| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Berberine (chloride hydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Berberine (chloride hydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.171741 |
| DST | dystonin | 0.100922 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0779259 |
| PDE10A | phosphodiesterase 10A | 0.0694524 |
| KYNU | kynureninase | 0.0666511 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0639007 |
| INTS6 | integrator complex subunit 6 | 0.059903 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0594354 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0526 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0492447 |
| VCL | vinculin | 0.0482948 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0475512 |
| FMNL2 | formin-like 2 | 0.047463 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0436566 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0418829 |
| GRAMD1B | GRAM domain containing 1B | 0.0417739 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0412592 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0389032 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0366721 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0336985 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0333221 |
| DNER | delta/notch-like EGF repeat containing | 0.0325822 |
| MCL1 | myeloid cell leukemia 1 | 0.0321924 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0318855 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0314979 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0310803 |
| COPA | coatomer protein complex, subunit alpha | 0.0309567 |
| EPHA4 | EPH receptor A4 | 0.0307752 |
| CTBP2 | C-terminal binding protein 2 | 0.0307586 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0307463 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0305099 |
| PCBP2 | poly(rC) binding protein 2 | 0.0305068 |
| NUP58 | nucleoporin 58 | 0.0303869 |
| FLNB | filamin B, beta | 0.0296797 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0291579 |
| HELZ | helicase with zinc finger | 0.0277741 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0277704 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0276039 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0274377 |
| SPAG9 | sperm associated antigen 9 | 0.0272506 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0266181 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0261658 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0259961 |
| POTEF | POTE ankyrin domain family, member F | 0.0258358 |
| ZNF638 | zinc finger protein 638 | 0.0255827 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0251603 |
| SMAD2 | SMAD family member 2 | 0.0250722 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0242698 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0242452 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0231253 |
| CDC73 | cell division cycle 73 | 0.0227242 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0224188 |
| RBM39 | RNA binding motif protein 39 | 0.022406 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0223607 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0221992 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0218296 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0216985 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0214877 |
| PTEN | phosphatase and tensin homolog | 0.0212132 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0212012 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0211511 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0207307 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0206372 |
| RNF145 | ring finger protein 145 | 0.0202901 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0197752 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0196879 |
| RCOR1 | REST corepressor 1 | 0.0194636 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.019425 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0193984 |
| USP53 | ubiquitin specific peptidase 53 | 0.0193752 |
| GPC6 | glypican 6 | 0.0192571 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0192094 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0190917 |
| TOP1 | topoisomerase (DNA) I | 0.0190751 |
| EZR | ezrin | 0.0189241 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0188838 |
| SPOPL | speckle-type POZ protein-like | 0.0188799 |
| CUL3 | cullin 3 | 0.018764 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0183352 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0181577 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.018088 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0180208 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0179595 |
| MORF4L2 | mortality factor 4 like 2 | 0.0177932 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.0177785 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0177395 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0175966 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0174397 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0172995 |
| DOCK4 | dedicator of cytokinesis 4 | 0.017243 |
| NBAS | neuroblastoma amplified sequence | 0.0171826 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0171533 |
| ERBIN | erbb2 interacting protein | 0.0170969 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0169198 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0169157 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0167852 |
