE ankyrin domain family, member F | 0.169997 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.101691 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.101281 |
| CANX | calnexin | 0.0995985 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0841994 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0681329 |
| RPS6 | ribosomal protein S6 | 0.0674033 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0559056 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0542785 |
| TPM4 | tropomyosin 4 | 0.0532046 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0466819 |
| DSPP | dentin sialophosphoprotein | 0.0466709 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0455521 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0455081 |
| TMSB4X | thymosin beta 4, X-linked | 0.0447604 |
| RPLP1 | ribosomal protein, large, P1 | 0.0446744 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0427142 |
| GOLGA4 | golgin A4 | 0.0409532 |
| TMF1 | TATA element modulatory factor 1 | 0.0402754 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0392616 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0387952 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0381084 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0379744 |
| CEP350 | centrosomal protein 350kDa | 0.037713 |
| RPS2 | ribosomal protein S2 | 0.0369013 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0362095 |
| RPL35A | ribosomal protein L35a | 0.0360035 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0359687 |
| GOLGB1 | golgin B1 | 0.0357255 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0342886 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0328771 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0328545 |
| FNIP1 | folliculin interacting protein 1 | 0.0314519 |
| FBXO32 | F-box protein 32 | 0.0313349 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0306475 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0303284 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0302465 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0293647 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0292755 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0284152 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0274835 |
| KLHL24 | kelch-like family member 24 | 0.0269822 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0265373 |
| RPL37A | ribosomal protein L37a | 0.0260238 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0259908 |
| RACK1 | receptor for activated C kinase 1 | 0.0255332 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0255011 |
| LMO7 | LIM domain 7 | 0.0253333 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0249872 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0242366 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0239193 |
| RPL31 | ribosomal protein L31 | 0.0235131 |
| RPS12 | ribosomal protein S12 | 0.0232815 |
| DSTN | destrin (actin depolymerizing factor) | 0.0231541 |
| VIRMA | vir like m6A methyltransferase associated | 0.0230638 |
| RAI14 | retinoic acid induced 14 | 0.0227733 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0226493 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0225032 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0222477 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0221937 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0221113 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0218312 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0217797 |
| SERINC5 | serine incorporator 5 | 0.0217326 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0216047 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0215816 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0215404 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0215064 |
| EFNA5 | ephrin-A5 | 0.0212619 |
| FBXO11 | F-box protein 11 | 0.0210908 |
| RPL7 | ribosomal protein L7 | 0.0210624 |
| VEGFA | vascular endothelial growth factor A | 0.0210302 |
| TPR | translocated promoter region, nuclear basket protein | 0.0210078 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0203403 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0203325 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0202388 |
| GPATCH8 | G patch domain containing 8 | 0.0200138 |
| RPS8 | ribosomal protein S8 | 0.0199699 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0199301 |
| CAVIN1 | caveolae associated protein 1 | 0.019714 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0196742 |
| RAB1A | RAB1A, member RAS oncogene family | 0.019584 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0195775 |
| SNX6 | sorting nexin 6 | 0.019554 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0194997 |
| USP53 | ubiquitin specific peptidase 53 | 0.0194611 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0194577 |
| TAOK1 | TAO kinase 1 | 0.019433 |
| JMJD1C | jumonji domain containing 1C | 0.0193237 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0192617 |
| RAB5A | RAB5A, member RAS oncogene family | 0.0190704 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0189504 |
| RAB10 | RAB10, member RAS oncogene family | 0.0188918 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0186458 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | 0.0185831 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0184682 |
| HMGB2 | high mobility group box 2 | 0.0184086 |
| FNBP1L | formin binding protein 1-like | 0.0183491 |
| SET | SET nuclear proto-oncogene | 0.0183028 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.255841 |
| UBC | ubiquitin C | -0.2078 |
| NDRG1 | N-myc downstream regulated 1 | -0.203793 |
| TMSB10 | thymosin beta 10 | -0.145927 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0876674 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0856005 |
| HMGA1 | high mobility group AT-hook 1 | -0.0852194 |
| MT2A | metallothionein 2A | -0.0841234 |
| S100A6 | S100 calcium binding protein A6 | -0.080362 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0723667 |
| G0S2 | G0/G1 switch 2 | -0.0707132 |
| ASPH | aspartate beta-hydroxylase | -0.0698855 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.068417 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.062443 |
| KRT7 | keratin 7, type II | -0.0556559 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0551793 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0517659 |
| PCBP2 | poly(rC) binding protein 2 | -0.0504798 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0487186 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0479561 |
| ENO1 | enolase 1, (alpha) | -0.0473566 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.041899 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0409162 |
| FLNA | filamin A, alpha | -0.0402214 |
| PLEC | plectin | -0.0400193 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0398633 |
| LAMC2 | laminin, gamma 2 | -0.0393449 |
| RPS27A | ribosomal protein S27a | -0.0386943 |
| SDC4 | syndecan 4 | -0.03858 |
| FTL | ferritin, light polypeptide | -0.0380883 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0373595 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0367797 |
| RHOA | ras homolog family member A | -0.0365205 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0354724 |
| NAV2 | neuron navigator 2 | -0.0354322 |
| AREG | amphiregulin | -0.0336312 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0332749 |
| FAM162A | family with sequence similarity 162, member A | -0.0326987 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0322669 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0312119 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0311192 |
| S100A10 | S100 calcium binding protein A10 | -0.0307574 |
| FAM3C | family with sequence similarity 3, member C | -0.0305553 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0305233 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0302651 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0300453 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0298929 |
| RUNX1 | runt-related transcription factor 1 | -0.0295607 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0293691 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0291799 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0287309 |
| CLDN4 | claudin 4 | -0.0283916 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0282033 |
| FHIT | fragile histidine triad | -0.0277272 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0276549 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0273319 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0270639 |
| TUBA1B | tubulin, alpha 1b | -0.0268832 |
| TAGLN2 | transgelin 2 | -0.0268311 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0268266 |
| CD47 | CD47 molecule | -0.02667 |
| RYBP | RING1 and YY1 binding protein | -0.0265365 |
| CTSB | cathepsin B | -0.0262144 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.025165 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0250402 |
| ZNF292 | zinc finger protein 292 | -0.0248008 |
| ACTN4 | actinin, alpha 4 | -0.0246892 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.024133 |
| RHEB | Ras homolog enriched in brain | -0.0240169 |
| CCNI | cyclin I | -0.023978 |
| PGK1 | phosphoglycerate kinase 1 | -0.0239705 |
| RPS23 | ribosomal protein S23 | -0.0235027 |
| PFN1 | profilin 1 | -0.0234848 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0234541 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0233516 |
| KLF6 | Kruppel-like factor 6 | -0.0232516 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0230591 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0229975 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0227531 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0225795 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.022093 |
| FOSL1 | FOS-like antigen 1 | -0.0220116 |
| PLSCR1 | phospholipid scramblase 1 | -0.0219652 |
| MSN | moesin | -0.0219459 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0218477 |
| TAPBP | TAP binding protein (tapasin) | -0.0216567 |
| TXNRD1 | thioredoxin reductase 1 | -0.0212618 |
| IFI44L | interferon-induced protein 44-like | -0.0212251 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0210854 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0210497 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0210262 |
| CCNL1 | cyclin L1 | -0.0210229 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0208151 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0205863 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0204188 |
| RPL32 | ribosomal protein L32 | -0.020393 |
| GPX4 | glutathione peroxidase 4 | -0.0203585 |
| ADAR | adenosine deaminase, RNA-specific | -0.0201737 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | -0.0201295 |
| CDK17 | cyclin-dependent kinase 17 | -0.0200965 |