| FNDC3B | fibronectin type III domain containing 3B | 0.016655 |
| NRXN3 | neurexin 3 | 0.0166366 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0166343 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0165567 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.275118 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.15362 |
| VIM | vimentin | -0.147142 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.126455 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.122415 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.104588 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.102821 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.101764 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.101407 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.100218 |
| CDH13 | cadherin 13 | -0.0800684 |
| RPS12 | ribosomal protein S12 | -0.0795217 |
| TMSB10 | thymosin beta 10 | -0.0759975 |
| RPS6 | ribosomal protein S6 | -0.0739642 |
| PTMA | prothymosin, alpha | -0.0697631 |
| EFNA5 | ephrin-A5 | -0.0680387 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0680077 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0680007 |
| CTSL | cathepsin L | -0.0650533 |
| RPL26 | ribosomal protein L26 | -0.0628498 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.062125 |
| COL5A2 | collagen, type V, alpha 2 | -0.0617405 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0607598 |
| NRCAM | neuronal cell adhesion molecule | -0.0597866 |
| INHBA | inhibin, beta A | -0.0595365 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0580425 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0557042 |
| PCBP3 | poly(rC) binding protein 3 | -0.0554276 |
| PGK1 | phosphoglycerate kinase 1 | -0.0551494 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0550232 |
| RPS3 | ribosomal protein S3 | -0.0532988 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0532348 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0530693 |
| RPL37A | ribosomal protein L37a | -0.0529731 |
| HLA-B | major histocompatibility complex, class I, B | -0.0525614 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0524185 |
| ENO1 | enolase 1, (alpha) | -0.0521622 |
| RPL31 | ribosomal protein L31 | -0.0519049 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.051287 |
| CD109 | CD109 molecule | -0.0509846 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0498065 |
| RPS8 | ribosomal protein S8 | -0.0487915 |
| SMYD3 | SET and MYND domain containing 3 | -0.0472204 |
| TBXT | T-box transcription factor T | -0.0466597 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0461599 |
| RPS24 | ribosomal protein S24 | -0.0454981 |
| BMERB1 | bMERB domain containing 1 | -0.0444678 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0443297 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.043798 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0435657 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0428617 |
| S100A6 | S100 calcium binding protein A6 | -0.0413781 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0407016 |
| RPLP1 | ribosomal protein, large, P1 | -0.0405198 |
| RPL12 | ribosomal protein L12 | -0.0399409 |
| RPL35A | ribosomal protein L35a | -0.0395076 |
| RPL9 | ribosomal protein L9 | -0.0391172 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0389337 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0387196 |
| OSMR | oncostatin M receptor | -0.0386945 |
| B2M | beta-2-microglobulin | -0.0386755 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0386371 |
| LAMB1 | laminin, beta 1 | -0.0383789 |
| RPS27A | ribosomal protein S27a | -0.038055 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0379003 |
| TXNRD1 | thioredoxin reductase 1 | -0.0374956 |
| NCKAP5 | NCK-associated protein 5 | -0.0372456 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.03644 |
| RPL37 | ribosomal protein L37 | -0.0364304 |
| PRSS23 | protease, serine, 23 | -0.0359826 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0356566 |
| RPL36A | ribosomal protein L36a | -0.0345327 |
| TPM4 | tropomyosin 4 | -0.0344589 |
| PYGL | phosphorylase, glycogen, liver | -0.0343234 |
| STC1 | stanniocalcin 1 | -0.0338791 |
| RPS19 | ribosomal protein S19 | -0.0334752 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0327577 |
| ASPH | aspartate beta-hydroxylase | -0.0326465 |
| RPL34 | ribosomal protein L34 | -0.0323209 |
| GPRIN3 | GPRIN family member 3 | -0.0320934 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0310016 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0309043 |
| RACK1 | receptor for activated C kinase 1 | -0.0306924 |
| TMSB4X | thymosin beta 4, X-linked | -0.0305778 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0296669 |
| RPS27 | ribosomal protein S27 | -0.029539 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0294775 |
| CANX | calnexin | -0.0290122 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0289896 |
| RPL23 | ribosomal protein L23 | -0.0289634 |
| RPS17 | ribosomal protein S17 | -0.0288727 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0288723 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0286402 |
| PTGR1 | prostaglandin reductase 1 | -0.0282609 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0282272 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0280953 |
| TENM3 | teneurin transmembrane protein 3 | -0.0280686 |
| CTSC | cathepsin C | -0.0277424 |
| HLA-A | major histocompatibility complex, class I, A | -0.027354 |
| FOXC1 | forkhead box C1 | -0.0264774 |
